Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Blood

• Publication date

  2001-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V98.13.3823PMID 11739192
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.

  2001cited by this paper
• Iron regulatory proteins and the molecular control of mammalian iron metabolism.

  2000cited by this paper
• Iron transport.

  2000influential reference
• Heterologous expression, functional characterization and localization of two isoforms of the monkey iron transporter Nramp2.

  2000cited by this paper
• Nramp2 Expression Is Associated with pH-dependent Iron Uptake across the Apical Membrane of Human Intestinal Caco-2 Cells*

  2000cited by this paper
• Natural Resistance to Intracellular Infections

  2000cited by this paper
• Nramp 2 (DCT1/DMT1) Expressed at the Plasma Membrane Transports Iron and Other Divalent Cations into a Calcein-accessible Cytoplasmic Pool*

  2000cited by this paper
• The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border.

  2000cited by this paper
• Iron homeostasis: insights from genetics and animal models

  2000influential reference
• Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1.

  1999cited by this paper
• Non‐transferrin‐bound iron uptake in Belgrade and normal rat erythroid cells

  1999cited by this paper
• Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron.

  1999cited by this paper
• The Iron Transport Protein NRAMP2 Is an Integral Membrane Glycoprotein That Colocalizes with Transferrin in Recycling Endosomes

  1999cited by this paper
• Identification of a Hypoxia Response Element in the Transferrin Receptor Gene*

  1999cited by this paper
• Mycobacterium tuberculosis Expresses a Novel Ph-Dependent Divalent Cation Transporter Belonging to the Nramp Family

  1999cited by this paper
• The Nramp1 protein and its role in resistance to infection and macrophage function.

  1999cited by this paper
• The transferrin receptor: role in health and disease.

  1999cited by this paper
• Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

  1998cited by this paper
• Carbohydrate‐mediated Golgi to cell surface transport and apical targeting of membrane proteins

  1998cited by this paper
• The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms.

  1998cited by this paper
• Transport mechanisms for iron and other transition metals in rat and rabbit erythroid cells

  1998cited by this paper
• The G185R mutation disrupts function of the iron transporter Nramp2.

  1998cited by this paper
• The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells.

  1997cited by this paper
• Cloning and characterization of a mammalian proton-coupled metal-ion transporter

  1997cited by this paper
• Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

  1997cited by this paper
• Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.

  1997cited by this paper
• Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

  1997cited by this paper
• Managed care for viruses

  1997cited by this paper
• Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

  1996cited by this paper
• Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

  1996cited by this paper
• Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents.

  1996cited by this paper
• Nramp defines a family of membrane proteins.

  1995cited by this paper
• Identification and characterization of a second mouse Nramp gene.

  1995cited by this paper
• Transferrin and the transferrin cycle in Belgrade rat reticulocytes.

  1993cited by this paper
• Uptake of transferrin‐bound and nontransferrin‐bound iron by reticulocytes from the belgrade laboratory rat: Comparison with wistar rat transferrin and reticulocytes

  1992cited by this paper
• Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

  1990cited by this paper
• Red cell iron uptake in hereditary microcytic anemia.

  1975cited by this paper
• Iron metabolism in Belgrade laboratory (b-b) rats.

  1972cited by this paper
• Marrow transplantation and iron therapy in mouse hereditary microcytic anemia.

  1972cited by this paper
• Hereditary Microcytic Anaemia in the Mouse; Studies in Iron Distribution and Metabolism

  1972cited by this paper
• Cleavage of the haem-protein link by acid methylethylketone.

  1959cited by this paper

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  2010cites this paper
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  2009cites this paper
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