Functional Expression and Localization of P-glycoprotein in the Central Nervous System: Relevance to the Pathogenesis and Treatment of Neurological Disorders

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Pharmaceutical Research

• Publication date

  2004-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1023/B:PHAM.0000036905.82914.8ePMID 15359566
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors

  2006cited by this paper
• The multidrug-resistance gene MDR1 is expressed in human glial tumors

  2004cited by this paper
• Spontaneous multidrug transport in human glioma cells is regulated by transforming growth factors type β

  2004cited by this paper
• Multidrug Resistance Protein (MRP) 4- and MRP 5-Mediated Efflux of 9-(2-Phosphonylmethoxyethyl)adenine by Microglia

  2004cited by this paper
• Cellular localization and functional expression of P‐glycoprotein in rat astrocyte cultures

  2004cited by this paper
• Involvement of P-Glycoprotein in the Transport of Saquinavir and Indinavir in Rat Brain Microvessel Endothelial and Microglia Cell Lines

  2004cited by this paper
• Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas

  2004cited by this paper
• Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein.

  2003cited by this paper
• Expression and functional characterization of ABCG2 in brain endothelial cells and vessels

  2003cited by this paper
• P‐glycoprotein in blood CD4 cells of HIV‐1‐infected patients treated with protease inhibitors

  2003cited by this paper
• The effects of protease inhibitors and nonnucleoside reverse transcriptase inhibitors on p-glycoprotein expression in peripheral blood mononuclear cells in vitro.

  2003cited by this paper
• Human immunodeficiency virus-associated dementia: An evolving disease

  2003cited by this paper
• P-Glycoprotein Expression by Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Patients Is Independent from Response to Highly Active Antiretroviral Therapy

  2003cited by this paper
• Proceedings of the Anatomical Society of Great Britain and Ireland

  2003cited by this paper
• Functional Expression of the Multidrug Resistance Protein 1 in Microglia

  2003cited by this paper
• The role of drug transporters at the blood-brain barrier.

  2003cited by this paper
• Saquinavir induces stable and functional expression of the multidrug transporter P‐glycoprotein in human CD4 T‐lymphoblastoid CEMrev cells

  2003cited by this paper
• Temporal and spatial profiles of ABCA2‐expressing oligodendrocytes in the developing rat brain

  2003cited by this paper
• Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors.

  2003cited by this paper
• The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution in mice.

  2003cited by this paper
• Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy

  2003cited by this paper
• Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier.

  2003cited by this paper
• Communication between astrocytes and neurons: a complex language.

  2002cited by this paper
• Transcytosis of plasma macromolecules in endothelial cells: A cell biological survey

  2002cited by this paper
• Single static view 99mTc-sestamibi scintimammography predicts response to neoadjuvant chemotherapy and is related to MDR expression.

  2002cited by this paper
• Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans.

  2002cited by this paper
• Insights into the role of immune activation in HIV neuropathogenesis

  2002cited by this paper
• A new multidrug resistance protein at the blood-brain barrier.

  2002cited by this paper
• Blood-brain barrier, brain metabolism and cerebral blood flow.

  2002cited by this paper
• Molecular and functional MDR1‐Pgp and MRPs expression in human glioblastoma multiforme cell lines

  2002cited by this paper
• Limbic Seizures Induce P-Glycoprotein in Rodent Brain: Functional Implications for Pharmacoresistance

  2002cited by this paper
• P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.

  2002cited by this paper
• A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system.

  2002cited by this paper
• Functional expression and localization of P‐glycoprotein at the blood brain barrier

  2002cited by this paper
• Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy.

  2002cited by this paper
• Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.

  2002cited by this paper
• Localisation of breast cancer resistance protein in microvessel endothelium of human brain

  2002cited by this paper
• Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones

  2002cited by this paper
• Analysis of the K+ Current Profile of Mature Rat Oligodendrocytes in situ

  2002cited by this paper
• P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals.

  2002cited by this paper
• Glial cells express multiple ATP binding cassette proteins which are involved in ATP release

  2002cited by this paper
• Role of multidrug transporters in pharmacoresistance to antiepileptic drugs.

  2002cited by this paper
• Expression and Functional Activity of the ABC-transporter Proteins P-glycoprotein and Multidrug-resistance Protein 1 in Human Brain Tumor Cells and Astrocytes

  2002cited by this paper
• Short Communication: Expression of P-Glycoprotein and Multidrug Resistance-Associated Protein in Healthy Volunteers and HIV-Infected Patients

  2001cited by this paper
• Pharmacogenomics of neurodegenerative diseases.

  2001cited by this paper
• beta-Amyloid efflux mediated by p-glycoprotein.

  2001cited by this paper
• β‐Amyloid efflux mediated by p‐glycoprotein

  2001cited by this paper
• Pathways to neuronal injury and apoptosis in HIV-associated dementia

  2001cited by this paper
• Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations.

  2001cited by this paper
• Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

  2001cited by this paper
• Multidrug-resistance protein 1 in focal cortical dysplasia.

  2001cited by this paper
• Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

  2001cited by this paper
• A novel zidovudine uptake system in microglia.

  2001cited by this paper
• Functional expression of P-glycoprotein in rat brain microglia.

  2001cited by this paper
• Differential expression of the cationic amino acid transporter 2(B) in the adult rat brain.

  2001cited by this paper
• Immune function of astrocytes

  2001cited by this paper
• Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory Epilepsy

  2001cited by this paper
• Primary care : epilepsy

  2001cited by this paper
• Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus

  2001cited by this paper
• Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter.

  2001cited by this paper
• Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors.

  2001cited by this paper
• HMG‐CoA reductase inhibitors and P‐glycoprotein modulation

  2001cited by this paper
• Anticancer drug resistance in primary human brain tumors.

  2001cited by this paper
• Immunological aspects of microglia: relevance to Alzheimer's disease.

  2001cited by this paper
• In Vivo Evidence for P‐Glycoprotein–Mediated Transport of Phenytoin at the Blood–Brain Barrier of Rats

  2001cited by this paper
• Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

  2001cited by this paper
• Expression of multidrug‐resistance P‐glycoprotein (MDR1) in human brain tumors

  2001cited by this paper
• Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line.

  2001cited by this paper
• Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.

  2001cited by this paper
• From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance

  2001cited by this paper
• Expression of P-glycoprotein and multidrug resistance-associated protein in healthy volunteers and HIV-infected patients.

  2001cited by this paper
• Carbamazepine is not a substrate for P-glycoprotein.

  2001cited by this paper
• Aβ Modulation: The Next Generation of AD Therapeutics

  2000cited by this paper
• P‐glycoprotein is localized in caveolae in resistant cells and in brain capillaries

  2000cited by this paper
• Toward a Comprehensive Theory for Alzheimer's Disease. Hypothesis: Alzheimer's Disease Is Caused by the Cerebral Accumulation and Cytotoxicity of Amyloid β‐Protein

  2000cited by this paper
• Expression and function of the protein tyrosine phosphatase SHP‐1 in oligodendrocytes

  2000cited by this paper
• Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.

  2000cited by this paper
• Functional expression of p‐glycoprotein and multidrug resistance‐associated protein (mrp1) in primary cultures of rat astrocytes

  2000cited by this paper
• AMPA–Kainate Subtypes of Glutamate Receptor in Rat Cerebral Microglia

  2000cited by this paper
• Development of Multidrug-Resistance Convertors: Sense or Nonsense?

  2000cited by this paper
• The Choroid Plexuses and the Barriers Between the Blood and the Cerebrospinal Fluid

  2000cited by this paper
• Neuroglial networks: neurons and glia talk to each other.

  2000cited by this paper
• Cell mediators of inflammation in the Alzheimer disease brain.

  2000cited by this paper
• Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs.

  2000cited by this paper
• A Na(+)-dependent nucleoside transporter in microglia.

  2000cited by this paper
• Chronic systemic pesticide exposure reproduces features of Parkinson's disease

  2000cited by this paper
• Galantamine in AD

  2000cited by this paper
• beta-peptide immunization: a possible new treatment for Alzheimer disease.

  2000cited by this paper
• Neuronal interaction determines the expression of the alpha-2 isoform of Na, K-ATPase in oligodendrocytes.

  2000cited by this paper
• Variability and validity of polymorphism association studies in Parkinson’s disease

  2000cited by this paper
• Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance.

  2000cited by this paper
• Aβ-modulation: The next generation of ad therapeutics

  2000cited by this paper
• HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia.

  2000cited by this paper
• The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells.

  2000cited by this paper
• Controversy surrounding the existence of discrete functional classes of astrocytes in adult gray matter

  2000cited by this paper
• Purine Uptake and Release in Rat C6 Glioma Cells

  2000cited by this paper
• A new ABC transporter mediating the detachment of lipid-modified proteins from membranes

  2000cited by this paper
• Voltage-gated proton currents in microglia of distinct morphology and functional state.

  1999cited by this paper
• Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy.

  1999cited by this paper
• Translating cell biology into therapeutic advances in Alzheimer's disease

  1999cited by this paper

• An Integrative Approach to the Current Treatment of HIV-Associated Neurocognitive Disorders and the Implementation of Leukemia Inhibitor Factor as a Mediator of Neurocognitive Preservation

  2023cites this paper
• The Sojourn of Polymeric Micelles for Effective Brain Drug Delivery System.

  2023cites this paper
• Recent Advances in Understanding the Structural and Functional Evolution of FtsH Proteases

  2022cites this paper
• [11C]K-2 image with positron emission tomography represents cell surface AMPA receptors.

  2021cites this paper
• Modulation of the Blood–Brain Barrier for Drug Delivery to Brain

  2021cites this paper
• Editorial: Organization and Functional Properties of the Blood-Brain Barrier

  2021cites this paper
• Interaction Between Genetic Variants and Serum Levels of Organochlorine Pesticides Contributes to Parkinson’s Disease

  2020cites this paper
• The Interplay of ABC Transporters in Aβ Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer’s Disease

  2020cites this paper
• Blood–Brain Barrier

  2019cites this paper
• [PET imaging for better understanding of normal and pathological neurotransmission].

  2019cites this paper
• Does G2677T Polymorphism of the MDR1 Gene Make a Difference in the Therapeutic Response to Paroxetine in Depressed Patients in a Slovakian Population?

  2018cites this paper
• A Conformationally Gated Model of Methadone and Loperamide Transport by P-Glycoprotein.

  2018influential citation
• Drug Delivery to the Brain by Liposomes : Understanding Factors Governing Delivery Outcomes In Vivo

  2018cites this paper
• Nrf2 overexpression protects against paraquat-induced A549 cell injury primarily by upregulating P-glycoprotein and reducing intracellular paraquat accumulation

  2018cites this paper
• NRDR inhibits estradiol synthesis and is associated with changes in reproductive traits in pigs

  2018cites this paper
• Physical insights into the blood–brain barrier translocation mechanisms

  2017cites this paper
• Genetic deletion of P-glycoprotein alters stress responsivity and increases depression-like behavior, social withdrawal and microglial activation in the hippocampus of female mice.

  2017cites this paper
• Insights Into the Molecular Mechanism of Triptan Transport by P-glycoprotein.

  2017cites this paper
• Targeted Nanoparticles for the Treatment of Alzheimer's Disease.

  2017cites this paper
• Nucleic Acids-based Nanotherapeutics Crossing the Blood Brain Barrier.

  2017cites this paper
• Investigating Glial Contributions During Parkinson’s Disease Pathogenesis Using Patient-Specific iPSC-Derived Cells

  2017cites this paper
• Brain and the Drug Transporters

  2017cites this paper
• Inhibition of p38 mitogen‐activated protein kinase signaling reduces multidrug transporter activity and anti‐epileptic drug resistance in refractory epileptic rats

  2016cites this paper
• ABCB1 Gene Polymorphisms Associated with Risk of ParkinsonâÂÂs Diseaseand Their Functional Relevance

  2016cites this paper
• Blood-Brain Barrier ABC-transporter P-glycoprotein in Alzheimer's Disease: Still a Suspect?

  2016cites this paper
• Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.

  2016cites this paper
• Rhenium and technetium complexes that bind to amyloid-β plaques.

  2015cites this paper
• Glial regulation of the blood-brain barrier in health and disease

  2015cites this paper
• Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery

  2015cites this paper
• P-Glycoprotein Transport of Neurotoxic Pesticides

  2015cites this paper
• Species Differences and Impact of Disease State on BBB

  2015cites this paper
• Neuronal-Glial-Endothelial Interactions Regulate Central Nervous System Homeostasis

  2015cites this paper
• Research on experimental models of neurodegenerative disorders and radiation-induced brain injury

  2014cites this paper
• Research on experimental models of neurodegenerative disorders and radiation-induced brain injury

  2014cites this paper
• Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary.

  2014cites this paper
• Absence of P-Glycoprotein Transport in the Pharmacokinetics and Toxicity of the Herbicide Paraquat

  2014cites this paper
• The impact of sustained and intermittent docetaxel chemotherapy regimens on cognition and neural morphology in healthy mice

  2014cites this paper
• Synthesis and bioevaluation of novel PET tracers for the imaging of P-glycoprotein

  2014cites this paper
• Drug Access to the Central Nervous System in Alzheimer’s Disease: Preclinical and Clinical Insights

  2014cites this paper
• Disease Influence on BBB Transport in Neurodegenerative Disorders

  2014cites this paper
• P-GLYCOPROTEIN TRANSPORT IN PESTICIDE PHARMACOKINETICS AND TOXICITY: INVESTIGATING A LINK TO PARKINSON'S DISEASE RISK

  2013cites this paper
• Frequency Evaluation of C3435T Polymorphism of the MDR1 Gene in a Healthy Population in Mazandaran Province

  2013cites this paper
• Alteration in P‐glycoprotein at the blood–brain barrier in the early period of MCAO in rats

  2013cites this paper
• Liposomes for brain delivery

  2013cites this paper
• Utility of CSF in translational neuroscience

  2013cites this paper
• Assessment of the role of multidrug resistance-associated proteins in MPTP neurotoxicity in mice.

  2013cites this paper
• Drug Transporters At Brain Barriers

  2013cites this paper
• Utility of CSF in translational neuroscience

  2013cites this paper
• Glutathione metabolism and Parkinson's disease.

  2013cites this paper
• Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice

  2013cites this paper
• Studies into the interaction between the plasminogen activating system and the blood-brain barrier

  2013cites this paper
• ABC Transporters and the Alzheimer’s Disease Enigma

  2012cites this paper
• Role of CNS efflux drug transporters in antiepileptic drug delivery: overcoming CNS efflux drug transport.

  2012cites this paper
• Microparticle‐associated nucleic acids mediate trait dominance in cancer

  2012cites this paper
• PET radiotracers for molecular imaging in the brain: Past, present and future

  2012cites this paper
• Modern methods for delivery of drugs across the blood-brain barrier.

  2012cites this paper
• Characterization of Tight Junction Formation in an In-Vitro Model of the Blood-Brain Barrier

  2012cites this paper
• Molecular and functional characterization of P-glycoprotein in vitro.

  2011cites this paper
• Morphology and properties of brain endothelial cells.

  2011cites this paper
• ABCB1 Genotype and CSF β-Amyloid in Alzheimer Disease

  2011cites this paper
• Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice

  2011cites this paper
• Age-dependent decline of blood-brain barrier P-glycoprotein expression in the canine brain.

  2011cites this paper
• Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting.

  2011cites this paper
• New Thinking on the Etiology and Pathogenesis of Late-Onset Alzheimer's Disease

  2011cites this paper
• O1‐07‐04: Blood‐brain barrier p‐glycoprotein function in Alzheimer's disease

  2011cites this paper
• Substrates, inhibitors and activators of P-glycoprotein: candidates for radiolabeling and imaging perspectives.

  2010cites this paper
• Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder

  2010cites this paper
• Modulating P‐glycoprotein regulation: Future perspectives for pharmacoresistant epilepsies?

  2010cites this paper
• Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach.

  2010cites this paper
• Neuroprotective effects of L-carnitine in a transgenic animal model of Huntington's disease.

  2010cites this paper
• Targeting the brain--surmounting or bypassing the blood-brain barrier.

  2010cites this paper
• Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: Effects of the novel P-glycoprotein inhibitor tariquidar

  2010cites this paper
• Aus dem Lehrstuhl für Pharmakologie, Toxikologie und Pharmazie des Veterinärwissenschaftlichen Departments der Tierärztlichen

  2010cites this paper
• Studies on pericytes in health and disease

  2010cites this paper
• P-gp transporter and its role in neurodegenerative diseases.

  2009cites this paper
• Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration.

  2009cites this paper
• Neurodegeneration and Ageing in the HAART Era

  2009cites this paper
• Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?

  2009cites this paper
• Drug transport across the blood-brain barrier and the impact of breast cancer resistance protein (ABCG2).

  2009cites this paper
• Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans

  2009cites this paper
• MDR1 variants and risk of Parkinson disease

  2009cites this paper
• Neuroprotective effects of probenecid in a transgenic animal model of Huntington’s disease

  2009cites this paper
• Mechanisms Controlling the Unique Phenotype of Brain Endothelium

  2009cites this paper
• in the Brain : Studies of Healthy Humans C-Verapamil 11 Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using

  2009cites this paper
• PET radiotracers: crossing the blood-brain barrier and surviving metabolism.

  2009cites this paper
• Serum amyloid beta peptides in patients with dementia and age-matched non-demented controls as detected by surface-enhanced laser desorption ionisation-time of flight mass spectrometry (SELDI-TOF MS).

  2008cites this paper
• Synergistic interaction of ABCB1 and ABCG2 polymorphisms predicts the prevalence of toxic encephalopathy during anticancer chemotherapy

  2008cites this paper
• Expression, Activity and Regulation of CYP3A in Human and Rodent Brain

  2008influential citation
• Barrière hémato-encéphalique humaine et endothéline 1 : régulation des transporteurs ABC et des cytokines inflammatoires

  2008cites this paper
• MDR1 gene polymorphism: therapeutic response to paroxetine among patients with major depression.

  2008cites this paper
• MRP (ABCC) Transporters-Mediated Efflux of Anti-HIV Drugs, Saquinavir and Zidovudine, from Human Endothelial Cells

  2008influential citation
• Amyloid beta protein and tau in cerebrospinal fluid and plasma as biomarkers for dementia: a review of recent literature.

  2008cites this paper
• Localization of P-glycoprotein at the nuclear envelope of rat brain cells.

  2007cites this paper
• Central Nervous System Pharmacokinetics of the Mdr1 P-Glycoprotein Substrate CP-615,003: Intersite Differences and Implications for Human Receptor Occupancy Projections from Cerebrospinal Fluid Exposures

  2007cites this paper
• Cell–cell Signaling in the Neurovascular Unit

  2007cites this paper
• CNS PHARMACOKINETICS OF THE MDR1 P-GLYCOPROTEIN SUBSTRATE CP- 615,003: INTER-SITE DIFFERENCES AND IMPLICATIONS FOR HUMAN RECEPTOR OCCUPANCY PROJECTIONS FROM CSF EXPOSURES

  2007cites this paper
• Pharmacotherapy, clinical pharmacology and biomarker research in geriatric patients

  2007cites this paper
• Pathway-based approaches for analysis of genomewide association studies.

  2007cites this paper
• The role of membrane transporters in drug delivery to brain tumors.

  2007cites this paper
• Acute Regulation of P-glycoprotein at the Blood-Brain Barrier by Peripheral Inflammatory Pain

  2007cites this paper