Protein kinase CK2 in human diseases.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Current Medicinal Chemistry

• Publication date

  2008-07-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/092986708785132933PMID 18691045
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer.

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• Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal.

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• Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies.

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• The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton.

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• Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.

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