A new angle on blood–CNS interfaces: A role for connexins?

No abstract is available for this paper.

• Publication year

  2014

• Venue

  FEBS Letters

• Publication date

  2014-04-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2014.02.060PMID 24631535
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clinical problem-solving. Kiss of death.

  2018cited by this paper
• A critical role for pannexin-1 in activation of innate immune cells of the choroid plexus

  2014cited by this paper
• Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study.

  2014cited by this paper
• Endothelial calcium dynamics, connexin channels and blood-brain barrier function.

  2013cited by this paper
• Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach

  2013cited by this paper
• High glucose-induced downregulation of connexin 30.2 promotes retinal vascular lesions: implications for diabetic retinopathy.

  2013cited by this paper
• Injection of neural progenitor cells attenuates decrease in level of connexin 43 in brain capillaries after cerebral ischemia.

  2013cited by this paper
• GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord

  2013cited by this paper
• Tanycyte‐like cells form a blood–cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

  2013cited by this paper
• Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules.

  2013cited by this paper
• Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells.

  2013cited by this paper
• Transporters of the blood-brain and blood-CSF interfaces in development and in the adult.

  2013cited by this paper
• How calcium signals in myocytes and pericytes are integrated across in situ microvascular networks and control microvascular tone☆

  2013cited by this paper
• Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

  2013cited by this paper
• Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?

  2013cited by this paper
• Paracrine signaling through plasma membrane hemichannels.

  2013cited by this paper
• Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates

  2013cited by this paper
• Low extracellular Ca 2 þ conditions induce an increase in brain endothelial permeability that involves intercellular Ca 2 þ waves

  2012cited by this paper
• Tuning Electrical Conduction Along Endothelial Tubes of Resistance Arteries Through Ca2+-Activated K+ Channels

  2012cited by this paper
• Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia.

  2012cited by this paper
• Hemichannels: permeants and their effect on development, physiology and death

  2012cited by this paper
• Spatial Domains of Progenitor‐Like Cells and Functional Complexity of a Stem Cell Niche in the Neonatal Rat Spinal Cord

  2012cited by this paper
• Downregulation of mitochondrial connexin 43 by high glucose triggers mitochondrial shape change and cytochrome C release in retinal endothelial cells.

  2012cited by this paper
• Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

  2012cited by this paper
• Cerebrospinal Fluid Glucose and Lactate: Age-Specific Reference Values and Implications for Clinical Practice

  2012cited by this paper
• Spreading the signal for vasodilatation: implications for skeletal muscle blood flow control and the effects of ageing

  2012cited by this paper
• Deletion of Astroglial Connexins Weakens the Blood–Brain Barrier

  2012cited by this paper
• Connexin and pannexin hemichannels in inflammatory responses of glia and neurons.

  2012cited by this paper
• Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+ Oscillations by Providing a Bimodal Ca2+-dependent Ca2+ Entry Pathway*

  2012cited by this paper
• Matrix Metalloprotease 8-Dependent Extracellular Matrix Cleavage at the Blood–CSF Barrier Contributes to Lethality during Systemic Inflammatory Diseases

  2012cited by this paper
• Gap junctions and blood-tissue barriers.

  2012cited by this paper
• Intercellular Ca(2+) waves: mechanisms and function.

  2012cited by this paper
• Tight Junction in Blood‐Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

  2012cited by this paper
• The effect of connexin43 on the level of vascular endothelial growth factor in human retinal pigment epithelial cells

  2012cited by this paper
• The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System

  2012cited by this paper
• Complexity and developmental changes in the expression pattern of claudins at the blood–CSF barrier

  2012cited by this paper
• Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

  2012cited by this paper
• Astrocytes acquire morphological and functional characteristics of ependymal cells following disruption of ependyma in hydrocephalus

  2012cited by this paper
• Angiopoietin-1 is associated with cerebral vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage

  2011cited by this paper
• Transcriptome signature of the adult mouse choroid plexus

  2011cited by this paper
• Purine receptors and Ca2+ signalling in the human blood–brain barrier endothelial cell line hCMEC/D3

  2011cited by this paper
• Alteration of connexin expression is an early signal for chronic kidney disease.

  2011cited by this paper
• Blood-Retinal Barrier

  2011cited by this paper
• Response of retinal Connexin43 to optic nerve injury.

  2011cited by this paper
• Connexin Channels Provide a Target to Manipulate Brain Endothelial Calcium Dynamics and Blood—Brain Barrier Permeability

  2011influential reference
• Tight junctions in neurological diseases.

  2011cited by this paper
• Central nervous system pericytes in health and disease

  2011cited by this paper
• ATP-mediated glucosensing by hypothalamic tanycytes

  2011cited by this paper
• Integration of tight junctions and claudins with the barrier functions of the retinal pigment epithelium.

  2011cited by this paper
• Connexon‐mediated cell adhesion drives microtissue self‐assembly

  2011cited by this paper
• The blood–spinal cord barrier: Morphology and Clinical Implications

  2011cited by this paper
• Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice.

  2010cited by this paper
• Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells.

  2010cited by this paper
• Müller cells in the healthy and diseased retina.

  2010cited by this paper
• Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches.

  2010cited by this paper
• Structure and function of the blood-brain barrier.

  2010influential reference
• Astroglial Wiring is Adding Complexity to Neuroglial Networking

  2010cited by this paper
• Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses

  2010cited by this paper
• The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: the former opens to the portal blood and the latter to the cerebrospinal fluid.

  2010cited by this paper
• Differential distribution of tight junction proteins suggests a role for tanycytes in blood‐hypothalamus barrier regulation in the adult mouse brain

  2010cited by this paper
• Involvement of the Cytoplasmic C-Terminal Domain of Connexin43 in Neuronal Migration

  2009cited by this paper
• Choroid Plexus Connexin 43 Expression and Gap Junction Flexibility Are Associated with Clinical Features of Acute EAE

  2009cited by this paper
• The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

  2009cited by this paper
• Ultrastructural descriptions of pericyte/endothelium peg-socket interdigitations in the microvasculature of human gastric carcinomas.

  2009cited by this paper
• Aquaporin-4 maintains ependymal integrity in adult mice.

  2009cited by this paper
• Reciprocal influence of connexins and apical junction proteins on their expressions and functions.

  2009cited by this paper
• Ependymal cells: biology and pathology

  2009influential reference
• High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells.

  2009cited by this paper
• Connexin 43 and plakophilin-2 as a protein complex that regulates blood–testis barrier dynamics

  2009cited by this paper
• Kinetic Profile of the Transcriptome Changes Induced in the Choroid Plexus by Peripheral Inflammation

  2009cited by this paper
• Hemichannels in cerebral ischemia.

  2009cited by this paper
• Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

  2009cited by this paper
• Reproductive hormones regulate the selective permeability of the blood-brain barrier.

  2008cited by this paper
• Adhesive properties of connexin hemichannels

  2008cited by this paper
• Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury.

  2008cited by this paper
• Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading*

  2008cited by this paper
• Connexons and cell adhesion: a romantic phase

  2008cited by this paper
• Role of Gap Junctions in Embryonic and Somatic Stem Cells

  2008cited by this paper
• Choroid Plexus–Cerebrospinal Fluid Circulatory Dynamics: Impact on Brain Growth, Metabolism, and Repair

  2008cited by this paper
• Connexin43 antisense oligodeoxynucleotide treatment down-regulates the inflammatory response in an in vitro interphase organotypic culture model of optic nerve ischaemia.

  2008cited by this paper
• Taurine suppresses the spread of cell death in electrically coupled RPE cells

  2008influential reference
• Barriers in the brain: a renaissance?

  2008cited by this paper
• Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo.

  2008cited by this paper
• Connexins Induce and Maintain Tight Junctions in Epithelial Cells

  2007cited by this paper
• Transforming growth factor-beta 1 impairs endothelin-1-mediated contraction of brain vessels by inducing mitogen-activated protein (MAP) kinase phosphatase-1 and inhibiting p38 MAP kinase.

  2007cited by this paper
• What is the blood-brain barrier (not)?

  2007cited by this paper
• Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential

  2007cited by this paper
• Cell–cell Signaling in the Neurovascular Unit

  2007cited by this paper
• A Novel Role for Connexin Hemichannel in Oxidative Stress and Smoking-Induced Cell Injury

  2007cited by this paper
• Pericytes from Brain Microvessels Strengthen the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells

  2007cited by this paper
• Endothelial connexin 37, connexin 40, and connexin 43 respond uniquely to substrate and shear stress.

  2007cited by this paper
• Cx43 Hemichannels and Gap Junction Channels in Astrocytes Are Regulated Oppositely by Proinflammatory Cytokines Released from Activated Microglia

  2007cited by this paper
• Gap junction adhesion is necessary for radial migration in the neocortex

  2007cited by this paper
• Development of the blood-brain barrier: a historical point of view.

  2006cited by this paper
• Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells

  2006cited by this paper
• Localization of Ang-1, -2, Tie-2, and VEGF expression at endothelial-pericyte interdigitation in rat angiogenesis

  2006cited by this paper
• Functional effectiveness of the blood‐brain barrier to small water‐soluble molecules in developing and adult opossum (Monodelphis domestica)

  2006cited by this paper
• The Unstoppable Connexin43 Carboxyl‐Terminus

  2006cited by this paper
• Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins 37 and 40.

  2006cited by this paper
• Connexin43 is required for production of the aqueous humor in the murine eye

  2006influential reference

• Efficient nose-to-brain delivery of chitosan-coated resveratrol nanoemulsion in rats: Formulation optimized using D-optimal mixture design

  2025cites this paper
• Choroid plexus: Insights from distinct epithelial cellular components.

  2025cites this paper
• Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice

  2024cites this paper
• Choroid plexus enlargement in patients with end-stage renal disease: implications for glymphatic system dysfunction

  2024cites this paper
• Relationship between tight junctions of the BBB and astrocyte connective function in epilepsy: Albumin and astrocyte activation

  2024cites this paper
• Structural and molecular characterization of astrocyte and vasculature connectivity in the mouse hippocampus and cortex

  2024cites this paper
• Microglia and Brain Disorders: The Role of Vitamin D and Its Receptor

  2023cites this paper
• Deciphering the role of nanocarrier-based nucleic acid delivery to the brain for the management of neurodegenerative disorders

  2023cites this paper
• Engineering choroid plexus-on-a-chip with oscillatory flow for modeling brain metastasis

  2023cites this paper
• Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging

  2023cites this paper
• Axonal ion homeostasis and glial differentiation

  2022cites this paper
• The choroid plexus and its role in the pathogenesis of neurological infections

  2022cites this paper
• Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

  2022cites this paper
• High-Precision Isotopic Analysis of Cu and Fe via Multi-Collector Inductively Coupled Plasma-Mass Spectrometry Reveals Lipopolysaccharide-Induced Inflammatory Effects in Blood Plasma and Brain Tissues

  2022cites this paper
• Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model

  2021cites this paper
• Mutant Cx30-A88V mice exhibit hydrocephaly and sex-dependent behavioral abnormalities, implicating a functional role for Cx30 in the brain

  2021cites this paper
• Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain

  2021cites this paper
• The Role of Microglia in Glioblastoma

  2021cites this paper
• Role of the Choroid Plexus in Health and Disease

  2020cites this paper
• Changes in the choroid plexuses and brain barriers associated with high blood pressure and ageing.

  2020cites this paper
• Brain Disorders and Chemical Pollutants: A Gap Junction Link? †

  2020influential citation
• Cx43 and the Actin Cytoskeleton: Novel Roles and Implications for Cell-Cell Junction-Based Barrier Function Regulation

  2020cites this paper
• Treating brain diseases using systemic parenterally-administered protein therapeutics: Dysfunction of the brain barriers and potential strategies.

  2020cites this paper
• Lanthanum chloride causes blood-brain barrier disruption through intracellular calcium-mediated RhoA/Rho kinase signaling and myosin light chain kinase.

  2020cites this paper
• A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury

  2020cites this paper
• Structural and Functional Remodeling of the Brain Vasculature Following Stroke

  2020cites this paper
• Neuroimaging considerations when investigating choroid plexus morphology in idiopathic psychosis.

  2020cites this paper
• Role of connexins in spinal cord injury: An update.

  2020cites this paper
• Roles of the Choroid Plexus in Aging

  2020cites this paper
• Behavioral research in zebrafish (Danio rerio): strain as source of variation

  2020cites this paper
• Glial connexins and pannexins in the healthy and diseased brain.

  2020cites this paper
• Current insights on lipid nanocarrier-assisted drug delivery in the treatment of neurodegenerative diseases.

  2020cites this paper
• Synaptic Functions of Astroglial Hemichannels

  2019cites this paper
• Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides

  2019cites this paper
• Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery

  2019cites this paper
• Neurotoxicity concern about the brain targeting delivery systems

  2019cites this paper
• The Importance and Control of Low-Grade Inflammation Due to Damage of Cellular Barrier Systems That May Lead to Systemic Inflammation

  2019influential citation
• Association of Choroid Plexus Enlargement With Cognitive, Inflammatory, and Structural Phenotypes Across the Psychosis Spectrum.

  2019cites this paper
• Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

  2019cites this paper
• Studies on structural and functional changes of mouse choroid plexus in the initiation of neuroinflammation

  2019cites this paper
• Neural activity regulates autoimmune diseases through the gateway reflex

  2019cites this paper
• Interferons: a molecular switch between damage and repair in ageing and Alzheimer's disease.

  2019cites this paper
• Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells.

  2019cites this paper
• Clinical and neuroimaging disparity between Chinese and German patients with cerebral small vessel disease: a comparative study

  2019cites this paper
• Advancement of polymer–based nanoparticles as smart drug delivery systems in neurodegenerative medicine

  2019cites this paper
• Changes in the choroid plexuses and brain barriers associated with high blood pressure and ageing.

  2018cites this paper
• Sustained Connexin43 Mimetic Peptide Release From Loaded Nanoparticles Reduces Retinal and Choroidal Photodamage.

  2018cites this paper
• Connexins and Pannexins in cerebral ischemia.

  2018cites this paper
• The choroid plexus is an important circadian clock component

  2018cites this paper
• Choroid Plexus Blood-CSF Barrier: Major Player in Brain Disease Modeling and Neuromedicine

  2018cites this paper
• Brain endothelial cell junctions after cerebral hemorrhage: Changes, mechanisms and therapeutic targets

  2018cites this paper
• Loss of Cx43-Mediated Functional Gap Junction Communication in Meningeal Fibroblasts Following Mouse Hepatitis Virus Infection

  2018cites this paper
• Connexin 30 is expressed in a subtype of mouse brain pericytes

  2017cites this paper
• Inhibitors of connexin and pannexin channels as potential therapeutics

  2017cites this paper
• Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

  2017cites this paper
• Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain

  2017cites this paper
• Microglia-glioma cross-talk: a two way approach to new strategies against glioma.

  2017cites this paper
• Estudio del transporte de sustancias a través de la barrera hematoencefálica mediante el anticuerpo 8D3 dirigido contra el receptor de transferrina

  2017cites this paper
• The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection.

  2017cites this paper
• Retinal biomarkers provide “insight” into cortical pharmacology and disease☆,☆☆

  2017cites this paper
• Connexins and their channels in inflammation

  2016cites this paper
• The effect of aging on brain barriers and the consequences for Alzheimer’s disease development

  2016cites this paper
• Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability

  2016cites this paper
• Current advances in cell electrophysiology: applications for the analysis of intercellular communications within the neurovascular unit

  2016cites this paper
• Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.

  2016cites this paper
• Into rather unexplored terrain—transcellular transport across the blood–brain barrier

  2016cites this paper
• Fibroblast activation protein‐α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations

  2016cites this paper
• 'Stealth' nanoparticles evade neural immune cells but also evade major brain cell populations: Implications for PEG-based neurotherapeutics.

  2016cites this paper
• Quinckes' pioneering 19th centuries CSF studies may inform 21th centuries research.

  2015cites this paper
• Hemichannels: new pathways for gliotransmitter release.

  2015cites this paper
• *Graphical Abstract ‘Stealth’ nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics

  2015cites this paper
• Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas.

  2015cites this paper
• NEUROSCIENCE FOREFRONT REVIEW HEMICHANNELS: NEW PATHWAYS FOR GLIOTRANSMITTER RELEASE

  2015cites this paper
• Connexin: a potential novel target for protecting the central nervous system?

  2015influential citation
• Contribution of Pannexin 1 and Connexin 43 Hemichannels to Extracellular Calcium–Dependent Transport Dynamics in Human Blood-Brain Barrier Endothelial Cells

  2015cites this paper
• Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases

  2015influential citation
• Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders.

  2015cites this paper
• Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders.

  2015cites this paper
• Immunological barriers: Functional histology of the spleen.

  2015cites this paper
• Maternal treatment with glucocorticoids modulates gap junction protein expression in the ovine fetal brain.

  2014cites this paper
• Immune Responses to Non-Tumor Antigens in the Central Nervous System

  2014influential citation
• Closing the gap between glia and neuroblast proliferation.

  2014cites this paper
• Connexins and Disease

  1996cites this paper
• DIFFERENT PATTERNS OF Ca SIGNALING DRIVE ACETYLCHOLINE AND GLUTAMATE INDUCED-NO RELEASE IN MOUSE AND HUMAN BRAIN MICROVASCULAR ENDOTHELIAL CELLS

  year unknowncites this paper