New developments in prion disease research using genetically modified mouse models

No abstract is available for this paper.

• Publication year

  2023

• Venue

  Cell and Tissue Research

• Publication date

  2023-03-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00441-023-03761-xPMID 36929219
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland

  2023influential reference
• Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains

  2022cited by this paper
• The shape of things to come: structural insights into how prion proteins encipher heritable information

  2022cited by this paper
• The first report of a strong association between genetic polymorphisms of the prion protein gene (PRNP) and susceptibility to chronic wasting disease (CWD) in sika deer (Cervus nippon).

  2022cited by this paper
• Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD

  2022cited by this paper
• Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein

  2021cited by this paper
• 2.7 Å cryo-EM structure of ex vivo RML prion fibrils

  2021cited by this paper
• Generation of human chronic wasting disease in transgenic mice

  2021cited by this paper
• Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis

  2021cited by this paper
• High-resolution structure and strain comparison of infectious mammalian prions.

  2021cited by this paper
• New and distinct chronic wasting disease strains associated with cervid polymorphism at codon 116 of the Prnp gene.

  2021cited by this paper
• North American and Norwegian Chronic Wasting Disease prions exhibit different potential for interspecies transmission and zoonotic risk.

  2021cited by this paper
• Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America

  2020cited by this paper
• Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe

  2019cited by this paper
• The emergence of classical BSE from atypical/Nor98 scrapie

  2019cited by this paper
• Chronic Wasting Disease in Cervids: Implications for Prion Transmission to Humans and Other Animal Species

  2019cited by this paper
• Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice

  2019influential reference
• Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay

  2019influential reference
• Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids.

  2018influential reference
• Prion Disease in Dromedary Camels, Algeria

  2018cited by this paper
• Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway

  2018cited by this paper
• Chronic wasting disease: an evolving prion disease of cervids.

  2018influential reference
• PrPSc formation and clearance as determinants of prion tropism

  2017cited by this paper
• Prion replication without host adaptation during interspecies transmissions

  2017cited by this paper
• Divergent prion strain evolution driven by PrPC expression level in transgenic mice

  2017cited by this paper
• First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer

  2016cited by this paper
• Mitigation of Prion Infectivity and Conversion Capacity by a Simulated Natural Process—Repeated Cycles of Drying and Wetting

  2015cited by this paper
• Grass plants bind, retain, uptake, and transport infectious prions.

  2015cited by this paper
• Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion

  2015cited by this paper
• Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains

  2015cited by this paper
• Transmission of scrapie prions to primate after an extended silent incubation period

  2015cited by this paper
• Structural effects of PrP polymorphisms on intra- and interspecies prion transmission

  2014influential reference
• Quinacrine promotes replication and conformational mutation of chronic wasting disease prions

  2014cited by this paper
• Evidence That Bank Vole PrP Is a Universal Acceptor for Prions

  2014cited by this paper
• Elements Modulating the Prion Species Barrier and Its Passage Consequences

  2014cited by this paper
• Chronic Wasting Disease Agents in Nonhuman Primates

  2014cited by this paper
• Evidence for zoonotic potential of ovine scrapie prions

  2014cited by this paper
• Chronic Wasting Disease in Bank Voles: Characterisation of the Shortest Incubation Time Model for Prion Diseases

  2013cited by this paper
• Experimental chronic wasting disease in wild type VM mice.

  2013cited by this paper
• Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy

  2013cited by this paper
• Intranasal Inoculation of White-Tailed Deer (Odocoileus virginianus) with Lyophilized Chronic Wasting Disease Prion Particulate Complexed to Montmorillonite Clay

  2013cited by this paper
• Epigenetic Dominance of Prion Conformers

  2013cited by this paper
• Facilitated Cross-Species Transmission of Prions in Extraneural Tissue

  2012influential reference
• Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model

  2012cited by this paper
• Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein

  2012cited by this paper
• Sensitivity of protein misfolding cyclic amplification versus immunohistochemistry in ante-mortem detection of chronic wasting disease.

  2012cited by this paper
• DETECTION OF PrPCWD IN FECES FROM NATURALLY EXPOSED ROCKY MOUNTAIN ELK (CERVUS ELAPHUS NELSONI) USING PROTEIN MISFOLDING CYCLIC AMPLIFICATION

  2012cited by this paper
• Detection of prion protein in the cerebrospinal fluid of elk (Cervus canadensis nelsoni) with chronic wasting disease using protein misfolding cyclic amplification

  2012cited by this paper
• Chronic wasting disease prion trafficking via the autonomic nervous system.

  2011cited by this paper
• Generation of a New Form of Human PrPSc in Vitro by Interspecies Transmission from Cervid Prions*

  2011cited by this paper
• Prion Protein Expression and Functional Importance in Skeletal Muscle

  2011cited by this paper
• Sheep and Goat BSE Propagate More Efficiently than Cattle BSE in Human PrP Transgenic Mice

  2011cited by this paper
• Alteration of the Chronic Wasting Disease Species Barrier by In Vitro Prion Amplification

  2011cited by this paper
• Transgenic mouse models and prion strains.

  2011cited by this paper
• Detection of Chronic Wasting Disease Prions in Salivary, Urinary, and Intestinal Tissues of Deer: Potential Mechanisms of Prion Shedding and Transmission

  2011cited by this paper
• Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein

  2010cited by this paper
• Minor Oral Lesions Facilitate Transmission of Chronic Wasting Disease

  2010cited by this paper
• B Cells and Platelets Harbor Prion Infectivity in the Blood of Deer Infected with Chronic Wasting Disease

  2010cited by this paper
• Pathogenesis of chronic wasting disease in cervidized transgenic mice.

  2010cited by this paper
• Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure

  2010cited by this paper
• Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein

  2010cited by this paper
• Aerosol and nasal transmission of chronic wasting disease in cervidized mice

  2010cited by this paper
• Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties

  2010cited by this paper
• Darwinian Evolution of Prions in Cell Culture

  2010cited by this paper
• Prion Infectivity in Fat of Deer with Chronic Wasting Disease

  2009cited by this paper
• Susceptibilities of Nonhuman Primates to Chronic Wasting Disease

  2009cited by this paper
• Trans-species amplification of PrP(CWD) and correlation with rigid loop 170N.

  2009cited by this paper
• Polymorphisms at the PRNP Gene Influence Susceptibility to Chronic Wasting Disease in Two Species of Deer (Odocoileus Spp.) in Western Canada

  2009cited by this paper
• Chronic Wasting Disease Prions in Elk Antler Velvet

  2009cited by this paper
• De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis

  2009cited by this paper
• NMR structure of the bank vole prion protein at 20 degrees C contains a structured loop of residues 165-171.

  2008cited by this paper
• Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD

  2008cited by this paper
• Accelerated High Fidelity Prion Amplification Within and Across Prion Species Barriers

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• Atypical BSE (BASE) Transmitted from Asymptomatic Aging Cattle to a Primate

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• Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

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• The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation.

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• Levels of Abnormal Prion Protein in Deer and Elk with Chronic Wasting Disease

  2007cited by this paper
• Resistance to Chronic Wasting Disease in Transgenic Mice Expressing a Naturally Occurring Allelic Variant of Deer Prion Protein

  2007cited by this paper
• The role of host PrP in Transmissible Spongiform Encephalopathies.

  2007cited by this paper
• Cross-sequence Transmission of Sporadic Creutzfeldt-Jakob Disease Creates a New Prion Strain*

  2007cited by this paper
• A General Model of Prion Strains and Their Pathogenicity

  2007influential reference
• Predicting susceptibility and incubation time of human-to-human transmission of vCJD.

  2006cited by this paper
• Transmission of Elk and Deer Prions to Transgenic Mice

  2006influential reference
• Prions in Skeletal Muscles of Deer with Chronic Wasting Disease

  2006cited by this paper
• Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC.

  2006cited by this paper
• Efficient Transmission and Characterization of Creutzfeldt–Jakob Disease Strains in Bank Voles

  2006cited by this paper
• Chronic Wasting Disease of Elk: Transmissibility to Humans Examined by Transgenic Mouse Models

  2005influential reference
• Highly bovine spongiform encephalopathy-sensitive transgenic mice confirm the essential restriction of infectivity to the nervous system in clinically diseased cattle.

  2005cited by this paper
• Prion protein NMR structures of elk and of mouse/elk hybrids.

  2005cited by this paper
• Additional cases of Chronic Wasting Disease in imported deer in Korea.

  2005influential reference
• Human Prion Protein with Valine 129 Prevents Expression of Variant CJD Phenotype

  2004cited by this paper
• Environmental Sources of Prion Transmission in Mule Deer

  2004cited by this paper
• Transmission of Prions from Mule Deer and Elk with Chronic Wasting Disease to Transgenic Mice Expressing Cervid PrP

  2004influential reference
• Humanized knock-in mice expressing chimeric prion protein showed varied susceptibility to different human prions.

  2003cited by this paper
• Early detection of PrPres in BSE-infected bovine PrP transgenic mice

  2003cited by this paper
• Cases of scrapie with unusual features in Norway and designation of a new type, Nor98

  2003cited by this paper
• A change in the conformation of prions accompanies the emergence of a new prion strain.

  2002cited by this paper
• Subclinical scrapie infection in a resistant species: persistence, replication, and adaptation of infectivity during four passages.

  2002cited by this paper
• Prions in skeletal muscle

  2002cited by this paper
• BSE prions propagate as either variant CJD‐like or sporadic CJD‐like prion strains in transgenic mice expressing human prion protein

  2002cited by this paper

• Lessons learned and lingering uncertainties after seven years of chronic wasting disease management in Norway

  2024cites this paper
• Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease

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• New developments in prion disease research

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