Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  American Journal of Physiology. Regulatory Integrative and Comparative Physiology

• Publication date

  2007-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPREGU.00059.2007PMID 17761517PMCID PMC2413069
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diabetes

  2009cited by this paper
• Abnormal diastolic currents in ventricular myocytes from spontaneous hypertensive heart failure rats.

  2006influential reference
• Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function.

  2006cited by this paper
• Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

  2006cited by this paper
• Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice.

  2006influential reference
• Trends in prevalence and outcome of heart failure with preserved ejection fraction.

  2006cited by this paper
• Mechanisms of [ Ca 2 ] i Transient Decrease in Cardiomyopathy of db / db Type 2 Diabetic Mice

  2006cited by this paper
• Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer.

  2006cited by this paper
• Diastolic heart failure can be diagnosed by comprehensive two-dimensional and Doppler echocardiography.

  2006cited by this paper
• Outcome of heart failure with preserved ejection fraction in a population-based study.

  2006cited by this paper
• Abnormal intrastore calcium signaling in chronic heart failure.

  2005influential reference
• Effects of diabetes on ryanodine receptor Ca release channel (RyR2) and Ca2+ homeostasis in rat heart.

  2005cited by this paper
• Paradoxical Cellular Ca2+ Signaling in Severe but Compensated Canine Left Ventricular Hypertrophy

  2005cited by this paper
• Tissue Doppler Imaging Identifies Asymptomatic Normotensive Diabetics with Diastolic Dysfunction and Reduced Exercise Tolerance

  2005cited by this paper
• Tei index as a method of evaluating left ventricular diastolic dysfunction in acute myocardial infarction.

  2005cited by this paper
• Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fraction.

  2005cited by this paper
• Paradoxical Cellular Ca 2 (cid:1) Signaling in Severe but Compensated Canine Left Ventricular Hypertrophy

  2005cited by this paper
• New insights into diastolic heart failure: role of diabetes mellitus.

  2004influential reference
• What Mechanisms Underlie Diastolic Dysfunction in Heart Failure?

  2004influential reference
• Diabetes decreases mRNA levels of calcium-release channels in human atrial appendage.

  2004cited by this paper
• Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart.

  2004cited by this paper
• Textbook of Clinical Echocardiography

  2004influential reference
• Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications.

  2004cited by this paper
• Return of calcium: manipulating intracellular calcium to prevent cardiac pathologies.

  2004cited by this paper
• Diabetes decreases mRNA levels of calcium-release channels in human atrial appendage

  2004cited by this paper
• Altered cardiac calcium handling in diabetes

  2004cited by this paper
• Attenuation of I(K,slow1) and I(K,slow2) in Kv1/Kv2DN mice prolongs APD and QT intervals but does not suppress spontaneous or inducible arrhythmias.

  2004cited by this paper
• Chronic diabetes alters function and expression of ryanodine receptor calcium-release channels in rat hearts

  2003cited by this paper
• Biochemical, histological and echocardiographic changes during experimental cardiomyopathy in STZ-induced diabetic rats.

  2003influential reference
• Dynamic Regulation of Sodium/Calcium Exchange Function in Human Heart Failure

  2003cited by this paper
• Correlation of the Tei index with invasive measurements of ventricular function in a porcine model.

  2003cited by this paper
• Diabetes and the Accompanying Hyperglycemia Impairs Cardiomyocyte Calcium Cycling through Increased Nuclear O-GlcNAcylation*

  2003cited by this paper
• Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.

  2002influential reference
• Left Ventricular Diastolic Dysfunction as an Early Manifestation of Diabetic Cardiomyopathy

  2002influential reference
• Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db-hGLUT4 mice.

  2002cited by this paper
• Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats.

  2002cited by this paper
• Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats.

  2002cited by this paper
• Defective intracellular Ca2+ signaling contributes to cardiomyopathy in Type 1 diabetic rats

  2002influential reference
• Targeted Replacement of Kv1.5 in the Mouse Leads to Loss of the 4-Aminopyridine-Sensitive Component of IK,slow and Resistance to Drug-Induced QT Prolongation

  2001cited by this paper
• Altered SR protein expression associated with contractile dysfunction in diabetic rat hearts.

  2001cited by this paper
• Echocardiographic characterization of fundamental mechanisms of abnormal diastolic filling in diabetic rats with a parameterized diastolic filling formalism.

  2001influential reference
• Prevalence of diastolic dysfunction in normotensive, asymptomatic patients with well-controlled type 2 diabetes mellitus.

  2001cited by this paper
• Diabetes related cardiomyopathy time dependent echocardiographic evaluation in an experimental rat model.

  2001cited by this paper
• Alteration in Left Ventricular Diastolic Filling and Accumulation of Myocardial Collagen at Insulin-Resistant Prediabetic Stage of a Type II Diabetic Rat Model

  2000cited by this paper
• Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model.

  2000cited by this paper
• The Effects of Streptozotocin‐induced Diabetes and Aldose Reductase Inhibition with Sorbinil, on Left and Right Atrial Function in the Rat

  2000cited by this paper
• Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway.

  1999cited by this paper
• Low insulin and high glucose induce abnormal relaxation in cultured adult rat ventricular myocytes.

  1997cited by this paper
• Altered Ca2+ handling in ventricular myocytes isolated from diabetic rats.

  1996cited by this paper
• Metabolic basis of decreased transient outward K+ current in ventricular myocytes from diabetic rats.

  1996cited by this paper
• Mitochondrial dysfunction accompanies diastolic dysfunction in diabetic rat heart.

  1996cited by this paper
• Transthoracic Doppler assessment of pattern of left ventricular dysfunction in hypertensive heart disease: combined analysis of mitral and pulmonary venous flow velocity patterns.

  1994influential reference
• Calcium and potassium currents in ventricular myocytes isolated from diabetic rats.

  1993cited by this paper
• Analysis of pulmonary venous flow velocity patterns in hypertensive hearts: its complementary value in the interpretation of mitral flow velocity patterns.

  1992cited by this paper
• Altered Acetylcholine and Norepinephrine Concentrations in Diabetic Rat Hearts: Role of Parasympathetic Nervous System in Diabetic Cardiomyopathy

  1989cited by this paper
• Enhanced adrenergic sensitivity of the diabetic neonatal heart.

  1985cited by this paper

• Enhanced negative modulation of urotensin II on cardiac function and [Ca2+]i regulation in a diabetic rat model: Insights into molecular and cellular mechanisms.

  2025cites this paper
• SERCA2a dysfunction in the pathophysiology of heart failure with preserved ejection fraction: a direct role is yet to be established

  2025cites this paper
• Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation.

  2025cites this paper
• From Cells to Systems: A Comprehensive Perspective on In-Vitro, In-Vivo, and 3D Culture Models of Heart Failure.

  2025cites this paper
• Guidelines for Diet-Induced Models of Cardiometabolic Syndrome.

  2025cites this paper
• Cardiac digital twins: a tool to investigate the function and treatment of the diabetic heart

  2025cites this paper
• Effects of Ellagic Acid on Myocardial Contractility in Isolated and Perfused Rat Hearts

  2025cites this paper
• ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism.

  2025cites this paper
• Calcium Signaling and Cardiac Adaptation to Stress: Focus on Pregnancy and Diabetes

  2025cites this paper
• LncRNA HCG18 affects diabetic cardiomyopathy and its association with miR-9-5p/IGF2R axis

  2024cites this paper
• Unlocking the potential: Baicalin's apoptosis-reducing power and activation of NRF2/P62 for alleviating diabetic cardiomyopathy in rats

  2024influential citation
• Emerging Therapy for Diabetic Cardiomyopathy: From Molecular Mechanism to Clinical Practice

  2023cites this paper
• Effect of Chronic Moderate Intensity Exercise on Ischemia - Reperfusion Injury in Diabetic Cardiomyopathy

  2023cites this paper
• Ketogenic Diet Regulates Cardiac Remodeling and Calcium Homeostasis in Diabetic Rat Cardiomyopathy

  2023cites this paper
• Advanced glycation end products modulate electrophysiological remodeling of right ventricular outflow tract cardiomyocytes: A novel target for diabetes‐related ventricular arrhythmogenesis

  2022cites this paper
• Muscarinic receptor regulation of chronic pain-induced atrial fibrillation

  2022cites this paper
• Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy

  2022cites this paper
• Ca2+ mishandling and mitochondrial dysfunction: a converging road to prediabetic and diabetic cardiomyopathy

  2022cites this paper
• Metabolic, structural and biochemical changes in diabetes and the development of heart failure

  2022cites this paper
• Regulation of Prepro-NeuropeptideW/B and Its Receptor in the Heart of ZDF Rats: An Animal Model of Type II DM

  2022cites this paper
• Glycemic Control and the Heart: The Tale of Diabetic Cardiomyopathy Continues

  2022cites this paper
• STZ‐diabetic rat heart maintains developed tension amplitude by increasing sarcomere length and crossbridge density

  2021cites this paper
• Diabetes-induced changes in cardiac voltage-gated ion channels

  2021cites this paper
• Application of Animal Models in Diabetic Cardiomyopathy

  2021cites this paper
• SIGNS OF DIASTOLIC DYSFUNCTION ARE GRADED BY SERUM TESTOSTERONE LEVELS IN AGING C57BL/6 MALE MICE.

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Increased myofilament calcium sensitivity is associated with decreased cardiac troponin I phosphorylation in the diabetic rat heart

  2021cites this paper
• Heart failure in diabetes.

  2021cites this paper
• Effects of prolactin on ventricular myocyte shortening and calcium transport in the streptozotocin-induced diabetic rat

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Calcium Homeostasis in Ventricular Myocytes of Diabetic Cardiomyopathy.

  2020cites this paper
• Calcium Homeostasis in Ventricular Myocytes of Diabetic Cardiomyopathy

  2020cites this paper
• Calcium signaling in endocardial and epicardial ventricular myocytes from streptozotocin‐induced diabetic rats

  2020cites this paper
• Protective effects of medicinal plant against diabetes induced cardiac disorder: A review.

  2020cites this paper
• Insulin Treatment Reduces Susceptibility to Atrial Fibrillation in Type 1 Diabetic Mice

  2020cites this paper
• Afterdepolarizations and abnormal calcium handling in atrial myocytes with modulated SERCA uptake: a sensitivity analysis of calcium handling channels

  2020cites this paper
• Basic Mechanisms of Diabetic Heart Disease.

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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• Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date

  2019cites this paper
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• ROCK2 promotes ryanodine receptor phosphorylation and arrhythmic calcium release in diabetic cardiomyocytes.

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• Aortic stenosis and diabetes mellitus: An ominous combination

  2019cites this paper
• Established and Emerging Mechanisms of Diabetic Cardiomyopathy

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