Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

Enhancing β-cell proliferation is a major goal for type 1 and type 2 diabetes research. Unraveling the network of β-cell intracellular signaling pathways that promote β-cell replication can provide the tools to address this important task. In a previous Perspectives in Diabetes article, we discussed what was known regarding several important intracellular signaling pathways in rodent β-cells, including the insulin receptor substrate/phosphatidylinositol-3 kinase/Akt (IRS-PI3K-Akt) pathways, glycogen synthase kinase-3 (GSK3) and mammalian target of rapamycin (mTOR) S6 kinase pathways, protein kinase Cζ (PKCζ) pathways, and their downstream cell-cycle molecular targets, and contrasted that ample knowledge to the small amount of complementary data on human β-cell intracellular signaling pathways. In this Perspectives, we summarize additional important information on signaling pathways activated by nutrients, such as glucose; growth factors, such as epidermal growth factor, platelet-derived growth factor, and Wnt; and hormones, such as leptin, estrogen, and progesterone, that are linked to rodent and human β-cell proliferation. With these two Perspectives, we attempt to construct a brief summary of knowledge for β-cell researchers on mitogenic signaling pathways and to emphasize how little is known regarding intracellular events linked to human β-cell replication. This is a critical aspect in the long-term goal of expanding human β-cells for the prevention and/or cure of type 1 and type 2 diabetes.

• Publication year

  2014

• Venue

  Diabetes

• Publication date

  2014-02-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/db13-1146PMID 24556859PMCID 3931400
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

  2013cited by this paper
• De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

  2013cited by this paper
• Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes

  2013cited by this paper
• Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.

  2012cited by this paper
• ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation

  2012cited by this paper
• Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.

  2012cited by this paper
• A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

  2012cited by this paper
• Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic β-cells.

  2012cited by this paper
• MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity.

  2012cited by this paper
• Importance of oestrogen receptors to preserve functional β-cell mass in diabetes

  2012cited by this paper
• TCF7L2 promotes beta cell regeneration in human and mouse pancreas

  2012cited by this paper
• Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes

  2012cited by this paper
• Human β-Cell Proliferation and Intracellular Signaling

  2012cited by this paper
• Importance of β-Catenin in glucose and energy homeostasis

  2012cited by this paper
• Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity

  2012cited by this paper
• Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

  2012cited by this paper
• Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca2+-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

  2011cited by this paper
• Signal transduction: How cells sense energy

  2011cited by this paper
• PDGF signalling controls age-dependent proliferation in pancreatic β-cells

  2011cited by this paper
• Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes.

  2011cited by this paper
• Heterozygous Inactivation of the Na/Ca Exchanger Increases Glucose-Induced Insulin Release, β-Cell Proliferation, and Mass

  2011cited by this paper
• Molecular mechanisms of tumor suppression by LKB1

  2011cited by this paper
• Control of pancreatic β cell regeneration by glucose metabolism.

  2011cited by this paper
• GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes

  2011cited by this paper
• Effects of leptin and adiponectin on pancreatic β-cell function.

  2011cited by this paper
• Betacellulin-Induced Beta Cell Proliferation and Regeneration Is Mediated by Activation of ErbB-1 and ErbB-2 Receptors

  2011influential reference
• Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation

  2011cited by this paper
• Insulinotropic and antidiabetic effects of 17β-estradiol and the GPR30 agonist G-1 on human pancreatic islets.

  2011cited by this paper
• Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels.

  2011cited by this paper
• LKB1 deletion with the RIP2.Cre transgene modifies pancreatic β-cell morphology and enhances insulin secretion in vivo

  2010cited by this paper
• Oestrogen regulates proliferation and differentiation of human islet‐derived precursor cells through oestrogen receptor alpha

  2010cited by this paper
• Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

  2010cited by this paper
• Neonatal growth and regeneration of beta-cells are regulated by the Wnt/beta-catenin signaling in normal and diabetic rats.

  2010cited by this paper
• Large islets, beta-cell proliferation, and a glucokinase mutation.

  2010cited by this paper
• Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

  2010cited by this paper
• Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF-α Gene Expression in Pancreatic Islet Endocrine Cells*

  2010cited by this paper
• Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass.

  2009cited by this paper
• Importance of Extranuclear Estrogen Receptor-α and Membrane G Protein–Coupled Estrogen Receptor in Pancreatic Islet Survival

  2009cited by this paper
• Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.

  2009cited by this paper
• Lack of β-catenin in early life induces abnormal glucose homeostasis in mice

  2009cited by this paper
• LKB1 regulates pancreatic beta cell size, polarity, and function.

  2009cited by this paper
• Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

  2009cited by this paper
• Exendin-4 Stimulation of Cyclin A2 in β-Cell Proliferation

  2008cited by this paper
• Wnt signaling: relevance to beta-cell biology and diabetes.

  2008cited by this paper
• Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets

  2008cited by this paper
• Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation*

  2008cited by this paper
• Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2

  2008cited by this paper
• Glucose Activates ChREBP by Increasing Its Rate of Nuclear Entry and Relieving Repression of Its Transcriptional Activity*

  2008cited by this paper
• Wnt/β-catenin signaling is required for development of the exocrine pancreas

  2007cited by this paper
• Wnt signaling regulates pancreatic beta cell proliferation.

  2007influential reference
• Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.

  2007cited by this paper
• Wnt signaling regulates pancreatic β cell proliferation

  2007cited by this paper
• Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth

  2006cited by this paper
• Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice.

  2006cited by this paper
• The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis.

  2006cited by this paper
• Stabilization of beta-catenin impacts pancreas growth.

  2006cited by this paper
• Stabilization of β-catenin impacts pancreas growth

  2006cited by this paper
• ChREBP•Mlx Is the Principal Mediator of Glucose-induced Gene Expression in the Liver*

  2006cited by this paper
• Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.

  2006cited by this paper
• Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function

  2006cited by this paper
• Neogenesis and proliferation of beta-cells induced by human betacellulin gene transduction via retrograde pancreatic duct injection of an adenovirus vector.

  2006cited by this paper
• Estrogen and exercise may enhance beta-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic rats.

  2005cited by this paper
• Effect of epiregulin on pancreatic beta cell growth and insulin secretion

  2005cited by this paper
• Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets

  2005cited by this paper
• Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

  2005cited by this paper
• Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.

  2005cited by this paper
• β-Catenin is essential for pancreatic acinar but not islet development

  2005cited by this paper
• Wnt signaling in disease and in development

  2005cited by this paper
• The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

  2005cited by this paper
• Convergence of Wnt, beta-catenin, and cadherin pathways.

  2004cited by this paper
• Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

  2004cited by this paper
• Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

  2004cited by this paper
• Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis.

  2004cited by this paper
• Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation.

  2004cited by this paper
• Convergence of Wnt, ß-Catenin, and Cadherin Pathways

  2004cited by this paper
• Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver

  2003cited by this paper
• Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.

  2003cited by this paper
• Regulation of cell cycle progression by calcium/calmodulin-dependent pathways.

  2003cited by this paper
• Progesterone receptor knockout mice have an improved glucose homeostasis secondary to β-cell proliferation

  2002cited by this paper
• Promotion of β-Cell Regeneration by Betacellulin in Ninety Percent-Pancreatectomized Rats.

  2001cited by this paper
• Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats.

  2001cited by this paper
• Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.

  2000cited by this paper
• Progesterone stimulates pancreatic cell proliferation in vivo.

  1999cited by this paper
• Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells.

  1999cited by this paper
• Transgenic expression of epidermal growth factor and keratinocyte growth factor in beta-cells results in substantial morphological changes.

  1999cited by this paper
• Risk for posttransplant Diabetes mellitus with current immunosuppressive medications.

  1999cited by this paper
• Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen.

  1998cited by this paper
• Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

  1997cited by this paper
• Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.

  1997cited by this paper
• Expression of the Functional Leptin Receptor mRNA in Pancreatic Islets and Direct Inhibitory Action of Leptin on Insulin Secretion

  1997cited by this paper
• Leptin receptors expressed on pancreatic beta-cells.

  1996cited by this paper
• Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

  1995cited by this paper
• Effects of steroid and lactogenic hormones on islets of Langerhans: a new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy.

  1993cited by this paper
• Betacellulin: a mitogen from pancreatic beta cell tumors.

  1993cited by this paper
• A chimera between platelet-derived growth factor beta-receptor and fibroblast growth factor receptor-1 stimulates pancreatic beta-cell DNA synthesis in the presence of PDGF-BB.

  1992cited by this paper
• Immunocytochemical localization of progesterone receptors in endocrine cells of the human pancreas.

  1990cited by this paper
• Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis.

  1990cited by this paper
• Short-term effects of oestradiol benzoate in normal, hypophysectomized and alloxan-diabetic male rats.

  1974cited by this paper
• Production or prevention of some types of experimental diabetes by oestrogens or corticosteroids.

  1954cited by this paper
• Production or prevention of some types of experimental diabetes by oestrogens or corticosteroids.

  1954cited by this paper

• Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice

  2025cites this paper
• SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2

  2025cites this paper
• SRSF1 is essential for pancreatic β-cell proliferation and the maintenance of glucose homeostasis in mice.

  2025cites this paper
• Allium hookeri root extract restores streptozotocin-induced pancreatic β-cells dysfunction in a type 1 diabetic rat model

  2025cites this paper
• Transcriptomic modifications in maternal pancreatic islets during the period around weaning in mice.

  2025cites this paper
• Pancreatic β-Cell Remodeling in Health and Aging: Lessons from Rodents and Humans.

  2025cites this paper
• Harnessing beta-cell replication: advancing molecular insights to regenerative therapies in diabetes

  2025cites this paper
• FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction

  2025cites this paper
• Degradation meets development: Implications in β‐cell development and diabetes

  2024cites this paper
• From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes

  2024cites this paper
• Acinar to β-like cell conversion through inhibition of focal adhesion kinase

  2024cites this paper
• Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

  2024cites this paper
• Advanced therapy to cure diabetes: mission impossible is now possible?

  2024cites this paper
• Phosphorylation Codes in IRS-1 and IRS-2 Are Associated with the Activation/Inhibition of Insulin Canonical Signaling Pathways

  2024cites this paper
• Serum from pregnant donors induces human beta cell proliferation

  2024cites this paper
• The Values and Perspectives of Organoids in the Field of Metabolic Syndrome

  2023cites this paper
• Serum from pregnant donors induces human beta cell proliferation and insulin secretion

  2023cites this paper
• Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes

  2023cites this paper
• Decellularized Wharton's jelly scaffold enhances differentiation of mesenchymal stem cells to insulin-secreting cells.

  2022cites this paper
• Therapeutic strategies targeting pancreatic islet β-cell proliferation, regeneration, and replacement.

  2022cites this paper
• Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis

  2022cites this paper
• Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation

  2022cites this paper
• Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

  2022cites this paper
• Targeting pancreatic β cells for diabetes treatment

  2022cites this paper
• Emerging diabetes therapies: Bringing back the β-cells

  2022cites this paper
• Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation

  2022cites this paper
• Exercise mode influences post‐exercise glucose sensitivity and insulin clearance in young, healthy males and females in a sex‐dependent manner: A randomized control trial

  2022cites this paper
• Tyrosine Kinase Targeting: A Potential Therapeutic Strategy for Diabetes

  2022cites this paper
• Dapagliflozin ameliorates pancreatic injury and activates kidney autophagy by modulating the AMPK/mTOR signaling pathway in obese rats

  2021cites this paper
• New Aspects of Diabetes Research and Therapeutic Development

  2021cites this paper
• Induction of ß Cell Replication by Small Molecule-Mediated Menin Inhibition and Combined PKC Activation and TGF-ß Inhibition as Revealed by A Refined Primary Culture Screening

  2021cites this paper
• A new shortened protocol to obtain islet-like cells from hESC-derived ductal cells

  2021cites this paper
• Islet Regeneration: Endogenous and Exogenous Approaches

  2021cites this paper
• What Is the Sweetest UPR Flavor for the β-cell? That Is the Question

  2021cites this paper
• Redox Homeostasis in Pancreatic β-Cells: From Development to Failure

  2021cites this paper
• Bee Pollen Polysaccharide From Rosa rugosa Thunb. (Rosaceae) Promotes Pancreatic β-Cell Proliferation and Insulin Secretion

  2021cites this paper
• Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion

  2021cites this paper
• The Human Islet: Mini-organ with Mega-impact.

  2021cites this paper
• In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR

  2021cites this paper
• Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass

  2021cites this paper
• A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke

  2021cites this paper
• New insights into ANGPTL8 in modulating the development of cardio-metabolic disorder diseases

  2021cites this paper
• ANGPTL8 in cardio-metabolic diseases.

  2021cites this paper
• Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation

  2021cites this paper
• Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice

  2021cites this paper
• Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling

  2020cites this paper
• β-cell replenishment: Possible curative approaches for diabetes mellitus.

  2020cites this paper
• In vivo generation and regeneration of β cells in zebrafish

  2020cites this paper
• Generation of Multipotent Stem Cells from Adult Human Peripheral Blood Following the Treatment with Platelet-Derived Mitochondria

  2020influential citation
• Genome-Wide Analysis Reveals Changes in Long Noncoding RNAs in the Differentiation of Canine BMSCs into Insulin-Producing Cells

  2020cites this paper
• Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP)

  2020cites this paper
• A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and β Cells in Late-Gestation Sheep.

  2020cites this paper
• Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in #-Cells

  2020cites this paper
• Establishing cell-intrinsic limitations in cell cycle progression controls graft growth and promotes differentiation of pancreatic endocrine cells

  2020cites this paper
• Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

  2020cites this paper
• Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans

  2020cites this paper
• TBK1 regulates regeneration of pancreatic β-cells

  2020cites this paper
• GLP-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice.

  2020cites this paper
• Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells

  2020cites this paper
• Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling

  2020cites this paper
• MANF AS A NEW REGULATOR OF THE UNFOLDED PROTEIN RESPONSE AND MAINTENANCE OF PANCREATIC β-CELLS IN MICE

  2020cites this paper
• Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep.

  2020cites this paper
• Strategies to promote beta-cell replication and regeneration

  2020cites this paper
• Naringin Ameliorates Streptozotocin-Induced Diabetes through Forkhead Box M1-Mediated Beta Cell Proliferation

  2019cites this paper
• Endogenous Pancreatic β Cell Regeneration: A Potential Strategy for the Recovery of β Cell Deficiency in Diabetes

  2019cites this paper
• Death versus dedifferentiation: The molecular bases of beta cell mass reduction in type 2 diabetes.

  2019cites this paper
• β-Cell Maturation and Identity in Health and Disease

  2019cites this paper
• Growth Factors in the Human Body: A Conceptual Update

  2019cites this paper
• Phoenixin-14 stimulates proliferation and insulin secretion in insulin producing INS-1E cells.

  2019cites this paper
• The pancreatic β-cell zinc response to chronic stimulation and extracellular zinc depletion

  2019cites this paper
• HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats

  2019cites this paper
• Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet

  2019cites this paper
• How, When, and Where Do Human β-Cells Regenerate?

  2019cites this paper
• Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism

  2019cites this paper
• Whole blueberry protects pancreatic beta-cells in diet-induced obese mouse

  2019cites this paper
• Quantifying the effect of experimental perturbations in single-cell RNA-sequencing data using graph signal processing

  2019influential citation
• mTOR: A double‐edged sword for diabetes

  2019cites this paper
• Single-Cell RNA-seq Reveals a Subpopulation of Cells Underlying β Cell Expansion in the Postnatal Islets

  2018cites this paper
• Roles of G protein-coupled estrogen receptor GPER in metabolic regulation.

  2018cites this paper
• The role of glucokinase and insulin receptor substrate-2 in the proliferation of pancreatic beta cells induced by short-term high-fat diet feeding in mice.

  2018cites this paper
• Pancreas regeneration

  2018cites this paper
• Advances in drug discovery for human beta cell regeneration

  2018cites this paper
• Pancreatic Beta-Cell Proliferation Induced by Estradiol-17β is Foxo1 Dependent

  2018cites this paper
• (Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives.

  2018cites this paper
• Adaptive beta-cell neogenesis in the adult mouse in response to glucocorticoid-induced insulin resistance

  2018cites this paper
• AMPK and Friends: Central Regulators of β Cell Biology.

  2018cites this paper
• Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice

  2018cites this paper
• Grape seed procyanidin extract ameliorates lead-induced liver injury via miRNA153 and AKT/GSK-3β/Fyn-mediated Nrf2 activation.

  2018cites this paper
• Pancreatic Beta-Cell Proliferation Induced by Estradiol-17 β is Foxo 1 Dependent

  2018cites this paper
• The adenosine, adrenergic and opioid pathways in the regulation of insulin secretion, beta cell proliferation and regeneration.

  2018cites this paper
• The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes.

  2018cites this paper
• Correction: Author Correction

  2018cites this paper
• Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue

  2018cites this paper
• Association between rs2278426 (C/T) and rs892066 (C/G) variants of ANGPTL8 (betatrophin) and susceptibility to type2 diabetes mellitus

  2018cites this paper
• Walking a fine line between β-cell secretion and proliferation

  2018cites this paper
• Cellular signaling pathways regulating β-cell proliferation as a promising therapeutic target in the treatment of diabetes

  2018cites this paper
• Haploinsufficiency of Insm1 Impairs Postnatal Baseline β-Cell Mass

  2018cites this paper
• Tub and β-catenin play a key role in insulin and leptin resistance-induced pancreatic beta-cell differentiation.

  2018cites this paper
• Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance

  2018cites this paper
• The Role of the TGFβ Receptor Signaling Pathway in Adult Beta Cell Proliferation

  2018cites this paper