miR‐9‐5p suppresses pro‐fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2

No abstract is available for this paper.

• Publication year

  2015

• Venue

  EMBO Reports

• Publication date

  2015-08-27

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.15252/embr.201540750PMID 26315535PMCID PMC4766462
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• miR‐9‐5p suppresses pro‐fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2

  2015cited by this paper
• Idiopathic pulmonary fibrosis.

  2014cited by this paper
• Cellular mechanisms of tissue fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis.

  2014cited by this paper
• FibromiRs: translating molecular discoveries into new anti-fibrotic drugs.

  2014influential reference
• Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

  2014cited by this paper
• Bleomycin Induces Molecular Changes Directly Relevant to Idiopathic Pulmonary Fibrosis: A Model for “Active” Disease

  2013cited by this paper
• Functional Relevance of the Switch of VEGF Receptors/Co-Receptors during Peritoneal Dialysis-Induced Mesothelial to Mesenchymal Transition

  2013cited by this paper
• Integrin-mediated regulation of TGFβ in fibrosis.

  2013cited by this paper
• Lentiviral vector production, titration, and transduction of primary neurons.

  2013cited by this paper
• Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis.

  2013cited by this paper
• Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis.

  2013cited by this paper
• Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs

  2013cited by this paper
• Pulmonary fibrosis: patterns and perpetrators.

  2012cited by this paper
• Tumour‐secreted miR‐9 promotes endothelial cell migration and angiogenesis by activating the JAK‐STAT pathway

  2012cited by this paper
• Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?

  2012cited by this paper
• Mechanisms of fibrosis: therapeutic translation for fibrotic disease

  2012influential reference
• Recent developments in myofibroblast biology: paradigms for connective tissue remodeling.

  2012cited by this paper
• microPIR: An Integrated Database of MicroRNA Target Sites within Human Promoter Sequences

  2012cited by this paper
• Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases.

  2012cited by this paper
• Incidence and prevalence of idiopathic pulmonary fibrosis: review of the literature

  2012cited by this paper
• Secreted microRNAs: a new form of intercellular communication.

  2012cited by this paper
• Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis.

  2011cited by this paper
• Integrating mechanisms of pulmonary fibrosis

  2011influential reference
• Regulation and function of miRNA-21 in health and disease

  2011cited by this paper
• Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis

  2011influential reference
• MicroRNAs in body fluids—the mix of hormones and biomarkers

  2011cited by this paper
• miR-29 is a major regulator of genes associated with pulmonary fibrosis.

  2011cited by this paper
• Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters

  2011cited by this paper
• NADPH oxidase 4 mediates TGF-β-induced smooth muscle α-actin via p38MAPK and serum response factor.

  2011cited by this paper
• MicroRNAs in idiopathic pulmonary fibrosis.

  2011cited by this paper
• Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

  2011cited by this paper
• Non-coding RNAs: a key to future personalized molecular therapy?

  2010cited by this paper
• miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

  2010cited by this paper
• p38 maintains E-cadherin expression by modulating TAK1–NF-κB during epithelial-to-mesenchymal transition

  2010cited by this paper
• Inhibition and role of let-7d in idiopathic pulmonary fibrosis.

  2010cited by this paper
• Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha.

  2010cited by this paper
• NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFβ1-induced fibroblast differentiation into myofibroblasts

  2010cited by this paper
• PPAR-γ agonist rosiglitazone protects peritoneal membrane from dialysis fluid-induced damage

  2010cited by this paper
• WNT 1-inducible signaling protein – 1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis

  2009cited by this paper
• Insights into the role of microRNAs in cardiac diseases: from biological signalling to therapeutic targets.

  2009cited by this paper
• MicroRNAs and apoptosis: implications in the molecular therapy of human disease

  2009cited by this paper
• NADPH Oxidase-4 Mediates Myofibroblast Activation and Fibrogenic Responses to Lung Injury

  2009cited by this paper
• MicroRNAs in the Pathogenesis of Lung Cancer

  2009cited by this paper
• WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis.

  2009cited by this paper
• Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-beta1 in vitro.

  2009cited by this paper
• Apoptosis in Pulmonary Fibrosis: Too Much or Not Enough?

  2008cited by this paper
• SMAD proteins control DROSHA-mediated microRNA maturation

  2008cited by this paper
• Cellular and molecular mechanisms of fibrosis

  2008cited by this paper
• MicroRNA-directed transcriptional gene silencing in mammalian cells

  2008cited by this paper
• Transforming growth factor-β and fibrosis

  2007cited by this paper
• Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions.

  2007cited by this paper
• Transforming growth factor-beta and fibrosis.

  2007cited by this paper
• MicroRNA Protocols

  2006cited by this paper
• MicroRNA protocols. Perspectives.

  2006cited by this paper
• Idiopathic pulmonary fibrosis: natural history and prognosis.

  2006cited by this paper
• Ex Vivo Analysis of Dialysis Effluent-Derived Mesothelial Cells as an Approach to Unveiling the Mechanism of Peritoneal Membrane Failure

  2006cited by this paper
• [Cellular and molecular mechanisms of fibrosis].

  2006cited by this paper
• MicroRNAs in cell proliferation, cell death, and tumorigenesis

  2006cited by this paper
• Smad transcription factors.

  2005cited by this paper
• NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

  2005cited by this paper
• Mesenchymal conversion of mesothelial cells as a mechanism responsible for high solute transport rate in peritoneal dialysis: role of vascular endothelial growth factor.

  2005cited by this paper
• Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy.

  2005cited by this paper
• Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

  2004cited by this paper
• Immunohistochemical characterization of fibroblast subpopulations in normal peritoneal tissue and in peritoneal dialysis-induced fibrosis

  2004cited by this paper
• Mechanisms of pulmonary fibrosis.

  2004cited by this paper
• The functions of animal microRNAs

  2004cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• TGF‐β signaling and the fibrotic response

  2004cited by this paper
• Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets

  2004cited by this paper
• DAVID: Database for Annotation, Visualization, and Integrated Discovery

  2003cited by this paper
• Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

  2003cited by this paper
• Basic Mechanisms and Clinical Implications of Peritoneal Fibrosis

  2003cited by this paper
• Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

  2003cited by this paper
• Myofibroblastic conversion of mesothelial cells.

  2003influential reference
• Functional Cooperation Between Smad Proteins and Activator Protein-1 Regulates Transforming Growth Factor-&bgr;–Mediated Induction of Endothelin-1 Expression

  2003cited by this paper
• DAVID: Database for Annotation, Visualization, and Integrated Discovery

  2003cited by this paper
• Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells.

  2003cited by this paper
• Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

  2002cited by this paper
• Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function.

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001influential reference
• An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

  2001cited by this paper
• Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

  2000cited by this paper
• Pathophysiology of Peritoneal Membrane Failure

  2000cited by this paper
• Transforming Growth Factor-β1 Promotes the Morphological and Functional Differentiation of the Myofibroblast

  2000cited by this paper
• Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast.

  2000cited by this paper
• Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene

  1998influential reference
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• Basic local alignment search tool.

  1990cited by this paper

• Early Detection of Pacing-Induced Cardiomyopathy Using MicroRNA-208b-3p and MicroRNA-9: A Prospective Cohort Analysis

  2026cites this paper
• CircHOMER1 promotes silica-induced pulmonary fibrosis by binding to HuR and stabilizing NOX4 mRNA.

  2025cites this paper
• miR-4324-containing extracellular vesicles released in pericardial drainage fluid facilitate postoperative atrial fibrillation.

  2025cites this paper
• Bone marrow MSCs-derived exosomes (BM-MSCs-Exo) expressed mir-181, mir-24, mir-9, mir-29, mir-338, and mir-486 ameliorated hepatic fibrosis in male rats via altering the expression of Menin-1/TGF-β/Smad pathway.

  2025cites this paper
• The interplay between microRNAs and oxidative stress and its implications in respiratory diseases

  2025cites this paper
• miR-9-5p regulates CCL5 mediated inflammatory responses in macrophages exposed to PM10.

  2025cites this paper
• MiR‐1 Is Regulated by Hydrogen Peroxide via MAPK and Limits Cell Migration and Invasion

  2025cites this paper
• Translational Regulators in Pulmonary Fibrosis: MicroRNAs, Long Non-Coding RNAs, and Transcript Modifications

  2025influential citation
• Emerging roles of non-coding RNAs in fibroblast to myofibroblast transition and fibrotic diseases

  2024cites this paper
• Inducible deletion of microRNA activity in kidney mesenchymal cells exacerbates renal fibrosis

  2024cites this paper
• Immunological Evaluation of TGF-β and Osteopontin of Idiopathic Pulmonary Fibrotic patients in Al-Diwaniyah province

  2024cites this paper
• MicroRNA‐guided drug discovery for mitigating persistent pulmonary complications in critical COVID‐19 survivors: A longitudinal pilot study

  2024cites this paper
• circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis

  2024cites this paper
• Identification of shared pathogenetic mechanisms between COVID-19 and IC through bioinformatics and system biology

  2024cites this paper
• Transforming Cardiotoxicity Detection in Cancer Therapies: The Promise of MicroRNAs as Precision Biomarkers

  2024cites this paper
• Revisiting the role of MicroRNAs in the pathogenesis of idiopathic pulmonary fibrosis

  2024cites this paper
• Regulation of idiopathic pulmonary fibrosis: a cross-talk between TGF-β signaling and MicroRNAs

  2024cites this paper
• Communication between alveolar macrophages and fibroblasts via the TNFSF12-TNFRSF12A pathway promotes pulmonary fibrosis in severe COVID-19 patients

  2024cites this paper
• Altered MicroRNA Maturation in Ischemic Hearts: Implication of Hypoxia on XPO5 and DICER1 Dysregulation and RedoximiR State

  2023cites this paper
• A positive TGF‐β/miR‐9 regulatory loop promotes the expansion and activity of tumour‐initiating cells in breast cancer

  2023cites this paper
• Delivery of anti-microRNA-21 by lung-targeted liposomes for pulmonary fibrosis treatment

  2023cites this paper
• Radiation-induced pulmonary fibrosis: roles of therapy-induced senescence and microRNAs

  2023influential citation
• Non-coding RNA-mediated endothelial-to-mesenchymal transition in human diabetic cardiomyopathy, potential regulation by DNA methylation

  2023cites this paper
• MicroRNA 9 Is a Regulator of Endothelial to Mesenchymal Transition in Diabetic Retinopathy

  2023cites this paper
• Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS

  2022cites this paper
• Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation International Immunopharmacology

  2022cites this paper
• Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation International Immunopharmacology

  2022cites this paper
• Role of MicroRNAs in Signaling Pathways Associated with the Pathogenesis of Idiopathic Pulmonary Fibrosis: A Focus on Epithelial-Mesenchymal Transition

  2022cites this paper
• Novel drug delivery systems and disease models for pulmonary fibrosis.

  2022cites this paper
• Targeting Histone Deacetylases in Idiopathic Pulmonary Fibrosis: A Future Therapeutic Option

  2022cites this paper
• The Mouse Anxa6/miR-9-5p/Anxa2 Axis Modulates TGF-β1-induced Mouse Hepatic Stellate Cell (mHSC) Activation and CCl4-caused Liver Fibrosis.

  2022cites this paper
• Noncoding RNAs in age-related cardiovascular diseases.

  2022cites this paper
• C-MYC induces idiopathic pulmonary fibrosis via modulation of miR-9-5p-mediated TBPL1.

  2022cites this paper
• Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation International Immunopharmacology

  2022cites this paper
• MicroRNA-9-5p Is Involved in Lipopolysaccharide-Induced Acute Lung Injury Via the Regulation of Macrophage Polarization

  2022cites this paper
• Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells

  2022cites this paper
• Non-coding RNA in idiopathic interstitial pneumonia and Covid-19 pulmonary fibrosis

  2022cites this paper
• A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

  2022cites this paper
• Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation

  2022cites this paper
• Construction and Analysis of a ceRNA Network in Cardiac Fibroblast During Fibrosis Based on in vivo and in vitro Data

  2021cites this paper
• Extracellular Vesicles in Pulmonary Fibrosis Models and Biological Fluids of Interstitial Lung Disease Patients: A Scoping Review

  2021cites this paper
• Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway.

  2021cites this paper
• Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases

  2021cites this paper
• Micro RNAs in Regulation of Cellular Redox Homeostasis

  2021cites this paper
• TGF-β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review)

  2021cites this paper
• Silica Particles Trigger Pulmonary Fibrosis Act Through Cell-To-Cell Delivery of Exosomal Mir-107

  2021cites this paper
• MiR-9-5p inhibits mitochondrial damage and oxidative stress in AD cell models by targeting GSK-3β

  2020cites this paper
• Redox distress in organ fibrosis: The role of noncoding RNAs

  2020cites this paper
• Biomarkers and their potential functions in idiopathic pulmonary fibrosis

  2020cites this paper
• miRNAs in Lung Development and Diseases

  2020cites this paper
• The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids—From Bench to Bedside

  2020cites this paper
• MicroRNA-9 Fine-Tunes Dendritic Cell Function by Suppressing Negative Regulators in a Cell-Type-Specific Manner.

  2020cites this paper
• lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis

  2020cites this paper
• MiR-9-5p promotes rabbit preadipocyte differentiation by suppressing leptin gene expression

  2020cites this paper
• MicroRNA and ROS Crosstalk in Cardiac and Pulmonary Diseases

  2020cites this paper
• Peritoneal fibrosis and epigenetic modulation

  2020cites this paper
• Autophagy-related MicroRNAs in chronic lung diseases and lung cancer.

  2020cites this paper
• Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

  2020cites this paper
• Increased miR-7641 Levels in Peritoneal Hyalinizing Vasculopathy in Long-Term Peritoneal Dialysis Patients

  2020cites this paper
• LncRNA Hoxaas3 promotes lung fibroblast activation and fibrosis by targeting miR-450b-5p to regulate Runx1

  2020cites this paper
• LncRNA NEAT1 regulates pulmonary fibrosis through miR-9-5p and TGF-β signaling pathway.

  2020cites this paper
• MicroRNAs and Polycystic Kidney Disease

  2020cites this paper
• LncRNA LINC01116 Promotes the Development of Colorectal Cancer by Targeting miR-9-5p/STMN1

  2020cites this paper
• MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β

  2020cites this paper
• Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β1/Smad2/Nrf2-NOX4 signaling pathways.

  2019cites this paper
• MicroRNAs in Respiratory Diseases

  2019cites this paper
• Exosome-derived microRNA-22 ameliorates pulmonary fibrosis by regulating fibroblast-to-myofibroblast differentiation both in vitro and in vivo.

  2019cites this paper
• MICRORNA-9-5P FUNCTIONS AS A TUMOR SUPPRESSOR IN PROSTATE CANCER VIA TARGETING UTRN

  2019cites this paper
• Role of MicroRNAs in the Regulation of Redox-Dependent Processes

  2019cites this paper
• miR-9-5p modulates the progression of Parkinson's disease by targeting SIRT1.

  2019cites this paper
• Role of MiR-148b in angiogenesis and endothelial cell plasticity

  2019influential citation
• Molecular determinants of mesenchymal cell activation in fibroproliferative diseases

  2019cites this paper
• Pulmonary Oxidative Stress and Antioxidant Defence System in the Lung Ageing and Fibrotic and Diabetic Lungs

  2019cites this paper
• Effect of oxidative stress and 3‐hydroxytyrosol on DNA methylation levels of miR‐9 promoters

  2019cites this paper
• Long non-coding RNA LINC00467 regulates hepatocellular carcinoma progression by modulating miR-9-5p/PPARA expression

  2019cites this paper
• EZH2 as a novel therapeutic target for atrial fibrosis and atrial fibrillation.

  2019cites this paper
• Local microRNAs in peritoneal dialysis-related peritonitis

  2019cites this paper
• Modulation of miRNA in Oxidative Stress-Induced Cardiac Remodeling

  2019cites this paper
• MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

  2019cites this paper
• MicroRNAs in idiopathic pulmonary fibrosis, new research progress and their pathophysiological implication

  2018cites this paper
• miR-9-5 p plays an important role in gestational diabetes mellitus ( GDM ) progression by targeting HK-2

  2018cites this paper
• MiR-3606-3p inhibits systemic sclerosis through targeting TGF-β type II receptor

  2018cites this paper
• Redox regulation of microRNAs in cancer.

  2018cites this paper
• The impact of Mir-9 regulation in normal and malignant hematopoiesis

  2018cites this paper
• microRNA expression profiles of scar and normal tissue from patients with posterior urethral stricture caused by pelvic fracture urethral distraction defects

  2018cites this paper
• Multi-posttranscriptional regulations lessen the repressive effect of SRPK1 on brown adipogenesis.

  2018cites this paper
• MicroRNAs‐mediated epithelial‐mesenchymal transition in fibrotic diseases

  2017cites this paper
• miRNA‐23 regulates high glucose induced epithelial to mesenchymal transition in human mesotheial peritoneal cells by targeting VDR

  2017cites this paper
• Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil

  2017influential citation
• European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

  2017cites this paper
• Role of MicroRNAs in TGF-β Signaling Pathway-Mediated Pulmonary Fibrosis

  2017cites this paper
• Epigenetics in fibrosis.

  2017cites this paper
• A systematic review of overlapping microRNA patterns in systemic sclerosis and idiopathic pulmonary fibrosis

  2017cites this paper
• Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death.

  2017cites this paper
• miR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF-β Receptor II.

  2017cites this paper
• Identification of novel therapeutics for chronic obstructive pulmonary disease

  2017cites this paper
• The role of microRNAs in chronic respiratory disease: recent insights

  2017cites this paper
• Protective role for miR-9-5p in the fibrogenic transformation of human dermal fibroblasts

  2016cites this paper
• MicroRNAs serve as a bridge between oxidative stress and gastric cancer (Review).

  2016influential citation
• MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1.

  2016cites this paper