Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Molecular and Cellular Biology

• Publication date

  1997-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.17.1.389PMID 8972219PMCID PMC231763
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA topoisomerases.

  1996cited by this paper
• Topoisomerase II inhibitors affect entry into mitosis and chromosome condensation in BHK cells.

  1996cited by this paper
• Structure and mechanism of DNA topoisomerase II

  1996cited by this paper
• Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene.

  1996cited by this paper
• The cell cycle-coupled expression of topoisomerase IIalpha during S phase is regulated by mRNA stability and is disrupted by heat shock or ionizing radiation

  1996cited by this paper
• Regulation of the Human Topoisomerase IIα Gene Promoter in Confluence-arrested Cells*

  1996cited by this paper
• Human TAFII31 protein is a transcriptional coactivator of the p53 protein.

  1995cited by this paper
• p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

  1995cited by this paper
• Essential role for p53-mediated transcription in E1A-induced apoptosis.

  1995cited by this paper
• Molecular Cloning and Characterization of the Promoter for the Chinese Hamster DNA Topoisomerase IIα Gene (*)

  1995influential reference
• DNA Topoisomerase IIα Gene Expression under Transcriptional Control in Etoposide/Teniposide-resistant Human Cancer Cells

  1995cited by this paper
• Isolation and Characterization of the Promoter Region of the Rat DNA Topoisomerase IIα Gene

  1995cited by this paper
• Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

  1995cited by this paper
• Gas1-induced growth suppression requires a transactivation-independent p53 function

  1995cited by this paper
• Isolation and characterization of the promoter region of the rat DNA topoisomerase II alpha gene.

  1995cited by this paper
• p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60.

  1995cited by this paper
• Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression

  1995cited by this paper
• Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

  1995cited by this paper
• The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited.

  1995cited by this paper
• Molecular cloning and characterization of the promoter for the Chinese hamster DNA topoisomerase II alpha gene.

  1995cited by this paper
• DNA topoisomerase II alpha gene expression under transcriptional control in etoposide/teniposide-resistant human cancer cells.

  1995cited by this paper
• Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung.

  1995cited by this paper
• Topoisomerase II alpha promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells.

  1995cited by this paper
• A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells

  1994cited by this paper
• Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

  1994cited by this paper
• Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53

  1994cited by this paper
• DNA topoisomerases: essential enzymes and lethal targets.

  1994influential reference
• Bcl-2 blocks p53-dependent apoptosis

  1994cited by this paper
• Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein.

  1994cited by this paper
• Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

  1994cited by this paper
• p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

  1994cited by this paper
• Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

  1994cited by this paper
• Roles of DNA topoisomerases in chromosomal replication and segregation.

  1994cited by this paper
• Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations.

  1994cited by this paper
• Molecular analysis of a potentially phorbol-regulatable region of the human topoisomerase II alpha gene promoter.

  1994cited by this paper
• Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

  1994cited by this paper
• p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

  1994cited by this paper
• Regulation of the human hsp70 promoter by p53.

  1993influential reference
• The p53-mdm-2 autoregulatory feedback loop.

  1993cited by this paper
• Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

  1993cited by this paper
• Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

  1993cited by this paper
• Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

  1993cited by this paper
• The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

  1993cited by this paper
• Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

  1993cited by this paper
• Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.

  1993cited by this paper
• DNA topoisomerase II inhibition and gene amplification in V79/B7 cells.

  1993cited by this paper
• Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro.

  1993cited by this paper
• Clinical implications of the p53 tumor-suppressor gene.

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993influential reference
• A comparison of the biological activities of wild‐type and mutant p53

  1993cited by this paper
• Inhibition of viral and cellular promoters by human wild-type p53

  1992cited by this paper
• Definition of a consensus binding site for p53

  1992cited by this paper
• Repression of the basal c-fos promoter by wild-type p53.

  1992cited by this paper
• Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

  1992cited by this paper
• Wild-type p53 binds to the TATA-binding protein and represses transcription.

  1992cited by this paper
• The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.

  1992cited by this paper
• Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

  1992cited by this paper
• A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

  1992influential reference
• Cloning and characterization of the 5'-flanking region of the human topoisomerase II alpha gene.

  1992cited by this paper
• Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24.

  1992cited by this paper
• p53 function and dysfunction.

  1992cited by this paper
• Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

  1992cited by this paper
• Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

  1992cited by this paper
• Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

  1992cited by this paper
• Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

  1992cited by this paper
• Participation of p53 protein in the cellular response to DNA damage.

  1991cited by this paper
• Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.

  1991cited by this paper
• A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration.

  1991cited by this paper
• Wild-type p53 can down-modulate the activity of various promoters.

  1991cited by this paper
• Regulation of transformation and the cell cycle by p53.

  1991cited by this paper
• Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

  1991cited by this paper
• Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication.

  1991cited by this paper
• p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

  1991cited by this paper
• Mutant p53 proteins bind DNA abnormally in vitro.

  1991cited by this paper
• The role of DNA topoisomerases in recombination and genome stability: a double-edged sword?

  1990cited by this paper
• A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter

  1990influential reference
• Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells.

  1990cited by this paper
• Suppression of human colorectal carcinoma cell growth by wild-type p53.

  1990cited by this paper
• Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

  1989cited by this paper
• Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro.

  1988cited by this paper
• Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

  1988cited by this paper
• Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26.

  1988cited by this paper
• Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle.

  1988cited by this paper
• DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe.

  1987cited by this paper
• Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene.

  1986cited by this paper
• Bacteriophage T4 DNA topoisomerase mediates illegitimate recombination in vitro.

  1986cited by this paper
• Topoisomerase II: A specific marker for cell proliferation

  1986cited by this paper
• DNA topoisomerases.

  1985cited by this paper
• A type-II DNA topoisomerase and a catenating protein from the transplantable VX2 carcinoma.

  1985cited by this paper
• DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

  1984cited by this paper
• Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.

  1980cited by this paper
• Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

  1980cited by this paper
• Okadaic acid-induced transcriptional downregulation of type I collagen gene expression is mediated by protein phosphatase 2A

  1979cited by this paper

• DNA TOPOISOMERASE II MUTATIONS IN CANCER: STRUCTURAL IMPACT AND DRUG RESPONSE IN HIGH-GRADE SEROUS OVARIAN CARCINOMA.

  2025cites this paper
• Using different zebrafish models to explore liver regeneration

  2024cites this paper
• Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity

  2022cites this paper
• Adaptive resistance is not responsible for long-term drug resistance in a cellular model of triple negative breast cancer.

  2022cites this paper
• The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection

  2021cites this paper
• Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells

  2021cites this paper
• Context is key: Understanding the regulation, functional control, and activities of the p53 tumour suppressor

  2020cites this paper
• 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha

  2020cites this paper
• 3,6-Disubstituted 1,2,4-Triazolo[3,4- b ] Thiadiazoles with Anticancer Activity Targeting Topoisomerase II Alpha

  2020cites this paper
• Evidence For p53-Mediated Induction of WRAP53a in Response to DNA Damage

  2019cites this paper
• Mutual regulation of MDM4 and TOP2A in cancer cell proliferation

  2019cites this paper
• THE ROLE OF GENE EXPRESSION NOISE IN MAMMALIAN CELL SURVIVAL

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• Secang Heartwood Ethanolic Extract (Caesalpinia sappan L.) Inhibits Mesenchymal Stem Cells Senescence

  2018cites this paper
• A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

  2018cites this paper
• Identification of a p53-repressed gene module in breast cancer cells

  2017cites this paper
• Patho)physiological function of the Multidrug Resistance protein MRP1

  2017cites this paper
• Overexpression of p53 protein is a marker of poor prognosis in Mexican women with breast cancer.

  2017cites this paper
• PTEN stabilizes TOP2A and regulates the DNA decatenation

  2015cites this paper
• Identification of pathogenesis pathway in basal-like breast cancer based on mutant p53 protein and topoisomerase-IIα expression

  2015cites this paper
• Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrum Extract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats

  2015cites this paper
• A novel oxiranylchromenone derivative, MHY336, induces apoptosis and cell cycle arrest via a p53- and p21-dependent pathway in HCT116 human colon cancer cells.

  2014cites this paper
• Topoisomerase IIα in Chromosome Instability and Personalized Cancer Therapy

  2014cites this paper
• Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile

  2014cites this paper
• P53, MAPK, topoisomerase II alpha and Ki67 immunohistochemical expression and KRAS/BRAF mutation in ovarian serous carcinomas

  2013cites this paper
• Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells

  2013influential citation
• The association between the p53/topoisomerase I and p53/ topoisomerase IIalpha immunophenotypes and the progression of ovarian carcinomas.

  2012cites this paper
• Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis

  2012cites this paper
• The Association Between the p53/ topoisomerase I and p53/ topoisomerase IIα Immunophenotypes and the Progression of Ovarian Carcinomas* Zależność między p53/topoizomerazą I i p53/topoizomerazą IIα immunofenotypem a progresją raka jajnika

  2012cites this paper
• A novel epoxypropoxy flavonoid derivative and topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells.

  2011cites this paper
• Expression and Amplification of Topoisomerase-2α in Type 1 and Type 2 Papillary Renal Cell Carcinomas and Its Correlation with HER2/neu Amplification

  2011cites this paper
• Dietary Isothiocyanate-induced Apoptosis via Thiol Modification of DNA Topoisomerase IIα*

  2011cites this paper
• One Function—Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor

  2011cites this paper
• Decreased topoisomerase IIα expression and altered histone and regulatory factors of topoisomerase IIα promoter in patients with chronic benzene poisoning.

  2011cites this paper
• DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy.

  2010cites this paper
• Biological markers in breast cancer and acute leukaemia

  2010cites this paper
• Transcriptional control of the proliferation cluster by the tumor suppressor p53.

  2010cites this paper
• HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIα

  2009influential citation
• Activation of p53/p21/PUMA alliance and disruption of PI‐3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata

  2009influential citation
• Topoisomerase IIα Is Required for Embryonic Development and Liver Regeneration in Zebrafish

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• BRCA1-Mediated Ubiquitination Inhibits Topoisomerase IIα Activity in Response to Oxidative Stress

  2008cites this paper
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  2008cites this paper
• The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells.

  2008cites this paper
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  2007cites this paper
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  2007cites this paper
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  2007cites this paper
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• Inhibition of CBF/NF-Y mediated transcription activation arrests cells at G2/M phase and suppresses expression of genes activated at G2/M phase of the cell cycle

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• The topoisomerase II–Hsp90 complex: A new chemotherapeutic target?

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• The Dual Specificity Phosphatase Cdc25C is a Direct Target for Transcriptional Repression by the Tumor Suppressor p53

  2006cites this paper
• Transcriptional Repression by the p53 Tumor Suppressor Protein

  2005cites this paper
• Human DNA topoisomerase II-alpha expression in laparoscopically treated renal cell carcinoma.

  2005cites this paper
• Enhances Sensitivity to Topoisomerase II A Targeting Anticancer Drug by Up-Regulating the Promoter Activity

  2005cites this paper
• The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation

  2005cites this paper
• Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer.

  2005cites this paper
• Topo II alpha reporter mice reveal proliferative regions in the epidermis and small intestine.

  2005cites this paper
• Topo IIa reporter mice reveal proliferative regions in the epidermis and small intestine

  2005influential citation
• Mechanisms of Action of Cancer Chemotherapeutic Agents: Topoisomerase Inhibitors

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• 9 - Immunohistochemical Detection of DNA Topoisomerase IIα in Hepatocellular Carcinoma

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• Creation of cis-regulatory elements during sea urchin evolution by co-option and optimization of a repetitive sequence adjacent to the spec2a gene.

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