IκBα and p65 Regulate the Cytoplasmic Shuttling of Nuclear Corepressors: Cross-talk between Notch and NFκB Pathways

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular Biology of the Cell

• Publication date

  2003-02-01

• Fields of study

  Biology

• Identifiers
  DOI 10.1091/MBC.E02-07-0404
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

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• Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

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• p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR.

  2002cited by this paper
• Osteoclast spreading kinetics are correlated with an oscillatory activation of a calcium-dependent potassium current

  2002influential reference
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• Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38*

  2001cited by this paper
• Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha.

  2001influential reference
• Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex

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• Phosphorylation of Ser2078 Modulates the Notch2 Function in 32D Cell Differentiation*

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression

  2001cited by this paper
• Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.

  2000cited by this paper
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  2000cited by this paper
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• Notch signaling directly controls cell proliferation in the Drosophila wing disc.

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• Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes.

  2000cited by this paper
• The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export

  2000cited by this paper
• NF-κB Is Required for the Positive Selection of CD8+ Thymocytes1

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• Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.

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• AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein.

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• Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors, as a Novel Transcriptional Corepressor Molecule of Activating Protein-1, Nuclear Factor-κB, and Serum Response Factor*

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• Cell Signaling Switches HOX-PBX Complexes from Repressors to Activators of Transcription Mediated by Histone Deacetylases and Histone Acetyltransferases

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• Dynamic Shuttling of Nuclear Factor κB between the Nucleus and Cytoplasm as a Consequence of Inhibitor Dissociation*

  2000cited by this paper
• A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes.

  2000cited by this paper
• A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes

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• Insulin-like Growth Factor-II, Phosphatidylinositol 3-Kinase, Nuclear Factor-κB and Inducible Nitric-oxide Synthase Define a Common Myogenic Signaling Pathway*

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  1999cited by this paper
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  1999cited by this paper
• Rel/NF‐κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

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• An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha.

  1999cited by this paper
• CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.

  1999cited by this paper
• Control of apoptosis by Rel/NF-κB transcription factors

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• Notch‐1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

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• NF-κB/Rel Proteins Are Required for Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells*

  1999cited by this paper
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  1999cited by this paper
• Delta-1 Activation of Notch-1 Signaling Results inHES-1 Transactivation

  1998cited by this paper
• Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300.

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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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