p53-Dependent Elevation of p21Waf1Expression by UV Light Is Mediated through mRNA Stabilization and Involves a Vanadate-Sensitive Regulatory System

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Molecular and Cellular Biology

• Publication date

  1998-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.18.3.1400PMID 9488455PMCID PMC108853
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells

  1997cited by this paper
• p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

  1997cited by this paper
• CREB is activated by UVC through a p38/HOG‐1‐dependent protein kinase

  1997cited by this paper
• p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells.

  1997cited by this paper
• Protein kinase cascades activated by stress and inflammatory cytokines

  1996cited by this paper
• UV activation of mammalian stress proteins.

  1996cited by this paper
• Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

  1996cited by this paper
• The stress activated protein kinase pathway.

  1996cited by this paper
• Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation.

  1996cited by this paper
• The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat.

  1996cited by this paper
• Peroxisome proliferators activate Kupffer cells in vivo.

  1996cited by this paper
• Role of p21 in prostaglandin A2-mediated cellular arrest and death.

  1996influential reference
• Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

  1996cited by this paper
• Activation of mammalian gene expression by the UV component of sunlight – from models to reality

  1996cited by this paper
• Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein (*)

  1996influential reference
• Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells

  1996cited by this paper
• Signaling events controlling the molecular response to genotoxic stress.

  1996cited by this paper
• p21WAF1/CIP1/SDI1 is elevated through a p53-independent pathway by mimosine.

  1996cited by this paper
• Wild-type p53 negatively regulates the expression of a microtubule-associated protein.

  1996cited by this paper
• The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c‐fos transcription in response to UV light.

  1996cited by this paper
• p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine.

  1996cited by this paper
• Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway.

  1996cited by this paper
• UV activation of mammalian stress protiens

  1996cited by this paper
• The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation.

  1996cited by this paper
• The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells

  1996cited by this paper
• P53 and its implication in apoptosis (review).

  1995cited by this paper
• p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.

  1995cited by this paper
• A conserved family of elav-like genes in vertebrates.

  1995cited by this paper
• Diversity of cytoplasmic functions for the 3' untranslated region of eukaryotic transcripts.

  1995cited by this paper
• Irradiation Induces WAF1 Expression through a p53-independent Pathway in KG-1 Cells (*)

  1995cited by this paper
• Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

  1995cited by this paper
• A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress *

  1995cited by this paper
• Transcription factor ATF2 regulation by the JNK signal transduction pathway

  1995cited by this paper
• Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers.

  1994cited by this paper
• Evidence for a p53‐independent pathway for upregulation of SDI1/CIP1/WAF1/P21 RNA in human cells

  1994cited by this paper
• Molecular cloning, sequencing, chromosomal localization and expression of mouse p21 (Waf1).

  1994cited by this paper
• Degradation of unstable interleukin-1 alpha mRNA in a rabbit reticulocyte cell-free system. Localization of an instability determinant to a cluster of AUUUA motifs.

  1994cited by this paper
• Induction of WAF1/CIP1 by a p53-independent pathway.

  1994cited by this paper
• Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.

  1994cited by this paper
• Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes.

  1994cited by this paper
• Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Genomic sequencing.

  1993cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993influential reference
• Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

  1993cited by this paper
• The regulation of transcription by phosphorylation.

  1992cited by this paper
• Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein.

  1991cited by this paper
• A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore.

  1991cited by this paper
• The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

  1991cited by this paper
• A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.

  1986cited by this paper
• Genomic sequencing.

  1984cited by this paper
• Transcriptional regulation of hemoglobin switching in chicken embryos

  1981cited by this paper

• MBNL2 Regulates DNA Damage Response via Stabilizing p21

  2021cites this paper
• Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer.

  2021cites this paper
• RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21

  2019cites this paper
• HuR stabilizes a polyadenylated form of replication‐dependent histone mRNAs under stress conditions

  2018cites this paper
• HuR stabilizes TFAM mRNA in an ATM/p38‐dependent manner in ionizing irradiated cancer cells

  2018cites this paper
• Thiol-linked alkylation for the metabolic sequencing of RNA

  2017cites this paper
• Thiol-linked alkylation for the metabolic sequencing of RNA (SLAMseq)

  2017cites this paper
• “Stockpile” of Slight Transcriptomic Changes Determines the Indirect Genotoxicity of Low-Dose BPA in Thyroid Cells

  2016cites this paper
• A Multi-Component Reaction to 6-Aminothiouracils: Synthesis, MechanisticStudy and Antitumor Activity

  2016cites this paper
• Alternative role of HuD splicing variants in neuronal differentiation

  2015cites this paper
• Poly(ADP-ribosyl)ation of p53 Contributes to TPEN-Induced Neuronal Apoptosis

  2015cites this paper
• Post-Transcriptional Regulation of DNA Damage-Responsive Gene Expression

  2014influential citation
• ATR controls the UV‐related upregulation of the CDKN1A mRNA in a Cdk1/HuR‐dependent manner

  2014cites this paper
• IL-12-dependent innate immunity arrests endothelial cells in G0–G1 phase by a p21Cip1/Waf1-mediated mechanism

  2012cites this paper
• Genome-wide technology for determining RNA stability in mammalian cells

  2012cites this paper
• The p53 circuit board.

  2012cites this paper
• Manganese induces p21 expression in PC12 cells at the transcriptional level.

  2012cites this paper
• Berberine potentizes apoptosis induced by X-rays irradiation probably through modulation of gap junctions.

  2011cites this paper
• p21WAF1/CIP1 Upregulation through the Stress Granule-Associated Protein CUGBP1 Confers Resistance to Bortezomib-Mediated Apoptosis

  2011cites this paper
• MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3′ untranslated region

  2011cites this paper
• Grape seed extract upregulates p21 (Cip1) through redox‐mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells

  2011cites this paper
• The role of mRNA decay in p53-induced gene expression.

  2011cites this paper
• The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability

  2010cites this paper
• Regulation of mRNA Turnover by Cellular Stress

  2010cites this paper
• Targeting p21-Dependent Pathways for Cell Death in Cancer Therapy

  2010cites this paper
• Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA

  2010cites this paper
• Beryllium sulfate induces p21CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types

  2010cites this paper
• Molecular characterization of novel interferon gamma receptor 1 isoforms in zebrafish (Danio rerio) and goldfish (Carassius auratus L.).

  2009cites this paper
• Metabolic tagging and purification of nascent RNA: implications for transcriptomics.

  2009cites this paper
• Analysis of high throughput data - protein protein interactions, protein complexes and RNA half life

  2009cites this paper
• Conserved principles of mammalian transcriptional regulation revealed by RNA half-life

  2009cites this paper
• p21Cip1 expression is increased in ambient oxygen, compared to estimated physiological (5%) levels in rat muscle precursor cell culture

  2008influential citation
• The role of corneal crystallins in the cellular defense mechanisms against oxidative stress.

  2008cites this paper
• Posttranscriptional regulation of p53 and its targets by RNA-binding proteins.

  2008cites this paper
• Regulation of the Arf tumor suppressor by E2F transcription factors

  2007cites this paper
• Post-transcriptional Regulation of RNase-L Expression Is Mediated by the 3′-Untranslated Region of Its mRNA*

  2007cites this paper
• The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light

  2006influential citation
• Up-regulation of p21WAF1 expression is mediated by Sp1/Sp3 transcription factors in TGFbeta1-arrested malignant B cells.

  2006cites this paper
• Genome wide analysis of dna repair by expression profiling

  2006cites this paper
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  2006cites this paper
• RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript.

  2006cites this paper
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  2006cites this paper
• Regulation of protease and protease inhibitor gene expression: the role of the 3'-UTR and lessons from the plasminogen activating system.

  2005cites this paper
• Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T Cells*

  2005cites this paper
• Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability

  2005cites this paper
• Involvement of Hu and Heterogeneous Nuclear Ribonucleoprotein K in Neuronal Differentiation through p21 mRNA Post-transcriptional Regulation*

  2005cites this paper
• p21WAF/CIP1/SDI1 is upregulated due to increased mRNA stability during hydroxyurea-induced senescence of human fibroblasts.

  2005cites this paper
• Cdk2-dependent Inhibition of p21 Stability via a C-terminal Cyclin-binding Motif*

  2005cites this paper
• Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.

  2005cites this paper
• The Role and Regulation of p21 in Myelopoiesis

  2005cites this paper
• Post‐transcriptional regulation in cancer

  2004cites this paper
• The ARE‐dependent mRNA‐destabilizing activity of BRF1 is regulated by protein kinase B

  2004cites this paper
• Prostaglandin A2-mediated Stabilization of p21 mRNA through an ERK-dependent Pathway Requiring the RNA-binding Protein HuR*

  2004cites this paper
• Role of the RNA-binding protein HuR in colon carcinogenesis

  2003cites this paper
• The 3′-Untranslated Region of p21WAF1 mRNA Is a Composite cis-Acting Sequence Bound by RNA-binding Proteins from Breast Cancer Cells, Including HuR and Poly(C)-binding Protein*

  2003cites this paper
• CHAPTER 312 – Regulation of mRNA Turnover by Cellular Stress

  2003cites this paper
• p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner.

  2003cites this paper
• p53 activates ICAM‐1 (CD54) expression in an NF‐κB‐independent manner

  2003cites this paper
• Role of HuR in Skeletal Myogenesis through Coordinate Regulation of Muscle Differentiation Genes

  2003cites this paper
• TPA activates p21WAF-1 promoter in human T-cells through its second most upstream Sp1 site.

  2003cites this paper
• Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate.

  2003cites this paper
• Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

  2003cites this paper
• Role of protein kinase C and the Sp1-p53 complex in activation of p21(WAF-1) expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells.

  2003cites this paper
• Hu protein R-mediated posttranscriptional regulation of VEGF expression in rat gastrocnemius muscle.

  2002influential citation
• Small Proline-Rich Repeat Protein 1A Is Expressed by Axotomized Neurons and Promotes Axonal Outgrowth

  2002cites this paper
• AMP-Activated Kinase Regulates Cytoplasmic HuR

  2002cites this paper
• Fibrillarin binds to a 3' cis-regulatory element in pre-mRNA of uvi15+ in fission yeast.

  2002cites this paper
• Identification of Promoter Elements Responsible for Transcriptional Inhibition of Polo-like Kinase 1 and Topoisomerase IIα Genes by p21WAF1/CIP1/ SDI1

  2002cites this paper
• Global analysis of stress-regulated mRNA turnover by using cDNA arrays

  2002cites this paper
• Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression.

  2002cites this paper
• Proliferate and survive: cell division cycle and apoptosis in human neuroblastoma.

  2002cites this paper
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  2002cites this paper
• Induction of p21 mRNA Synthesis After Short-wavelength UV Light Visualized in Individual Cells by RNA FISH

  2002cites this paper
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  2001cites this paper
• p21 gene regulation during enterocyte differentiation.

  2001cites this paper
• HuR and mRNA stability

  2001cites this paper
• p53-independent elevation of p21 expression by PMA results from PKC-mediated mRNA stabilization.

  2001cites this paper
• p53 protein accumulation in addition to the transactivation activity is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin

  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
• Rays and arrays: the transcriptional program in the response of human epidermal keratinocytes to UVB illumination

  2001cites this paper
• Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.

  2001cites this paper
• Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle.

  2000cites this paper
• RNase-L-dependent Destabilization of Interferon-induced mRNAs

  2000cites this paper
• mdm2 mRNA Level is a Prognostic Factor in Soft Tissue Sarcoma

  2000cites this paper
• CHOP/GADD153 Gene Expression Response to Cellular Stresses Inhibited by Prior Exposure to Ultraviolet Light Wavelength Band C (UVC)

  2000cites this paper
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  2000cites this paper
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  2000influential citation
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper