Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cellular Signalling

• Publication date

  2015-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cellsig.2015.07.001PMID 26148936
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death.

  2014cited by this paper
• Association of Cardiotrophin-1 With Myocardial Fibrosis in Hypertensive Patients With Heart Failure

  2014cited by this paper
• OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators.

  2014cited by this paper
• Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide‐dependent TRAF3IP2/JNK signaling

  2013cited by this paper
• Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK.

  2013cited by this paper
• TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation.

  2013cited by this paper
• Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure

  2012cited by this paper
• Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1.

  2012cited by this paper
• CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy.

  2012cited by this paper
• Effects of interleukin-18 on cardiac fibroblast function and gene expression.

  2011cited by this paper
• IL-17-induced NF-κB Activation via CIKS/Act1

  2011cited by this paper
• A role for cardiotrophin-1 in myocardial remodeling induced by aldosterone.

  2011cited by this paper
• Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.

  2011cited by this paper
• Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury*

  2009cited by this paper
• Role of the renin-angiotensin-aldosterone system and inflammatory processes in the development and progression of diastolic dysfunction.

  2009cited by this paper
• Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes.

  2008cited by this paper
• Matrix Metalloproteinases in Hypertensive Heart Disease: New Mechanistic Insights

  2008cited by this paper
• Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction.

  2007cited by this paper
• Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload.

  2007cited by this paper
• Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy

  2007cited by this paper
• The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure.

  2006cited by this paper
• Aldosterone increases plasminogen activator inhibitor-1 synthesis in rat cardiomyocytes.

  2005cited by this paper
• Role of Angiotensin II in the Evolution of Diastolic Heart Failure

  2005cited by this paper
• Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes*

  2005cited by this paper
• Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure.

  2005cited by this paper
• Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice.

  2005cited by this paper
• Aldosterone Stimulates Matrix Metalloproteinases and Reactive Oxygen Species in Adult Rat Ventricular Cardiomyocytes

  2005cited by this paper
• Role of interleukin‐6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation

  2005cited by this paper
• Distinct functions of junD in cardiac hypertrophy and heart failure.

  2005cited by this paper
• Effect of Aldosterone Antagonism on Myocardial Dysfunction in Hypertensive Patients With Diastolic Heart Failure

  2004cited by this paper
• Role of the adaptor protein CIKS in the activation of the IKK complex.

  2003cited by this paper
• A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.

  2003cited by this paper
• Aldosterone-induced inflammation in the rat heart : role of oxidative stress.

  2002cited by this paper
• Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure.

  2002cited by this paper
• Aldosterone in congestive heart failure.

  2001cited by this paper
• Interleukin-6 Family of Cytokines Mediate Angiotensin II-induced Cardiac Hypertrophy in Rodent Cardiomyocytes*

  2000cited by this paper
• CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.

  2000cited by this paper
• Act1, an NF-κB-activating protein

  2000cited by this paper
• Act1, an NF-kappa B-activating protein.

  2000cited by this paper
• Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy

  1996cited by this paper
• Mineralocorticoids, hypertension, and cardiac fibrosis.

  1994cited by this paper
• Tissue renin-angiotensin system in myocardial hypertrophy and failure.

  1993cited by this paper
• Mineralocorticoid excess, dietary sodium, and myocardial fibrosis.

  1992cited by this paper
• Reactive and reparative myocardial fibrosis in arterial hypertension in the rat.

  1992cited by this paper
• Remodeling of the rat right and left ventricles in experimental hypertension.

  1990cited by this paper

• The burden of cold-induced hypertension: Integrating molecular mechanisms and preventive strategies.

  2026cites this paper
• Research progress on the correlation between renin-angiotensin-aldosterone system (RAAS) and cardiovascular and cerebrovascular diseases

  2025cites this paper
• LOX and LOXL2 Expression in Canine Mammary Carcinomas

  2025cites this paper
• Sirtuin-Mediated Modulation of Cardiac Fibrosis: Emerging Molecular Insights and Therapeutic Perspectives.

  2025cites this paper
• Multimodality Imaging in Aldosterone-Induced Cardiomyopathy: Early Detection and Prognostic Implications

  2025cites this paper
• The Senescent Heart—“Age Doth Wither Its Infinite Variety”

  2024cites this paper
• The role of pyroptosis in heart failure and related traditional chinese medicine treatments

  2024cites this paper
• Bidirectional relation between dipeptidyl peptidase 4 and angiotensin II type I receptor (AT1R) signaling.

  2024cites this paper
• The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy

  2023cites this paper
• Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration

  2023influential citation
• TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis

  2023cites this paper
• A Review of Therapeutic Strategies against Cardiac Fibrosis: From Classical Pharmacology to Novel Molecular, Epigenetic, and Biotechnological Approaches

  2023cites this paper
• BST-1 aggravates aldosterone-induced cardiac hypertrophy via the Ca2+ /CaN/NFATc3 pathway.

  2023influential citation
• Cardiovascular interactions of renin angiotensin aldosterone system assessed by cardiac magnetic resonance: The Multi-Ethnic Study of Atherosclerosis.

  2023cites this paper
• The Effect of Aldosterone on Cardiorenal and Metabolic Systems

  2023cites this paper
• Diabetes mellitus is associated with more adverse non-hemodynamic left ventricular remodeling and less recovery in patients with primary aldosteronism

  2023cites this paper
• Effect of Anti-Hypertensive Medication on Plasma Concentrations of Lysyl Oxidase: Evidence for Aldosterone-IL-6-Dependent Regulation of Lysyl Oxidase Blood Concentration

  2022cites this paper
• Eplerenone inhibits the macrophage-to-myofibroblast transition in rats with UUO-induced type 4 cardiorenal syndrome through the MR/CTGF pathway.

  2022cites this paper
• Themed Issue: Emerging Fields for Therapeutic Targeting of the Aldosterone-Mineralocorticoid Receptor Signaling Pathway

  2022cites this paper
• Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1β Pathway

  2021cites this paper
• Mineralocorticoid receptor actions in cardiovascular development and disease.

  2021cites this paper
• The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy

  2021cites this paper
• Vasonatrin peptide, a synthetic natriuretic peptide, attenuates myocardial injury and oxidative stress in isoprenaline-induced cardiomyocyte hypertrophy.

  2020cites this paper
• Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload

  2020cites this paper
• Tissue-Specific Cell Signaling

  2020cites this paper
• Key Signaling Pathways in the Cardiovascular System

  2020cites this paper
• Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-κB/iNOS/NO-dependent cardiomyocyte contractile depression and death.

  2020cites this paper
• Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?

  2020cites this paper
• Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

  2020cites this paper
• Left ventricular remodeling and dysfunction in primary aldosteronism

  2020cites this paper
• Cardiac fibrosis.

  2020cites this paper
• The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion.

  2020cites this paper
• Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition.

  2019cites this paper
• Cardiomyopathy Associated with Diabetes: The Central Role of the Cardiomyocyte

  2019cites this paper
• A Novel Circular RNA Mediates Pyroptosis of Diabetic Cardiomyopathy by Functioning as a Competing Endogenous RNA

  2019cites this paper
• Therapeutic progress and knowledge basis about natriuretic peptide system in heart failure.

  2019cites this paper
• Role of Fibroblast Growth Factor 23 on Cardiac Remodelling in Experimental Heart Failure

  2019cites this paper
• Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK suppression.

  2019cites this paper
• Interleukin-18 in Health and Disease

  2019cites this paper
• Synthesis, secretion, function, metabolism and application of natriuretic peptides in heart failure

  2018cites this paper
• Mutual Homeostatic Regulation Between Natriuretic Peptides And Mineralocorticoids In The Cardiovascular System

  2018cites this paper
• IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis

  2018cites this paper
• Cardiac hypertrophy in chronic kidney disease—role of Aldosterone and FGF23

  2018cites this paper
• Biomarker‐based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo‐DHF trial

  2018cites this paper
• Metformin and its anti-inflammatory and anti-oxidative effects; new concepts

  2018cites this paper
• The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin

  2018cites this paper
• Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12

  2018cites this paper
• Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women.

  2018cites this paper
• Pathophysiological aldosterone levels modify the secretory activity of cardiac progenitor cells.

  2017cites this paper
• Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice

  2017influential citation
• NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy

  2017cites this paper
• Dipeptidyl Peptidase‐4 Inhibition With Saxagliptin Ameliorates Angiotensin II‐Induced Cardiac Diastolic Dysfunction in Male Mice

  2017cites this paper
• The Inhibitory Effect of Eplerenone on Cell Proliferation in the Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction

  2017cites this paper
• Lipopolysaccharide ( LPS ) regulates peroxide to affect the development of nasopharyngeal carcinoma by suppressing Act 1 expression

  2017cites this paper
• The renal and cardiovascular effects of natriuretic peptides.

  2017cites this paper
• Increased aldosterone‐dependent Kv1.5 recycling predisposes to pacing‐induced atrial fibrillation in Kcne3‐/‐ mice

  2016cites this paper
• TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE(-/-) mice.

  2016cites this paper
• Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo.

  2016cites this paper
• TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis.

  2016influential citation
• Regulación de la viabilidad y el metabolismo cardiomiocitario por fármacos (aliskiren) y hormonas (chemerina) con capacidad de modular procesos inflamatorios

  2016cites this paper
• Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload–Induced Heart Failure

  2016cites this paper
• The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin‐II‐Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4

  2016cites this paper
• ScholarWorks @ UTRGV ScholarWorks @ UTRGV

  year unknowncites this paper
• Evaluation of TRAF3IP2 Gene Expression in Brain Tumor Tissue of Patients with Glioblastoma Multiforme in Comparison to Non-Tumoral Brain Tissue

  year unknowncites this paper