The Tetrodotoxin‐Resistant Na+ Channel Nav1.8 is Essential for the Expression of Spontaneous Activity in Damaged Sensory Axons of Mice

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Physiology

• Publication date

  2003-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/jphysiol.2003.046110PMID 12824446PMCID PMC2343086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Redistribution of NaV1.8 in Uninjured Axons Enables Neuropathic Pain

  2003cited by this paper
• Burst discharge in primary sensory neurons: triggered by subthreshold oscillations, maintained by depolarizing afterpotentials.

  2002cited by this paper
• Inhibition of neuropathic pain by decreased expression of the tetrodotoxin‐resistant sodium channel, NaV1.8

  2002cited by this paper
• Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: an in vivo study.

  2001influential reference
• A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain

  2001cited by this paper
• Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers

  2001cited by this paper
• Responses of nerve fibres of the rat saphenous nerve neuroma to mechanical and chemical stimulation: an in vitro study

  2000cited by this paper
• SNS/PN3 and SNS2/NaN sodium channel‐like immunoreactivity in human adult and neonate injured sensory nerves

  2000cited by this paper
• Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states

  2000cited by this paper
• A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain.

  1999cited by this paper
• Letter to Neuroscience DISTRIBUTION OF SENSORY PROPERTIES AMONG AXOTOMIZED CUTANEOUS C-FIBRES IN ADULT RATS

  1999cited by this paper
• Pathophysiology of damaged nerves in relation to chronic pain

  1999influential reference
• Sodium channels, excitability of primary sensory neurons, and the molecular basis of pain

  1999cited by this paper
• The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

  1999cited by this paper
• Ectopic mechanosensitivity in injured sensory axons arises from the site of spontaneous electrogenesis

  1998cited by this paper
• Distribution of the Tetrodotoxin-Resistant Sodium Channel PN3 in Rat Sensory Neurons in Normal and Neuropathic Conditions

  1998cited by this paper
• Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain.

  1997cited by this paper
• QX-314 inhibits ectopic nerve activity associated with neuropathic pain.

  1997cited by this paper
• Down-Regulation of Transcripts for Na Channel α -SNS in Spinal Sensory Neurons Following Axotomy

  1996cited by this paper
• Mechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na+ Channel Heterogeneity

  1996cited by this paper
• Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy.

  1996cited by this paper
• Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+ channels.

  1994cited by this paper
• Na+ channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation

  1993cited by this paper
• Painful neuropathy: altered central processing maintained dynamically by peripheral input

  1992cited by this paper
• Ectopic excitability of injured nerves in monkey: entrained responses to vibratory stimuli.

  1991cited by this paper
• Mechanically evoked responses of afferent fibres innervating the guinea‐pig's ureter: an in vitro study.

  1989cited by this paper

• From nociception in aneural animals to human suffering: toward a comparative biology of pain.

  2025cites this paper
• Botulinum Neurotoxin A Signaling in Pain Modulation Within Human Sensory Neurons

  2025cites this paper
• Ablation of VEGFA following a lumbar intervertebral disc injury attenuates intradiscal neurovascular features and prevents chronic low back pain symptoms

  2025cites this paper
• Pharmacological Frontiers: The Rise of Selective NaV1.8 Inhibition for Pain Management

  2025cites this paper
• Loss of Glutaminase 1 in Small Sensory Neurons Prevents Nerve Injury Induced Mechanical Allodynia: Insights From Conditional Knockout Mice

  2025cites this paper
• Complex alterations in inflammatory pain and analgesic sensitivity in young and ageing female rats: involvement of ASIC3 and Nav1.8 in primary sensory neurons

  2024cites this paper
• Novel therapies for cancer-induced bone pain

  2024cites this paper
• The role of the ubiquitin system in the onset and reversal of neuropathic pain.

  2024cites this paper
• Insights into the voltage-gated sodium channel, NaV1.8, and its role in visceral pain perception

  2024cites this paper
• Over-expression of miR-3584-5p Represses Nav1.8 Channel Aggravating Neuropathic Pain caused by Chronic Constriction Injury

  2023cites this paper
• Exaptation and Evolutionary Adaptation in Nociceptor Mechanisms Driving Persistent Pain

  2023cites this paper
• Chemogenetic Silencing of NaV1.8-Positive Sensory Neurons Reverses Chronic Neuropathic and Bone Cancer Pain in FLEx PSAM4-GlyR Mice

  2023influential citation
• Selective Inhibition of NaV1.8 with VX-548 for Acute Pain.

  2023cites this paper
• Targeting a Peripheral Sodium Channel to Treat Pain.

  2023cites this paper
• Local translation in primary afferents and its contribution to pain.

  2022cites this paper
• KCNQ/Kv7 channels as therapeutic target to treat neuropathic pain

  2022cites this paper
• Mechanisms behind the Development of Chronic Low Back Pain and Its Neurodegenerative Features

  2022cites this paper
• Role of voltage-gated sodium channels in axonal signal propagation of trigeminal ganglion neurons after infraorbital nerve entrapment

  2022influential citation
• Electrophysiological characterization of ectopic spontaneous discharge in axotomized and intact fibers upon nerve transection: a role in spontaneous pain?

  2022cites this paper
• Peripheral mechanisms contributing to central neuropathic pain following SCI

  2022cites this paper
• Behavior and electrophysiology studies of the peripheral neuropathy induced by individual and co-administration of paclitaxel and oxaliplatin in rat.

  2021cites this paper
• The physiological function of different voltage-gated sodium channels in pain

  2021cites this paper
• Mechanical sensitization, increased axonal excitability and spontaneous activity in C-nociceptors following UVB irradiation in pig skin.

  2021cites this paper
• Activation of the regeneration‐associated gene STAT3 and functional changes in intact nociceptors after peripheral nerve damage in mice

  2020cites this paper
• Neuropathic pain: From mechanisms to treatment.

  2020cites this paper
• Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability.

  2020cites this paper
• Lysophosphatidic Acid and Glutamatergic Transmission

  2019cites this paper
• Topical Ambroxol 20% for the Treatment of Classical Trigeminal Neuralgia – A New Option? Initial Clinical Case Observations

  2019cites this paper
• Avaliação dos efeitos diretos de Aloxana e Estreptozotocina sobre neurônios nociceptivos em culturas primárias de gânglios da raiz dorsal de ratos

  2019cites this paper
• The Role of Voltage-Gated Sodium Channels in Pain Signaling.

  2019cites this paper
• From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain

  2018cites this paper
• Alterations of L‐type voltage dependent calcium channel alpha 1 subunit in the hippocampal CA3 region during and after pilocarpine‐induced epilepsy

  2018cites this paper
• May a sigma‐1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?

  2018cites this paper
• The role of axonal transport disruption in the development of axonal mechanical sensitivity in intact C-fibre neurons

  2018cites this paper
• Differential use-dependent inactivation of Nav1.8 in the subpopulation of cultured dorsal root ganglion

  2018cites this paper
• The influence of voltage‐gated sodium channels on human gastrointestinal nociception

  2018cites this paper
• Therapeutic opportunities for pain medicines via targeting of specific translation signaling mechanisms

  2018cites this paper
• EXPLORATION OF METFORMIN EFFECT OVER OXALIPLATIN ANTINEOPLASIC PROPERTIES IN MKN45, KATOIII AND HS746T GASTRIC CANCER CELL LINES IN VITRO AND OVER OXALIPLATIN INDUCED RAT PAINFUL SENSORY NEUROPATHY IN VIVO.

  2018cites this paper
• Behavioral Insights into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms in Rats

  2018cites this paper
• Ambroxol for the treatment of fibromyalgia: science or fiction?

  2017cites this paper
• Breaking barriers to novel analgesic drug development

  2017cites this paper
• Pain thresholds, supra‐threshold pain and lidocaine sensitivity in patients with erythromelalgia, including the I848Tmutation in NaV 1.7

  2017cites this paper
• The Relationship Between Ocular Itch, Ocular Pain, and Dry Eye Symptoms (An American Ophthalmological Society Thesis).

  2017cites this paper
• Voltage-dependent sodium (NaV) channels in group IV sensory afferents

  2016cites this paper
• Spontaneous activity in C‐fibres after partial damage to the saphenous nerve in mice: Effects of retigabine

  2016cites this paper
• Descending controls and peripheral contribution to pain in the monosodium iodoacetate model of osteoarthritis

  2016cites this paper
• Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats

  2016cites this paper
• A pharmacological and transcriptomic approach to exploring novel pain targets

  2016cites this paper
• CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain

  2016cites this paper
• Ion channels in pain

  2015cites this paper
• Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition

  2015cites this paper
• channels in identified muscle afferent neurons Tetrodotoxin-resistant voltage-dependent sodium

  2015cites this paper
• A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability

  2015cites this paper
• Orofacial Pain Operant Analysis with Concomitant Investigation of Peripherally Restricted Cannabinoids and Nav1.8 Axonal Accumulation for the Potential Treatment of Neuropathic Pain

  2015cites this paper
• Topical ambroxol for the treatment of neuropathic pain

  2015cites this paper
• De novo expression of Nav1.7 in injured putative proprioceptive afferents: Multiple tetrodotoxin-sensitive sodium channels are retained in the rat dorsal root after spinal nerve ligation.

  2015cites this paper
• Papel de los receptores sigma-1 en la transmisión y modulación nociceptiva a través de la médula espinal

  2015cites this paper
• Topisches Ambroxol zur Behandlung neuropathischer Schmerzen

  2015cites this paper
• Handbook of ion channels

  2015cites this paper
• The role of the dorsal root ganglion in the development of neuropathic pain.

  2014cites this paper
• Promédicaments d'amides de pyridone utiles en tant que modulateurs des canaux sodiques

  2014cites this paper
• Stimulation-induced ectopicity and propagation windows in model damaged axons

  2014cites this paper
• Histamine Upregulates Nav1.8 Expression in Primary Afferent Neurons via H2 Receptors: Involvement in Neuropathic Pain

  2014cites this paper
• Persistent Pain after Spinal Cord Injury Is Maintained by Primary Afferent Activity

  2014cites this paper
• Stimulation-induced ectopicity and propagation windows in model damaged axons

  2014cites this paper
• NaV1.8 channels are expressed in large, as well as small, diameter sensory afferent neurons

  2013cites this paper
• TRPV1 Channels Contribute to Behavioral Hypersensitivity and Spontaneous Activity in Nociceptors After Spinal Cord Injury

  2013cites this paper
• Chronic Pain Following Spinal Cord Injury: The Role of Immunogenetics and Time of Injury Pain Treatment

  2013cites this paper
• Probing Functional Properties of Nociceptive Axons Using a Microfluidic Culture System

  2013cites this paper
• Mechanisms of neuropathic pain.

  2012cites this paper
• Nociceptors as chronic drivers of pain and hyperreflexia after spinal cord injury: an adaptive-maladaptive hyperfunctional state hypothesis

  2012cites this paper
• Prolonged nerve blockade delays the onset of neuropathic pain

  2012cites this paper
• Conus Venom Peptide Pharmacology

  2012cites this paper
• Tetrodotoxin-resistant voltage-dependent sodium channels in identified muscle afferent neurons.

  2012cites this paper
• Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy

  2012cites this paper
• Fragile X mental retardation protein (FMRP) and the spinal sensory system.

  2012cites this paper
• Mechanisms of neuritis-induced C-fibre hyperexcitability: a role for nerve inflammation in chronic pain

  2012cites this paper
• Biophysical and Pharmacological Characterisation of Native Human NaV1.8 Channels from Isolated Dorsal Root Ganglia (DRG)

  2012cites this paper
• Chapter 23 – Pain

  2012cites this paper
• Dérivés d'arylalkylaminocarboxamides fluorés

  2012cites this paper
• Studies on chronic pain mechanisms in the central nervous system

  2011cites this paper
• Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood

  2011cites this paper
• Uncovering new pharmacological targets to treat neuropathic pain by understanding how the organism reacts to nerve injury.

  2011cites this paper
• SNO-ing at the Nociceptive Synapse?

  2011cites this paper
• The roles of sodium channels in nociception: implications for mechanisms of neuropathic pain.

  2011cites this paper
• Temporal expression pattern of sodium channel Nav 1.8 messenger RNA in pulpitis.

  2011cites this paper
• Association of NaV1.8 with lipid rafts in DRG sensory neurons

  2011cites this paper
• Sodium channels in normal and pathological pain.

  2010cites this paper
• Pain as a channelopathy.

  2010cites this paper
• Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites.

  2010cites this paper
• PAIN When does acute pain become chronic ?

  2010cites this paper
• Sodium channelopathies and pain

  2010cites this paper
• Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice.

  2010cites this paper
• DREAM differently regulates spinal and trigeminal nociception

  2010cites this paper
• Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells

  2010cites this paper
• The tetrodotoxin-resistant Na+ channel Nav1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors

  2010cites this paper
• When does acute pain become chronic?

  2010cites this paper
• VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.

  2010cites this paper
• PKA-Induced Internalization of Slack KNa Channels Produces Dorsal Root Ganglion Neuron Hyperexcitability

  2010cites this paper
• Ion channel blockers for the treatment of neuropathic pain.

  2010cites this paper