Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2015-10-12

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1073/pnas.1507300112PMID 26460028PMCID PMC4653164
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetically based low oxygen affinities of felid hemoglobins: lack of biochemical adaptation to high-altitude hypoxia in the snow leopard

  2015cited by this paper
• Intraspecific Polymorphism, Interspecific Divergence, and the Origins of Function-Altering Mutations in Deer Mouse Hemoglobin

  2015cited by this paper
• Comparative genomics reveals insights into avian genome evolution and adaptation

  2014cited by this paper
• Epistasis Constrains Mutational Pathways of Hemoglobin Adaptation in High-Altitude Pikas

  2014cited by this paper
• Modeling Evolution Using the Probability of Fixation: History and Implications

  2014cited by this paper
• Diverse avian malaria and other haemosporidian parasites in Andean house wrens: evidence for regional co-diversification by host-switching

  2014influential reference
• Gene Turnover in the Avian Globin Gene Families and Evolutionary Changes in Hemoglobin Isoform Expression

  2014cited by this paper
• Integrating evolutionary and functional tests of adaptive hypotheses: a case study of altitudinal differentiation in hemoglobin function in an Andean Sparrow, Zonotrichia capensis.

  2014cited by this paper
• Brain transcriptome sequencing and assembly of three songbird model systems for the study of social behavior

  2014cited by this paper
• SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

  2014cited by this paper
• Development of Recombinant Hemoglobin-Based Oxygen Carriers

  2013cited by this paper
• Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

  2013cited by this paper
• Repeated elevational transitions in hemoglobin function during the evolution of Andean hummingbirds

  2013cited by this paper
• Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin.

  2013cited by this paper
• Stacks: an analysis tool set for population genomics

  2013cited by this paper
• Mutation-Driven Evolution

  2013cited by this paper
• The genetic causes of convergent evolution

  2013cited by this paper
• Gene duplication, genome duplication, and the functional diversification of vertebrate globins.

  2013cited by this paper
• The Evolutionary Genomics of Birds

  2013cited by this paper
• Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges

  2013cited by this paper
• Genome‐wide association genetics of an adaptive trait in lodgepole pine

  2012cited by this paper
• Oxygenation properties and oxidation rates of mouse hemoglobins that differ in reactive cysteine content.

  2012cited by this paper
• Gene Duplication and the Evolution of Hemoglobin Isoform Differentiation in Birds*

  2012influential reference
• Fast gapped-read alignment with Bowtie 2

  2012cited by this paper
• Whole-genome duplications spurred the functional diversification of the globin gene superfamily in vertebrates.

  2012cited by this paper
• The global diversity of birds in space and time

  2012cited by this paper
• Protein frustratometer: a tool to localize energetic frustration in protein molecules

  2012cited by this paper
• Expression and Purification of Recombinant Hemoglobin in Escherichia coli

  2011cited by this paper
• Blocking the Gate to Ligand Entry in Human Hemoglobin*

  2010cited by this paper
• FISHER'S MODEL AND THE GENOMICS OF ADAPTATION: RESTRICTED PLEIOTROPY, HETEROGENOUS MUTATION, AND PARALLEL EVOLUTION

  2010cited by this paper
• POPULATION GENETICS, PLEIOTROPY, AND THE PREFERENTIAL FIXATION OF MUTATIONS DURING ADAPTIVE EVOLUTION

  2010cited by this paper
• Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates

  2010cited by this paper
• The profound influence of the Late-Pliocene Panamanian uplift on the exchange, diversification, and distribution of New World Birds

  2010cited by this paper
• Lineage-specific patterns of functional diversification in the alpha- and beta-globin gene families of tetrapod vertebrates.

  2010cited by this paper
• Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer

  2010cited by this paper
• Phylogenetic and structural analysis of the HbA (alphaA/betaA) and HbD (alphaD/betaA) hemoglobin genes in two high-altitude waterfowl from the Himalayas and the Andes: Bar-headed goose (Anser indicus) and Andean goose (Chloephaga melanoptera).

  2010cited by this paper
• Genetic differences in hemoglobin function between highland and lowland deer mice

  2010cited by this paper
• Variation partitioning as a tool to distinguish between niche and neutral processes

  2010cited by this paper
• Is Genetic Evolution Predictable?

  2009cited by this paper
• Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin

  2009cited by this paper
• The causes of repeated genetic evolution.

  2009cited by this paper
• Climbing mount probable: mutation as a cause of nonrandomness in evolution.

  2009cited by this paper
• Mechanisms of Hemoglobin Adaptation to High Altitude Hypoxia

  2008cited by this paper
• The Loci of Evolution: How Predictable is Genetic Evolution?

  2008cited by this paper
• Evo‐Devo and an Expanding Evolutionary Synthesis

  2008cited by this paper
• The αD-Globin Gene Originated via Duplication of an Embryonic α-Like Globin Gene in the Ancestor of Tetrapod Vertebrates

  2007cited by this paper
• The alphaD-globin gene originated via duplication of an embryonic alpha-like globin gene in the ancestor of tetrapod vertebrates.

  2007cited by this paper
• High-altitude adaptations in vertebrate hemoglobins.

  2007cited by this paper
• Mutation-biased adaptation in a protein NK model.

  2006cited by this paper
• Mutationism and the dual causation of evolutionary change

  2006cited by this paper
• Strong regional biases in nucleotide substitution in the chicken genome.

  2006cited by this paper
• The allosteric properties of hemoglobin: insights from natural and site directed mutants.

  2006cited by this paper
• APE: Analyses of Phylogenetics and Evolution in R language

  2004cited by this paper
• Two steps forward, one step back: the pleiotropic effects of favoured alleles

  2004cited by this paper
• Direct estimates of human per nucleotide mutation rates at 20 loci causing mendelian diseases

  2003cited by this paper
• Bias in the introduction of variation as an orienting factor in evolution

  2001cited by this paper
• Estimate of the mutation rate per nucleotide in humans.

  2000cited by this paper
• Mutant hemoglobins (alpha 119-Ala and beta 55-Ser): functions related to high-altitude respiration in geese.

  1993cited by this paper
• Use of ionic and zwitterionic (Tris/BisTris and HEPES) buffers in studies on hemoglobin function.

  1992cited by this paper
• Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein engineering.

  1991cited by this paper
• Mechanisms of cooperativity and allosteric regulation in proteins:by Max Perutz, Cambridge University Press, 1990. £11.95/$17.95 (x + 101 pages) ISBN 0 521 38648 9

  1990cited by this paper
• Mechanisms of cooperativity and allosteric regulation in proteins

  1989cited by this paper
• Estimating the recombination parameter of a finite population model without selection.

  1987cited by this paper
• Effect of change in P50 on exercise tolerance at high altitude: a theoretical study.

  1982cited by this paper
• Theoretical analysis of optimal P50.

  1982cited by this paper
• Blood O2 content, cardiac output, and flow to organs at several levels of oxygenation in rats with a left-shifted blood oxygen dissociation curve

  1978cited by this paper

• Non-B DNA structures and their contributions to genetic diversity, aging, and disease

  2026cites this paper
• Convergent Evolution and the Epigenome

  2025cites this paper
• Continental diversification and insular speciation in a widespread passerine (Troglodytes musculus) in southern South America

  2025cites this paper
• Effects of Hemoglobin-O2 Affinity on Breathing and Gas Exchange in Deer Mice.

  2025cites this paper
• Hypoxia and Tissue Regeneration: Adaptive Mechanisms and Therapeutic Opportunities

  2025cites this paper
• Canalization of globins in the adaptive evolution of birds

  2025cites this paper
• Conservation of Wildlife Populations

  2025cites this paper
• Mutation-biased adaptation is consequential even in large bacterial populations

  2025cites this paper
• Cardiovascular Plasticity and Adaptation of High-Altitude Birds and Mammals.

  2025cites this paper
• Weak population structure in the North American house wren Troglodytes aedon

  2025cites this paper
• Gas exchange, oxygen transport and metabolism in high-altitude waterfowl

  2025cites this paper
• Integrating spatial analyses of genomic and physiological data to understand avian responses to environmental change.

  2024cites this paper
• Interspecific and Intraspecific Transcriptomic Variations Unveil the Potential High-Altitude Adaptation Mechanisms of the Parnassius Butterfly Species

  2024cites this paper
• On the physiology of high-altitude flight and altitudinal migration in birds.

  2024cites this paper
• Unravelling the factors of evolutionary repeatability: insights and perspectives on predictability in evolutionary biology

  2024cites this paper
• Lineage diversity in a widely distributed New World passerine bird, the House Wren

  2023cites this paper
• Genomic Variation, Population History, and Long-Term Genetic Adaptation to High Altitudes in Tibetan Partridge (Perdix hodgsoniae)

  2023cites this paper
• Ornithology Alpha-globin variation does not predict avian malaria infection in the West Indian Bananaquit ( Coereba flaveola )

  2023cites this paper
• Convergent genomic signatures of local adaptation across a continental-scale environmental gradient

  2023cites this paper
• Mutation bias and the predictability of evolution

  2023cites this paper
• Variation in avian morphology along a short tropical elevational gradient

  2022influential citation
• Hummingbird blood traits track oxygen availability across space and time

  2022cites this paper
• Environmental Adaptation of Genetically Uniform Organisms with the Help of Epigenetic Mechanisms—An Insightful Perspective on Ecoepigenetics

  2022influential citation
• Transcriptomic Analyses Suggest the Adaptation of Bumblebees to High Altitudes

  2022cites this paper
• Dynamic alternative DNA structures in biology and disease

  2022cites this paper
• The Mutagenic Consequences of DNA Methylation within and across Generations

  2022cites this paper
• A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae).

  2022cites this paper
• A New Homotetramer Hemoglobin in the Pulmonary Surfactant of Plateau Zokors (Myospalax Baileyi)

  2022cites this paper
• Genetic variation in haemoglobin alters breathing in high-altitude deer mice

  2021cites this paper
• The adaptive potential of non-heritable somatic mutations

  2021cites this paper
• Comparative Genomics and Evolution of Avian Specialized Traits

  2021cites this paper
• Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice.

  2021cites this paper
• Protein innovation through template switching in the Saccharomyces cerevisiae lineage

  2021cites this paper
• Introgressive Hybridization and Hypoxia Adaptation in High-Altitude Vertebrates

  2021cites this paper
• Elevational niche-shift migration: Why the degree of elevational change matters for the ecology, evolution, and physiology of migratory birds

  2021cites this paper
• A mutational hotspot that determines highly repeatable evolution can be built and broken by silent genetic changes

  2021cites this paper
• Adaptive introgression of the beta-globin cluster in two Andean waterfowl

  2021cites this paper
• High-Altitude Adaptation: Mechanistic Insights from Integrated Genomics and Physiology

  2021cites this paper
• Pervasive genomic signatures of local adaptation to altitude across highland specialist Andean hummingbird populations.

  2021cites this paper
• Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope

  2020cites this paper
• Biochemical paedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope

  2020cites this paper
• Synthesis of Recombinant Human Hemoglobin With NH2‐Terminal Acetylation in Escherichia coli

  2020cites this paper
• Convergent changes in muscle metabolism depend on duration of high-altitude ancestry across Andean waterfowl

  2020cites this paper
• Comparative transcriptome analysis reveals regulatory genes involved in cold tolerance and hypoxic adaptation of high-altitude Tibetan bumblebees

  2020cites this paper
• Effect of NH2-terminal acetylation on the oxygenation properties of vertebrate haemoglobin.

  2020cites this paper
• Physiological Genomics of Adaptation to High-Altitude Hypoxia.

  2020cites this paper
• Evolved increases in hemoglobin-oxygen affinity and the Bohr effect coincided with the aquatic specialization of penguins

  2020cites this paper
• Life-long exposure to hypoxia affects metabolism and respiratory physiology across life stages in high-altitude deer mice (Peromyscus maniculatus)

  2020cites this paper
• Adaptive evolution of β-globin gene in subterranean in South America octodontid rodents.

  2020cites this paper
• Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirds

  2020cites this paper
• Predictability and the unpredictable. Life, evolution and behaviour ,

  2020cites this paper
• DNA fragility in the parallel evolution of pelvic reduction in stickleback fish

  2019cites this paper
• Exploiting the “survival of the likeliest” to enable evolution-guided drug design

  2019cites this paper
• The role of mutation bias in adaptive molecular evolution: insights from convergent changes in protein function

  2019cites this paper
• Life Ascending: Mechanism and Process in Physiological Adaptation to High-Altitude Hypoxia.

  2019cites this paper
• The Role of Mutation Bias in Adaptive Evolution.

  2019cites this paper
• Association of alpha-a globin gene polymorphism with its expression level in racing pigeons

  2019cites this paper
• Evolution of physiological performance capacities and environmental adaptation: insights from high-elevation deer mice (Peromyscus maniculatus).

  2019cites this paper
• High-altitude adaptation in birds: From phenomics to genomics

  2019cites this paper
• Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau

  2018cites this paper
• Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus

  2018cites this paper
• Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis

  2018cites this paper
• Molecular basis for the evolution of species-specific hemoglobin capture by pathogenic Staphylococcus

  2018cites this paper
• Disentangling the effects of genetic architecture, mutational bias and selection on evolutionary forecasting

  2018cites this paper
• Gene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates

  2018cites this paper
• Neutral and functionally important genes shed light on phylogeography and the history of high‐altitude colonization in a widespread New World duck

  2018cites this paper
• Allosteric mechanisms underlying the adaptive increase in hemoglobin–oxygen affinity of the bar-headed goose

  2018cites this paper
• In Cold Blood: Compositional Bias and Positive Selection Drive the High Evolutionary Rate of Vampire Bats Mitochondrial Genomes

  2018cites this paper
• Continuous environmental tracking: An engineering framework to understand adaptation and diversification

  2018cites this paper
• Predicting mutational routes to new adaptive phenotypes

  2018cites this paper
• Understanding Bias in the Introduction of Variation as an Evolutionary Cause

  2018cites this paper
• Mutational Biases Influence Parallel Adaptation

  2017cites this paper
• Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose

  2017cites this paper
• Why are tropical mountain passes ‘low’ for some species? Genetic and stable-isotope tests for differentiation, migration, and expansion in elevational generalist songbirds

  2017influential citation
• Mutation-Driven Parallel Evolution during Viral Adaptation

  2017cites this paper
• Predicting the genetic loci of past evolution

  2017cites this paper
• The effects of atmospheric pressure on inter-specific competition and the morphological and hematological characteristics of elevational distributions of hummingbirds

  2017cites this paper
• Flying High: The Unique Physiology of Birds that Fly at High Altitudes

  2017cites this paper
• High altitude flights by ruddy shelduck Tadorna ferruginea during trans‐Himalayan migrations

  2017cites this paper
• Elevational divergence in the great tit complex revealed by major hemoglobin genes

  2017cites this paper
• Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin

  2017cites this paper
• Darwin was right: where now for experimental evolution?

  2017cites this paper
• How does mutation affect the distribution of phenotypes?

  2017cites this paper
• Predictable convergence in hemoglobin function has unpredictable molecular underpinnings

  2016cites this paper
• Altitude matters: differences in cardiovascular and respiratory responses to hypoxia in bar-headed geese reared at high and low altitudes

  2016cites this paper
• Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation.

  2016cites this paper
• Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation

  2016cites this paper
• The dual role of Andean topography in primary divergence: functional and neutral variation among populations of the hummingbird, Metallura tyrianthina

  2016cites this paper
• Hemoglobin–oxygen affinity in high-altitude vertebrates: is there evidence for an adaptive trend?

  2016cites this paper
• Gene Duplication and Evolutionary Innovations in Hemoglobin-Oxygen Transport.

  2016cites this paper
• Genome Duplication , and the Origin of Hemoglobin as an O 2

  2016cites this paper
• Mutation and Genome Evolution

  2016cites this paper
• Hemoglobins and High-altitude Adaptive Evolution in Vertebrates

  2016cites this paper
• Diversity, Ecology, And Conservation Of Bird Communities Of Polylepis Woodlands In The Northern Andes Of Peru

  2016cites this paper
• Protein Frustratometer 2: a tool to localize energetic frustration in protein molecules, now with electrostatics

  2016cites this paper
• Causes of molecular convergence and parallelism in protein evolution

  2016cites this paper
• Identifying molecular signatures of hypoxia adaptation from sex chromosomes: A case for Tibetan Mastiff based on analyses of X chromosome

  2016cites this paper
• Mutation-biased adaptation in Andean house wrens

  2015cites this paper
• Oxygenation properties and isoform diversity of snake hemoglobins.

  2015cites this paper
• Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level

  2015cites this paper