Cellular DNA replicases: components and dynamics at the replication fork.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Annual Review of Biochemistry

• Publication date

  2005-06-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/ANNUREV.BIOCHEM.73.011303.073859PMID 15952889
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• NMR solution structure of the θ subunit of DNA polymerase III from Escherichia coli

  2008cited by this paper
• Opposing Effects of Ubiquitin Conjugation and SUMO Modification of PCNA on Replicational Bypass of DNA Lesions in Saccharomyces cerevisiae

  2004cited by this paper
• Identification of specific amino acid residues in the E. coli beta processivity clamp involved in interactions with DNA polymerase III, UmuD and UmuD'.

  2004cited by this paper
• Distinct roles of DNA polymerases delta and epsilon at the replication fork in Xenopus egg extracts

  2004cited by this paper
• The theta subunit of Escherichia coli DNA polymerase III: a role in stabilizing the epsilon proofreading subunit.

  2004cited by this paper
• Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae.

  2004cited by this paper
• Structural and biochemical analysis of sliding clamp/ligand interactions suggest a competition between replicative and translesion DNA polymerases.

  2004cited by this paper
• Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.

  2004cited by this paper
• The θ Subunit of Escherichia coli DNA Polymerase III: a Role in Stabilizing the ε Proofreading Subunit

  2004cited by this paper
• DNA Polymerase γ, The Mitochondrial Replicase1

  2004cited by this paper
• Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

  2004cited by this paper
• Mechanism of Loading the Escherichia coli DNA Polymerase III Sliding Clamp

  2004cited by this paper
• Mechanisms of replication fork restart in Escherichia coli.

  2004cited by this paper
• The Pol32 Subunit of DNA Polymerase δ Contains Separable Domains for Processive Replication and Proliferating Cell Nuclear Antigen (PCNA) Binding*

  2004cited by this paper
• Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex

  2004cited by this paper
• Functional Uncoupling of Twin Polymerases

  2004cited by this paper
• Eukaryotic MCM Proteins: Beyond Replication Initiation

  2004cited by this paper
• The PCNA-RFC families of DNA clamps and clamp loaders.

  2004cited by this paper
• Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding.

  2004cited by this paper
• Mechanism of Loading the Escherichia coli DNA Polymerase III Sliding Clamp

  2004cited by this paper
• DNA polymerase gamma, the mitochondrial replicase.

  2004cited by this paper
• Noncompetitive Counteractions of DNA Polymerase ε and ISW2/yCHRAC for Epigenetic Inheritance of Telomere Position Effect in Saccharomyces cerevisiae

  2004cited by this paper
• The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit.

  2004cited by this paper
• The Protein Components and Mechanism of Eukaryotic Okazaki Fragment Maturation

  2003cited by this paper
• Schizosacchromyces pombe Dpb2 binds to origin DNA early in S phase and is required for chromosomal DNA replication.

  2003cited by this paper
• Proliferating cell nuclear antigen (PCNA): a dancer with many partners

  2003cited by this paper
• Substrate Requirements for Duplex DNA Translocation by the Eukaryal and Archaeal Minichromosome Maintenance Helicases*

  2003cited by this paper
• ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C

  2003cited by this paper
• Elucidation of the epsilon-theta subunit interface of Escherichia coli DNA polymerase III by NMR spectroscopy.

  2003cited by this paper
• Mechanism of the δ Wrench in Opening the β Sliding Clamp*

  2003cited by this paper
• Competitive processivity‐clamp usage by DNA polymerases during DNA replication and repair

  2003cited by this paper
• The Quaternary Structure of DNA Polymerase ε from Saccharomyces cerevisiae *

  2003cited by this paper
• Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint

  2003cited by this paper
• Chromosomal replicases as asymmetric dimers: studies of subunit arrangement and functional consequences

  2003cited by this paper
• Mechanism of the E. coli tau processivity switch during lagging-strand synthesis.

  2003cited by this paper
• Mcm4,6,7 Uses a “Pump in Ring” Mechanism to Unwind DNA by Steric Exclusion and Actively Translocate along a Duplex*

  2003cited by this paper
• Three-Dimensional Structure of the p Subunit of E . coli DNA Polymerase Ill Haloenzyme : A Sliding DNA Clamp

  2003cited by this paper
• A peptide switch regulates DNA polymerase processivity

  2003cited by this paper
• Ordered ATP hydrolysis in the gamma complex clamp loader AAA+ machine.

  2003cited by this paper
• GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.

  2003cited by this paper
• Reconstitution of the Mcm2-7p Heterohexamer, Subunit Arrangement, and ATP Site Architecture*

  2003cited by this paper
• Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA

  2003cited by this paper
• Mechanism of the delta wrench in opening the beta sliding clamp.

  2003cited by this paper
• Fate of DNA replication fork encountering a single DNA lesion during oriC plasmid DNA replication in vitro

  2003cited by this paper
• Architecture of the Replication Complex and DNA Loops at the Fork Generated by the Bacteriophage T4 Proteins*

  2003cited by this paper
• Elg1 forms an alternative RFC complex important for DNA replication and genome integrity

  2003cited by this paper
• A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication.

  2003cited by this paper
• Replication Factor C Clamp Loader Subunit Arrangement within the Circular Pentamer and Its Attachment Points to Proliferating Cell Nuclear Antigen*

  2003cited by this paper
• Okazaki Fragment Maturation in Yeast

  2003cited by this paper
• Ordered ATP Hydrolysis in the γ Complex Clamp Loader AAA+ Machine*

  2003cited by this paper
• Archaeal DNA Replication: Eukaryal Proteins in a Bacterial Context

  2003cited by this paper
• The structure and function of MCM from archaeal M. Thermoautotrophicum

  2003cited by this paper
• Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability.

  2003cited by this paper
• Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp.

  2003cited by this paper
• Okazaki Fragment Maturation in Yeast

  2003cited by this paper
• Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

  2003cited by this paper
• Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the β‐clamp

  2003cited by this paper
• Replication protein A-mediated recruitment and activation of Rad17 complexes

  2003cited by this paper
• Fidelity of DNA polymerase delta holoenzyme from Saccharomyces cerevisiae: the sliding clamp proliferating cell nuclear antigen decreases its fidelity.

  2003cited by this paper
• Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit.

  2003cited by this paper
• Motors and switches: AAA+ machines within the replisome

  2002cited by this paper
• DNA replication in eukaryotic cells.

  2002cited by this paper
• Fidelity of DNA Polymerase ε Holoenzyme from Budding YeastSaccharomyces cerevisiae *

  2002cited by this paper
• Eukaryotic DNA polymerases.

  2002cited by this paper
• On the Specificity of Interaction between the Saccharomyces cerevisiae Clamp Loader Replication Factor C and Primed DNA Templates during DNA Replication*

  2002cited by this paper
• Replication fork reversal in DNA polymerase III mutants of Escherichia coli: a role for the β clamp

  2002cited by this paper
• In vivo reconstitution of Saccharomyces cerevisiae DNA polymerase epsilon in insect cells. Purification and characterization.

  2002cited by this paper
• DnaB drives DNA branch migration and dislodges proteins while encircling two DNA strands.

  2002cited by this paper
• Structural basis for proofreading during replication of the Escherichia coli chromosome.

  2002cited by this paper
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

  2002cited by this paper
• Reconstitution of human DNA polymerase delta using recombinant baculoviruses: the p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme.

  2002cited by this paper
• Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae.

  2002cited by this paper
• The Influence of the Cdc27 Subunit on the Properties of theSchizosaccharomyces pombe DNA Polymerase δ*

  2002cited by this paper
• The DNA Polymerase Domain of polε Is Required for Rapid, Efficient, and Highly Accurate Chromosomal DNA Replication, Telomere Length Maintenance, and Normal Cell Senescence inSaccharomyces cerevisiae *

  2002cited by this paper
• The A20R Protein Is a Stoichiometric Component of the Processive Form of Vaccinia Virus DNA Polymerase

  2001cited by this paper
• Crystal Structure of the Processivity Clamp Loader Gamma ( ) Complex of E. coli DNA Polymerase III

  2001cited by this paper
• A universal protein–protein interaction motif in the eubacterial DNA replication and repair systems

  2001cited by this paper
• Interaction of the β sliding clamp with MutS, ligase, and DNA polymerase I

  2001cited by this paper
• τ Binds and Organizes Escherichia coli Replication Proteins through Distinct Domains

  2001cited by this paper
• τ Binds and Organizes Escherichia coli Replication Proteins through Distinct Domains

  2001cited by this paper
• Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures.

  2001cited by this paper
• Mechanism of β Clamp Opening by the δ Subunit ofEscherichia coli DNA Polymerase III Holoenzyme*

  2001cited by this paper
• Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication.

  2001cited by this paper
• Carboxyl-terminal Domain III of the δ′ Subunit of DNA Polymerase III Holoenzyme Binds DnaX and Supports Cooperative DnaX Complex Assembly*

  2001cited by this paper
• The DNA polymerase III holoenzyme: an asymmetric dimeric replicative complex with leading and lagging strand polymerases.

  2001cited by this paper
• A unified nomenclature for the subunits of eukaryotic DNA polymerase delta.

  2001cited by this paper
• Interplay of Clamp Loader Subunits in Opening the β Sliding Clamp of Escherichia coli DNA Polymerase III Holoenzyme*

  2001cited by this paper
• ATP Utilization by Yeast Replication Factor C

  2001cited by this paper
• Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.

  2001cited by this paper
• Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III.

  2001cited by this paper
• Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III.

  2001cited by this paper
• Purification and characterization of human DNA damage checkpoint Rad complexes

  2001cited by this paper
• Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae

  2001cited by this paper
• DNA polymerase ɛ is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts

  2001cited by this paper
• ATP Utilization by Yeast Replication Factor C

  2001cited by this paper
• Structure of DNA Polymerase δ from Saccharomyces cerevisiae *

  2001cited by this paper
• Mechanism of beta clamp opening by the delta subunit of Escherichia coli DNA polymerase III holoenzyme.

  2001cited by this paper
• Chl12 (Ctf18) Forms a Novel Replication Factor C-Related Complex and Functions Redundantly with Rad24 in the DNA Replication Checkpoint Pathway

  2001cited by this paper
• Replisome-mediated DNA replication.

  2001cited by this paper
• Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.

  2001cited by this paper

• The E. coli DnaX clamp loader sharply bends DNA to load β-clamp at nicks and small gaps

  2026cites this paper
• Phage Mu enlists the β-sliding clamp for late gene transcription.

  2026cites this paper
• A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis.

  2026cites this paper
• The B. subtilis replicative polymerases bind the sliding clamp with different strengths to tune their activity in DNA replication

  2025influential citation
• The proofreading mechanism of the human leading-strand DNA polymerase ε holoenzyme

  2025cites this paper
• A starvation-triggered AAA+ ATPase halts chromosome replication progression by disassembling the bacterial DNA sliding clamp

  2025cites this paper
• Real-time analysis of initiation regulation systems during the progression of the reconstituted chromosomal replication cycle

  2025cites this paper
• DNA polymerase α-primase can function as a translesion DNA polymerase

  2025cites this paper
• Hallmarks of DNA replication stress responses in Escherichia coli and Bacillus subtilis

  2025cites this paper
• DNA polymerase α-primase can function as a translesion DNA polymerase

  2025cites this paper
• “The B. subtilis replicative polymerases bind the sliding clamp with different strengths to tune replication processivity and fidelity”

  2025cites this paper
• Development of Genetic Toxicology in the Context of M.E. Lobashev’s Physiological Hypothesis of the Mutation Process

  2025cites this paper
• The proofreading mechanism of the human leading strand DNA polymerase ε holoenzyme

  2025cites this paper
• Targeting the "Undruggable": Small-Molecule Inhibitors of Proliferating Cell Nuclear Antigen (PCNA) in the Spotlight in Cancer Therapy.

  2025cites this paper
• Long-Range Destabilizing Effects of Mutations at the β Clamp Dimer Interface

  2025cites this paper
• A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis

  2025cites this paper
• Exploring the molecular aspect and updating evolutionary approaches to the DNA polymerase enzymes for biotechnological needs: A comprehensive review.

  2024cites this paper
• Clues to transcription/replication collision‐induced DNA damage: it was RNAP, in the chromosome, with the fork

  2024cites this paper
• C-terminal domain of T4 gene 32 protein enables rapid filament reorganization and dissociation.

  2024cites this paper
• The backbone NMR resonance assignments of the stabilized E. coli β clamp

  2024cites this paper
• Transposition with Tn3-family elements occurs through interaction with the host β-sliding clamp processivity factor

  2024cites this paper
• Enhanced sampling strategies for molecular simulation of DNA

  2024cites this paper
• Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species: Inhibition of Nucleic Acid Synthesis

  2023cites this paper
• Understanding Chromosome Replication and Segregation Unit of Mycobacterium and Its Comparative Analysis with Model Organisms: From Drug Targets to Drug Identification

  2023cites this paper
• Impact of R-loops on oncogene-induced replication stress in cancer cells.

  2023cites this paper
• Dynamic structure of T4 gene 32 protein filaments facilitates rapid noncooperative protein dissociation

  2023cites this paper
• The translesion polymerase Pol Y1 is a constitutive component of the B. subtilis replication machinery

  2023cites this paper
• Conformational Changes and ATP Hydrolysis in Zika Helicase: The Molecular Basis of a Biomolecular Motor Unveiled by Multiscale Simulations

  2023cites this paper
• The evolving tale of Pol2 function

  2023cites this paper
• Impact des R-loops sur le stress réplicatif induit par les oncogènes dans les cellules cancéreuses

  2023cites this paper
• Toxin-antitoxin systems in bacterial pathogenesis.

  2023cites this paper
• Distal Mutations in the β-Clamp of DNA Polymerase III* Disrupt DNA Orientation and Affect Exonuclease Activity.

  2023cites this paper
• Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice

  2022cites this paper
• Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics

  2022cites this paper
• Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ϵ.

  2022cites this paper
• Mechanistic behavior and subtle key events during DNA clamp opening and closing in T4 bacteriophage.

  2022cites this paper
• Abundant and cosmopolitan lineage of cyanopodoviruses lacking a DNA polymerase gene

  2022cites this paper
• The multiple de novo copy number variant (MdnCNV) phenomenon presents with peri-zygotic DNA mutational signatures and multilocus pathogenic variation

  2022cites this paper
• Processive Depolymerization Catalysts: A Population Balance Model for Chemistry’s “While” Loop

  2022cites this paper
• Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

  2021cites this paper
• Structure of an open conformation of T7 DNA Polymerase reveals novel structural features regulating primer-template stabilization at the polymerization active-site.

  2021cites this paper
• DNA replication: In vitro single-molecule manipulation data analysis and models

  2021cites this paper
• The DNA Replication Machine: Structure and Dynamic Function.

  2021cites this paper
• Macromolecular Protein Complexes III: Structure and Function

  2021cites this paper
• Replication | Processivity Clamps in DNA Replication

  2021cites this paper
• Mycobacterium tuberculosis Endonuclease VIII 2 (Nei2) forms a prereplicative BER complex with DnaN: Identification, characterization, and disruption of complex formation

  2021cites this paper
• DNA mismatch repair in mammals

  2021cites this paper
• In vitro single-molecule manipulation studies of viral DNA replication.

  2021cites this paper
• Strategies for the Purification of β-Clamp in Complex with the CTD of the DnaE of Pol III (α-Subunit)

  2021cites this paper
• Double Porphyrin Cage Compounds

  2020cites this paper
• Relative Biological Effectiveness Studies Using 3 MeV Proton Beam from Folded Tandem Ion Accelerator: An Experimental and Theoretical Approach

  2020cites this paper
• DNA Polymerases at the Eukaryotic Replication Fork Thirty Years after: Connection to Cancer

  2020cites this paper
• Eukaryotic clamp loaders and unloaders in the maintenance of genome stability

  2020cites this paper
• DNA Recognition/Processing | DNA Polymerase III, Bacterial

  2020cites this paper
• Genetic Inheritance and Its Contribution to Tinnitus.

  2020cites this paper
• Potassium Glutamate and Glycine Betaine Induce Self-Assembly of Sliding Clamps into Higher Order Oligomers

  2020cites this paper
• Novel Antibiotics Targeting Bacterial Replicative DNA Polymerases

  2020cites this paper
• Protein-protein complexes as targets for drug discovery against infectious diseases.

  2020cites this paper
• Small-molecule drug repurposing to target DNA damage repair and response pathways.

  2020cites this paper
• Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation.

  2020cites this paper
• OsMFS1/OsHOP2 Complex Participates in Rice Male and Female Development

  2020cites this paper
• Molecular dynamics simulations of DNA-DNA and DNA-protein interactions.

  2020cites this paper
• Potassium Glutamate and Glycine Betaine Induce Self-Assembly of the PCNA and β Sliding Clamps.

  2020cites this paper
• Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path

  2020cites this paper
• In vivo demonstration of enhanced binding between β-clamp and DnaE of pol III bearing consensus i-CBM

  2019cites this paper
• DNA replication and replication termination in Escherichia coli

  2019influential citation
• Lawrence Berkeley National Laboratory Recent Work Title Target preference of Type IIIA CRISPR-Cas complexes at the transcription bubble

  2019cites this paper
• Plant DNA Polymerases

  2019cites this paper
• Responses of marine mussel Mytilus galloprovincialis (Bivalvia: Mytilidae) after infection with the pathogen Vibrio splendidus.

  2019cites this paper
• Characterization of DNA bound cyclic GMP-AMP synthase using atomic force microscopy imaging.

  2019cites this paper
• E. coli primase and DNA polymerase III holoenzyme are able to bind concurrently to a primed template during DNA replication

  2019cites this paper
• Bacillus subtilis RarA acts at the interplay between replication and repair-by-recombination.

  2019cites this paper
• Replicative DNA polymerases promote active displacement of SSB proteins during lagging strand synthesis

  2019cites this paper
• Dynamic Exchange of Two Essential DNA Polymerases during Replication and after Fork Arrest.

  2019cites this paper
• Synthesis, binding and threading properties of double porphyrin cage compounds

  2019cites this paper
• Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble

  2019cites this paper
• NPGRJ_NSMB_1413 338..345

  2019cites this paper
• An Overview of AAA+ Superfamily Proteins Associated Helicases

  2019cites this paper
• Caulobacter crescentus β sliding clamp employs a noncanonical regulatory model of DNA replication

  2019cites this paper
• What is all this fuss about Tus? Comparison of recent findings from biophysical and biochemical experiments

  2018cites this paper
• Biophysical and kinetic analysis of Escherichia coli DNA ligase activity and inhibition

  2018cites this paper
• Fidelity of DNA replication—a matter of proofreading

  2018cites this paper
• The dynamic role of the conserved WhiA and MinD proteins in chromosome segregation, fatty acid metabolism and cell division in Bacillus subtilis

  2018cites this paper
• coli DNA replication in the absence of free beta clamps

  2018influential citation
• A tough row to hoe: when replication forks encounter DNA damage.

  2018cites this paper
• Single-molecule live cell imaging of Rep reveals the dynamic interplay between an accessory replicative helicase and the replisome

  2018cites this paper
• Protein–protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics

  2018cites this paper
• DNA Replication: From Radioisotopes to Click Chemistry

  2018cites this paper
• Visualizing bacterial DNA replication and repair with molecular resolution.

  2018cites this paper
• Super-resolution Imaging of DNA Replisome Architecture and Dynamics in Live Bacillus Subtilis

  2018cites this paper
• Role of MCM2–7 protein phosphorylation in human cancer cells

  2018cites this paper
• CLPXP FUNCTIONS IN CAULOBACTER AS A UNIVERSAL AND SPECIES-SPECIFIC PROTEASE

  2018influential citation
• Studying the effects of DNA replication stress on genome integrity and cell viability

  2018cites this paper
• Photophysical characterization of interchromophoric interactions between rhodamine dyes conjugated to proteins

  2018cites this paper
• Efficient Arrangement of the Replication Fork Trap for In Vitro Propagation of Monomeric Circular DNA in the Chromosome-Replication Cycle Reaction

  2018cites this paper
• Transcriptomics reveal potential vaccine antigens and a drastic increase of upregulated genes during Theileria parva development from arthropod to bovine infective stages

  2018cites this paper
• Escherichia coli β-clamp slows down DNA polymerase I dependent nick translation while accelerating ligation

  2018cites this paper
• Electrostatic Interactions at the Dimer Interface Stabilize the E. coli β Sliding Clamp.

  2017cites this paper
• Using microsecond single-molecule FRET to determine the assembly pathways of T4 ssDNA binding protein onto model DNA replication forks

  2017cites this paper
• Structural and Functional Studies of the β2-Sliding Clamp from Pathogenic Bacteria

  2017cites this paper