Brd4 Is Required for E2-Mediated Transcriptional Activation but Not Genome Partitioning of All Papillomaviruses

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Virology

• Publication date

  2006-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.01105-06PMID 16973557PMCID PMC1617221
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Variations in the association of papillomavirus E2 proteins with mitotic chromosomes.

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  2006influential reference
• Bromodomain Protein 4 Mediates the Papillomavirus E2 Transcriptional Activation Function

  2006influential reference
• The clinical importance of the nomenclature, evolution and taxonomy of human papillomaviruses

  2005cited by this paper
• Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

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• Inhibition of E2 Binding to Brd4 Enhances Viral Genome Loss and Phenotypic Reversion of Bovine Papillomavirus-Transformed Cells

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• The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

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• Interaction of Bovine Papillomavirus E2 Protein with Brd4 Stabilizes Its Association with Chromatin

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• Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein.

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  2004cited by this paper
• Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning

  2004cited by this paper
• Classification of papillomaviruses.

  2004cited by this paper
• Global Nature of Dynamic Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins

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• Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes.

  2004influential reference
• Analysis of Chromatin Attachment and Partitioning Functions of Bovine Papillomavirus Type 1 E2 Protein

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• Metaphase Chromosome Tethering Is Necessary for the DNA Synthesis and Maintenance of oriP Plasmids but Is Insufficient for Transcription Activation by Epstein-Barr Nuclear Antigen 1

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• The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

  2003influential reference
• Human papillomavirus: epidemiology and public health.

  2003cited by this paper
• A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase

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• Cooperative Activation of Human Papillomavirus Type 8 Gene Expression by the E2 Protein and the Cellular Coactivator p300

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• Growth and Early Postimplantation Defects in Mice Deficient for the Bromodomain-Containing Protein Brd4

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• Interaction of the papillomavirus E2 protein with mitotic chromosomes.

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  2000cited by this paper
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• Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen.

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• Bovine Papillomavirus Type 1 Genomes and the E2 Transactivator Protein Are Closely Associated with Mitotic Chromatin

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• Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation.

  1998cited by this paper
• Transactivation by the E2 Protein of Oncogenic Human Papillomavirus Type 31 Is Not Essential for Early and Late Viral Functions

  1998cited by this paper
• Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein

  1997cited by this paper
• Cis and trans requirements for stable episomal maintenance of the BPV‐1 replicator.

  1996cited by this paper
• Enhanced transcriptional activation by E2 proteins from the oncogenic human papillomaviruses

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  1996cited by this paper
• Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements

  1994cited by this paper
• During negative regulation of the human papillomavirus-16 E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element.

  1992cited by this paper
• Functional analysis of E2-mediated repression of the HPV18 P105 promoter.

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• Regulation of early gene expression from the bovine papillomavirus genome in transiently transfected C127 cells

  1991cited by this paper
• The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes

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• The bovine papillomavirus P2443 promoter is E2 trans‐responsive: evidence for E2 autoregulation.

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• The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2‐dependent enhancer.

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• Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product

  1987cited by this paper
• Trans‐activation of an upstream early gene promoter of bovine papilloma virus‐1 by a product of the viral E2 gene.

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• Transcriptional regulation of the human papillomavirus‐16 E6‐E7 promoter by a keratinocyte‐dependent enhancer, and by viral E2 trans‐activator and repressor gene products: implications for cervical carcinogenesis.

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• Random association of Epstein-Barr virus genomes with host cell metaphase chromosomes in Burkitt's lymphoma-derived cell lines

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• Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

  1985cited by this paper
• Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene product.

  1985cited by this paper
• Two Epstein-Barr viral nuclear neoantigens distinguished by gene transfer, serology, and chromosome binding.

  1983cited by this paper
• Mouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequences.

  1981cited by this paper
• Microtubule initiation at kinetochores and centrosomes in lysed mitotic cells. Inhibition of site-specific nucleation by tubulin antibody

  1979cited by this paper
• Identification of a nuclear protein matrix.

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