Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Cell Science

• Publication date

  2003-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1242/jcs.00678PMID 12876220
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Peroxisomes, lipid metabolism, and human disease

  2007cited by this paper
• Peroxisome biogenesis.

  2003cited by this paper
• Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica

  2002cited by this paper
• Peroxisomal-protein import: is it really that complex?

  2002cited by this paper
• Recognition of a subset of signal sequences by Ssh 1 p , a Sec 61 p related protein in the membrane of the endoplasmic reticulum of the yeast S . cerevisiae

  2002cited by this paper
• Peroxisome Remnants in pex3Δ Cells and the Requirement of Pex3p for Interactions Between the Peroxisomal Docking and Translocation Subcomplexes

  2002cited by this paper
• The SH 3 Domain of the Saccharomyces cerevisiae Peroxisomal Membrane Protein Pex 13 p Functions as a Docking Site for Pex 5 p , a Mobile Receptor for the Import of PTSl-containing Proteins

  2002cited by this paper
• Analysis of Mammalian Peroxin Interactions Using a Non-transcription-based Bacterial Two-hybrid Assay*

  2002cited by this paper
• Recognition of a subset of signal sequences by Ssh1p, a Sec61p-related protein in the membrane of endoplasmic reticulum of yeast Saccharomyces cerevisiae.

  2002cited by this paper
• PEX11 promotes peroxisome division independently of peroxisome metabolism

  2002cited by this paper
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

  2002cited by this paper
• Functional organization of the yeast proteome by systematic analysis of protein complexes

  2002cited by this paper
• Peroxisome biogenesis.

  2001cited by this paper
• Protein translocation machineries of peroxisomes

  2001cited by this paper
• Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import.

  2001cited by this paper
• The life cycle of the peroxisome

  2001cited by this paper
• Mechanisms underlying ubiquitination.

  2001cited by this paper
• Characterization of the Mammalian Peroxisomal Import Machinery

  2001cited by this paper
• Characterization of the Mammalian Peroxisomal Import Machinery Pex2p, Pex5p, Pex12p, AND Pex14p ARE SUBUNITS OF THE SAME PROTEIN ASSEMBLY*

  2001cited by this paper
• Peroxisome biogenesis disorders: genetics and cell biology.

  2000cited by this paper
• Peroxisomal matrix protein import. Suppression of protein import defects in Hansenula polymorpha pex mutants by overproduction of the PTS1 receptor Pex5p.

  2000cited by this paper
• PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G.

  2000cited by this paper
• Felix Hoppe-Seyler Lecture 2000. The ubiquitin system and the N-end rule pathway.

  2000influential reference
• The Peroxin Pex19p Interacts with Multiple, Integral Membrane Proteins at the Peroxisomal Membrane

  2000cited by this paper
• The Structural Properties of Plant Peroxisomes and Their Metabolic Significance

  2000cited by this paper
• Saccharomyces cerevisiae Pex3p and Pex19p are required for proper localization and stability of peroxisomal membrane proteins

  2000cited by this paper
• Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis

  2000cited by this paper
• Two RING finger proteins mediate cooperation between ubiquitin‐conjugating enzymes in DNA repair

  2000cited by this paper
• Molecular Anatomy of the Peroxin Pex12p

  2000cited by this paper
• Import of peroxisomal matrix and membrane proteins.

  2000cited by this paper
• Biochemical and molecular approaches to understanding protein import into peroxisomes.

  2000cited by this paper
• A new screen for protein interactions reveals that the Saccharomyces cerevisiae high mobility group proteins Nhp6A/B are involved in the regulation of the GAL1 promoter.

  2000cited by this paper
• A missense mutation in the RING finger motif of PEX2 protein disturbs the import of peroxisome targeting signal 1 (PTS1)-containing protein but not the PTS2-containing protein.

  2000cited by this paper
• Peroxisome biogenesis and peroxisome biogenesis disorders

  2000cited by this paper
• The genetics of peroxisome biogenesis.

  2000influential reference
• A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

  2000cited by this paper
• The E2–E3 interaction in the N‐end rule pathway: the RING‐H2 finger of E3 is required for the synthesis of multiubiquitin chain

  1999cited by this paper
• Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris.

  1999cited by this paper
• Peroxisomes: simple in function but complex in maintenance.

  1999cited by this paper
• Peroxisome Synthesis in the Absence of Preexisting Peroxisomes

  1999cited by this paper
• Involvement of Pex13p in Pex14p Localization and Peroxisomal Targeting Signal 2–dependent Protein Import into Peroxisomes

  1999cited by this paper
• Import of proteins into peroxisomes.

  1999cited by this paper
• Pex22p of Pichia pastoris, Essential for Peroxisomal Matrix Protein Import, Anchors the Ubiquitin-Conjugating Enzyme, Pex4p, on the Peroxisomal Membrane

  1999cited by this paper
• Pex12 Interacts with Pex5 and Pex10 and Acts Downstream of Receptor Docking in Peroxisomal Matrix Protein Import

  1999cited by this paper
• Probing the molecular environment of membrane proteins in vivo.

  1999influential reference
• Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.

  1999cited by this paper
• Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum.

  1999cited by this paper
• Pex 22 p of Pichia pastoris , Essential for Peroxisomal Matrix Protein Import , Anchors the Ubiquitin-conjugating Enzyme , Pex 4 p , on the Peroxisomal Membrane

  1999cited by this paper
• Epitope tagging of yeast genes using a PCR‐based strategy: more tags and improved practical routines

  1999cited by this paper
• Recombinant Human Peroxisomal Targeting Signal Receptor PEX5

  1999cited by this paper
• Peroxisome biogenesis: from yeast to man.

  1998cited by this paper
• PEX12, the Pathogenic Gene of Group III Zellweger Syndrome: cDNA Cloning by Functional Complementation on a CHO Cell Mutant, Patient Analysis, and Characterization of Pex12p

  1998cited by this paper
• A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo.

  1998cited by this paper
• The ubiquitin‐conjugating enzyme Pex4p of Hansenula polymorpha is required for efficient functioning of the PTS1 import machinery

  1998cited by this paper
• The Difference in Recognition of Terminal Tripeptides as Peroxisomal Targeting Signal 1 between Yeast and Human Is Due to Different Affinities of Their Receptor Pex5p to the Cognate Signal and to Residues Adjacent to It*

  1998cited by this paper
• Lipid metabolism in peroxisomes in relation to human disease.

  1998cited by this paper
• Epitope tagging.

  1998cited by this paper
• Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis

  1998cited by this paper
• Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B.

  1998cited by this paper
• Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders

  1997cited by this paper
• Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane

  1997cited by this paper
• Isolation and characterization of peroxisome-deficient Chinese hamster ovary cell mutants representing human complementation group III.

  1997cited by this paper
• Peroxisome biogenesis

  1997cited by this paper
• Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways.

  1997cited by this paper
• Overexpression of Pex 15 p , a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S . cerevisiae , causes proliferation of the endoplasmic reticulum membrane

  1997cited by this paper
• Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal division

  1996cited by this paper
• Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor

  1996cited by this paper
• Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor

  1996cited by this paper
• Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor

  1996cited by this paper
• The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins

  1996cited by this paper
• Protein Insertion into the Peroxisomal Membrane

  1996cited by this paper
• A new efficient gene disruption cassette for repeated use in budding yeast

  1996cited by this paper
• The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation

  1995cited by this paper
• Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p

  1995cited by this paper
• Formation of the peroxisome lumen is abolished by loss of Pichia pastoris Pas7p, a zinc-binding integral membrane protein of the peroxisome

  1995cited by this paper
• An Essential Yeast Gene Encoding a Homolog of Ubiquitin-activating Enzyme (*)

  1995cited by this paper
• Split ubiquitin as a sensor of protein interactions in vivo.

  1994cited by this paper
• The Pichia pastoris PAS4 gene encodes a ubiquitin-conjugating enzyme required for peroxisome assembly.

  1994cited by this paper
• Ring finger in the peroxisome assembly factor‐1

  1992cited by this paper
• The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes

  1992cited by this paper
• Restoration by a 35K membrane protein of peroxisome assembly in a peroxisome-deficient mammalian cell mutant

  1991cited by this paper
• Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae.

  1989cited by this paper
• A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

  1989cited by this paper
• Biogenesis of peroxisomes.

  1985cited by this paper

• The Interplay of Immune Response and Dental Enamel Formation in Health and Sickness.

  2026cites this paper
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  2025cites this paper
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  2023cites this paper
• Anaerobic peroxisomes in Entamoeba histolytica metabolize myo-inositol

  2021cites this paper
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  2021cites this paper
• Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer’s Disease

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• Protein Topology Prediction Algorithms Systematically Investigated in the Yeast Saccharomyces cerevisiae

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• Ubiquitination, quality control and degradation of membrane proteins – chance for therapies?

  2018cites this paper
• The cell polarity proteins Boi1p and Boi2p stimulate vesicle fusion at the plasma membrane of yeast cells

  2017cites this paper
• The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane

  2017influential citation
• A Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering Mutations

  2016cites this paper
• The birth of yeast peroxisomes.

  2016cites this paper
• Genome-Wide Localization Study of Yeast Pex11 Identifies Peroxisome–Mitochondria Interactions through the ERMES Complex

  2015cites this paper
• Colletotrichum orbiculare FAM1 Encodes a Novel Woronin Body-Associated Pex22 Peroxin Required for Appressorium-Mediated Plant Infection

  2015cites this paper
• A protein complex containing Epo1p anchors the cortical endoplasmic reticulum to the yeast bud tip

  2015cites this paper
• The Peroxisomal Exportomer

  2014cites this paper
• Stepwise and cooperative assembly of a cytokinetic core complex in yeast Saccharomyces cerevisiae

  2014cites this paper
• Stepwise and cooperative assembly of a cytokinetic core complex in Saccharomyces cerevisiae

  2014cites this paper
• The exportomer: the peroxisomal receptor export machinery

  2013cites this paper
• Assembly of the heteromeric Pex 1 p-Pex 6 p-complex of the peroxisomal matrix protein import machinery

  2013cites this paper
• Arabidopsis peroxisome proteomics

  2013cites this paper
• A fluorescent reporter for mapping cellular protein-protein interactions in time and space

  2013cites this paper
• The RING‐type ubiquitin ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an ubiquitin conjugating enzyme‐selective manner

  2012cites this paper
• Sho1p connects the plasma membrane with proteins of the cytokinesis network through multiple isomeric interaction states

  2012cites this paper
• Evolutionary and Biochemical Aspects of Chemical Stress Resistance in Saccharomyces cerevisiae

  2012cites this paper
• Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis.

  2012cites this paper
• Detecting protein-protein interactions with the Split-Ubiquitin sensor.

  2012cites this paper
• Peroxisome Dynamics: Molecular Players, Mechanisms, and (Dys)functions

  2012cites this paper
• Analysis of Telomere Healing of DNA Double-strand Breaks

  2012cites this paper
• A systematic analysis of human transmembrane E3-RING proteins

  2011cites this paper
• Functions of the ubiquitin system in mammalian spermatogenesis and skeletal muscle

  2011cites this paper
• University of Alberta

  2011cites this paper
• Characterization of homologs of peroxisome assembly genes in the fruitfly Drosophila melanogaster

  2011cites this paper
• A constraint network of interactions: protein–protein interaction analysis of the yeast type II phosphatase Ptc1p and its adaptor protein Nbp2p

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• Insights into ubiquitin‐conjugating enzyme/ co‐activator interactions from the structure of the Pex4p:Pex22p complex

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• Basic translocation unit composition of the twin arginine translocase (Tat) system in pea thylakoids

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• Genome-Wide Analysis of Effectors of Peroxisome Biogenesis

  2010cites this paper
• Robustness and evolvability in natural chemical resistance: identification of novel systems properties, biochemical mechanisms and regulatory interactions.

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• Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import

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• Ubiquitin Chain Elongation Enzyme Ufd2 Regulates a Subset of Doa10 Substrates*

  2010cites this paper
• De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks.

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  2009cites this paper
• Proteins involved in microbody biogenesis and degradation in Aspergillus nidulans.

  2009cites this paper
• Yeast Two-Hybrid, a Powerful Tool for Systems Biology

  2009cites this paper
• Protein Quality Control in Peroxisomes

  2009cites this paper
• Regulation of peroxisome dynamics.

  2009influential citation
• The Peroxisome RING‐Finger Complex is Required for Meiocyte Formation in the Fungus Podospora anserina

  2008influential citation
• Members of the E2D (UbcH5) Family Mediate the Ubiquitination of the Conserved Cysteine of Pex5p, the Peroxisomal Import Receptor*

  2008cites this paper
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  2008cites this paper
• A plant split-ubiquitin system and TAP-tagging to study in vivo protein interactions in the chloroplast protein import machinery

  2008influential citation
• Shuttles and cycles: transport of proteins into the peroxisome matrix (Review)

  2008influential citation
• Split‐Ubiquitin and the Split‐Protein Sensors: Chessman for the Endgame

  2008cites this paper
• Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p.

  2008cites this paper
• The peroxisomal protein import machinery – a case report of transient ubiquitination with a new flavor

  2008cites this paper
• Pex5p and ubiquitin : regulation of the PTS1 protein import receptor

  2007influential citation
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  2007cites this paper
• Protein translocation across the peroxisomal membrane

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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  2006cites this paper
• Identification of Proteomic Signatures of Exposure to Marine Pollutants in Mussels (Mytilus edulis)*S

  2006cites this paper
• Pex14p, more than just a docking protein.

  2006cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
• Peroxisome protein import: some answers, more questions.

  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
• The Arabidopsis PEX12 Gene Is Required for Peroxisome Biogenesis and Is Essential for Development1[w]

  2005cites this paper
• Peroxisomal matrix protein import: the transient pore model

  2005cites this paper
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  2004influential citation
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  2004cites this paper
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  2004cites this paper
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