Experimental evidence for curcumin and its analogs for management of diabetes mellitus and its associated complications.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  European Journal of Pharmacology

• Publication date

  2015-06-05

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.ejphar.2015.02.045PMID 25769841
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation.

  2015cited by this paper
• Therapeutic strategies of diabetic nephropathy: recent progress and future perspectives.

  2015cited by this paper
• 4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl) vinyl)-2-methoxy-phenol) (CNB-001) Does Not Regulate Human Recombinant Protein-Tyrosine Phosphatase1B (PTP1B) Activity in vitro

  2014cited by this paper
• Glycemic Variability and Oxidative Stress: A Link between Diabetes and Cardiovascular Disease?

  2014cited by this paper
• Modeling type 2 diabetes in rats using high fat diet and streptozotocin

  2014cited by this paper
• Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

  2014cited by this paper
• Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression.

  2014cited by this paper
• Targeting inflammation in diabetes: Newer therapeutic options.

  2014cited by this paper
• HMGB1 mediates hyperglycaemia-induced cardiomyocyte apoptosis via ERK/Ets-1 signalling pathway

  2014cited by this paper
• Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro

  2014cited by this paper
• Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line.

  2014cited by this paper
• Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial.

  2014cited by this paper
• From Beta Cell Replacement to Beta Cell Regeneration

  2014cited by this paper
• Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy

  2014cited by this paper
• Novel Curcumin Derivative CNB-001 Mitigates Obesity-Associated Insulin Resistance

  2014cited by this paper
• Inhibition of JNK by compound C66 prevents pathological changes of the aorta in STZ-induced diabetes

  2014cited by this paper
• Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis

  2014cited by this paper
• Advances in management of type 1 diabetes mellitus.

  2014cited by this paper
• Metformin in patients with type 2 diabetes and kidney disease: a systematic review.

  2014cited by this paper
• Curcumin prevents diabetic nephropathy against inflammatory response via reversing caveolin-1 Tyr14 phosphorylation influenced TLR4 activation.

  2014cited by this paper
• Curcumin decreases renal triglyceride accumulation through AMPK-SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats.

  2013cited by this paper
• Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart.

  2013cited by this paper
• Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial.

  2013cited by this paper
• Stable and potent analogues derived from the modification of the dicarbonyl moiety of curcumin.

  2013cited by this paper
• Antidiabetic Potential of the Heme Oxygenase-1 Inducer Curcumin Analogues

  2013cited by this paper
• A review of therapeutic effects of curcumin.

  2013cited by this paper
• Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats

  2013cited by this paper
• Microbial Transformation of Curcumin to Its Derivatives with a Novel Pichia kudriavzevii ZJPH0802 Strain

  2013cited by this paper
• Inhibition of MAPK-mediated ACE expression by compound C66 prevents STZ-induced diabetic nephropathy

  2013cited by this paper
• Development, Characterization and Permeability Assessment Based on Caco-2 Monolayers of Self-Microemulsifying Floating Tablets of Tetrahydrocurcumin

  2013cited by this paper
• Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

  2013cited by this paper
• Matrix metalloproteinases, atherosclerosis, proteinuria and kidney disease: Linkage-based approaches.

  2013cited by this paper
• Targeting JNK by a New Curcumin Analog to Inhibit NF-kB-Mediated Expression of Cell Adhesion Molecules Attenuates Renal Macrophage Infiltration and Injury in Diabetic Mice

  2013cited by this paper
• The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study)

  2013cited by this paper
• Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats.

  2013cited by this paper
• Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway.

  2013cited by this paper
• Curcumin Alleviates Diabetic Cardiomyopathy in Experimental Diabetic Rats

  2012cited by this paper
• Extrapolating from Animals to Humans

  2012cited by this paper
• Inhibition of high glucose‐induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats

  2012cited by this paper
• Curcumin Prevents High Fat Diet Induced Insulin Resistance and Obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes

  2012cited by this paper
• Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway.

  2012cited by this paper
• Formation of Tetrahydrocurcumin by Reduction of Curcumin with Cultured Plant Cells of Marchantia Polymorpha

  2012cited by this paper
• Recent discovery of plant-derived anti-diabetic natural products.

  2012cited by this paper
• Ability of Procalcitonin to Discriminate Infection from Non-Infective Inflammation Using Two Pleural Disease Settings

  2012cited by this paper
• Curcumin Extract for Prevention of Type 2 Diabetes

  2012cited by this paper
• Effect of novel water soluble curcumin derivative on experimental type- 1 diabetes mellitus (short term study)

  2012cited by this paper
• Design, synthesis and biological activity of new polyenolic inhibitors of matrix metalloproteinases: a focus on chemically-modified curcumins.

  2012cited by this paper
• Pharmacological and clinical properties of curcumin

  2011cited by this paper
• Type 2 diabetes as an inflammatory disease

  2011cited by this paper
• The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids.

  2011cited by this paper
• Abstract P348: High Glucose Induces Smad Activation via the Transcriptional Coregulator P300 and Contributes to Cardiac Fibrosis and Hypertrophy

  2011cited by this paper
• Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

  2011cited by this paper
• Obesity, diabetes mellitus, and liver fibrosis.

  2011cited by this paper
• Reactions of reactive oxygen species (ROS) with curcumin analogues: Structure–activity relationship

  2011cited by this paper
• Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats.

  2011cited by this paper
• Curcumin improves insulin resistance in skeletal muscle of rats.

  2011cited by this paper
• Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition

  2010cited by this paper
• Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes

  2010cited by this paper
• Role of heme oxygenase in preserving vascular bioactive NO.

  2010cited by this paper
• Novel therapeutic concepts: the epidemic of cardiovascular disease in the developing world: global implications.

  2010cited by this paper
• Curcumin and Gemcitabine in Patients With Advanced Pancreatic Cancer

  2010cited by this paper
• Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.

  2009cited by this paper
• Matrix metalloproteinases in subjects with type 1 diabetes

  2009cited by this paper
• Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells.

  2009cited by this paper
• Etiopathogenesis of type 1 diabetes mellitus: prognostic factors for the evolution of residual β cell function

  2009cited by this paper
• Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes.

  2009cited by this paper
• Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes

  2008cited by this paper
• Dimethoxycurcumin, a Synthetic Curcumin Analogue, Induces Heme Oxygenase-1 Expression through Nrf2 Activation in RAW264.7 Macrophages

  2008cited by this paper
• Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice.

  2008cited by this paper
• A broadly neuroprotective derivative of curcumin

  2008cited by this paper
• Integrative Survival Response Evoked by Heme Oxygenase-1 and Heme Metabolites

  2008cited by this paper
• Change in post‐translational modifications of histone H3, heat‐shock protein‐27 and MAP kinase p38 expression by curcumin in streptozotocin‐induced type I diabetic nephropathy

  2008cited by this paper
• Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.

  2008cited by this paper
• Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

  2008cited by this paper
• Human matrix metalloproteinases: Characteristics and pathologic role in altering mesangial homeostasis

  2008cited by this paper
• Bioavailability of curcumin: problems and promises.

  2007cited by this paper
• Distinguishing diabetic nephropathy from other causes of glomerulosclerosis: an update

  2007cited by this paper
• Comparative effects of curcuminoids on endothelial heme oxygenase-1 expression: ortho-methoxy groups are essential to enhance heme oxygenase activity and protection

  2006cited by this paper
• The effect of the holiday season on body weight and composition in college students

  2006cited by this paper
• Increased circulatory MMP-2 and MMP-9 levels and activities in patients with type 1 diabetes mellitus.

  2006cited by this paper
• Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats.

  2006cited by this paper
• CURCUMIN, THE ACTIVE PRINCIPLE OF TURMERIC (CURCUMA LONGA), AMELIORATES DIABETIC NEPHROPATHY IN RATS

  2006cited by this paper
• Differential effects of curcumin on vasoactive factors in the diabetic rat heart

  2006cited by this paper
• Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation

  2006cited by this paper
• Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice.

  2005cited by this paper
• EFFECT OF TETRAHYDROCURCUMIN ON BLOOD GLUCOSE, PLASMA INSULIN AND HEPATIC KEY ENZYMES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

  2005cited by this paper
• Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells.

  2005cited by this paper
• Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

  2005cited by this paper
• Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications.

  2004cited by this paper
• Enzymology of a carbonyl reduction clearance pathway for the HIV integrase inhibitor, S-1360: role of human liver cytosolic aldo-keto reductases.

  2004cited by this paper
• Phase I Clinical Trial of Oral Curcumin

  2004cited by this paper
• Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells.

  2004cited by this paper
• Anticancer potential of curcumin: preclinical and clinical studies.

  2003cited by this paper
• Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH2-terminal Kinase

  2003cited by this paper
• The intrarenal renin-angiotensin system and diabetic nephropathy.

  2003cited by this paper
• β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

  2003cited by this paper
• Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

  2003cited by this paper
• Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

  2003cited by this paper
• Role of Sterol Regulatory Element-binding Protein 1 in Regulation of Renal Lipid Metabolism and Glomerulosclerosis in Diabetes Mellitus*

  2002cited by this paper
• Hypoglycemic, hypolipidemic and antioxidant properties of combination ofCurcumin fromCurcuma longa, Linn, and partially purified product fromAbroma augusta, Linn. in streptozotocin induced diabetes

  2002cited by this paper

• A plasma metabolomic analysis revealed the metabolic regulatory mechanism of the water extract of Dendrobium huoshanense in improving streptozotocin-induced type 1 diabetes model rats

  2025cites this paper
• Synthetic Curcumin Analogs in Nephrotoxicity: Mechanisms and Therapeutic Advances.

  2025cites this paper
• Curcumin and its novel formulations for diabetes mellitus and its complications: a review.

  2025cites this paper
• The Effect of Curcumin Supplementation on Irisin, Nesfatin-1, and Leptin Levels in Rats Subjected to Long-Term Treadmill Exercise

  2025cites this paper
• Antidiabetic Potential of Underutilized Crops: Nutritional, Phytochemical Insights, and Prospects for Diabetes Management

  2025cites this paper
• Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a.

  2024cites this paper
• Advancements in curcumin-loaded PLGA nanoparticle delivery systems: progressive strategies in cancer therapy

  2024cites this paper
• Development and characterization of palmitoyl-modified arginine containing curcumin-loaded niosomal vesicles for improved antioxidant and anticancer activities

  2024cites this paper
• Synergistic anticancer effect of polymersome‐encapsulated curcumin and cytarabine: A spectroscopic and theoretical approach

  2024cites this paper
• Turmeric trends: analyzing consumer preferences and willingness to pay

  2024cites this paper
• Novel N′-substituted benzylidene benzohydrazides linked to 1,2,3-triazoles: potent α-glucosidase inhibitors

  2023cites this paper
• Therapeutic Effects of Curcumin Derivatives against Obesity and Associated Metabolic Complications: A Review of In Vitro and In Vivo Studies

  2023cites this paper
• Formulation and design optimization of repaglinide loaded transferosomes for management of type II diabetes mellitus

  2023cites this paper
• Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced diabetes mellitus

  2023cites this paper
• The beneficial effects of curcumin supplementation on blood lipid levels among patients with metabolic related diseases in Asia area: a systematic review and meta-analysis of randomized controlled trials

  2023cites this paper
• Dual-stimuli responsive skin-core structural fibers with an in situ crosslinked alginate ester for hydrophobic drug delivery.

  2023cites this paper
• Synthesis, in silico, in vitro and in vivo studies of novel natural-based arylidenes curcumin as potential glycohydrolase digestive enzymes inhibitors

  2023cites this paper
• Quinazolinone-1,2,3-triazole-acetamide conjugates as potent α-glucosidase inhibitors: synthesis, enzyme inhibition, kinetic analysis, and molecular docking study.

  2023cites this paper
• Anti-diabetic and anti-obesity: Efficacy evaluation and exploitation of polyphenols in fruits and vegetables.

  2022cites this paper
• Design, synthesis, spectroscopic characterizations, antidiabetic, in silico and kinetic evaluation of novel curcumin-fused aldohexoses.

  2022cites this paper
• Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model

  2022cites this paper
• Effect of Curcuma longa L. and curcumin on diabetes and it’s complications: A review

  2021cites this paper
• Pi-Dan-Jian-Qing Decoction Ameliorates Type 2 Diabetes Mellitus Through Regulating the Gut Microbiota and Serum Metabolism

  2021cites this paper
• Role of Curcuma Longa in Type 2 Diabetes and its Associated Complications

  2021cites this paper
• Preparation, Characterization and Dissolution Behaviour of Freeze Dried Complexes of Curcumin-Gamma Cyclodextrin

  2021cites this paper
• SUPLEMEN HERBAL UNTUK DIABETES MELLITUS TIPE II : SYSTEMATIC REVIEW

  2021cites this paper
• Dietary polyphenols as antidiabetic agents: Advances and opportunities

  2020cites this paper
• Attempts to enhance the anti-cancer activity of curcumin as a magical oncological agent using transdermal delivery

  2020cites this paper
• Curcumin derivatives for Type 2 Diabetes management and prevention of complications

  2020cites this paper
• Synthesis of new curcumin derivatives as influential antidiabetic α-glucosidase and α-amylase inhibitors with anti-oxidant activity.

  2020cites this paper
• Hypoglycemic and antioxidant effects of five commercial turmeric (Curcuma longa) supplements.

  2020cites this paper
• Attempts to enhance the anti-cancer activity of curcumin as a magical oncological agent using transdermal delivery

  2020cites this paper
• Curcumin analog A13 alleviates oxidative stress by activating Nrf2/ARE pathway and ameliorates fibrosis in the myocardium of high-fat-diet and streptozotocin-induced diabetic rats

  2020cites this paper
• Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

  2020cites this paper
• Recent advances in encapsulation of curcumin in nanoemulsions: A review of encapsulation technologies, bioaccessibility and applications.

  2020cites this paper
• Assessment and comparison of the antioxidant defense system in patients with type 2 diabetes, diabetic nephropathy and healthy people: A case-control study.

  2020cites this paper
• Protective Effect of Curcumin on Quality Parameters of Sperm and Testicular Tissue Alterations in Alloxan-induced Diabetic Rats as Animal Model

  2019cites this paper
• The effects of curcumin supplementation on high‐sensitivity C‐reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled trial

  2019cites this paper
• The Beneficial Effects of Curcumin on Cardiovascular Diseases and Their Risk Factors

  2019cites this paper
• The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial

  2019cites this paper
• A Systematic Review and Meta-analysis of Randomized Controlled Trials on the Effects of Turmeric and Curcuminoids on Blood Lipids in Adults with Metabolic Diseases.

  2019cites this paper
• Effects of Turmeric (Curcuma longa) Extract in streptozocin-induced diabetic model.

  2019cites this paper
• Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism.

  2019cites this paper
• Solubility profile of linagliptin: designing of transdermal formulation

  2019cites this paper
• An Ayurvedic Anti‐Diabetic Formulation Made from Curcuma longa L. and Emblica officinalis L. Inhibits α‐Amylase, α‐Glucosidase, and Starch Digestion, In Vitro

  2018cites this paper
• A novel bioavailable hydrogenated curcuminoids formulation (CuroWhite™) improves symptoms and diagnostic indicators in rheumatoid arthritis patients - A randomized, double blind and placebo controlled study

  2018cites this paper
• PCSK9 and diabetes: is there a link?

  2017cites this paper
• Facile preparation of thermosensitive and water-soluble fluorescent polymer containing curcumin and its cell imaging

  2017cites this paper
• The Effects of Curcumin Supplementation on Control Glycemic and Anthropometric Indices in Overweight Patients with Type 2 Diabetes

  2017cites this paper
• Insights into the percutaneous penetration of antidiabetic agents

  2017cites this paper
• Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives.

  2017cites this paper
• Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art.

  2017cites this paper
• “mTOR Signaling Pathway”: A Potential Target of Curcumin in the Treatment of Spinal Cord Injury

  2017cites this paper
• Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum

  2017cites this paper
• Food Components in Health Promotion and Disease Prevention.

  2017cites this paper
• Curcuma longa L. extract improves the cortical neural connectivity during the aging process

  2017cites this paper
• A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study

  2017cites this paper
• Curcumin directly inhibits the transport activity of GLUT1.

  2016cites this paper
• On the properties of the curcumin molecule in water. Exploration of the OPLS - United atom model by molecular dynamics computer simulation *

  2016cites this paper
• Enzyme‐free Glucose Sensor Fabricated by Nanorods Decorated Nanopore Arrays on Biomedical Stainless Steel

  2016cites this paper
• Mechanisms of Action of Curcumin on Aging: Nutritional and Pharmacological Applications

  2016cites this paper
• Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives.

  2016cites this paper
• Antidiabetic efficacy of citronellol, a citrus monoterpene by ameliorating the hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.

  2016cites this paper
• Natural Nrf2 activators in diabetes.

  2015cites this paper
• Role of natural antioxidants and potential use of bergamot in treating rheumatoid arthritis

  2015cites this paper
• Curcumin: a natural product for diabetes and its complications.

  2015cites this paper
• Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review.

  2015cites this paper
• Transdermal delivery of antidiabetic drugs: formulation and delivery strategies.

  2015cites this paper