Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Stem Cell Reviews and Reports

• Publication date

  2011-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12015-010-9210-xPMID 21181307
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

  2010cited by this paper
• Friedreich ataxia: The clinical picture

  2009cited by this paper
• Small‐Molecule Induction of Neural Crest‐like Cells Derived from Human Neural Progenitors

  2009cited by this paper
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  2009cited by this paper
• Derivation of induced pluripotent stem cells from pig somatic cells

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• Integration of functional bacterial artificial chromosomes into human cord blood-derived multipotent stem cells

  2009cited by this paper
• Reprogramming of human somatic cells to pluripotency with defined factors

  2008cited by this paper
• Disease-specific induced pluripotent stem cells.

  2008cited by this paper
• Generation of human induced pluripotent stem cells from dermal fibroblasts

  2008cited by this paper
• Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

  2008cited by this paper
• Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

  2008cited by this paper
• Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

  2008cited by this paper
• Progressive gaa expansions in dorsal root ganglia of Friedreich's ataxia patients

  2007influential reference
• KLF4 suppresses transformation of pre-B cells by ABL oncogenes.

  2007cited by this paper
• Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract.

  2007cited by this paper
• Generation of germline-competent induced pluripotent stem cells

  2007cited by this paper
• Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

  2007cited by this paper
• The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues.

  2007cited by this paper
• Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

  2007cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• The GAA triplet-repeat is unstable in the context of the human FXN locus and displays age-dependent expansions in cerebellum and DRG in a transgenic mouse model

  2006cited by this paper
• Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration.

  2006cited by this paper
• Friedreich's Ataxia, No Changes in Mitochondrial Labile Iron in Human Lymphoblasts and Fibroblasts

  2005cited by this paper
• Transcriptional regulation and transformation by Myc proteins

  2005cited by this paper
• BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing

  2005cited by this paper
• Frataxin overexpressing mice

  2004cited by this paper
• Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin

  2004cited by this paper
• Prospects for gene therapy.

  2004cited by this paper
• GAA repeat instability in Friedreich ataxia YAC transgenic mice.

  2004cited by this paper
• Human Embryonic Stem Cells Form Embryoid Bodies Containing Visceral Endoderm-Like Derivatives

  2004cited by this paper
• Neural progenitors from human embryonic stem cells

  2001cited by this paper
• Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

  2001cited by this paper
• Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro

  2000cited by this paper
• Influence of GAA expansion size and disease duration on central nervous system impairment in Friedreich's ataxia: contribution to the understanding of the pathophysiology of the disease.

  2000cited by this paper
• Clinical and genetic study of Friedreich ataxia in an Australian population.

  1999cited by this paper
• Embryonic stem cell lines derived from human blastocysts.

  1998cited by this paper
• A mild case of Friedreich ataxia: Lymphocyte and sural nerve analysis for GAA repeat length reveals somatic mosaicism

  1998cited by this paper
• Arylsulfatase B activities and glycosaminoglycan levels in retrovirally transduced mucopolysaccharidosis type VI cells. Prospects for gene therapy.

  1996cited by this paper
• Simplified mammalian DNA isolation procedure.

  1991cited by this paper
• Molecular Cell Biology

  1986cited by this paper
• Brief report Generation of induced pluripotent stem cells from human blood

  year unknowncited by this paper

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  2025cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
• Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response

  2022cites this paper
• Perspectives on current models of Friedreich’s ataxia

  2022cites this paper
• Treatment and Management of Autosomal Recessive Cerebellar Ataxias: Current Advances and Future Perspectives.

  2022cites this paper
• Patient-derived iPSC modeling of rare neurodevelopmental disorders: Molecular pathophysiology and prospective therapies.

  2020influential citation
• Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons

  2020cites this paper
• Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling

  2019cites this paper
• Genetic and physiological studies in Friedreich's ataxia

  2019cites this paper
• Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons

  2019cites this paper
• Inducing pluripotency in livestock somatic cells to enhance genome-editing opportunities

  2019cites this paper
• Progress in understanding Friedreich’s ataxia using human induced pluripotent stem cells

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• KÖK HÜCRELERİN TOKSİKOLOJİ ÇALIŞMALARINDA KULLANIMI

  2018cites this paper
• Paradigm for disease deconvolution in rare neurodegenerative disorders in Indian population: insights from studies in cerebellar ataxias

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• An Overview of Direct Somatic Reprogramming: The Ins and Outs of iPSCs

  2016cites this paper
• Modeling simple repeat expansion diseases with iPSC technology

  2016cites this paper
• Using human pluripotent stem cells to study Friedreich ataxia cardiomyopathy.

  2016cites this paper
• Action Potential Shape Is a Crucial Measure of Cell Type of Stem Cell-Derived Cardiocytes.

  2016cites this paper
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  2016cites this paper
• Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A.

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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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• Frataxin Silencing Inactivates Mitochondrial Complex I in NSC34 Motoneuronal Cells and Alters Glutathione Homeostasis

  2014cites this paper
• Neural crest cells: from developmental biology to clinical interventions.

  2014cites this paper
• Autologous stem cell transplant with gene therapy for Friedreich ataxia.

  2014influential citation
• Cell and Gene Therapy for Friedreich Ataxia: Progress to Date

  2014influential citation
• Induced pluripotent stem cells for modeling of pediatric neurological disorders

  2014cites this paper
• The Current Status of iPS Cells in Cardiac Research and Their Potential for Tissue Engineering and Regenerative Medicine

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• An Introduction to Cellular Reprogramming: The Plasticity of Cell Fates and Identities

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013influential citation
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  2013influential citation
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012influential citation
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  2012cites this paper
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  2012influential citation
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper