Antimitotic natural products and their interactions with tubulin

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Medicinal research reviews (Print)

• Publication date

  1996-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/(SICI)1098-1128(199603)16:2<207::AID-MED4>3.0.CO;2-4PMID 8656780
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.

  1995cited by this paper
• Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues.

  1995cited by this paper
• Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra.

  1995cited by this paper
• Substoichiometric binding of taxol suppresses microtubule dynamics.

  1995cited by this paper
• Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.

  1995cited by this paper
• Interaction of ustiloxin A with bovine brain tubulin.

  1994cited by this paper
• Rhazinilam mimics the cellular effects of taxol by different mechanisms of action.

  1994cited by this paper
• Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides.

  1994cited by this paper
• Effects of the tubulin-colchicine complex on microtubule dynamic instability.

  1994cited by this paper
• Interaction of marine toxin dolastatin 10 with porcine brain tubulin: competitive inhibition of rhizoxin and phomopsin A binding.

  1994cited by this paper
• Phase II trial of docetaxel in patients with stage III and IV non-small-cell lung cancer.

  1994cited by this paper
• 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

  1994cited by this paper
• Ustiloxins, antimitotic cyclic peptides from false smut balls on rice panicles caused by Ustilaginoidea virens.

  1994cited by this paper
• Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri.

  1994cited by this paper
• Cryptophycin: a new antimicrotubule agent active against drug-resistant cells.

  1994cited by this paper
• 3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin.

  1994cited by this paper
• Predominant labeling of beta- over alpha-tubulin from porcine brain by a photoactivatable taxoid derivative.

  1994cited by this paper
• Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine.

  1993cited by this paper
• Immunosuppression by Discodermolide

  1993cited by this paper
• Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.

  1993cited by this paper
• Localization of the colchicine-binding site of tubulin.

  1993cited by this paper
• Removal of beta III isotype enhances taxol induced microtubule assembly.

  1993cited by this paper
• Paclitaxel for platinum-refractory ovarian cancer: results from the first 1,000 patients registered to National Cancer Institute Treatment Referral Center 9103.

  1993cited by this paper
• Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

  1993cited by this paper
• Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.

  1993cited by this paper
• Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin.

  1993cited by this paper
• Exchangeable GTP binding site of beta-tubulin. Identification of cysteine 12 as the major site of cross-linking by direct photoaffinity labeling.

  1993cited by this paper
• Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin.

  1993cited by this paper
• Identification of the fragment photoaffinity-labeled with azidodansyl-rhizoxin as Met-363-Lys-379 on beta-tubulin.

  1993cited by this paper
• Taxol: the first of the taxanes, an important new class of antitumor agents.

  1992cited by this paper
• Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site.

  1992cited by this paper
• Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis.

  1992cited by this paper
• Interaction of dolastatin 10 with bovine brain tubulin.

  1992cited by this paper
• Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

  1992cited by this paper
• Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B.

  1992cited by this paper
• Chloroacetates of 2- and 3-demethylthiocolchicine: specific covalent interactions with tubulin with preferential labeling of the beta-subunit.

  1992cited by this paper
• Phase I and pharmacokinetic study of rhizoxin.

  1992cited by this paper
• Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules.

  1991cited by this paper
• Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents.

  1991cited by this paper
• Interactions of colchicine with tubulin.

  1991cited by this paper
• Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp.

  1991cited by this paper
• Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

  1991cited by this paper
• Distinct colchicine binding kinetics of bovine brain tubulin lacking the type III isotype of beta-tubulin.

  1991cited by this paper
• Physical and spectroscopic methods for the evaluation of the interactions of antimitotic agents with tubulin.

  1991cited by this paper
• Interaction of rhizoxin with bovine brain tubulin.

  1990cited by this paper
• Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.

  1990cited by this paper
• Effect of phomopsin A on the alkylation of tubulin.

  1990cited by this paper
• Molecular basis for determining the sensitivity of eucaryotes to the antimitotic drug rhizoxin

  1990cited by this paper
• Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

  1990cited by this paper
• Rhizoxin resistant mutants with an altered beta-tubulin gene in Aspergillus nidulans.

  1989cited by this paper
• The interaction of phomopsin A with bovine brain tubulin.

  1989cited by this paper
• Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

  1989cited by this paper
• Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.

  1989cited by this paper
• Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

  1989cited by this paper
• The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells.

  1989cited by this paper
• Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

  1988cited by this paper
• Absence of 7‐acetyl taxol binding to unassembled brain tubulin

  1988cited by this paper
• The importance of the phenyl‐tropolone ‘aS’ configuration in colchicine's binding to tubulin

  1988cited by this paper
• Photoaffinity labeling of tubulin subunits with a photoactive analogue of vinblastine.

  1987cited by this paper
• Rhizoxin binding to tubulin at the maytansine-binding site.

  1987cited by this paper
• Interaction of vinblastine with calf brain tubulin: multiple equilibria.

  1986cited by this paper
• Interaction of vinblastine with calf brain tubulin: effects of magnesium ions.

  1986cited by this paper
• Identification of a distinct class of vinblastine binding sites on microtubules.

  1986cited by this paper
• Maytansine-resistant mutants of Chinese hamster ovary cells with an alteration in alpha-tubulin.

  1985cited by this paper
• Effects of Tau and MAP2 on the interaction of maytansine with tubulin: inhibitory effect of maytansine on vinblastine-induced aggregation of tubulin.

  1985cited by this paper
• Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis.

  1985cited by this paper
• Maytansine inhibits nucleotide binding at the exchangeable site of tubulin.

  1985cited by this paper
• Studies on macrocyclic lactone antibiotics. VII. Structure of a phytotoxin "rhizoxin" produced by Rhizopus chinensis.

  1984cited by this paper
• Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules.

  1984cited by this paper
• Taxol: an antimitotic agent with a new mechanism of action.

  1984cited by this paper
• Tubulin bound to colchicine forms polymers different from microtubules.

  1982cited by this paper
• Polymerization of the tubulin-colchicine complex and guanosine 5'-triphosphate hydrolysis.

  1982cited by this paper
• Concentrations of 2-methoxyoestrogens in human serum measured by a heterologous immunoassay with an 125I-labelled ligand.

  1982cited by this paper
• Taxol-induced polymerization of purified tubulin. Mechanism of action.

  1981cited by this paper
• GTPase activity of the tubulin-colchicine in relation with tubulin-tubulin interactions.

  1981cited by this paper
• Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores.

  1981cited by this paper
• Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins.

  1981cited by this paper
• A fluorescence stopped flow study of colchicine binding to tubulin.

  1981cited by this paper
• Taxol induces microtubule assembly at low temperature.

  1981cited by this paper
• Interactions of taxol, microtubule-associated proteins, and guanine nucleotides in tubulin polymerization.

  1981cited by this paper
• Taxol binds to polymerized tubulin in vitro

  1981cited by this paper
• The co-polymerization of tubulin and tubulin chochicine complex in the absence and presence of associated proteins.

  1980cited by this paper
• Taxol stabilizes microtubules in mouse fibroblast cells.

  1980cited by this paper
• Polymerization of tubulin in the presence of colchicine or podophyllotoxin. Formation of a ribbon structure induced by guanylyl-5'-methylene diphosphonate.

  1979cited by this paper
• Promotion of microtubule assembly in vitro by taxol

  1979cited by this paper
• Cytologic evidence that taxol, an antineoplastic agent from Taxus brevifolia, acts as a mitotic spindle poison.

  1978cited by this paper
• Steganacin: an inhibitor of HeLa cell growth and microtubule assembly in vitro.

  1978cited by this paper
• Kinetics and mechanism of colchicine binding to tubulin: evidence for ligand-induced conformational change.

  1978cited by this paper
• Maytansine binding to the vinblastine sites of tubulin

  1977cited by this paper
• Binding of maytansine to rat brain tubulin.

  1976cited by this paper
• Steganacin and steganangin, novel antileukemic lignan lactones from Steganotaenia araliacea.

  1973cited by this paper
• Definition of three classes of binding sites in isolated microtubule crystals.

  1972cited by this paper
• Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus.

  1972cited by this paper
• Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.

  1971cited by this paper
• The colchicine-binding protein of mammalian brain and its relation to microtubules.

  1968cited by this paper
• The binding of colchicine by sarcoma 180 cells.

  1968cited by this paper

• Anti-Bacterial evaluation of 1,3-Benzodioxole derived imidazolium and pyridinium based ionic liquids

  2025cites this paper
• Linearly ring-fused coumarins: A review of their cancer-fighting attributes

  2024cites this paper
• Dioxolocoumarins: Bridging chemistry and pharmacology with multifunctional therapeutics

  2024cites this paper
• Design and Synthesis of Substituted Anilino 6-(3,4,5-Trimethoxyphenyl)Pteridine Derivatives and Invitro Evaluation as Potential Cytotoxic Agents

  2023cites this paper
• Extraction, Isolation, Characterization, and Bioactivity of Polypropionates and Related Polyketide Metabolites from the Caribbean Region

  2023cites this paper
• Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems of Larotaxel for Oral Administration

  2023cites this paper
• In Vitro and In Silico Biological Studies of 4-Phenyl-2-quinolone (4-PQ) Derivatives as Anticancer Agents

  2023influential citation
• Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties

  2022cites this paper
• In silico designed microtubule-stabilizer drugs against tauopathy in Alzheimer’s disease

  2022cites this paper
• Microtubules Destabilizing Agents Binding Sites in Tubulin

  2022cites this paper
• Assessment of Cardiotoxicity after a Single Dose of Combretastatin A4-Phosphate in Dogs Using Two-Dimensional Speckle-Tracking Echocardiography

  2022cites this paper
• Synthesis of dibenzocyclohepta[1,2-a]naphthalene derivatives from phenylacetaldehyde and alkynyl benzyl alcohols via sequential electrophilic addition and double Friedel-Crafts reactions.

  2021cites this paper
• Exploration of Benzimidazoles as Potential Microtubule Modulators: An Insight in the Synthetic and Therapeutic Evolution

  2021cites this paper
• Unbiased Phenotype-Based Screen Identifies Therapeutic Agents Selective for Metastatic Prostate Cancer

  2021cites this paper
• Therapeutic progression of quinazolines as targeted chemotherapeutic agents.

  2020cites this paper
• Exploring Diverse-Ring Analogues on Combretastatin A4 (CA-4) Olefin as Microtubule-Targeting Agents

  2020cites this paper
• Design, synthesis, and evaluation of novel combretastatin A‐4 based chalcone derivatives as anticancer agents

  2020cites this paper
• Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review

  2020cites this paper
• Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.

  2020cites this paper
• Cytotoxicity Evaluation of Dimethoxy and Trimethoxy Indanonic Spiroisoxazolines Against Cancerous Liver Cells

  2020cites this paper
• Synthesis and biological evaluation of oxazinonaphthalene-3-one derivatives as potential anticancer agents and tubulin inhibitors

  2020cites this paper
• GSH-responsive anti-mitotic cell penetrating peptide-linked podophyllotoxin conjugate for improving water solubility and targeted synergistic drug delivery.

  2019cites this paper
• Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases.

  2019cites this paper
• Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy

  2019cites this paper
• Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.

  2019cites this paper
• Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain.

  2019cites this paper
• An overview on the synthetic and medicinal perspectives of indenopyrazoles.

  2019cites this paper
• Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways

  2018cites this paper
• Lignans: A Chemometric Analysis

  2018cites this paper
• Effect of extraction Alkaloids from Zephyranthes candida induces cell death through destruction microtubules in (China hamster cell line)

  2018cites this paper
• Preclinical evaluation and molecular docking of 1,3-benzodioxole propargyl ether derivatives as novel inhibitor for combating the histone deacetylase enzyme in cancer

  2018cites this paper
• Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors.

  2018cites this paper
• Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound.

  2018cites this paper
• Dicitrinone D, an antimitotic polyketide isolated from the marine-derived fungus Penicillium citrinum

  2017cites this paper
• Total Synthesis of (±)-Allocolchicine and Its Analogues Using Co-Catalyzed Alkyne [2 + 2 + 2]-Cyclotrimerization

  2017cites this paper
• Synthesis, biological evaluation and molecular modeling of imidazo[1,2-a]pyridine derivatives as potent antitubulin agents.

  2017cites this paper
• Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site

  2017cites this paper
• Design, synthesis and anti-cancer evaluation of novel podophyllotoxin derivatives as potent tubulin-targeting agents

  2017cites this paper
• Constructing novel dihydrofuran and dihydroisoxazole analogues of isocombretastatin-4 as tubulin polymerization inhibitors through [3+2] reactions.

  2017cites this paper
• Combretastatin A4‐phosphate and its potential in veterinary oncology: a review

  2017cites this paper
• The Rhazinilam-Leuconoxine-Mersicarpine Triad of Monoterpenoid Indole Alkaloids.

  2017cites this paper
• Total Synthesis of (.+-.)-Dihydroisosubamol

  2017cites this paper
• Synergistic Anticancer Effect of Peptide‐Docetaxel Nanoassembly Targeted to Tubulin: Toward Development of Dual Warhead Containing Nanomedicine

  2017cites this paper
• Identification of novel 1‐indolyl acetate‐5‐nitroimidazole derivatives of combretastatin A‐4 as potential tubulin polymerization inhibitors

  2017cites this paper
• α-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain.

  2016cites this paper
• Synthesis of colchifulvin, a colchicine–griseofulvin hybrid

  2016cites this paper
• Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents.

  2016cites this paper
• Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs.

  2016cites this paper
• Computer-Aided Drug Discovery Approaches against the Tropical Infectious Diseases Malaria, Tuberculosis, Trypanosomiasis, and Leishmaniasis.

  2016cites this paper
• Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety.

  2016cites this paper
• Investigation of N-Arylsulfonylimidazole as Novel Scaffold for Anticancer Agents

  2016cites this paper
• A Computational Analysis of Indomethacin Derivative as Tubulin Inhibitor: Insights into Development of Chemotherapeutic Agents.

  2016cites this paper
• Synthesis of analogues of natural antimitotic glaziovianin A based on dill and parsley seed essential oils

  2016cites this paper
• Novel tubulin-targeted cell penetrating antimitotic octapeptide.

  2016cites this paper
• α-Cyclodextrin Interacts Close to Vinblastine Site of Tubulin and Delivers Curcumin Preferentially to the Tubulin Surface of Cancer Cell.

  2016cites this paper
• Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity.

  2016cites this paper
• Anticancer activity of gallic acid template‐based benzylidene indanone derivative as microtubule destabilizer

  2016cites this paper
• Chapter 9 – Anticancer Drugs Targeting Tubulin and Microtubules

  2015cites this paper
• Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents

  2015cites this paper
• Synthesis and Fluorescence Properties of new Monastrol Analogs Conjugated Fluorescent Coumarin Scaffolds

  2015cites this paper
• Synthesis, biological evaluation and 3D-QSAR studies of novel 5-phenyl-1H-pyrazol cinnamamide derivatives as novel antitubulin agents.

  2015cites this paper
• Biological Properties of Lignans

  2015cites this paper
• Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer.

  2015cites this paper
• Polyalkoxyflavonoids as inhibitors of cell division

  2015cites this paper
• In-silico Investigation of Tubulin Binding Modes of a Series of Novel Antiproliferative Spiroisoxazoline Compounds Using Docking Studies

  2015cites this paper
• Synthesis and antimitotic activity of alkoxy-substituted 1-aryl-3-(arylamino)alkenones

  2015cites this paper
• Natural antitubulin agents: importance of 3,4,5-trimethoxyphenyl fragment.

  2015cites this paper
• Selected hybrid natural products as tubulin modulators.

  2015cites this paper
• Imidazoles and benzimidazoles as tubulin-modulators for anti-cancer therapy.

  2015cites this paper
• Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.

  2015cites this paper
• Synthesis of 2-anilinopyridine–arylpropenone conjugates as tubulin inhibitors and apoptotic inducers

  2015cites this paper
• Small molecule modulators of protein-protein interactions: selected case studies.

  2014cites this paper
• Synthesis, biological evaluation, and molecular docking studies of novel chalcone oxime derivatives as potential tubulin polymerization inhibitors

  2014cites this paper
• Podoverine A--a novel microtubule destabilizing natural product from the Podophyllum species.

  2014cites this paper
• Lipid fractions from Scutellaria ramosissima tested on the microtubular array of cancer cell models

  2014cites this paper
• QSAR and 3D-QSAR models in the field of tubulin inhibitors as anticancer agents.

  2014cites this paper
• Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors.

  2014cites this paper
• Synthesis and biological evaluation of 6H-pyrido[2',1':2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization.

  2014cites this paper
• Highly efficient gold-catalyzed synthesis of dibenzocycloheptatrienes.

  2014cites this paper
• Synthesis, Cytotoxicity, Docking Study, and Tubulin Polymerization Inhibitory Activity of Novel 1‐(3,4‐Dimethoxyphenyl)‐5‐(3,4,5‐trimethoxyphenyl)‐1H‐1,2,4‐triazole‐3‐carboxanilides

  2014cites this paper
• Thymoquinone inhibits microtubule polymerization by tubulin binding and causes mitotic arrest following apoptosis in A549 cells.

  2014cites this paper
• From bacteria to antineoplastic: epothilones a successful history.

  2013cites this paper
• Molecular Classification of 5-Amino-2-Aroylquinolines and 4-Aroyl-6, 7, 8-Trimethoxyquinolines as Highly Potent Tubulin Polymerization Inhibitors

  2013influential citation
• The novel equisetin-like compound, TA-289, causes aberrant mitochondrial morphology which is independent of the production of reactive oxygen species in Saccharomyces cerevisiae.

  2013cites this paper
• Total Synthesis of the Unusual Peptide Celogentin C

  2013cites this paper
• 1,3,5-Triazine as a modular scaffold for covalent inhibitors with streamlined target identification.

  2013cites this paper
• Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

  2013cites this paper
• Design, synthesis and biological studies of novel tubulin inhibitors.

  2013cites this paper
• Furanylazaindoles: potent anticancer agents in vitro and in vivo.

  2013cites this paper
• Polyalkoxy substituted 4H-chromenes: synthesis by domino reaction and anticancer activity.

  2012cites this paper
• An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

  2012cites this paper
• Marine Natural Products That Target Microtubules

  2012cites this paper
• Identification of Leads from Marine Seaweeds against Human β-tubulin

  2012cites this paper
• Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents.

  2012cites this paper
• A novel Cu(II)–mal–picoline complex induces mitotic catastrophe mediated by deacetylation of histones and α-tubulin leading to apoptosis in human cell lines

  2012cites this paper
• Part I Nucleic Acid Site-Selective Binding Studies of Isomers of Dihydrodioxin-Masked Ortho-Quinones as Potential Antitumor Drugs Part II The Role of Non-Watson-Crick Base Pairs in Stabilizing Recurrent RNA Motif

  2012cites this paper
• (Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.

  2012cites this paper
• Natural taxanes: developments since 1828.

  2011cites this paper
• Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents.

  2011cites this paper
• Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

  2011cites this paper