Tumor suppressor genes.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Current Opinion in Genetics and Development

• Publication date

  1994-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0959-437X(94)90102-3PMID 8193533
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Apoptosis (the 1992 Frank Rose Memorial Lecture).

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• Thymocyte apoptosis induced by p53-dependent and independent pathways

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• Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

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• The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

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• Inhibition of DNA replication factor RPA by p53

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• Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea.

  1993cited by this paper
• Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

  1993cited by this paper
• A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

  1993cited by this paper
• The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication.

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• Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis.

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• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.

  1993cited by this paper
• Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

  1993cited by this paper
• The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein

  1993cited by this paper
• p53 binds to the TATA-binding protein-TATA complex.

  1993cited by this paper
• Identification of the von Hippel-Lindau disease tumor suppressor gene.

  1993cited by this paper
• Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.

  1993cited by this paper
• Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

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• Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F

  1993cited by this paper
• Physical interaction of the retinoblastoma protein with human D cyclins.

  1993cited by this paper
• Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

  1993cited by this paper
• Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

  1993cited by this paper
• Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

  1993cited by this paper
• Transcriptional repression by the Rb-related protein p107.

  1993cited by this paper
• Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

  1993cited by this paper
• Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

  1993cited by this paper
• TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest.

  1993cited by this paper
• Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

  1993cited by this paper
• The APC gene product in normal and tumor cells.

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
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  1993cited by this paper
• Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.

  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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  1993cited by this paper
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  1993cited by this paper
• Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

  1992cited by this paper
• Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein.

  1992cited by this paper
• A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

  1992cited by this paper
• Effects of an Rb mutation in the mouse

  1992cited by this paper
• Retinoblastoma protein switches the E2F site from positive to negative element

  1992cited by this paper
• Oncogenic forms of p53 inhibit p53-regulated gene expression.

  1992cited by this paper
• Wild-type p53 activates transcription in vitro

  1992cited by this paper
• Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

  1992cited by this paper
• Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

  1992cited by this paper
• Regulation of retinoblastoma protein functions by ectopic expression of human cyclins.

  1992cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• Requirement for a functional Rb-1 gene in murine development

  1992cited by this paper
• E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

  1992cited by this paper
• Corrections and Clarifications: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene

  1992cited by this paper
• Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

  1992cited by this paper
• Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

  1992cited by this paper
• Oncogenic forms of p53 inhibit p53-regulated gene expression

  1992cited by this paper
• Definition of a consensus binding site for p53

  1992cited by this paper
• The retinoblastoma protein and the regulation of cell cycling.

  1992cited by this paper
• The transcriptional transactivation function of wild‐type p53 is inhibited by SV40 large T‐antigen and by HPV‐16 E6 oncoprotein.

  1992cited by this paper
• Wild-type p53 binds to the TATA-binding protein and represses transcription.

  1992cited by this paper
• Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.

  1992cited by this paper
• Wilms' tumour: reconciling genetics and biology.

  1992cited by this paper
• Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

  1992cited by this paper
• Association of human cyclin E with a periodic G1-S phase protein kinase.

  1992cited by this paper
• Interaction between human cyclin A and adenovirus E1A-associated p107 protein.

  1992cited by this paper
• Erratum: Multiple Intestinal Neoplasia Caused By a Mutation in the Murine Homolog of the APC Gene

  1992cited by this paper
• A transcriptionally active DNA-binding site for human p53 protein complexes

  1992cited by this paper
• Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins.

  1992cited by this paper
• The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.

  1992cited by this paper
• Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

  1992cited by this paper
• Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

  1991cited by this paper
• Apoptosis: mechanisms and roles in pathology.

  1991cited by this paper
• Participation of p53 protein in the cellular response to DNA damage.

  1991cited by this paper

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