A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Developmental Biology

• Publication date

  1996-11-25

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/DBIO.1996.0308PMID 8948598
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.

  1996cited by this paper
• Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.

  1996cited by this paper
• Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

  1996cited by this paper
• Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal.

  1996cited by this paper
• IRAK: A Kinase Associated with the Interleukin-1 Receptor

  1996cited by this paper
• Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.

  1995cited by this paper
• Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

  1995cited by this paper
• Regulation of dorsal in cultured cells by Toll and tube: tube function involves a novel mechanism.

  1995cited by this paper
• The death domain: a module shared by proteins with diverse cellular functions.

  1995cited by this paper
• Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

  1995cited by this paper
• Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.

  1995influential reference
• Phosphorylation of human I kappa B‐alpha on serines 32 and 36 controls I kappa B‐alpha proteolysis and NF‐kappa B activation in response to diverse stimuli.

  1995cited by this paper
• Cactus protein degradation mediates Drosophila dorsal-ventral signaling.

  1995cited by this paper
• Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo.

  1995cited by this paper
• Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

  1995cited by this paper
• The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo.

  1994cited by this paper
• A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo.

  1994cited by this paper
• Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo

  1994cited by this paper
• Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll

  1994cited by this paper
• Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo.

  1993cited by this paper
• Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo.

  1993cited by this paper
• Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.

  1993cited by this paper
• Dif, a dorsal-related gene that mediates an immune response in Drosophila.

  1993cited by this paper
• A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.

  1993cited by this paper
• pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo.

  1993cited by this paper
• Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal

  1993cited by this paper
• Relocalization of Drosophila dorsal protein can be induced by a rise in cytoplasmic calcium concentration and the expression of constitutively active but not wild-type Toll receptors.

  1993cited by this paper
• The origin of pattern and polarity in the Drosophila embryo.

  1992influential reference
• dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo.

  1992cited by this paper
• Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins.

  1992influential reference
• Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A.

  1992cited by this paper
• cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the I kappa B gene family of vertebrates.

  1992cited by this paper
• Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.

  1991cited by this paper
• Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

  1991cited by this paper
• The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal.

  1991influential reference
• Drosophila Toll and IL-1 receptor

  1991cited by this paper
• cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos.

  1991cited by this paper
• Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen.

  1990cited by this paper
• Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function.

  1989cited by this paper
• Synergistic activation and repression of transcription by Drosophila homeobox proteins.

  1989cited by this paper
• A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo.

  1989cited by this paper
• Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations.

  1989cited by this paper
• The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila.

  1989cited by this paper
• Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNA

  1984cited by this paper

• Mechanisms for controlling Dorsal nuclear levels

  2024cites this paper
• Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus in Drosophila blastoderm embryos

  2024cites this paper
• Expression and Function of Toll Pathway Components in the Early Development of the Wasp Nasonia vitripennis

  2022cites this paper
• The role of micro RNAs (miRNAs) in the regulation of Drosophila melanogaster’s innate immunity

  2022cites this paper
• cGMP signaling pathway that modulates NF-κB activation in innate immune responses

  2021cites this paper
• A reaction-diffusion network model predicts a dual role of Cactus/I κ B to regulate Dorsal/ NF κ B nuclear translocation in Drosophila

  2021influential citation
• Genetic determinants of antiviral immunity in dipteran insects - compiling the experimental evidence.

  2021cites this paper
• Light-dependent N-end rule-mediated disruption of protein function in Saccharomyces cerevisiae and Drosophila melanogaster

  2021cites this paper
• Mechanism and implications of morphogen shuttling: Lessons learned from dorsal and Cactus in Drosophila.

  2020cites this paper
• A reaction-diffusion network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila

  2020influential citation
• Formation, interpretation, and regulation of the Drosophila Dorsal/NF-κB gradient.

  2020cites this paper
• Progress in Bioinspired Dry and Wet Gradient Materials from Design Principles to Engineering Applications

  2020cites this paper
• Shuttling of Dorsal by Cactus: mechanism and implications

  2019cites this paper
• A tissue communication network coordinating innate immune response during muscle stress

  2018cites this paper
• Genomic analysis of NF‐&kgr;B signaling pathway reveals its complexity in Crassostrea gigas

  2018cites this paper
• Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo

  2018cites this paper
• A role of tumor susceptibility gene 101 (TSG101) in innate immune response of crayfish Procambarus clarkii

  2017cites this paper
• A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in the Drosophila embryo

  2017cites this paper
• USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

  2017cites this paper
• A Novel function for Cactus/IκB inhibitor to promote Toll signals in the Drosophila embryo

  2016cites this paper
• A facilitated diffusion mechanism establishes the Drosophila Dorsal gradient

  2016cites this paper
• The Drosophila Toll Pathway: A Model of Innate Immune Signalling Activated by Endogenous Ligands

  2016cites this paper
• Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila.

  2016cites this paper
• The Presence of Nuclear Cactus in the Early Drosophila Embryo May Extend the Dynamic Range of the Dorsal Gradient

  2015cites this paper
• Toll-Dorsal Pathway Regulates Immunity as well as Dorso-V entral Patterning in Drosophila

  2015cites this paper
• Genome-wide RNAi screening implicates the E3 ubiquitin ligase Sherpa in mediating innate immune signaling by Toll in Drosophila adults

  2015cites this paper
• The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-κB Signaling*

  2015cites this paper
• Alternative NF-κB Isoforms in the Drosophila Neuromuscular Junction and Brain

  2015cites this paper
• TAK1-Mediated Post-Translational ModificationsModulate Immune Response: A Dissertation

  2015cites this paper
• Signaling Cascades, Gradients, and Gene Networks in Dorsal/Ventral Patterning

  2015cites this paper
• Analysis of the dorsal-ventral gene regulatory network of Nasonia vitripennis

  2014cites this paper
• Components of the dorsal-ventral pathway also contribute to anterior-posterior patterning in honeybee embryos (Apis mellifera)

  2014cites this paper
• Maternal control of the Drosophila dorsal–ventral body axis

  2014cites this paper
• The role of the BMP and Toll pathways in patterning the dorsal-ventral axis of the jewel wasp Nasonia vitripennis

  2014influential citation
• Notch and PKC Are Involved in Formation of the Lateral Region of the Dorso-Ventral Axis in Drosophila Embryos

  2013cites this paper
• Calpain A modulates Toll responses by limited Cactus/IκB proteolysis

  2013cites this paper
• The IRAK Homolog Pelle Is the Functional Counterpart of IκB Kinase in the Drosophila Toll Pathway

  2013cites this paper
• Maternal-effect genes as the recording genes of Turing-Child patterns: sequential compartmentalization in Drosophila.

  2012cites this paper
• The Role of Retromer in Regulating the Apical-Basal Polarity and the Immune Response during Drosophila Development

  2012cites this paper
• Phagocytosis and signaling in the innate immune system

  2012cites this paper
• Formation and interpretation of morphogen gradients: Insights from mathematical modeling

  2012cites this paper
• Toll-7 and Toll-6: central nervous system functions as Drosophila neurotrophin receptors

  2012cites this paper
• NF‐κB: where did it come from and why?

  2012cites this paper
• Control of NF-κB activity by proteolysis.

  2011cites this paper
• NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.

  2011cites this paper
• Identification of mechanisms controlling the transcriptional activity of nuclear factor kappa B (NF-κB) p65/RelA

  2011cites this paper
• Interpretation and scaling of positional information during development

  2011cites this paper
• A View of the IMD Pathway from the RHIM

  2010cites this paper
• Endocytosis is required for Toll signaling and shaping of the Dorsal/NF-κB morphogen gradient during Drosophila embryogenesis

  2010cites this paper
• Endocytic pathway is required for Drosophila Toll innate immune signaling

  2010influential citation
• Studies of the regulation of serine protease activity in the establishment of the dorsal-ventral axis of the Drosophila embryo

  2010cites this paper
• NF-k B in the Immune Response of Drosophila

  2009cites this paper
• NF-kappaB in the immune response of Drosophila.

  2009cites this paper
• Caspase Mediated Cleavage, IAP Binding, Ubiquitination and Kinase Activation : Defining the Molecular Mechanisms Required for Drosophila NF-кB Signaling: A Dissertation

  2009cites this paper
• Investigations of the role of the Pipe sulfotransferase in the establishment of Drosophila embryonic dorsal-ventral polarity

  2008influential citation
• Bug Versus Bug: Humoral Immune Responses in Drosophila melanogaster

  2008cites this paper
• Regulation of the NF-кB Precursor relish by the Drosophila I-кB Kinase Complex: A Dissertation

  2008influential citation
• Positive and negative regulation of the Drosophila immune response.

  2008cites this paper
• IKK ϵ Signaling: Not Just NF- κ B

  2008cites this paper
• NF-κB, IκB, and IRAK Control Glutamate Receptor Density at the Drosophila NMJ

  2007cites this paper
• Regulation of Nkx2.2 gene expression in the vertebrate neural tube; a target of graded Sonic hedgehog signalling.

  2007cites this paper
• COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis

  2007cites this paper
• The role of Drosophila sumo conjugating enzyme lesswright in larval hematopoiesis : effects on cactus, dorsal and dorsal-related immunity factor (DIF).

  2007cites this paper
• Nucleocytoplasmic shuttling mediates the dynamic maintenance of nuclear Dorsal levels during Drosophila embryogenesis

  2007cites this paper
• ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila

  2007influential citation
• Regulation of dorso/ventral patterning in the drosophila embryo by multiple dorsal-interacting proteins

  2007cites this paper
• Fungal Peptide Destruxin A Plays a Specific Role in Suppressing the Innate Immune Response in Drosophila melanogaster*

  2007cites this paper
• Neuromuscular junction in abdominal muscles of Drosophila melanogaster during adulthood and aging

  2007cites this paper
• NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ.

  2007cites this paper
• Role of NF-kappaB/Rel proteins in mediating innate immune responses in Drosophila melanogaster

  2006cites this paper
• Vertebrate rel proteins exhibit dorsal‐like activities in early Drosophila embryogenesis

  2006cites this paper
• Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila

  2006cites this paper
• IKK epsilon signaling: not just NF-kappaB.

  2006cites this paper
• Nuclear factor-kappa B pathways in Drosophila

  2006cites this paper
• IKKϵ Signaling: Not Just NF-κB

  2006cites this paper
• Dorsoventral axis formation in the Drosophila embryo--shaping and transducing a morphogen gradient.

  2005cites this paper
• The lesswright mutation activates Rel-related proteins, leading to overproduction of larval hemocytes in Drosophila melanogaster.

  2005cites this paper
• Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo

  2005cites this paper
• The inhibitorκB-ortholog Cactus is necessary for normal neuromuscular function in Drosophila melanogaster

  2005cites this paper
• Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning

  2004cites this paper
• The maternal JAK/STAT pathway of Drosophila regulates embryonic dorsal-ventral patterning.

  2004cites this paper
• Directed expression of the HIV‐1 accessory protein Vpu in Drosophila fat‐body cells inhibits Toll‐dependent immune responses

  2003cites this paper
• The IкB Kinase (IKK) Complex

  2003cites this paper
• At the crossroads of SUMO and NF-κB

  2003cites this paper
• Synaptic activity modifies the levels of Dorsal and Cactus at the neuromuscular junction of Drosophila.

  2003cites this paper
• Dorsal/Cactus Complex

  2002cites this paper
• Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo

  2002cites this paper
• A conserved F-box gene with unusual transcript localization

  2002cites this paper
• fusilli, an essential gene with a maternal role in Drosophila embryonic dorsal-ventral patterning.

  2001cites this paper
• Spätzle regulates the shape of the Dorsal gradient in the Drosophila embryo.

  2001cites this paper
• Activation of Nuclear Factor-κB

  2001cites this paper
• NF-(cid:1) B signaling pathways in mammalian and insect innate immunity

  2001cites this paper
• Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation.

  2001influential citation
• Conservation and divergence in molecular mechanisms of axis formation.

  2001cites this paper
• Ubiquitin-mediated proteolysis and Drosophila embryogenesis

  2000cites this paper
• Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.

  2000cites this paper
• Proteolysis and developmental signal transduction.

  2000cites this paper
• Lipopolysaccharide-activated Kinase, an Essential Component for the Induction of the Antimicrobial Peptide Genes inDrosophila melanogaster Cells*

  2000cites this paper
• Toll signaling: the enigma variations.

  2000cites this paper
• CBP/p300 in cell growth, transformation, and development.

  2000cites this paper