To live or let die: Unclear task of autophagy in the radiosensitization battle.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Radiotherapy and Oncology

• Publication date

  2016-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.radonc.2016.02.028PMID 26993419
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells.

  2015influential reference
• Canonical autophagy does not contribute to cellular radioresistance.

  2015cited by this paper
• The Autophagic Response to Radiation: Relevance for Radiation Sensitization in Cancer Therapy

  2014cited by this paper
• When cytoprotective autophagy isn’t… and even when it is

  2014cited by this paper
• The four faces of autophagy: implications for cancer therapy.

  2014cited by this paper
• Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation.

  2014cited by this paper
• Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition.

  2014influential reference
• Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway.

  2014cited by this paper
• A dual role for autophagy in a murine model of lung cancer

  2014cited by this paper
• Combined MTOR and autophagy inhibition

  2014cited by this paper
• Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation

  2014influential reference
• Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells

  2014cited by this paper
• A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

  2014cited by this paper
• Torc1/Torc2 inhibitor, Palomid 529, enhances radiation response modulating CRM1‐mediated survivin function and delaying DNA repair in prostate cancer models

  2014cited by this paper
• Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells

  2014cited by this paper
• NVP-BEZ-235 enhances radiosensitization via blockade of the PI3K/mTOR pathway in cisplatin-resistant non-small cell lung carcinoma

  2014cited by this paper
• PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

  2014cited by this paper
• Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy.

  2014cited by this paper
• Beclin 1 and UVRAG Confer Protection from Radiation-Induced DNA Damage and Maintain Centrosome Stability in Colorectal Cancer Cells

  2014influential reference
• Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis

  2014cited by this paper
• Role of Autophagy in Cancer and Tumor Progression

  2013cited by this paper
• The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia.

  2013cited by this paper
• Role of the Crosstalk between Autophagy and Apoptosis in Cancer

  2013cited by this paper
• Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

  2013cited by this paper
• Nelfinavir and bortezomib inhibit mTOR activity via ATF4‐mediated sestrin‐2 regulation

  2013cited by this paper
• Mechanisms of Radiation Toxicity in Transformed and Non-Transformed Cells

  2013cited by this paper
• The Tumor Suppressor, p53, Contributes to Radiosensitivity of Lung Cancer Cells by Regulating Autophagy and Apoptosis

  2013cited by this paper
• Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance

  2013cited by this paper
• Autophagy: regulation and role in development.

  2013cited by this paper
• Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.

  2013cited by this paper
• ATM pathway is essential for ionizing radiation-induced autophagy.

  2013cited by this paper
• Autophagy regulation and its role in cancer.

  2013cited by this paper
• CD47 deficiency confers cell and tissue radioprotection by activation of autophagy

  2012cited by this paper
• Lys05

  2012cited by this paper
• Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death

  2012cited by this paper
• [Mechanism of radiosensitization of 3-methyladenine in human hypopharynx cancer cells].

  2012influential reference
• Guidelines for the use and interpretation of assays for monitoring autophagy

  2012cited by this paper
• Novel Insights into the Interplay between Apoptosis and Autophagy

  2012cited by this paper
• Beclin1-induced autophagy abrogates radioresistance of lung cancer cells by suppressing osteopontin.

  2012influential reference
• Lapatinib and Obatoclax Kill Breast Cancer Cells through Reactive Oxygen Species-Dependent Endoplasmic Reticulum Stress

  2012cited by this paper
• Autophagy and cancer.

  2012cited by this paper
• Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

  2012cited by this paper
• Inhibition of Autophagy as a Strategy to Augment Radiosensitization by the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235

  2012cited by this paper
• Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy.

  2012influential reference
• Molecules and their functions in autophagy

  2012cited by this paper
• Dual functions of autophagy in the response of breast tumor cells to radiation

  2012cited by this paper
• Look people, “Atg” is an abbreviation for “autophagy-related.” That’s it.

  2012cited by this paper
• The end of autophagic cell death?

  2012cited by this paper
• Autophagy and Cancer

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Microautophagy: lesser-known self-eating

  2011cited by this paper
• The multiple roles of autophagy in cancer

  2011influential reference
• Autophagy: Renovation of Cells and Tissues

  2011cited by this paper
• Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger.

  2011cited by this paper
• Induction of autophagy promotes differentiation of glioma‐initiating cells and their radiosensitivity

  2011cited by this paper
• Autophagy contributes to resistance of tumor cells to ionizing radiation.

  2011influential reference
• Autophagy is required for self-renewal and differentiation of adult human stem cells

  2011cited by this paper
• A Switch Between Cytoprotective and Cytotoxic Autophagy in the Radiosensitization of Breast Tumor Cells by Chloroquine and Vitamin D

  2011influential reference
• Autophagy basics

  2011cited by this paper
• Chaperone‐mediated autophagy in health and disease

  2010cited by this paper
• Mammalian autophagy: core molecular machinery and signaling regulation.

  2010cited by this paper
• Autophagy: cellular and molecular mechanisms

  2010influential reference
• Autophagosome formation in mammalian cells

  2010cited by this paper
• The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

  2010influential reference
• Targeting Epidermal Growth Factor Receptor–Associated Signaling Pathways in Non–Small Cell Lung Cancer Cells: Implication in Radiation Response

  2010influential reference
• Autophagy and the integrated stress response.

  2010cited by this paper
• Overview of macroautophagy regulation in mammalian cells

  2010influential reference
• Understanding autophagy in cell death control.

  2010influential reference
• Targeting HER2 signaling pathway for radiosensitization: Alternative strategy for therapeutic resistance

  2009influential reference
• Radiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor

  2009cited by this paper
• Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

  2009cited by this paper
• Combined Bcl-2/Mammalian Target of Rapamycin Inhibition Leads to Enhanced Radiosensitization via Induction of Apoptosis and Autophagy in Non–Small Cell Lung Tumor Xenograft Model

  2009cited by this paper
• Promotion of autophagy as a mechanism for radiation sensitization of breast tumor cells.

  2009cited by this paper
• Autophagy: from basic science to clinical application

  2009cited by this paper
• The induction of autophagy by γ‐radiation contributes to the radioresistance of glioma stem cells

  2009cited by this paper
• Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

  2008cited by this paper
• Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer

  2008cited by this paper
• To die or not to die: that is the autophagic question.

  2008cited by this paper
• The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy

  2008cited by this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

  2008cited by this paper
• Autophagic cell death: the story of a misnomer

  2008cited by this paper
• The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.

  2008cited by this paper
• Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy.

  2008cited by this paper
• Autophagy suppresses tumor progression by limiting chromosomal instability.

  2007cited by this paper
• Role of autophagy in cancer

  2007cited by this paper
• Induction of autophagy during extracellular matrix detachment promotes cell survival.

  2007cited by this paper
• Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy.

  2007cited by this paper
• BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

  2007cited by this paper
• Chaperone-Mediated Autophagy

  2007cited by this paper
• Pathways that Regulate Autophagy and their Role in Mediating Tumor Response to Treatment

  2006cited by this paper
• Autophagy for Cancer Therapy through Inhibition of Pro-apoptotic Proteins and Mammalian Target of Rapamycin Signaling*

  2006cited by this paper
• Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.

  2006cited by this paper
• Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells.

  2005cited by this paper
• Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy.

  2005influential reference
• PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas

  2005cited by this paper
• Growth factor regulation of autophagy and cell survival in the absence of apoptosis.

  2005cited by this paper
• Inhibition of Macroautophagy Triggers Apoptosis

  2005cited by this paper
• Phosphatidylinositide 3-kinase/AKT in radiation responses.

  2004cited by this paper
• LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

  2004cited by this paper
• Development by self-digestion: molecular mechanisms and biological functions of autophagy.

  2004cited by this paper

• Atovaquone-induced activation of the PERK/eIF2α signaling axis mitigates metabolic radiosensitisation

  2025cites this paper
• AOP Report: Development of an adverse outcome pathway for deposition of energy leading to bone loss

  2024cites this paper
• CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy

  2024cites this paper
• Blocking ACSL6 Compromises Autophagy via FLI1‐Mediated Downregulation of COLs to Radiosensitize Lung Cancer

  2024cites this paper
• Role of autophagy in modulating tumor cell radiosensitivity: Exploring pharmacological interventions for glioblastoma multiforme treatment.

  2024cites this paper
• Myriad factors and pathways influencing tumor radiotherapy resistance

  2024cites this paper
• Enhancing autophagy leads to increased cell death in radiation-treated cervical cancer cells

  2023cites this paper
• Oligodendrocyte Progenitors Display Enhanced Proliferation and Autophagy after Space Flight

  2023cites this paper
• Association of ATG16L1 rs2241880 and TP53 rs1042522 with characteristics and course of diffuse large B-cell lymphoma.

  2022cites this paper
• Mechanisms of radioresistance and the underlying signaling pathways in colorectal cancer cells

  2022cites this paper
• Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing

  2021cites this paper
• Ubiquitin-specific protease 14 promotes radio-resistance and suppresses autophagy in oral squamous cell carcinoma.

  2020cites this paper
• The role of Atg7-mediated autophagy in ionizing radiation-induced neural stem cell damage.

  2020cites this paper
• Fibroblast Growth Factor Receptors as Targets for Radiosensitization in Head and Neck Squamous Cell Carcinomas.

  2020cites this paper
• FGFR Inhibition Enhances Sensitivity to Radiation in Non–Small Cell Lung Cancer

  2020cites this paper
• Lys05 – A Promising Autophagy Inhibitor in the Radiosensitization Battle: Phosphoproteomic Perspective

  2020cites this paper
• Effect of autophagy on irradiation-induced damage in osteoblast-like MC3T3-E1 cells

  2020cites this paper
• Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells

  2020cites this paper
• Dual effects of gossypol on human hepatocellular carcinoma via endoplasmic reticulum stress and autophagy.

  2019cites this paper
• A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299

  2019cites this paper
• Rationale for combination of radiation therapy and immune checkpoint blockers to improve cancer treatment

  2019cites this paper
• Targeting autophagy in thyroid cancers.

  2019cites this paper
• Insulin-like growth factor-1 receptor knockdown enhances radiosensitivity via the HIF-1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells.

  2018cites this paper
• Radiosensitization by Marine Sponge Agelas sp. Extracts in Hepatocellular Carcinoma Cells with Autophagy Induction

  2018cites this paper
• Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells

  2018cites this paper
• Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

  2018cites this paper
• Autophagy-regulating microRNAs: potential targets for improving radiotherapy

  2018cites this paper
• The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

  2018cites this paper
• Molecular radiation biology/oncology and its impact on preclinical and clinical research in radiotherapy.

  2017cites this paper
• The inhibitory effect of minocycline on radiation-induced neuronal apoptosis via AMPKα1 signaling-mediated autophagy

  2017cites this paper
• Influence of autophagy on the efficacy of radiotherapy

  2017cites this paper
• Egr-1 regulates irradiation-induced autophagy through Atg4B to promote radioresistance in hepatocellular carcinoma cells

  2017cites this paper
• Stress and the nonsense-mediated RNA decay pathway

  2017cites this paper
• Role of autophagy in regulating the radiosensitivity of tumor cells

  2017cites this paper
• The Role of Autophagy in Cancer.

  2017cites this paper
• Stress and the nonsense-mediated RNA decay pathway

  2017cites this paper
• Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer.

  2016cites this paper
• Treatment Induced Autophagy Associated with Tumor Dormancy and Relapse

  2016cites this paper
• The Traditional Chinese Medicine DangguiBuxue Tang Sensitizes Colorectal Cancer Cells to Chemoradiotherapy

  2016cites this paper
• The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy.

  2016cites this paper
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  2016cites this paper