Structural insights into the catalysis and regulation of E3 ubiquitin ligases

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2016-08-03

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nrm.2016.91PMID 27485899PMCID PMC6211636
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ubiquitin System

  2018cited by this paper
• Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

  2016cited by this paper
• RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

  2015cited by this paper
• Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

  2015cited by this paper
• Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation

  2015cited by this paper
• Mechanism of phospho-ubiquitin induced PARKIN activation

  2015cited by this paper
• University of Dundee Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

  2015cited by this paper
• Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity

  2015cited by this paper
• A Ubl/ubiquitin switch in the activation of Parkin

  2015cited by this paper
• Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B*

  2015cited by this paper
• Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

  2015cited by this paper
• Atomic structure of the APC/C and its mechanism of protein ubiquitination

  2015cited by this paper
• Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation*

  2015cited by this paper
• Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

  2015cited by this paper
• Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin.

  2015cited by this paper
• Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

  2014cited by this paper
• Enhanced protein degradation by branched ubiquitin chains.

  2014cited by this paper
• Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.

  2014cited by this paper
• Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

  2014cited by this paper
• RBR E3 ubiquitin ligases: new structures, new insights, new questions

  2014cited by this paper
• Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis.

  2014cited by this paper
• RBR E3‐ligases at work

  2014cited by this paper
• Internal motions prime cIAP1 for rapid activation

  2014cited by this paper
• Ubiquitin is phosphorylated by PINK1 to activate parkin

  2014cited by this paper
• Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

  2014cited by this paper
• The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

  2014cited by this paper
• Molecular architecture and mechanism of the anaphase-promoting complex

  2014cited by this paper
• Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

  2014cited by this paper
• Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

  2014cited by this paper
• Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate.

  2014cited by this paper
• PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

  2014cited by this paper
• PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

  2014cited by this paper
• Ubiquitination in disease pathogenesis and treatment

  2014cited by this paper
• E6AP/UBE3A Ubiquitin Ligase Harbors Two E2∼ubiquitin Binding Sites*

  2013cited by this paper
• Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

  2013cited by this paper
• Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase promoting complex

  2013cited by this paper
• Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

  2013cited by this paper
• Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

  2013cited by this paper
• A conserved asparagine plays a structural role in ubiquitin-conjugating enzymes

  2013cited by this paper
• Auto-ubiquitination of Mdm2 Enhances Its Substrate Ubiquitin Ligase Activity*

  2013cited by this paper
• Activation of UbcH5c~Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B.

  2013cited by this paper
• EM Structure of human APC/CCDH1-EMI1 reveals multimodal mechanism of E3 ligase shutdown

  2013cited by this paper
• A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

  2013cited by this paper
• Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

  2013cited by this paper
• A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms.

  2013cited by this paper
• Structure of the human Parkin ligase domain in an autoinhibited state

  2013cited by this paper
• Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine

  2013cited by this paper
• Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

  2013cited by this paper
• Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

  2013cited by this paper
• Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.

  2013cited by this paper
• Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase

  2013cited by this paper
• Building and remodelling Cullin–RING E3 ubiquitin ligases

  2013cited by this paper
• Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3

  2013cited by this paper
• Synthesis of atypical diubiquitin chains.

  2012cited by this paper
• Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

  2012cited by this paper
• The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

  2012cited by this paper
• Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.

  2012cited by this paper
• The role of ubiquitylation in receptor endocytosis and endosomal sorting

  2012cited by this paper
• PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

  2012cited by this paper
• Targeting IAP proteins for therapeutic intervention in cancer

  2012cited by this paper
• PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

  2012cited by this paper
• BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

  2012cited by this paper
• LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

  2012cited by this paper
• Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates.

  2012cited by this paper
• Ubiquitin-binding proteins: decoders of ubiquitin-mediated cellular functions.

  2012cited by this paper
• The ubiquitin code.

  2012cited by this paper
• Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

  2012cited by this paper
• The tripartite motif: structure and function.

  2012cited by this paper
• Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.

  2012cited by this paper
• Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

  2012cited by this paper
• Expanded click conjugation of recombinant proteins with ubiquitin-like modifiers reveals altered substrate preference of SUMO2-modified Ubc9.

  2011cited by this paper
• Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

  2011cited by this paper
• UbcH7 reactivity profile reveals Parkin and HHARI to be RING/HECT hybrids

  2011cited by this paper
• The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

  2011cited by this paper
• Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization*

  2011cited by this paper
• Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

  2011cited by this paper
• Generation of a Mono‐ubiquitinated PCNA Mimic by Click Chemistry

  2011cited by this paper
• Mechanism of ubiquitylation by dimeric RING ligase RNF4

  2011cited by this paper
• Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate.

  2011cited by this paper
• E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

  2011cited by this paper
• Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

  2011cited by this paper
• Structure and function of a HECT domain ubiquitin‐binding site

  2011cited by this paper
• Ubiquitin in motion: structural studies of the ubiquitin-conjugating enzyme∼ubiquitin conjugate.

  2011cited by this paper
• A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

  2011cited by this paper
• CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.

  2011cited by this paper
• Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination

  2011cited by this paper
• Autoregulation of Parkin activity through its ubiquitin‐like domain

  2011cited by this paper
• Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis.

  2010cited by this paper
• Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates.

  2010cited by this paper
• Calcium Activates Nedd4 E3 Ubiquitin Ligases by Releasing the C2 Domain-mediated Auto-inhibition*

  2010cited by this paper
• Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.

  2010cited by this paper
• Ubiquitin signalling in DNA replication and repair

  2010cited by this paper
• RING domain E3 ubiquitin ligases.

  2009cited by this paper
• Regulation of the RSP5 Ubiquitin Ligase by an Intrinsic Ubiquitin-binding Site*

  2009cited by this paper
• E2 interaction and dimerization in the crystal structure of TRAF6

  2009cited by this paper
• Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.

  2009cited by this paper
• Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays

  2009cited by this paper
• Physiological functions of the HECT family of ubiquitin ligases

  2009cited by this paper
• Recognition and processing of ubiquitin-protein conjugates by the proteasome.

  2009cited by this paper
• Nonproteolytic functions of ubiquitin in cell signaling.

  2009cited by this paper

• Modulation of Ube2R1 activity by a nanobody that binds near its N-terminus.

  2026cites this paper
• Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation.

  2026cites this paper
• RNF26 regulating tumor immunogenicity of hepatocellular carcinoma by degrading GRP78 and instigating ER stress.

  2026cites this paper
• Fundus albipunctatus disease-associated RDH5/L310delinsEV mutation undertakes AMFR-mediated polyubiquitination and degradation in proteasome.

  2026cites this paper
• Identification of Fish Interferon-Stimulated Genes and Their Antiviral Mechanisms

  2026cites this paper
• Ubiquitin Receptor-Induced Proximity is Sufficient for Ubiquitin-Independent Targeted Protein Degradation via the 26S Proteasome

  2026cites this paper
• Cryo-EM structures of UBA6 reveal mechanisms of E1-E2 specificity and dual FAT10/ubiquitin thioester transfer.

  2026cites this paper
• Fusobacterium nucleatum manipulates host autophagy to promote its intracellular survival and treatment resistance in nasopharyngeal carcinoma.

  2026cites this paper
• UFMylation: biology mechanisms, functions, and clinical implications.

  2026cites this paper
• Cis or trans: a puzzle of Parkin activation mechanism.

  2026cites this paper
• PROTAC-mediated degradation of peroxisomal d-aspartate oxidase: A novel strategy to modulate d-aspartate homeostasis for schizophrenia treatment.

  2026cites this paper
• Tumor PD-L1 induces β2m ubiquitylation and degradation for cancer cell immune evasion

  2026cites this paper
• CB2R-mediated GPX4 stabilization: a new avenue for treating cognitive impairment in elderly migraine patients.

  2026cites this paper
• Molecular insights for the tumor suppressor role of SPOP in prostate cancer.

  2026cites this paper
• Kitasamycin overcomes ferroptosis and immunotherapy resistance by targeting the HUWE1-NCOA4-FTH1 Axis.

  2026cites this paper
• Chemical strategies for trapping fleeting enzymatic complexes in nucleosome ubiquitylation.

  2026cites this paper
• Pancancer Analyses of KISS1 as a Potential Biomarker for Tumor Metastasis and Immunotherapy and Therapeutic Target for Breast Cancer

  2026cites this paper
• F-Box Protein-Mediated Proteolytic Regulation of Phenylpropanoid Metabolism in Response to Biotic and Abiotic Stresses.

  2026cites this paper
• aCBLC-mediated ubiquitin transfer from UBE2L6 to p53 accelerates ovarian cancer development

  2026cites this paper
• Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex

  2026cites this paper
• Obestatin Treatment Counteracts Muscle Wasting by Reactivation of Autophagy in Duchenne Muscular Dystrophy

  2026cites this paper
• Engineering an orthogonal ubiquitin transfer cascade with Ring E3 RNF38 by phage display to reveal its regulation of nuclear transport.

  2026cites this paper
• Research Progress of E3 Ubiquitin Ligase RNF25 in Tumorigenesis and Development

  2026cites this paper
• FBXO6 mediated ubiquitination of SLC3A2 drives ferroptosis in ulcerative colitis: a machine learning and SHAP discovery

  2026cites this paper
• Mechanistic Insights Into the Assembly of Functional CRL3 Dimeric Complexes

  2025cites this paper
• The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin

  2025cites this paper
• Interaction Between Glycoside Hydrolase FsGH28c from Fusarium solani and PnPUB35 Confers Resistance in Piper nigrum

  2025cites this paper
• RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

  2025cites this paper
• E3 ligase Trim63 promotes the chondrogenic differentiation of mesenchymal stem cells by catalyzing K27-linked cysteine ubiquitination of Myh11.

  2025cites this paper
• Global Analysis of Protein and Small-Molecule Substrates of Ubiquitin-Like Proteins

  2025cites this paper
• Perception of viral infections and initiation of antiviral defence in rice

  2025cites this paper
• Can we develop effective direct or indirect inhibitors of transcription factors? On the clinical evolution of protein degraders for multiple myeloma therapy

  2025cites this paper
• Illuminating ubiquitination mechanisms: How cryo-EM has shed light on Cullin RING E3 ligase function.

  2025cites this paper
• The role of ubiquitination and deubiquitination in cancer lipid metabolism

  2025cites this paper
• Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai

  2025cites this paper
• E3 ubiquitin ligase WWP2 regulates stability of the chromatin remodeler ARID1B

  2025cites this paper
• Proteasome Inhibitors: Potential in Rheumatoid Arthritis Therapy?

  2025cites this paper
• Evolution, composition and functions of cullin E3 ubiquitin ligases in trypanosomes

  2025influential citation
• Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response.

  2025cites this paper
• Allosteric zinc inhibition and interdomain regulation govern the catalytic mechanism of the E3-independent ubiquitin-conjugating enzyme hUBE2O

  2025cites this paper
• RNF13 Regulates the Endolysosomal Pathway Through Interaction with the Small GTPase Arl8B

  2025cites this paper
• Targeting the Ubiquitin–Proteasome System for Cancer

  2025cites this paper
• TRIM29 inhibits PRRSV replication by targeting nsp11 for degradation

  2025cites this paper
• Diacetyl-induced bronchiolitis obliterans involves ubiquitin C upregulation and fibrosis-related gene activation in rats

  2025cites this paper
• The multifaceted role of E3 ubiquitin ligases in cancer metastasis: mechanisms, targets, and therapeutic implications

  2025cites this paper
• Dissecting usuranme biquitin-mediated circadian clock regulation in Arabidopsis via high-throughput yeast screens.

  2025cites this paper
• PROTAC‐Based HDAC Degradation: A Paradigm Shift in Targeted Epigenetic Therapies

  2025cites this paper
• Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms

  2025cites this paper
• Unraveling the role of deubiquitinating enzymes on cisplatin resistance in several cancers.

  2025cites this paper
• The Potential of Pharmacological Intervention Targeting NEDD4 in Glioma

  2025cites this paper
• Systematic analysis of the rice E2 ubiquitin-conjugating enzyme family identifies seven genes essential for seed germination

  2025cites this paper
• E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases.

  2025cites this paper
• Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase

  2025cites this paper
• TRIM49 Deficiency Stabilizes a Galectin-3/EGR1 Transcriptional Complex that Drives Invasiveness of Gastric Adenocarcinoma.

  2025cites this paper
• Radiation-induced nuclear translocation of NPRL2 hijacks E3 ubiquitin ligases to enhance DNA repair via the AMPK/WDR24 axis, contributing to CRC radioresistance

  2025cites this paper
• Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control

  2025cites this paper
• Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains

  2025cites this paper
• Truncating Mutations in BBS10 and BBS12 Impair Proteostasis and Ciliary Architecture in Bardet-Biedl Syndrome.

  2025cites this paper
• The Roles of E3 Ubiquitin Ligases in Cerebral Ischemia–Reperfusion Injury

  2025cites this paper
• The ubiquitin code of RAS proteins: Decoding its role in cancer progression

  2025cites this paper
• Genome-wide analysis of the RING-H2 E3 ubiquitin ligase SlATL family in tomato

  2025cites this paper
• Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

  2025cites this paper
• USP39 at the crossroads of cancer immunity: regulating immune evasion and immunotherapy response through RNA splicing and ubiquitin signaling

  2025influential citation
• E3 Ubiquitin Ligase TRIM16-Mediated K63-linked Ubiquitination of DAB2 Enhances Integrin β1 Endocytosis to Facilitate Vascular Calcification.

  2025cites this paper
• Expression and purification of functional recombinant Cullin1-Rbx1/2 in E. coli.

  2025cites this paper
• Linear Ubiquitination of Hemocyanin Mediated by LUBEL Regulates Innate Immunity in Penaeus vannamei

  2025cites this paper
• Arkadia and Ark2C promote substrate ubiquitylation with multiple E2 enzymes.

  2025cites this paper
• Deubiquitylating Enzymes in Hepatocellular Carcinoma

  2025cites this paper
• Therapeutic targeting of ubiquitin-specific protease 7 (USP7): Mechanistic insights, dysregulation, and advances in drug discovery.

  2025cites this paper
• Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination.

  2025cites this paper
• Unveiling the biochemical catalysis and regulatory mechanisms of the E3-independent E2 enzyme hUBE2O

  2025influential citation
• Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes

  2025cites this paper
• Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance

  2025cites this paper
• Mechanisms and Research Methods of Protein Modification in Virus Entry

  2025cites this paper
• MARCH5 Promotes Cardiac Hypertrophy by Regulating Akt/mTOR/Gsk‐3β/GATA4 Signalling Pathway

  2025cites this paper
• Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue

  2025influential citation
• CYLD suppresses infectious Bursal disease virus replication by deubiquitinating VP1.

  2025cites this paper
• Covalent Bifunctional Molecules (CBMs): Achievements and Challenges

  2025cites this paper
• An m6A methyltransferase confers host resistance by degrading viral proteins through ubiquitination

  2025cites this paper
• SPOP Is a Key Trigger of Pathological Cardiac Hypertrophy and Heart Failure.

  2025cites this paper
• How histone modifications influence cellular radiosensitivity: Pharmaceutically targeting epigenetic regulators as a promising avenue to overcome radioresistance

  2025cites this paper
• UBR5: A New Player in Protein Quality Control for Skeletal Muscle Growth and Remodeling

  2025cites this paper
• Genome-Wide Analysis of the HECT-Type E3 Ubiquitin Ligase Gene Family in Nicotiana benthamiana: Evidence Implicating NbHECT6 and NbHECT13 in the Response to Tomato Yellow Leaf Curl Virus Infection

  2025cites this paper
• Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance

  2025cites this paper
• Interplay between ubiquitination and ADP-ribosylation and the case of dual modification ADPr-Ub

  2025influential citation
• Clonal hematopoiesis meets an autoinflammatory disease: the new paradigm of VEXAS syndrome

  2025cites this paper
• Cadmium-triggered degradation of auxin transporters inhibits root elongation in Arabidopsis.

  2025cites this paper
• Ubiquitin choreography in nasopharyngeal carcinoma: USP18 scaffolds radioresistance.

  2025cites this paper
• The Role of Ubiquitination and Deubiquitination in the Pathogenesis of Acute Kidney Injury: Progress in Research

  2025cites this paper
• Recent Developments in Cyclin-Dependent Kinase (CDK) PROTAC in Cancer Therapy.

  2025cites this paper
• The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders

  2025cites this paper
• E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

  2025cites this paper
• The RING-finger domain of Arabidopsis RMR functions as an E3 ligase essential for post-Golgi trafficking

  2025cites this paper
• Complexes Formed by the K63-Specific Deubiquitinating Enzyme BRCC36: New Promising Therapeutic Targets in Human Disease

  2025cites this paper
• TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains

  2025cites this paper
• NEDD4 signaling: a new frontier in the diagnosis and treatment of breast and ovarian cancers

  2025influential citation
• NEDD4–Mediated GSNOR Degradation Aggravates Cardiac Hypertrophy and Dysfunction

  2025cites this paper
• NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets

  2025cites this paper
• TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression

  2025cites this paper
• USP25 directly interacts with and deubiquitinates PPARα to increase PPARα stability in hepatocytes and attenuate high-fat diet-induced MASLD in mice

  2025cites this paper