Microbial natural products as a source of antifungals.

The vast number and variety of chemotherapeutic agents isolated from microbial natural products and used to treat bacterial infections have greatly contributed to the improvement of human health during the past century. However, only a limited number of antifungal agents (polyenes and azoles, plus the recently introduced caspofungin acetate) are currently available for the treatment of life-threatening fungal infections. Furthermore, the prevalence of systemic fungal infections has increased significantly during the past decade. For this reason, the development of new antifungal agents, preferably with novel mechanisms of action, is an urgent medical need. A selection of antifungal agents in early stages of development, produced by micro-organisms, is summarized in this review. The compounds are classified according to their mechanisms of action, covering inhibitors of the synthesis of cell wall components (glucan, chitin and mannoproteins), of sphingolipid synthesis (serine palmitoyltransferase, ceramide synthase, inositol phosphoceramide synthase and fatty acid elongation) and of protein synthesis (sordarins). In addition, some considerations related to the chemotaxonomy of the producing organisms and some issues relevant to antifungal drug discovery are also discussed.

• Publication year

  2003

• Venue

  Clinical Microbiology and Infection

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1046/J.1469-0691.2003.00489.XPMID 12691539
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Translation elongation factor-3 (EF-3): An evolving eukaryotic ribosomal protein?

  2004cited by this paper
• Chitin Biosynthesis in Fungi

  2003cited by this paper
• Antifungal Activities and Cytotoxicity Studies of Six New Azasordarins

  2001cited by this paper
• Correlation between Antifungal Susceptibilities ofCoccidioides immitis In Vitro and Antifungal Treatment with Caspofungin in a Mouse Model

  2001cited by this paper
• Arundifungin, a novel antifungal compound produced by fungi: biological activity and taxonomy of the producing organisms

  2001cited by this paper
• Arborcandins A, B, C, D, E, and F, Novel 1,3-β-Glucan Synthase Inhibitors: Production and Biological Activity.

  2001cited by this paper
• Antimicrobial activity of ergokonin A from Trichoderma longibrachiatum

  2001influential reference
• New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 1. Taxonomy, fermentation, isolation, and biological properties.

  2001cited by this paper
• New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 2. Structure analysis.

  2001cited by this paper
• Dosage-Dependent Antifungal Efficacy of V-Echinocandin (LY303366) against Experimental Fluconazole-Resistant Oropharyngeal and Esophageal Candidiasis

  2001cited by this paper
• Phellinsin A, a novel chitin synthases inhibitor produced by Phellinus sp. PL3.

  2000cited by this paper
• In Vitro Pharmacodynamic Parameters of Sordarin Derivatives in Comparison with Those of Marketed Compounds against Pneumocystis carinii Isolated from Rats

  2000cited by this paper
• The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.

  2000cited by this paper
• [Invasive fungal infections. Epidemiology and new therapies].

  2000cited by this paper
• The effect of the echinocandin analogue caspofungin on cell wall glucan synthesis by Cryptococcus neoformans.

  2000cited by this paper
• Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors

  2000cited by this paper
• Isolation and characterization of novel inhibitors of sphingolipid synthesis: australifungin, viridiofungins, rustmicin, and khafrefungin.

  2000influential reference
• FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.

  2000cited by this paper
• Efficacy of FK463, a New Lipopeptide Antifungal Agent, in Mouse Models of Disseminated Candidiasis and Aspergillosis

  2000cited by this paper
• Screening of basidiomycetes for antimicrobial activities

  2000cited by this paper
• Efficacies of Sordarin Derivatives GM193663, GM211676, and GM237354 in a Murine Model of Systemic Coccidioidomycosis

  2000cited by this paper
• Arborcandins A, B, C, D, E and F, novel 1,3-beta-glucan synthase inhibitors: production and biological activity.

  2000cited by this paper
• Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina.

  1999cited by this paper
• Reclassification of a pneumocandin-producing anamorph, Glarea lozoyensis gen. et sp. nov., previously identified as Zalerion arboricola

  1999cited by this paper
• Hypoxysordarin, a New Sordarin Derivative from Hypoxylon croceum

  1999cited by this paper
• Activities of Sordarins in Murine Histoplasmosis

  1999cited by this paper
• In Vitro Antifungal Activity of Nikkomycin Z in Combination with Fluconazole or Itraconazole

  1999cited by this paper
• Human mycoses and current antifungal therapy.

  1998cited by this paper
• Sordarins: A New Class of Antifungals with Selective Inhibition of the Protein Synthesis Elongation Cycle in Yeasts

  1998cited by this paper
• Inhibition of fungal sphingolipid biosynthesis by rustmicin, galbonolide B and their new 21-hydroxy analogs.

  1998cited by this paper
• Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition.

  1998cited by this paper
• Efficacy of MK-991 (L-743,872), a Semisynthetic Pneumocandin, in Murine Models ofPneumocystis carinii

  1998cited by this paper
• Rustmicin, a Potent Antifungal Agent, Inhibits Sphingolipid Synthesis at Inositol Phosphoceramide Synthase*

  1998influential reference
• Human mycoses and current antifungal therapy.

  1998cited by this paper
• Identification of Elongation Factor 2 as the Essential Protein Targeted by Sordarins in Candida albicans

  1998cited by this paper
• Sordarins: In Vitro Activities of New Antifungal Derivatives against Pathogenic Yeasts, Pneumocystis carinii, and Filamentous Fungi

  1998cited by this paper
• BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties.

  1998cited by this paper
• Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. II. Isolation and structure determination.

  1998cited by this paper
• Endophytic fungi from plants living on gypsum soils as a source of secondary metabolites with antimicrobial activity

  1998cited by this paper
• Elongation Factor 2 as a Novel Target for Selective Inhibition of Fungal Protein Synthesis*

  1998cited by this paper
• UK-3A, a novel antifungal antibiotic from Streptomyces sp. 517-02: fermentation, isolation, structural elucidation and biological properties.

  1997cited by this paper
• ELO2 and ELO3, Homologues of theSaccharomyces cerevisiae ELO1 Gene, Function in Fatty Acid Elongation and Are Required for Sphingolipid Formation*

  1997cited by this paper
• Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis

  1997cited by this paper
• Sphingolipid Synthesis as a Target for Antifungal Drugs

  1997cited by this paper
• Clinically significant azole cross‐resistance in Candida isolates from HIV‐positive patients with oral candidosis

  1997cited by this paper
• Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae

  1997cited by this paper
• Viridiofungins, novel inhibitors of sphingolipid synthesis.

  1997influential reference
• Antimicrobial activity of viridiofungins.

  1997influential reference
• Khafrefungin, a Novel Inhibitor of Sphingolipid Synthesis*

  1997influential reference
• Corynecandin: a novel antifungal glycolipid from Coryneum modonium.

  1997cited by this paper
• ECHINOCANDIN ANTIFUNGAL AGENTS

  1997cited by this paper
• A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.

  1996cited by this paper
• Arthrichitin. A New Cell Wall Active Metabolite from Arthrinium phaeospermum.

  1996cited by this paper
• UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties.

  1996cited by this paper
• Preparation and antifungal activity of fusacandin analogs: C-6′ sidechain esters

  1996cited by this paper
• The retention mechanism of cell wall proteins in Saccharomyces cerevisiae. Wall-bound Cwp2p is beta-1,6-glucosylated.

  1996cited by this paper
• Xylarin, an Antifungal Xylaria Metabolite with an Unusual Tricyclic Uronic Acid Moiety

  1995cited by this paper
• The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Producing organism, fermentation, isolation, and biological activity.

  1995influential reference
• Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin.

  1995cited by this paper
• Cyclic hexapeptides having antibiotic activity

  1995cited by this paper
• SCH57404, an antifungal agent possessing the rare sodaricin skeleton and a tricyclic sugar moiety.

  1995cited by this paper
• Regulation of Lipid Biosynthesis in Saccharomyces cerevisiae by Fumonisin B1(*)

  1995cited by this paper
• The fungal cell wall as a drug target.

  1995cited by this paper
• Human mycoses: drugs and targets for emerging pathogens.

  1994cited by this paper
• Synthesis and Antifungal Activity of Novel Cationic Pneumocandin Bo Derivatives

  1994cited by this paper
• Inhibition of serine palmitoyl-transferase activity by lipoxamycin.

  1994cited by this paper
• Synthesis and antifungal activity of novel cationic pneumocandin B(o) derivatives.

  1994cited by this paper
• Chitin synthesis and degradation as targets for pesticide action.

  1993cited by this paper
• BU-4794F, a new beta-1,3-glucan synthase inhibitor.

  1993cited by this paper
• AMPHOTERICIN B THERAPY: PAST, PRESENT, AND FUTURE

  1993cited by this paper
• Mer-WF3010, a new member of the papulacandin family. I. Fermentation, isolation and characterization.

  1993cited by this paper
• Biological properties of aureobasidin A, a cyclic depsipeptide antifungal antibiotic.

  1993cited by this paper
• Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System.

  1993cited by this paper
• Pneumocandins from Zalerion arboricola. I. Discovery and isolation.

  1992cited by this paper
• Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase.

  1992influential reference
• Sphingofungins E and F: novel serinepalmitoyl transferase inhibitors from Paecilomyces variotii.

  1992cited by this paper
• Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.

  1992cited by this paper
• Screening assays for protein synthesis inhibitors.

  1992cited by this paper
• L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity.

  1991cited by this paper
• Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties.

  1991cited by this paper
• The function of chitin synthases 2 and 3 in the Saccharomyces cerevisiae cell cycle

  1991cited by this paper
• Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins

  1991cited by this paper
• The growing problem of mycoses in patients infected with the human immunodeficiency virus.

  1991cited by this paper
• An echinocandin from an endophytic Cryptosporiopsis sp. and Pezicula sp. in Pinus sylvestris and Fagus sylvatica

  1991cited by this paper
• Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme.

  1991cited by this paper
• Role of yeast elongation factor 3 in the elongation cycle.

  1989cited by this paper
• New antifungal antibiotics, benanomicins A and B from an actinomycete.

  1988cited by this paper
• Pradimicin, a novel class of potent antifungal antibiotics.

  1988cited by this paper
• Mulundocandin, a new lipopeptide antibiotic. I. Taxonomy, fermentation, isolation and characterization.

  1987cited by this paper
• MULUNDOCANDIN, A NEW LIPOPEPTIDE ANTIBIOTIC

  1987cited by this paper
• Rustmicin, a new macrolide antibiotic active against wheat stem rust fungus.

  1987cited by this paper
• Synergistic action of nikkomycins X and Z with papulacandin B on whole cells and regenerating protoplasts of Candida albicans

  1986cited by this paper
• Philosophy of new drug discovery

  1986cited by this paper
• Galbonolides A and B--two non-glycosidic antifungal macrolides.

  1986cited by this paper
• Neorustmicin A, a new macrolide antibiotic active against wheat stem rust fungus.

  1985cited by this paper
• New applications of microbial products.

  1983cited by this paper
• The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids.

  1983cited by this paper
• STUDIES ON ACULEACIN

  1977cited by this paper
• Dissimilarity in protein chain elongation factor requirements between yeast and rat liver ribosomes.

  1977cited by this paper
• Papulacandins, a new family of antibiotics with antifungal activity, I. Fermentation, isolation, chemical and biological characterization of papulacandins A, B, C, D and E.

  1977cited by this paper

• Beyond antibiotics: the expanding horizon of microbial natural products

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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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