Bicarbonate increases tumor pH and inhibits spontaneous metastases.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Cancer Research

• Publication date

  2009-03-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1158/0008-5472.CAN-07-5575PMID 19276390PMCID PMC2834485
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion.

  2009influential reference
• A microenvironmental model of carcinogenesis

  2008cited by this paper
• Causes and Consequences of Increased Glucose Metabolism of Cancers

  2008cited by this paper
• Molecular definition of breast tumor heterogeneity.

  2007cited by this paper
• Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?

  2007cited by this paper
• Regulation of tumor pH and the role of carbonic anhydrase 9

  2007cited by this paper
• Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.

  2007cited by this paper
• Cysteine cathepsins: multifunctional enzymes in cancer

  2006cited by this paper
• Acid-mediated tumor invasion: a multidisciplinary study.

  2006influential reference
• CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

  2006cited by this paper
• Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.

  2006cited by this paper
• Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis

  2005cited by this paper
• Otto Schmitt and the Archaeus Project: adventures in the anomalous

  2004cited by this paper
• Cancer metabolism: facts, fantasy, and fiction.

  2004cited by this paper
• pH imaging. A review of pH measurement methods and applications in cancers.

  2004cited by this paper
• CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion*

  2004cited by this paper
• Thermostability of firefly luciferases affects efficiency of detection by in vivo bioluminescence.

  2004cited by this paper
• Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion

  2004cited by this paper
• Extracellular acidification alters lysosomal trafficking in human breast cancer cells.

  2003cited by this paper
• Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited.

  2002cited by this paper
• MRI of the tumor microenvironment

  2002cited by this paper
• Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

  2001cited by this paper
• Mathematical models of tumour invasion mediated by transformation-induced alteration of microenvironmental pH.

  2001cited by this paper
• High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice.

  2001cited by this paper
• Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells

  2001cited by this paper
• pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.

  2001cited by this paper
• High-Dose Dexamethasone Accentuates Nuclear Factor- κ B Activation in Endotoxin-Treated Mice

  2001cited by this paper
• Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells.

  2000cited by this paper
• Acidic environment causes apoptosis by increasing caspase activity

  1999cited by this paper
• pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs.

  1999cited by this paper
• An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis

  1999cited by this paper
• Exocytosis of active cathepsin B enzyme activity at pH 7.0, inhibition and molecular mass.

  1999cited by this paper
• Association of hyaluronidase and breast adenocarcinoma invasiveness.

  1999cited by this paper
• Acidic pH enhances the invasive behavior of human melanoma cells

  1996cited by this paper
• How cancer spreads.

  1996cited by this paper
• Pericellular pH affects distribution and secretion of cathepsin B in malignant cells.

  1994cited by this paper
• 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate.

  1994cited by this paper
• Biological and clinical significance of cathepsin D in breast cancer.

  1992cited by this paper
• Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro

  1991cited by this paper
• Are cancer cells acidic?

  1991cited by this paper
• Cancer metastasis.

  1991cited by this paper
• Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells.

  1991cited by this paper
• Cathepsin D in breast cancer

  1990cited by this paper
• Biological and clinical significance of cathepsin D in breast cancer.

  1990cited by this paper
• Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

  1989cited by this paper
• The relevance of tumour pH to the treatment of malignant disease.

  1984cited by this paper
• The Transformed cell

  1981cited by this paper
• Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis

  1979cited by this paper
• Control of proliferation in animal cells

  1974cited by this paper
• Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

  1966cited by this paper
• ©1999 Cancer Research Campaign Article no. bjoc.1998.0455 Enhancement of chemotherapy by manipulation of tumour pH

  year unknowninfluential reference

• X-Ray Visible Gelatin/NaHCO3/BaSO4 Ternary Composite Microspheres for Improved Drug Uptake in Simulated Transcatheter Arterial Embolization.

  2026cites this paper
• Tumor Responsive Nanoplatforms for TME Modulation: From Extracellular Matrix to Intracellular Organelles

  2026cites this paper
• Enzymatic and microenvironmental regulation in adenosine metabolism-mediated immunosuppression

  2026cites this paper
• pH-neutralization strategy to suppress GPCR68 spatiotemporally activates T cells and enhances anti-tumor immunity.

  2026cites this paper
• Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification

  2025cites this paper
• Tumor Microenvironment in Glioblastoma: The Central Role of the Hypoxic-Necrotic Core.

  2025cites this paper
• Bicarbonate-integrated transarterial chemoembolization (TACE) in real-world hepatocellular carcinoma

  2025cites this paper
• A strategy for challenging tumorous bone regeneration by borosilicate bioactive glass boosting moderate magnetic hyperthermia

  2025cites this paper
• Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore.

  2025cites this paper
• The role of lactylation in breast cancer development: mechanisms, clinical translation and new strategies for treatment

  2025cites this paper
• Chemical modulation of the tumor microenvironment enabled by nanomaterials for enhanced cancer treatment

  2025cites this paper
• Microengineered Breast Cancer Models: Shaping the Future of Personalized Oncology

  2025cites this paper
• Acidic Microenvironment Enhances Cisplatin Resistance in Bladder Cancer via Bcl-2 and XIAP

  2025cites this paper
• Photoacoustic Chemical Imaging of Tumor Microenvironment pH for Prediction of Chemotherapeutic Efficacy in Breast Cancer.

  2025cites this paper
• Can the Tumor Microenvironment Alter Ion Channels? Unraveling Their Role in Cancer

  2025cites this paper
• Adaptation to acidic conditions that mimic the tumor microenvironment, downregulates miR-193b-3p, and induces EMT via TGFβ2 in A549 cells

  2025cites this paper
• Advances and applications of hyperthermia in tumor therapy: Mechanisms, techniques, and clinical integration

  2025cites this paper
• Lactate and lactylation in cancer

  2025cites this paper
• Exploring therapeutic and diagnostic potential of cysteine cathepsin as targets for cancer therapy with nanomedicine.

  2025cites this paper
• Hyperbaric Oxygen Regulates Tumor pH to Boost Copper‐Doped Hydroxyethyl Starch Conjugate Nanoparticles Against Cancer Stem Cells

  2025cites this paper
• Glucose Metabolism Reprogramming of Immune Cells in the Microenvironment of Pancreatic and Hepatobiliary Cancers

  2025cites this paper
• Metabolic Signatures in Lung Cancer: Prognostic Value of Acid–Base Disruptions and Serum Indices

  2025influential citation
• MRI/CT dual-model guided multifunctional acid neutralization nanoplatform for tumor alkalization combined photothermal-chemotherapy.

  2025cites this paper
• Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche

  2025cites this paper
• Preparation and performance study of lithium‑zinc doped bio-glass/chitosan/polyacrylamide composite hydrogel loaded with doxorubicin hydrochloride.

  2025cites this paper
• Regulating Intratumoral Fungi With Hydrogels: A Novel Approach to Modulating the Tumor Microbiome for Cancer Therapy

  2025cites this paper
• The Role of Tumor pH in Breast Cancer Imaging: Biology, Diagnostic Applications, and Emerging Techniques

  2025influential citation
• Antibodies toward Na+,HCO3–-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

  2024cites this paper
• Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift

  2024cites this paper
• Metabolic instruction of the graft-versus-leukemia immunity

  2024cites this paper
• L-DOS47 Elevates Pancreatic Cancer Tumor pH and Enhances Response to Immunotherapy

  2024cites this paper
• Potassium bicarbonate, not sodium bicarbonate, maintains acidosis-mediated bone dissolution.

  2024cites this paper
• Mechanism of the Warburg effect and its role in breast cancer immunotherapy

  2024cites this paper
• Acid affairs in anti-tumour immunity

  2024cites this paper
• Cationic liposomes as a drug-free system for efficient anticancer therapy by intracytoplasmic delivery of sodium bicarbonate.

  2024cites this paper
• Clinical significance of acidic extracellular microenvironment modulated genes

  2024cites this paper
• Beyond genetics: integrative oncology and the metabolic perspective on cancer treatment

  2024cites this paper
• How Does Cancer Occur? How Should It Be Treated? Treatment from the Perspective of Alkalization Therapy Based on Science-Based Medicine

  2024cites this paper
• Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance

  2024cites this paper
• Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate.

  2024cites this paper
• Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity

  2024cites this paper
• Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironment

  2024cites this paper
• Biochemical hallmarks-targeting antineoplastic nanotherapeutics

  2024cites this paper
• Mitochondrial bioenergetics of breast cancer.

  2024cites this paper
• Adenovirus-mediated expression of MOAP-1, Bax and RASSF1A antagonizes chemo-drug resistance of human breast cancer cells expressing cancer stem cell markers.

  2024cites this paper
• Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis

  2024cites this paper
• Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy

  2024cites this paper
• Rapid intracellular pH measurement based on electroporation- surface-enhanced Raman scattering.

  2024cites this paper
• pH-Dependent Non-Covalent Release of Chemotherapy from Carriers

  2024cites this paper
• Microenvironmental alkalization promotes the therapeutic effects of MSLN-CAR-T cells

  2024cites this paper
• Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors

  2023cites this paper
• Harnessing the Electrochemical Effects of Electroporation-Based Therapies to Enhance Anti-tumor Immune Responses

  2023cites this paper
• The emerging role of glycolysis and immune evasion in gastric cancer

  2023cites this paper
• Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model

  2023influential citation
• How protons pave the way to aggressive cancers

  2023cites this paper
• Targeting acidic pre-metastatic niche in lungs by pH low insertion peptide and its utility for anti-metastatic therapy

  2023cites this paper
• In Situ Insonation of Alkaline Buffer Containing Liposomes Leads to a Net Improvement of the Therapeutic Outcome in a Triple Negative Breast Cancer Murine Model

  2023cites this paper
• Targeted hyperalkalization with NaOH-loaded starch implants enhances doxorubicin efficacy in tumor treatment

  2023cites this paper
• L-DOS47 enhances response to immunotherapy in pancreatic cancer tumor

  2023cites this paper
• Increasing Chemotherapeutic Efficacy Using pH Modulating and Doxorubicin Releasing Injectable Chitosan-Polyethylene Glycol Hydrogels

  2023cites this paper
• Tumor Abnormality-Oriented Nanomedicine Design.

  2023cites this paper
• Amorphous Calcium Carbonate Shows Anti-Cancer Properties That are Attributed to Its Buffering Capacity

  2023cites this paper
• Increasing chemotherapeutic efficacy using doxorubicin and sodium bicarbonate releasing injectable chitosan-polyethylene glycol hydrogels

  2023cites this paper
• Molecular Imaging Investigations of Polymer-Coated Cerium Oxide Nanoparticles as a Radioprotective Therapeutic Candidate

  2023cites this paper
• Delivery of Chemotherapy Agents and Nucleic Acids with pH-Dependent Nanoparticles

  2023cites this paper
• Anticancer Effect of Gallic Acid on Acidity-Induced Invasion of MCF7 Breast Cancer Cells

  2023cites this paper
• Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting

  2023cites this paper
• Molecular Resonance Imaging of the CAIX Expression in Mouse Mammary Adenocarcinoma Cells

  2023cites this paper
• Intraperitoneal Delivery of Iopamidol to Assess Extracellular pH of Orthotopic Pancreatic Tumor Model by CEST-MRI

  2023cites this paper
• Blood pH and COVID‐19

  2023cites this paper
• Recent Developments in the Study of the Microenvironment of Cancer and Drug Delivery.

  2023cites this paper
• Warburg Effect Revisited: Embodiment of Classical Biochemistry and Organic Chemistry. Current State and Prospects

  2023cites this paper
• Tumor Vasculature as an Emerging Pharmacological Target to Promote Anti-Tumor Immunity

  2023cites this paper
• Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironment

  2023cites this paper
• Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation

  2023cites this paper
• Metal Phenolic Networks (MPNs)-based pH-sensitive stimulus responsive nanosystems for drug delivery in tumor microenvironment

  2023cites this paper
• Radiometal-Based PET/MRI Contrast Agents for Sensing Tumor Extracellular pH

  2022cites this paper
• Extracellular pH Mapping as Therapeutic Readout of Drug Delivery in Glioblastoma.

  2022cites this paper
• Expression of GPR68, an Acid-Sensing Orphan G Protein-Coupled Receptor, in Breast Cancer

  2022cites this paper
• CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

  2022cites this paper
• Effect of Esomeprazole Treatment on Extracellular Tumor pH in a Preclinical Model of Prostate Cancer by MRI-CEST Tumor pH Imaging

  2022cites this paper
• Zn0.4Mg0.6Fe2O4 nanoenzyme: a novel chemo-sensitizer for the chemotherapy treatment of oral squamous cell carcinoma

  2022cites this paper
• Monitor Tumor pHe and Response Longitudinally during Treatment Using CEST MRI-Detectable Alginate Microbeads

  2022cites this paper
• An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice

  2022cites this paper
• Targeting glycolysis for cancer therapy using drug delivery systems.

  2022cites this paper
• Commons@Becker Digital Commons@Becker

  2022cites this paper
• Engineered Oncolytic Adenoviruses: An Emerging Approach for Cancer Therapy

  2022cites this paper
• The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment

  2022cites this paper
• Back to basic: Trials and tribulations of alkalizing agents in cancer

  2022cites this paper
• Clinical review of alkalization therapy in cancer treatment

  2022cites this paper
• Tumor acidity: From hallmark of cancer to target of treatment

  2022cites this paper
• Unraveling tumor microenvironment of small-cell lung cancer: implications for immunotherapy.

  2022cites this paper
• Metabolic targeting of malignant tumors: a need for systemic approach

  2022cites this paper
• Targeting Tumor Acidosis and Regulatory T Cells Unmasks Anti-Metastatic Potential of Local Tumor Ablation in Triple-Negative Breast Cancer

  2022cites this paper
• In Vivo MRI-CEST Tumor pH Imaging Detects Resistance to Proton Pump Inhibitors in Human Prostate Cancer Murine Models

  2022cites this paper
• Meaning and Significance of “Alkalization Therapy for Cancer”

  2022cites this paper
• Efficient Immunotherapy of Drug-Free Layered Double Hydroxide Nanoparticles via Neutralizing Excess Acid and Blocking Tumor Cell Autophagy.

  2022cites this paper
• The acidic tumor microenvironment enhances PD-L1 expression via activation of STAT3 in MDA-MB-231 breast cancer cells

  2022cites this paper
• Role of stiffness and physico-chemical properties of tumour microenvironment on breast cancer cell stemness.

  2022cites this paper
• A pH-sensor scaffold for mapping spatiotemporal gradients in three-dimensional in vitro tumour models.

  2022cites this paper