Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver

Whole-body and liver-specific ATF4–knockout mice are used to evaluate the role of ATF4 transcription factor in the unfolded protein response (UPR). ATF4 directs a small subset of UPR gene expression, and deletion of ATF4 in the liver triggers enhanced oxidative stress, disrupts cholesterol metabolism, and enhances cell death.

• Publication year

  2016

• Venue

  Molecular Biology of the Cell

• Publication date

  2016-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1091/mbc.E16-01-0039PMID 26960794PMCID 4850040
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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