Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Diabetes

• Publication date

  2005-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2337/DIABETES.54.7.2041PMID 15983205
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Deficiencies in Gut NK Cell Number and Function Precede Diabetes Onset in BB Rats1

  2004cited by this paper
• Aktan, F.: iNOS-mediated nitric oxide production and its regulation. Life Sci. 75, 639-653

  2004cited by this paper
• Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm-iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus

  2004cited by this paper
• iNOS-mediated nitric oxide production and its regulation.

  2004cited by this paper
• From beast to bedside: a commentary

  2004cited by this paper
• Type 1 diabetes: molecular, cellular and clinical immunology.

  2004cited by this paper
• Immunoregulation by cytokines in autoimmune diabetes.

  2003cited by this paper
• In Situ β Cell Death Promotes Priming of Diabetogenic CD8 T Lymphocytes1

  2002cited by this paper
• In situ beta cell death promotes priming of diabetogenic CD8 T lymphocytes.

  2002cited by this paper
• beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes.

  2001cited by this paper
• Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunity.

  2001cited by this paper
• Apoptosis and disease progression in the spontaneously diabetic BB/S rat

  2001cited by this paper
• β-Cell death during progression to diabetes

  2001cited by this paper
• The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus

  2001cited by this paper
• beta-Cell death during progression to diabetes.

  2001cited by this paper
• Immunoexpression of Interleukin-1β in Pancreatic Islets of NOD Mice during Cyclophosphamide-accelerated Diabetes: Co-localization in Macrophages and Endocrine Cells and its Attenuation with Oral Nicotinamide

  2001cited by this paper
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  2001cited by this paper
• Protection Against Diabetes and Improved NK/NKT Cell Performance in NOD.NK1.1 Mice Congenic at the NK Complex1

  2001cited by this paper
• B lymphocytes not required for progression from insulitis to diabetes in non‐obese diabetic mice

  2001cited by this paper
• IFN-γ Affects Homing of Diabetogenic T Cells1

  2001cited by this paper
• Analysis of Cytokine mRNA Expression in Pancreatic Islets of Nonobese Diabetic Mice

  2000cited by this paper
• Diabetes prone BB rats are severely deficient in natural killer T cells.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
• β-Cell Apoptosis in an Accelerated Model of Autoimmune Diabetes

  1998cited by this paper
• IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes.

  1998cited by this paper
• Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus.

  1998cited by this paper
• In situ reverse transcription‐polymerase chain reaction. Applications for light and electron microscopy

  1998cited by this paper
• Beta-cell behaviour during the prediabetic stage. Part II. Non-insulin-dependent and insulin-dependent diabetes mellitus.

  1997cited by this paper
• Insulin-dependent diabetes mellitus: Islet changes in relation to etiology and pathogenesis

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• Cytokine Gene Expression in Pancreatic Islet-Infiltrating Leukocytes of BB Rats: Expression of Th1 Cytokines Correlates With β-Cell Destructive Insulitis and IDDM

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.

  1996cited by this paper
• The role of NK cell activity in the pathogenesis of poly I:C accelerated and spontaneous diabetes in the diabetes prone BB rat.

  1995cited by this paper
• Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

  1995cited by this paper
• Methods for the detection of apoptosis.

  1994cited by this paper
• Immunohistochemical Characterization of Monocytes-Macrophages and Dendritic Cells Involved in the Initiation of the Insulitis and β-Cell Destruction in NOD Mice

  1994cited by this paper
• Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin 2 and interferon gamma mRNA expression correlate with graft rejection and interleukin 10 with graft survival

  1994cited by this paper
• Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
• Textbook of Diabetes

  1991cited by this paper
• Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

  1991cited by this paper
• Dendritic Cells and Scavenger Macrophages in Pancreatic Islets of Prediabetic BB Rats

  1989cited by this paper
• Progression From Insulitis to β-Cell Destruction in NOD Mouse Requires L3T4+ T-Lymphocytes

  1988cited by this paper
• Prevention of Recurrent Autoimmune Diabetes in BB Rats by Anti-Asialo-GM1 Antibody

  1988cited by this paper
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  1988cited by this paper
• Prevention of lymphocytic thyroiditis and insulitis in diabetes-prone BB rats by the depletion of macrophages

  1988cited by this paper
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  1988cited by this paper
• Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells

  1987cited by this paper
• The BB rat.

  1987cited by this paper
• Large increase of cytotoxic/suppressor T-lymphoblasts and eosinophils around manifestation of diabetes in BB rats.

  1986cited by this paper
• Administration of Silica Prevents Diabetes in BB-Rats

  1985cited by this paper
• The Onset and Progression of Pancreatic Insulitis in the Overt, Spontaneously Diabetic, Young Adult BB Rat Studied by Pancreatic Biopsy

  1984cited by this paper
• Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

  1981cited by this paper

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  2023cites this paper
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  2023cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020influential citation
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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