The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Neuroendocrinology

• Publication date

  2018-04-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000489263PMID 29660735
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model.

  2018cited by this paper
• A Precision Medicine Approach to Oxytocin Trials.

  2018cited by this paper
• Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay

  2018cited by this paper
• Biased Oxytocinergic Modulation of Midbrain Dopamine Systems.

  2017cited by this paper
• Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation

  2017cited by this paper
• Effects of Endogenous Oxytocin Receptor Signaling in Nucleus Tractus Solitarius on Satiation‐Mediated Feeding and Thermogenic Control in Male Rats

  2017cited by this paper
• Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice

  2017cited by this paper
• Inhibitory role of oxytocin on TNFα expression assessed in vitro and in vivo.

  2017cited by this paper
• Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward

  2017cited by this paper
• High-Sugar, but Not High-Fat, Food Activates Supraoptic Nucleus Neurons in the Male Rat

  2017cited by this paper
• Orexin action on oxytocin neurons in the paraventricular nucleus of the hypothalamus

  2017cited by this paper
• Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand.

  2017cited by this paper
• Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats.

  2017cited by this paper
• Oxytocin and social functioning

  2017cited by this paper
• Projections from a single NUCB2/nesfatin-1 neuron in the paraventricular nucleus to different brain regions involved in feeding

  2016cited by this paper
• Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles.

  2016cited by this paper
• Oxytocin-dependent consolation behavior in rodents

  2016cited by this paper
• Oxytocin Pathway Genes: Evolutionary Ancient System Impacting on Human Affiliation, Sociality, and Psychopathology.

  2016cited by this paper
• Reduced circulating oxytocin and High-Molecular-Weight adiponectin are risk factors for metabolic syndrome.

  2016cited by this paper
• Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization.

  2016cited by this paper
• Intranasal Oxytocin: Myths and Delusions.

  2016cited by this paper
• Metabolic effects of subchronic peripheral oxytocin administration in lean and obese zucker rats.

  2016cited by this paper
• Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake

  2016cited by this paper
• Oxytocin's inhibitory effect on food intake is stronger in obese than normal-weight men

  2016cited by this paper
• Neural mechanisms of mother-infant bonding and pair bonding: Similarities, differences, and broader implications.

  2016cited by this paper
• A rapidly-acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

  2016cited by this paper
• Effects of peripherally administered cholecystokinin-8 and secretin on feeding/drinking and oxytocin-mRFP1 fluorescence in transgenic rats.

  2016cited by this paper
• Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit

  2016cited by this paper
• Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells

  2016cited by this paper
• Oxytocin reduces caloric intake in men

  2015cited by this paper
• Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling.

  2015cited by this paper
• The Regulation of Oxytocin Receptor Gene Expression during Adipogenesis

  2015cited by this paper
• Oxytocin treatment prevents the cardiomyopathy observed in obese diabetic male db/db mice.

  2015cited by this paper
• Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity.

  2015cited by this paper
• Nasal Oxytocin Administration Reduces Food Intake without Affecting Locomotor Activity and Glycemia with c-Fos Induction in Limited Brain Areas

  2015cited by this paper
• Medial nucleus tractus solitarius oxytocin receptor signaling and food intake control: the role of gastrointestinal satiation signal processing.

  2015cited by this paper
• Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys.

  2015cited by this paper
• Can oxytocin treat autism?

  2015cited by this paper
• The Brain on Drugs: From Reward to Addiction.

  2015cited by this paper
• New opportunities in vasopressin and oxytocin research: a perspective from the amygdala.

  2015cited by this paper
• Chronic Oxytocin Administration as a Treatment Against Impaired Leptin Signaling or Leptin Resistance in Obesity

  2015cited by this paper
• Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes.

  2014cited by this paper
• Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model

  2014cited by this paper
• The brain melanocortin system, sympathetic control, and obesity hypertension.

  2014cited by this paper
• Integrative and Translational Physiology : Integrative Aspects of Energy Homeostasis and Metabolic Diseases Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors

  2014cited by this paper
• Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism.

  2014cited by this paper
• A Novel Excitatory Paraventricular Nucleus to AgRP Neuron Circuit that Drives Hunger

  2014cited by this paper
• The biology of mammalian parenting and its effect on offspring social development

  2014cited by this paper
• Anxiolytic effects of oxytocin in cue-induced cocaine seeking behavior in rats

  2014cited by this paper
• Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats.

  2014cited by this paper
• Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure.

  2014cited by this paper
• Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients.

  2014cited by this paper
• A double‐blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome

  2014cited by this paper
• Endogenous GLP-1 acts on paraventricular nucleus to suppress feeding: projection from nucleus tractus solitarius and activation of corticotropin-releasing hormone, nesfatin-1 and oxytocin neurons.

  2014cited by this paper
• Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus

  2014cited by this paper
• Fluorescent Visualisation of the Hypothalamic Oxytocin Neurones Activated by Cholecystokinin‐8 in Rats Expressing c‐fos‐Enhanced Green Fluorescent Protein and Oxytocin‐Monomeric Red Fluorescent Protein 1 Fusion Transgenes

  2014cited by this paper
• Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue.

  2014cited by this paper
• Oxytocin as a novel therapeutic option for type I diabetes and diabetic osteopathy.

  2014cited by this paper
• Faculty Opinions recommendation of An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.

  2014cited by this paper
• Oxytocin action in the ventral tegmental area affects sucrose intake.

  2013cited by this paper
• Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity

  2013cited by this paper
• Treatment of Obesity and Diabetes Using Oxytocin or Analogs in Patients and Mouse Models

  2013cited by this paper
• Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

  2013cited by this paper
• Intranasal administration of oxytocin: Behavioral and clinical effects, a review

  2013cited by this paper
• Social reward requires coordinated activity of accumbens oxytocin and 5HT

  2013cited by this paper
• Oxytocin Reduces Reward-Driven Food Intake in Humans

  2013cited by this paper
• Melanocortin 4 receptor distribution in the human hypothalamus.

  2013cited by this paper
• Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting.

  2013cited by this paper
• An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure

  2012cited by this paper
• Deconstruction of a neural circuit for hunger

  2012cited by this paper
• Refeeding-activated glutamatergic neurons in the hypothalamic paraventricular nucleus (PVN) mediate effects of melanocortin signaling in the nucleus tractus solitarius (NTS).

  2012cited by this paper
• From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

  2012cited by this paper
• Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats.

  2012cited by this paper
• Activation of VTA GABA neurons disrupts reward consumption.

  2012cited by this paper
• Oxytocin‐immunoreactive innervation of identified neurons in the rat dorsal vagal complex

  2012cited by this paper
• Whole-brain mapping of direct inputs to midbrain dopamine neurons.

  2012cited by this paper
• Mechanisms of the Anti-Obesity Effects of Oxytocin in Diet-Induced Obese Rats

  2011cited by this paper
• Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance.

  2011cited by this paper
• Plasticity of vagal brainstem circuits in the control of gastrointestinal function.

  2011cited by this paper
• Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis

  2011cited by this paper
• Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior

  2011cited by this paper
• Reward mechanisms in obesity: new insights and future directions.

  2011cited by this paper
• Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass

  2011cited by this paper
• Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment.

  2011cited by this paper
• Long‐term Infusion of Brain‐Derived Neurotrophic Factor Reduces Food Intake and Body Weight via a Corticotrophin‐Releasing Hormone Pathway in the Paraventricular Nucleus of the Hypothalamus

  2010cited by this paper
• AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

  2010cited by this paper
• The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist.

  2010cited by this paper
• A new oxytocin-saporin cytotoxin for lesioning oxytocin-receptive neurons in the rat hindbrain.

  2010cited by this paper
• Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats

  2010cited by this paper
• Intranasal oxytocin increases fathers' observed responsiveness during play with their children: a double-blind within-subject experiment.

  2010cited by this paper
• Molecular, immunohistochemical, and pharmacological evidence of oxytocin's role as inhibitor of carbohydrate but not fat intake.

  2010cited by this paper
• Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium

  2009cited by this paper
• Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway.

  2009cited by this paper
• Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice.

  2008cited by this paper
• Novel Leptin-Regulated Genes Revealed by Transcriptional Profiling of the Hypothalamic Paraventricular Nucleus

  2008cited by this paper
• Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding.

  2008cited by this paper
• Oxytocin receptor-deficient mice developed late-onset obesity

  2008cited by this paper
• Oxytocin, Vasopressin, and the Neurogenetics of Sociality

  2008cited by this paper
• Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS.

  2008cited by this paper
• CD38 is critical for social behaviour by regulating oxytocin secretion

  2007cited by this paper

• Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study

  2026cites this paper
• The Neuroendocrine Role of Oxytocinergic Pathways in Obesity.

  2026cites this paper
• Olanzapine-induced metabolic syndrome is partially mediated by oxytocinergic system dysfunction in female Sprague-Dawley rats

  2025cites this paper
• Neural Circuit Remodeling Underlying Enhanced Feeding During Pregnancy in Mice

  2025cites this paper
• The serum oxytocin correlated with serum leptin and body mass index in Japanese adolescents

  2025cites this paper
• Vagal Oxytocin Receptors as Molecular Targets in Gut–Brain Signaling: Implications for Appetite, Satiety, Obesity, and Esophageal Motility—A Narrative Review

  2025cites this paper
• Oxytocin as a modulator of adaptive behavior: integrating ingestive and social mechanisms.

  2025cites this paper
• Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets

  2025cites this paper
• Regulatory Role of Oxytocin in Ionocyte Functions During Zebrafish Cold Acclimation

  2025cites this paper
• Elevated Oxytocin Levels and Their Relationship to Metabolic Syndrome and Obesity Among Young Sudanese Adults: A Cross-Sectional Analysis

  2025influential citation
• Extended kangaroo mother care - Examining the utility of skin-to-skin contact over the first year of life.

  2025cites this paper
• Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders

  2025cites this paper
• Oxytocin Signaling Bridges Social and Appetitive Functions in the Rodent Hippocampus.

  2025cites this paper
• Kamikihito contributes to visceral fat reduction and appetite suppression in PCOS model rats by increasing OTR and leptin expression in visceral fat.

  2025cites this paper
• Intranasal Oxytocin for Obesity.

  2024cites this paper
• Flexible adjustment of oxytocin neuron activity in mouse dams revealed by microendoscopy

  2024cites this paper
• Oxytocin shortens spreading depolarization-induced periorbital allodynia

  2024cites this paper
• Systemic Co-Administration of Low-Dose Oxytocin and Glucagon-Like Peptide 1 Additively Decreases Food Intake and Body Weight

  2024cites this paper
• New discoveries on the interaction between testosterone and oxytocin in male rats - Testosterone-mediated effects of oxytocin in the prevention of obesity.

  2023cites this paper
• Oxytocin Response to Food Intake in Avoidant/Restrictive Food Intake Disorder.

  2023cites this paper
• Microbes, oxytocin and stress: Converging players regulating eating behavior

  2023cites this paper
• Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study

  2022cites this paper
• Prenatal Progestin Exposure-Mediated Oxytocin Suppression Contributes to Social Deficits in Mouse Offspring

  2022cites this paper
• Hypothalamic Nesfatin-1 Resistance May Underlie the Development of Type 2 Diabetes Mellitus in Maternally Undernourished Non-obese Rats

  2022cites this paper
• Treatment of Acquired Hypothalamic Obesity: Now and the Future

  2022cites this paper
• The central melanocortin system as a treatment target for obesity and diabetes: A brief overview.

  2022cites this paper
• Possible interaction of central noradrenergic, serotoninergic and oxytocin systems with nesfatin-1 induced hypophagia and feeding behavior in newborn broiler.

  2022cites this paper
• Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats

  2022cites this paper
• Elevated Glucagon-like Peptide-1 Receptor Level in the Paraventricular Hypothalamic Nucleus of Type 2 Diabetes Mellitus Patients

  2022cites this paper
• Oxytocin signaling in the posterior hypothalamus prevents hyperphagic obesity in mice

  2021cites this paper
• Oxytocin, eating behavior, and metabolism in humans.

  2021cites this paper
• Oxytocin stimulates lipolysis, prostaglandin E2 synthesis, and leptin secretion in 3T3-L1 adipocytes.

  2021cites this paper
• Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats.

  2021cites this paper
• The Neural Network of Neuropeptide S (NPS): Implications in Food Intake and Gastrointestinal Functions

  2021cites this paper
• Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges.

  2021cites this paper
• Maternal Diabetes-Induced Suppression of Oxytocin Receptor Contributes to Social Deficits in Offspring

  2021cites this paper
• Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia

  2021cites this paper
• Intestinal Electrical Stimulation Alters Hypothalamic Expression of Oxytocin and Orexin and Ameliorates Diet-Induced Obesity in Rats

  2021cites this paper
• Can intranasal oxytocin reduce craving in automated addictive behaviours? A systematic review

  2021cites this paper
• Pancreas-Brain Crosstalk

  2021cites this paper
• The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans

  2021cites this paper
• Increased neuronal activation in sympathoregulatory regions of the brain and spinal cord in type 2 diabetic rats

  2021cites this paper
• Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms

  2021cites this paper
• Birth with synthetic oxytocin and the risk of being overweight or obese during childhood

  2021cites this paper
• Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice

  2020cites this paper
• The effects of chronic oxytocin administration on body weight and food intake in DHT-induced PCOS model rats

  2020cites this paper
• Sex and age influence gonadal steroid hormone receptor distributions relative to estrogen receptor β‐containing neurons in the mouse hypothalamic paraventricular nucleus

  2020cites this paper
• Oxytocin for treating Prader-Willi Syndrome

  2020cites this paper
• Oral oxytocin delivery with proton pump inhibitor pretreatment decreases food intake.

  2020cites this paper
• Oxytocin in the neural control of eating: At the crossroad between homeostatic and non-homeostatic signals.

  2020cites this paper
• Oxytocin neurons: integrators of hypothalamic and brainstem circuits in the regulation of macronutrient-specific satiety

  2019cites this paper
• Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care.

  2019cites this paper
• Convergent neuronal projections from paraventricular nucleus, parabrachial nucleus, and brainstem onto gastrocnemius muscle, white and brown adipose tissue in male rats

  2019cites this paper
• Oxytocin treatment reduced food intake and body fat and ameliorated obesity in ovariectomized female rats.

  2019cites this paper
• Role of oxytocin in the control of stress and food intake

  2019cites this paper
• Sex Differences and Estrous Influences on Oxytocin Control of Food Intake.

  2019cites this paper
• Circulating oxytocin is genetically determined and associated with obesity and impaired glucose tolerance.

  2019cites this paper
• Mechanisms of gustatory perception of dietary lipids : cross-talk with bitter taste and endocannabinoid receptors

  2018cites this paper