Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Arthritis & Rheumatism

• Publication date

  2004-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/ART.20678PMID 15593217
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll‐like receptors

  2007cited by this paper
• High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcγR triggering

  2004cited by this paper
• The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.

  2004cited by this paper
• Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages

  2004cited by this paper
• High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering.

  2004cited by this paper
• Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium.

  2003cited by this paper
• Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis

  2003cited by this paper
• DNA Fragments of the Human 60-kDa Heat Shock Protein (HSP60) Vaccinate Against Adjuvant Arthritis: Identification of a Regulatory HSP60 Peptide 1

  2003cited by this paper
• Modulation of Toll-Like Receptor 4 Expression on Human Monocytes by Tumor Necrosis Factor and Interleukin-6: Tumor Necrosis Factor Evokes Lipopolysaccharide Hyporesponsiveness, Whereas Interleukin-6 Enhances Lipopolysaccharide Activity

  2003cited by this paper
• Recognition of pathogen-associated molecular patterns by TLR family.

  2003cited by this paper
• Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis.

  2003cited by this paper
• Cytokines in rheumatoid arthritis

  2002cited by this paper
• Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis.

  2002cited by this paper
• Receptor-Mediated Monitoring of Tissue Well-Being Via Detection of Soluble Heparan Sulfate by Toll-Like Receptor 41

  2002cited by this paper
• Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

  2002cited by this paper
• Activation of APCs Through CD40 or Toll-Like Receptor 9 Overcomes Tolerance and Precipitates Autoimmune Disease1

  2002cited by this paper
• Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

  2002cited by this paper
• Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis

  2002cited by this paper
• In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation1

  2002cited by this paper
• A role for Toll in autoimmunity

  2002cited by this paper
• The Danger Model: A Renewed Sense of Self

  2002cited by this paper
• Bacterial Lipopolysaccharide and IFN-γ Induce Toll-Like Receptor 2 and Toll-Like Receptor 4 Expression in Human Endothelial Cells: Role of NF-κB Activation1

  2001cited by this paper
• Reduced Incidence and Severity of Collagen-Induced Arthritis in Mice Lacking IL-181

  2001cited by this paper
• The stressed synovium

  2001cited by this paper
• Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation.

  2001cited by this paper
• The Extra Domain A of Fibronectin Activates Toll-like Receptor 4*

  2001cited by this paper
• Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex1

  2000cited by this paper
• The structure and origin of rheumatoid factors.

  2000cited by this paper
• Synovial tissue analysis in rheumatoid arthritis.

  1999cited by this paper
• Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

  1999cited by this paper
• Natural adjuvants: Endogenous activators of dendritic cells

  1999cited by this paper
• Interleukin-18: a novel cytokine that augments both innate and acquired immunity.

  1998cited by this paper
• A family of human receptors structurally related to Drosophila Toll.

  1998cited by this paper
• IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

  1997cited by this paper
• Pathogenesis of rheumatoid arthritis.

  1997cited by this paper
• Dual role of IL-12 in early and late stages of murine collagen type II arthritis.

  1997cited by this paper
• Augmented humoral and anaphylactic responses in FcγRII-deficient mice

  1996cited by this paper
• Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice.

  1996cited by this paper
• Role of cytokines in rheumatoid arthritis.

  1996cited by this paper
• Pro- and antiinflammatory cytokine balance in rheumatoid arthritis.

  1995cited by this paper
• Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis.

  1995cited by this paper
• Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

  1993cited by this paper
• Revised criteria for the classification of rheumatoid arthritis.

  1990cited by this paper
• Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

  1989cited by this paper
• The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.

  1988cited by this paper
• Association of the B-cell alloantigen DRw4 with rheumatoid arthritis.

  1978cited by this paper
• Thl/Th2 CYTOKINE BALANCE IN ARTHRITIS

  year unknowncited by this paper

• Modulation of inflammatory pathways by omega-3 fatty acids in knee joint health for the management of post-traumatic osteoarthritis: a review.

  2026cites this paper
• CXCL8 and GZMB genes promote cartilaginous and synovial lesion formation via NF-κB and MAPK signaling pathways in Kaschin-Beck disease.

  2025cites this paper
• Anti-β2GPI antibodies induce trophoblast pyroptosis and placental inflammation through TLR4/NLRP3/GSDMD axis.

  2025cites this paper
• How to Distinguish Non-Inflammatory from Inflammatory Pain in RA?

  2024cites this paper
• Infectious and Commensal Bacteria in Rheumatoid Arthritis—Role in the Outset and Progression of the Disease

  2024cites this paper
• Myeloid-specific deletion of autotaxin inhibits rheumatoid arthritis and osteoclastogenesis

  2024cites this paper
• Toll-like receptor signalling as a cannabinoid target.

  2024cites this paper
• Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models

  2024cites this paper
• Targeting TLR Signaling Cascades in Systemic Lupus Erythematosus and Rheumatoid Arthritis: An Update

  2024cites this paper
• Autoimmunity: A New Focus on Nasal Polyps

  2023cites this paper
• The prepared and characterized polysaccharide polymer in Saposhnikovia divaricata(Trucz.) Schischk effectively controls the course of rheumatoid arthritis via TLR4/TRAF6–NF-κB/IκB-α signaling pathway

  2023cites this paper
• New Potentiality of Bioactive Substances: Regulating the NLRP3 Inflammasome in Autoimmune Diseases

  2023cites this paper
• The Underlying Mechanism of Duanteng Yimu Decoction in Inhibiting Synovial Hyperplasia in Rheumatoid Arthritis

  2023cites this paper
• Interplay of Chemokines Receptors, Toll-like Receptors, and Host Immunological Pathways

  2023cites this paper
• Investigating the link between miR-34a-5p and TLR6 signaling in sepsis-induced ARDS

  2023cites this paper
• Autoimmunity and autoinflammation — the key to understanding the pathogenesis of osteoarthritis and developing new ways for its prevention and therapy

  2023cites this paper
• A potential inflammatory role of Toll-like receptor-2 in psoriatic arthritis

  2023cites this paper
• Elderly-onset rheumatoid arthritis vs. polymyalgia rheumatica: Differences in pathogenesis

  2023influential citation
• Evaluating TLR4 Gene Expression to Monitor Disease Progression in Iraqi Patients with Rheumatoid Arthritis

  2023cites this paper
• HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases

  2023cites this paper
• Identification of diagnostic biomarkers and immuno-infiltration analysis for rheumatoid arthritis based on biological information and WGCNA.

  2023cites this paper
• Dopamine D3 receptor signaling alleviates mouse rheumatoid arthritis by promoting Toll-like receptor 4 degradation in mast cells

  2022cites this paper
• Disease-modifying anti-rheumatic drugs improve the cardiovascular profile in patients with rheumatoid arthritis

  2022cites this paper
• Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments

  2022cites this paper
• Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity

  2022cites this paper
• The role of S100A12 and Toll‐like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis

  2022cites this paper
• A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

  2022cites this paper
• Host-pathogen protein-nucleic acid interactions: A comprehensive review

  2022cites this paper
• Immunomodulatory effects of Simvastatin in Toll-like receptor-2 stimulated Rheumatoid arthritis synoviocytes

  2022influential citation
• Elevated expression of TLR2 and its correlation with disease activity and clinical manifestations in adult-onset Still’s disease

  2022cites this paper
• Innate Immunity at the Core of Sex Differences in Osteoarthritic Pain?

  2022cites this paper
• RA Fibroblast-Like Synoviocytes Derived Extracellular Vesicles Promote Angiogenesis by miRNA-1972 Targeting p53/mTOR Signaling in Vascular Endotheliocyte

  2022cites this paper
• The Mechanisms of SAA/TLR4 Inducing Angiogenesis in Rheumatoid Arthritis through NETs Formation

  2022cites this paper
• Contribution of Toll-Like Receptors and the NLRP3 Inflammasome in Rheumatoid Arthritis Pathophysiology

  2021cites this paper
• Association of Toll-Like Receptor 9 Gene Polymorphisms With Remission in Patients With Rheumatoid Arthritis Receiving Tumor Necrosis Factor Alpha Inhibitors and Development of Machine Learning Models

  2021cites this paper
• Toll-Like Receptors Gene Polymorphisms in Autoimmune Disease

  2021cites this paper
• TLR expression profiles are a function of disease status in rheumatoid arthritis and experimental arthritis.

  2021cites this paper
• Minimal role of interleukin 6 and toll-like receptor 2 and 4 in murine models of immune-mediated bone marrow failure

  2021influential citation
• Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury

  2021cites this paper
• Is there an Inflammation Role for MYD88 in Rheumatoid Arthritis?

  2021cites this paper
• Biologics and atherosclerotic cardiovascular risk in rheumatoid arthritis: a review of evidence and mechanistic insights

  2021cites this paper
• Multipotent Mesenchymal Stromal Cells in Rheumatoid Arthritis and Systemic Lupus Erythematosus; From a Leading Role in Pathogenesis to Potential Therapeutic Saviors?

  2021cites this paper
• Association Between Severity of Leptospirosis and Subsequent Major Autoimmune Diseases: A Nationwide Observational Cohort Study

  2021cites this paper
• Effects of intra-articular inoculation with Mycoplasma bovis on immunological responses in calf joints.

  2021cites this paper
• Euphorbia Factor L2 ameliorates the Progression of K/BxN Serum-Induced Arthritis by Blocking TLR7 Mediated IRAK4/IKKβ/IRF5 and NF-kB Signaling Pathways

  2021cites this paper
• Association of TLR 9 gene polymorphisms with remission in patients with rheumatoid arthritis receiving TNF-α inhibitors and development of machine learning models

  2021cites this paper
• The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease.

  2021cites this paper
• Dynamics of local gene regulations in synovial fluid leukocytes from horses with lipopolysaccharide-induced arthritis.

  2021cites this paper
• Association of KIR and TLR genes with Rheumatoid Arthritis

  2020cites this paper
• Transcriptional profiling of murine macrophages stimulated with cartilage fragments revealed a strategy for treatment of progressive osteoarthritis

  2020cites this paper
• TLR4 contributes to the damage of cartilage and subchondral bone in discectomy‐induced TMJOA mice

  2020cites this paper
• ДОБОВА ВАРІАБЕЛЬНІСТЬ РІВНЯ РОЗЧИННИХ ТОЛ-ПОДІБНИХ РЕЦЕПТОРІВ 2 В СИРОВАТЦІ КРОВІ ЖІНОК, ХВОРИХ НА РЕВМАТОЇДНИЙ АРТРИТ: ЗВ’ЯЗОК З ПЕРЕБІГОМ ЗАХВОРЮВАННЯ

  2020cites this paper
• Differential synovial tissue expression of TLRs in seropositive and seronegative rheumatoid arthritis: A preliminary report

  2020cites this paper
• TlR2 and TlR4 are involved in the treatment of rheumatoid arthritis synovial fibroblasts with a medicated serum of asarinin through inhibition of Th1/Th17 cytokines

  2020cites this paper
• Roles of Interactions Between Toll-Like Receptors and Their Endogenous Ligands in the Pathogenesis of Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still’s Disease

  2020cites this paper
• Ortho-vanillin nanoparticle-doped glucan microspheres exacerbate the anti-arthritic effects of methotrexate in adjuvant-induced arthritis in rats

  2020cites this paper
• Association between serum Toll-like receptor 4 and 8-hydroxy-2′-deoxyguanosine levels with disease activity in rheumatoid arthritis patients

  2020cites this paper
• miR-221-3p Drives the Shift of M2-Macrophages to a Pro-Inflammatory Function by Suppressing JAK3/STAT3 Activation

  2020cites this paper
• Minor C allele of the SNP rs7873784 associated with rheumatoid arthritis and type-2 diabetes mellitus binds PU.1 and enhances TLR4 expression.

  2019cites this paper
• Evaluation of Toll-like Receptor 2 Gene Expression in Rheumatoid Arthritis and Correlation with the Disease Activity

  2019cites this paper
• Dual RNA-Seq Unveils the Role of the Pseudomonas plecoglossicida fliA Gene in Pathogen-Host Interaction with Larimichthys crocea

  2019cites this paper
• Toll-like receptors activation, signaling, and targeting: an overview

  2019cites this paper
• MiRNA-506 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targetting TLR4

  2019cites this paper
• Higher levels of serum TLR2 and TLR4 in patients with Hashimoto's Thyroiditis.

  2019cites this paper
• [Role and progress of innate immunity in pathogenesis of osteoarthritis].

  2019cites this paper
• High-Mobility Group Box 1 Is Associated with the Inflammatory Pathogenesis of Graves' Orbitopathy

  2019cites this paper
• Gene expression of Interleukin-18 in rheumatoid arthritis patients on disease modifying anti-rheumatic drug therapy

  2019cites this paper
• Antagonistic Property of G2013 (α-L-Guluronic Acid) on Gene Expression of MyD88, Tollip, and NF-κB in HEK293 TLR2 and HEK293 TLR4.

  2019cites this paper
• Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway

  2019cites this paper
• Relevance of Receptor for Advanced Glycation end Products (RAGE) in Murine Antibody-Mediated Autoimmune Diseases

  2019cites this paper
• University of Groningen Expression of Lectin-Like Transcript 1 , the Ligand for CD 161 , in Rheumatoid Arthritis

  2019cites this paper
• MiR-3926 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion through targeting toll like receptor 5.

  2019cites this paper
• Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis

  2019cites this paper
• Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium

  2019cites this paper
• Innate immunity as the trigger of systemic autoimmune diseases.

  2019cites this paper
• Physiologic and pathologic effects of dietary free fatty acids on cells of the joint

  2019cites this paper
• Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug.

  2019cites this paper
• Human Toll-Like Receptor 4 (hTLR4): Structural and functional dynamics in cancer.

  2019cites this paper
• Systemic Inflammatory Response and Atherosclerosis: The Paradigm of Chronic Inflammatory Rheumatic Diseases

  2018cites this paper
• The involvement of Toll‐like receptor 9 in the pathogenesis of erosive autoimmune arthritis

  2018cites this paper
• IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases

  2018cites this paper
• Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis

  2018cites this paper
• ACPA mediates the interplay between innate and adaptive immunity in rheumatoid arthritis.

  2018cites this paper
• Triptolide prevents osteoarthritis via inhibiting hsa-miR-20b

  2018cites this paper
• The Profile of Toll-like Receptor 2 (TLR2), TLR4 and Their Cytosolic Downstream Signaling Pathway in Common Variable Immunodeficiency (CVID) Patients.

  2018cites this paper
• TLR10 and NFKBIA contributed to the risk of hip osteoarthritis: systematic evaluation based on Han Chinese population

  2018cites this paper
• Bergenin loaded gum xanthan stabilized silver nanoparticles suppress synovial inflammation through modulation of the immune response and oxidative stress in adjuvant induced arthritic rats.

  2018cites this paper
• Investigations on the Role of Toll-like Receptors in Animal Models of Rheumatoid Arthritis

  2018cites this paper
• Toll‐like receptors signaling network in pre‐eclampsia: An updated review

  2018cites this paper
• Foxc1 promotes the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis via PI3K/AKT signalling pathway.

  2018cites this paper
• Exosome‐encapsulated miR‐6089 regulates inflammatory response via targeting TLR4

  2018cites this paper
• Danger of frustrated sensors: Role of Toll-like receptors and NOD-like receptors in aseptic and septic inflammations around total hip replacements

  2017cites this paper
• Effects of CTLA4-Ig on human monocytes

  2017cites this paper
• Direct recognition of LPS drive TLR4 expressing CD8+ T cell activation in patients with rheumatoid arthritis

  2017cites this paper
• Persistent RNA virus infections: do PAMPS drive chronic disease?

  2017cites this paper
• TLRs, future potential therapeutic targets for RA.

  2017cites this paper
• Dietary Fats and Osteoarthritis: Insights, Evidences, and New Horizons

  2017cites this paper
• The role of anti-collagen type II antibodies in the pathogenesis and prognosis of rheumatoid arthritis

  2017cites this paper
• Chapter 69 – Etiology and Pathogenesis of Rheumatoid Arthritis

  2017cites this paper
• The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response

  2017cites this paper