Role of telomerase in cellular proliferation and cancer

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Cellular Physiology

• Publication date

  1999-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/(SICI)1097-4652(199907)180:1<10::AID-JCP2>3.0.CO;2-DPMID 10362013
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

  1999cited by this paper
• Toward identifying a cellular determinant of telomerase repression.

  1999cited by this paper
• Telomerase activity does not always imply telomere maintenance.

  1999cited by this paper
• Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

  1999cited by this paper
• Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells.

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• Loss of heterozygosity at chromosome 3p correlates with telomerase activity in renal cell carcinoma.

  1998cited by this paper
• Evidence for a putative telomerase repressor gene in the 3p14.2–p21.1 region

  1998cited by this paper
• Telomerase activity in the female reproductive tract and neoplasms.

  1998cited by this paper
• Inhibition of human telomerase by 2'-O-methyl-RNA.

  1998cited by this paper
• Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.

  1998cited by this paper
• Minimal deletion of 3p13→14.2 associated with immortalization of human uroepithelial cells

  1998cited by this paper
• Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA.

  1998cited by this paper
• Reconstitution of human telomerase activity in vitro.

  1998cited by this paper
• Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span.

  1998cited by this paper
• Myc activates telomerase.

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• Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA

  1998cited by this paper
• Extension of life-span by introduction of telomerase into normal human cells.

  1998cited by this paper
• Growth arrest of immortalized human keratinocytes and suppression of telomerase activity by p21WAF1 gene expression

  1998cited by this paper
• Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence

  1998cited by this paper
• Essential role of mouse telomerase in highly proliferative organs

  1998cited by this paper
• Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells.

  1998cited by this paper
• Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants.

  1998cited by this paper
• Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

  1998cited by this paper
• Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

  1998cited by this paper
• Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA

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• Proliferation-associated regulation of telomerase activity in human endometrium and its potential implication in early cancer diagnosis.

  1997cited by this paper
• A survey of telomerase activity in human cancer.

  1997cited by this paper
• In vivo telomere dynamics of human hematopoietic stem cells.

  1997cited by this paper
• Telomerase activity in human endometrium.

  1997cited by this paper
• Solid cancers after bone marrow transplantation.

  1997cited by this paper
• Reverse transcriptase motifs in the catalytic subunit of telomerase.

  1997cited by this paper
• A Mammalian Telomerase-Associated Protein

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• Lack of cell cycle regulation of telomerase activity in human cells.

  1997cited by this paper
• Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

  1997cited by this paper
• Telomere lengthening and telomerase activation during human B cell differentiation.

  1997cited by this paper
• Regulation of telomerase RNA template expression in human T lymphocyte development and activation.

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• Downregulation of telomerase activity in HL60 cells by differentiating agents is accompanied by increased expression of telomerase‐associated protein

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• Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine

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• Telomerase activity concentrates in the mitotically active segments of human hair follicles.

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• Evaluation of the telomeric repeat amplification protocol (TRAP) assay for telomerase as a diagnostic modality in recurrent bladder cancer.

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• Changes in telomerase activity and telomere length during human T lymphocyte senescence.

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• TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family.

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• Telomerase activity during the cell cycle and in gamma-irradiated hematopoietic cells

  1997cited by this paper
• Human telomerase contains evolutionarily conserved catalytic and structural subunits.

  1997cited by this paper
• Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.

  1997cited by this paper
• Telomerase activity is induced in human peripheral B lymphocytes by the stimulation to antigen receptor.

  1997cited by this paper
• Detection of telomerase activity in exfoliated cells in urine from patients with bladder cancer.

  1997cited by this paper
• hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.

  1997cited by this paper
• Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells.

  1997cited by this paper
• Telomerase activity in normal and neoplastic breast.

  1997cited by this paper
• Telomerase catalytic subunit homologs from fission yeast and human.

  1997cited by this paper
• Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas

  1996cited by this paper
• Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.

  1996cited by this paper
• Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

  1996cited by this paper
• Telomerase activity in normal human epithelial cells.

  1996cited by this paper
• Telomerase activity in human breast tumors.

  1996cited by this paper
• Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

  1996cited by this paper
• Telomerase regulation during entry into the cell cycle in normal human T cells.

  1996cited by this paper
• Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents.

  1996cited by this paper
• Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines.

  1996cited by this paper
• Regulation of telomerase activity in immortal cell lines

  1996cited by this paper
• Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.

  1996cited by this paper
• Telomerase activity in human cancer.

  1996cited by this paper
• Down-regulation of telomerase activity is an early event in the differentiation of HL60 cells.

  1996cited by this paper
• Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines.

  1996cited by this paper
• Telomerase activity in human germline and embryonic tissues and cells.

  1996cited by this paper
• Cell cycle-dependent modulation of telomerase activity in tumor cells.

  1996cited by this paper
• Inhibition of human telomerase activity by peptide nucleic acids

  1996cited by this paper
• Telomerase activity in hematopoietic cells is associated with self-renewal potential.

  1996cited by this paper
• Telomerase activity in human intestine.

  1996cited by this paper
• Mechanism of telomerase induction during T cell activation.

  1996cited by this paper
• Supression of telomerase activity in HL60 cells after treatment with differentiating agents.

  1996cited by this paper
• Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas.

  1996cited by this paper
• Telomerase activity in human bladder cancer.

  1996cited by this paper
• Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.

  1995cited by this paper
• Telomerase activity in normal and malignant hematopoietic cells.

  1995cited by this paper
• Correlating telomerase activity levels with human neuroblastoma outcomes

  1995cited by this paper
• Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3

  1995cited by this paper
• The RNA component of human telomerase

  1995cited by this paper
• Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)

  1995cited by this paper
• Telomerase activity in normal leukocytes and in hematologic malignancies.

  1995cited by this paper
• Telomerase activity in gastric cancer.

  1995cited by this paper
• Differentiation of immortal cells inhibits telomerase activity.

  1995cited by this paper
• Telomerase activity in germline and embryonic cells of Xenopus.

  1994cited by this paper
• Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

  1994cited by this paper
• Specific association of human telomerase activity with immortal cells and cancer.

  1994cited by this paper
• Telomere length predicts replicative capacity of human fibroblasts.

  1992cited by this paper
• The two-stage mechanism controlling cellular senescence and immortalization.

  1992cited by this paper
• A role for both RB and p53 in the regulation of human cellular senescence.

  1991cited by this paper
• In vivo loss of telomeric repeats with age in humans.

  1991cited by this paper
• Telomeres shorten during ageing of human fibroblasts

  1990cited by this paper
• Telomere reduction in human colorectal carcinoma and with ageing

  1990cited by this paper
• Hypervariable ultra-long telomeres in mice

  1990cited by this paper
• Structure and variability of human chromosome ends

  1990cited by this paper
• Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen.

  1989cited by this paper
• Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

  1989cited by this paper

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• Available online at www.sciencedirect.com Biochimie 90 (2008) 156e172 Review

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