Mammalian Cdc7–Dbf4 protein kinase complex is essential for initiation of DNA replication

No abstract is available for this paper.

• Publication year

  1999

• Venue

  EMBO Journal

• Publication date

  1999-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/18.20.5703PMID 10523313PMCID PMC1171637
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell Cycle Control of Cdc7p Kinase Activity through Regulation of Dbf4p Stability

  1999cited by this paper
• First the CDKs, now the DDKs.

  1999influential reference
• Cell Cycle Regulation of DNA Replication Initiator Factor Dbf4p

  1999cited by this paper
• A Fission Yeast Gene,him1+/dfp1+, Encoding a Regulatory Subunit for Hsk1 Kinase, Plays Essential Roles in S-Phase Initiation as Well as in S-Phase Checkpoint Control and Recovery from DNA Damage

  1999influential reference
• nimO, an Aspergillus gene related to budding yeast Dbf4, is required for DNA synthesis and mitotic checkpoint control.

  1999cited by this paper
• Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase.

  1999cited by this paper
• A Novel Growth- and Cell Cycle-Regulated Protein, ASK, Activates Human Cdc7-Related Kinase and Is Essential for G1/S Transition in Mammalian Cells

  1999cited by this paper
• Purification of Hsk1, a Minichromosome Maintenance Protein Kinase from Fission Yeast*

  1998influential reference
• Cdc7 is required throughout the yeast S phase to activate replication origins.

  1998cited by this paper
• Cell Cycle- and Chromatin Binding State-dependent Phosphorylation of Human MCM Heterohexameric Complexes

  1998cited by this paper
• The Cdc7 protein kinase is required for origin firing during S phase.

  1998cited by this paper
• A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines.

  1998cited by this paper
• PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis.

  1998cited by this paper
• Biochemical Function of Mouse Minichromosome Maintenance 2 Protein*

  1998cited by this paper
• MCM proteins: evolution, properties, and role in DNA replication.

  1998cited by this paper
• A DNA Helicase Activity Is Associated with an MCM4, -6, and -7 Protein Complex*

  1997cited by this paper
• Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs.

  1997cited by this paper
• Identification and characterization of a human protein kinase related to budding yeast Cdc7p.

  1997cited by this paper
• Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.

  1997influential reference
• mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p.

  1997cited by this paper
• Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.

  1997cited by this paper
• In Vivo Interaction of Human MCM Heterohexameric Complexes with Chromatin

  1997cited by this paper
• Initiation of DNA replication in eukaryotic cells.

  1997influential reference
• Human and Xenopus cDNAs encoding budding yeast Cdc7‐related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7

  1997influential reference
• The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts.

  1996cited by this paper
• …Functional motifs…

  1996cited by this paper
• Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae

  1996cited by this paper
• BRCA1 protein products ... Functional motifs...

  1996cited by this paper
• Cell Cycle Control of DNA Replication

  1996cited by this paper
• Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

  1995cited by this paper
• Purification of an MCM-containing complex as a component of the DNA replication licensing system

  1995cited by this paper
• BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication

  1995influential reference
• Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor.

  1995cited by this paper
• Cell cycle control of DNA replication.

  1995cited by this paper
• hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication.

  1995cited by this paper
• Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.

  1994cited by this paper
• Cdc7 protein kinase for DNA metabolism comes of age

  1994cited by this paper
• Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein

  1993cited by this paper
• The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.

  1993cited by this paper
• Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

  1993cited by this paper
• Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

  1992cited by this paper
• Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates.

  1991cited by this paper

• CDC7 is a targetable regulator of advanced prostate cancer

  2025cites this paper
• Ataxin-2 preserves oocyte genome integrity by promoting timely premeiotic DNA replication

  2025cites this paper
• Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma

  2025cites this paper
• Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombination

  2024cites this paper
• Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase

  2024cites this paper
• Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency

  2024cites this paper
• DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks

  2024cites this paper
• Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks

  2024cites this paper
• Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets

  2023cites this paper
• Homozygous DBF4 mutation as a cause for severe congenital neutropenia.

  2023cites this paper
• Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner

  2023cites this paper
• Activation of the pre-replicative complex

  2022cites this paper
• Safety, Tolerability, and Pharmacokinetics of TAK-931, a Cell Division Cycle 7 Inhibitor, in Patients with Advanced Solid Tumors: A Phase I First-in-Human Study

  2022influential citation
• Snapshot imprinting as a tool for surface mapping and identification of novel biomarkers of senescent cells

  2022cites this paper
• Novel insights into the roles of Cdc7 in response to replication stress

  2022cites this paper
• DDK: The Outsourced Kinase of Chromosome Maintenance

  2022cites this paper
• CDC7-independent G1/S transition revealed by targeted protein degradation

  2022cites this paper
• A rethink about enzymes that drive DNA replication

  2022cites this paper
• Palbociclib interferes with replication origin firing in a pRb independent manner

  2022cites this paper
• Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

  2022cites this paper
• Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13

  2021cites this paper
• A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes

  2021cites this paper
• Identification of novel anti-tumor therapeutic target via proteomic characterization of ubiquitin receptor ADRM1/Rpn13

  2021cites this paper
• A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery

  2021cites this paper
• Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Anti-Tumor Agent.

  2020cites this paper
• Disruption of ruminal homeostasis by malnutrition involved in systemic ruminal microbiota-host interactions in a pregnant sheep model

  2020influential citation
• Control of DNA replication timing in the 3D genome

  2019cites this paper
• Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

  2019cites this paper
• A Dual Inhibitor of Cdc7/Cdk9 Potently Suppresses T Cell Activation

  2019cites this paper
• Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1

  2018cites this paper
• The Key Role of E2F in Tumor Suppression through Specific Regulation of Tumor Suppressor Genes in Response to Oncogenic Changes

  2018cites this paper
• Regulation of the initiation of DNA replication in human cells.

  2018cites this paper
• Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.

  2018cites this paper
• Uncoupling fork speed and origin activity to identify the primary cause of replicative stress phenotypes

  2018cites this paper
• 2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.

  2017cites this paper
• Recent advances of pyrrolopyridines derivatives: a patent and literature review

  2017cites this paper
• Reversal of DDK-Mediated MCM Phosphorylation by Rif 1-PP 1 Regulates Replication Initiation and Replisome Stability Independently of ATR / Chk 1 Graphical

  2017cites this paper
• Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.

  2017influential citation
• Mechanisms and regulation of DNA replication initiation in eukaryotes

  2017cites this paper
• Medicinal Attributes of Thienopyrimidine Based Scaffold Targeting Tyrosine Kinases and Their Potential Anticancer Activities

  2017cites this paper
• Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1

  2017cites this paper
• Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches

  2017cites this paper
• DNA Replication Modulates R-loop Levels to Maintain Genome Stability

  2017cites this paper
• DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach

  2016influential citation
• Role of DDK in Replication Initiation

  2016cites this paper
• Cdk1-mediated phosphorylation of Cdc7 suppresses DNA re-replication

  2016cites this paper
• Synthesis and biological evaluation of pyrrolo[2,3-b]pyridine analogues as antiproliferative agents and their interaction with calf thymus DNA.

  2016cites this paper
• Identification potential biomarkers and therapeutic agents in multiple myeloma based on bioinformatics analysis.

  2016cites this paper
• Subcellular proteomic approach for identifying the signaling effectors of protein kinase C-β2 under high glucose conditions in human umbilical vein endothelial cells

  2015cites this paper
• A High Through-Put Screen for Small Molecules Modulating MCM2 Phosphorylation Identifies Ryuvidine as an Inducer of the DNA Damage Response

  2014cites this paper
• CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

  2014cites this paper
• hepatocellular carcinoma CDK 9-mediated transcription elongation is required for MYC addiction Material Supplemental

  2014cites this paper
• Characterization of a Drosophila Ortholog of the Cdc7 Kinase

  2014cites this paper
• Regulation and roles of Cdc7 kinase under replication stress

  2014cites this paper
• The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds

  2014influential citation
• Maturation‐associated Dbf4 expression is essential for mouse zygotic DNA replication

  2014cites this paper
• MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells

  2014cites this paper
• Examining a new class of dual CDC7/CDK9 inhibitors, mechanisms of proliferation, and proliferation-based stratification in myeloma

  2014cites this paper
• University of Dundee Xenopus Cdc 7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

  2013cites this paper
• Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint

  2013cites this paper
• Molecular and cellular evaluation of novel DNA sequence selective polyamides

  2013cites this paper
• MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells

  2013cites this paper
• MCM 3 AP , a novel acetyltransferase that acetylates replication protein MCM 3

  2013cites this paper
• Classic "broken cell" techniques and newer live cell methods for cell cycle assessment.

  2013cites this paper
• ATR–Chk1–APC/CCdh1-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

  2013cites this paper
• UCSD MOLECULE PAGES Cdc7l1

  2013cites this paper
• Novel pyrrolopyridinone derivatives as anticancer inhibitors towards Cdc7: QSAR studies based on dockings by solvation score approach.

  2013cites this paper
• Transcription Factor Binding Profiles Reveal Cyclic Expression of Human Protein-coding Genes and Non-coding RNAs

  2013cites this paper
• Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.

  2013cites this paper
• The optimization of aminooxadiazoles as orally active inhibitors of Cdc7.

  2013cites this paper
• Regulating DNA replication in eukarya.

  2013cites this paper
• Blow phosphatase 1 and is counteracted by checkpoint-regulated protein Cdc 7 executes its essential function early in S phase Xenopus

  2013cites this paper
• Back to the origin: reconsidering replication, transcription, epigenetics, and cell cycle control.

  2012cites this paper
• The role of Cdc7 and cyclin-dependent kinases in DNA replication and S phase

  2012influential citation
• Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication

  2012cites this paper
• Interactions of the Human MCM-BP Protein with MCM Complex Components and Dbf4

  2012cites this paper
• DNA mediated chromatin pull-down: a novel method for the study of chromatin replication

  2012cites this paper
• Mechanism of Cancer Cell Death Induced by Depletion of an Essential Replication Regulator

  2012cites this paper
• Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation

  2011cites this paper
• Identification of prognostic targets in breast cancer using immunohistochemical and in situ hybridisation methodologies

  2011cites this paper
• 3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors.

  2011cites this paper
• Molecular Mechanism of Activation of Human Cdc7 Kinase

  2011cites this paper
• Dbf4 Is Direct Downstream Target of Ataxia Telangiectasia Mutated (ATM) and Ataxia Telangiectasia and Rad3-related (ATR) Protein to Regulate Intra-S-phase Checkpoint*

  2011cites this paper
• A Synthetic Human Kinase Can Control Cell Cycle Progression in Budding Yeast

  2011cites this paper
• Quantitative proteomics reveals a "poised quiescence" cellular state after triggering the DNA replication origin activation checkpoint.

  2010cites this paper
• System biology analysis of cell cycle pathway involved in hepatocellular carcinoma.

  2010influential citation
• Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy

  2010cites this paper
• Drf1-dependent Kinase Interacts with Claspin through a Conserved Protein Motif*

  2010cites this paper
• The role of the Mcm2 subunit in regulating the activities of the Mcm2-7 helicase

  2010cites this paper
• Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

  2010cites this paper
• Cdc7 kinase - a new target for drug development.

  2010cites this paper
• Integrating DNA replication with trans-lesion synthesis via Cdc7

  2010cites this paper
• Molecular Characterization of the Dbf4/Drf1-Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts

  2010cites this paper
• The role of protein kinases in DNA replication in Saccharomyces cerevisiae

  2010cites this paper
• Expression profile reveals novel prognostic biomarkers in hepatocellular carcinoma.

  2010cites this paper
• Damage-Induced Phosphorylation of Sld3 is Important to Block Late Origin Firing

  2010cites this paper
• Transcriptional Co-activator LEDGF Interacts with Cdc7-Activator of S-phase Kinase (ASK) and Stimulates Its Enzymatic Activity*

  2009cites this paper
• Papillomavirus Replication Machinery Induces Genomic Instability in its Host Cell

  2009cites this paper
• First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.

  2009cites this paper
• Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry.

  2009cites this paper