Pro‐inflammatory dopamine‐2 receptor‐specific T cells in paediatric movement and psychiatric disorders

D. Pilli,A. Zou,R. Dawes,Joseph A Lopez,F. Tea,Ganesha Liyanage,Fiona X. Z. Lee,V. Merheb,Samuel D Houston,A. Pillay,H. Jones,S. Ramanathan,S. Mohammad,A. Kelleher,S. Alexander,R. Dale,F. Brilot

Published 2020 in Clinical & Translational Immunology

ABSTRACT

A dysregulated inflammatory response against the dopamine‐2 receptor (D2R) has been implicated in movement and psychiatric disorders. D2R antibodies were previously reported in a subset of these patients; however, the role of T cells in these disorders remains unknown. Our objective was to identify and characterise pro‐inflammatory D2R‐specific T cells in movement and psychiatric disorders.

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