ABC Transporters during Epilepsy and Mechanisms Underlying Multidrug Resistance in Refractory Epilepsy

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Epilepsia

• Publication date

  2007-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1528-1167.2007.01302.xPMID 17910594
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of the MDR-1 Gene-encoded P-glycoprotein in Cardiomyocytes of Conscious Sheep Undergoing Acute Myocardial Ischemia Followed by Reperfusion

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• Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.

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• Neuronal mdr-1 gene expression after experimental focal hypoxia: a new obstacle for neuroprotection?

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• Vascular colocalization of P‐glycoprotein, multidrug‐resistance associated protein 1, breast cancer resistance protein and major vault protein in human epileptogenic pathologies

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• New proteins configure a brain drug resistance map in tuberous sclerosis.

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• 99mTechnetium-SESTAMIBI Uptake in Malignant Lymphomas. Correlation with Chemotherapy Response

  2006influential reference
• Multidrug resistance gene (MDR-1) expression in the colonic mucosa of patients with refractory ulcerative colitis.

  2006cited by this paper
• Calcium‐channel Blocker Verapamil Administration in Prolonged and Refractory Status Epilepticus

  2005cited by this paper
• Cardiomyocytes of Chronically Ischemic Pig Hearts Express the MDR-1 Gene-encoded P-glycoprotein

  2005cited by this paper
• Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

  2005influential reference
• ATP-binding cassette (ABC) transporters in human metabolism and diseases.

  2004cited by this paper
• Expression and Cellular Distribution of Multidrug Resistance–related Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy

  2004cited by this paper
• Expression and Cellular Distribution of Major Vault Protein: A Putative Marker for Pharmacoresistance in a Rat Model for Temporal Lobe Epilepsy

  2004cited by this paper
• Neuronal MDR-1 Gene Expression and Persistent Low Levels of Anticonvulsants in a Child with Refractory Epilepsy

  2004influential reference
• Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy.

  2004cited by this paper
• Neuronal and Glial Expression of the Multidrug Resistance Gene Product in an Experimental Epilepsy Model

  2004influential reference
• Transient Expression of MDR-1/P-Glycoprotein in a Model of Partial Cortical Devascularization

  2004cited by this paper
• Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.

  2004cited by this paper
• Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy.

  2004influential reference
• A Kindling Model of Pharmacoresistant Temporal Lobe Epilepsy in Sprague–Dawley Rats Induced by Coriaria Lactone and Its Possible Mechanism

  2003cited by this paper
• Major Vault Protein, a Marker of Drug Resistance, Is Upregulated in Refractory Epilepsy

  2003cited by this paper
• Relationship between expression of multiple drug resistance proteins and p53 tumor suppressor gene proteins in human brain astrocytes.

  2003influential reference
• Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier.

  2003cited by this paper
• Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors.

  2003cited by this paper
• Widespread Upregulation of Drug‐resistance Proteins in Fatal Human Status Epilepticus

  2003influential reference
• Expression and functional characterization of ABCG2 in brain endothelial cells and vessels

  2003cited by this paper
• Limbic Seizures Induce P-Glycoprotein in Rodent Brain: Functional Implications for Pharmacoresistance

  2002cited by this paper
• Localisation of breast cancer resistance protein in microvessel endothelium of human brain

  2002cited by this paper
• Multidrug resistance and cancer: the role of the human ABC transporter ABCG2.

  2002cited by this paper
• Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

  2002cited by this paper
• Regional Expression of Multidrug Resistance Genes in Genetically Epilepsy‐prone Rat Brain after a Single Audiogenic Seizure

  2002cited by this paper
• Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy.

  2002influential reference
• Expression of the Multidrug Transporter P‐glycoprotein in Brain Capillary Endothelial Cells and Brain Parenchyma of Amygdala‐kindled Rats

  2002cited by this paper
• High‐Resolution Imaging in Epilepsy

  2002cited by this paper
• Antiepileptogenesis and Seizure Prevention Trials with Antiepileptic Drugs: Meta‐Analysis of Controlled Trials

  2001influential reference
• Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory Epilepsy

  2001cited by this paper
• Early identification of refractory epilepsy.

  2000cited by this paper
• What is the precise role of human MDR 1 protein in chemotherapeutic drug resistance?

  2000cited by this paper
• Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.

  1999cited by this paper
• Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin.

  1999cited by this paper
• Over-expression of P-glycoprotein in malformations of cortical development.

  1999cited by this paper
• Technetium-99m sestamibi imaging in paediatric neuroblastoma and ganglioneuroma and its relation to P-glycoprotein

  1999cited by this paper
• Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy.

  1999cited by this paper
• 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein.

  1998cited by this paper
• p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines.

  1998cited by this paper
• Lung cancer--management and outcome in Glasgow, 1991-92.

  1998cited by this paper
• 4-17-07 Expression of P-glycoprotein and related proteins in brain of patients with refractory temporal lobe epilepsy (TLE)

  1997cited by this paper
• Use of antiepileptic drugs in nontraumatic neurosurgical procedures. Is there any best route and time of administration?

  1997cited by this paper
• Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells

  1997cited by this paper
• P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain.

  1997influential reference
• Biophysical aspects of P-glycoprotein-mediated multidrug resistance.

  1997cited by this paper
• 1-17-22 High expression of multidrug resistance gene (MDR-1) and persistant low levels of phenytoin (PHT) on a patient with refractary epilepsy due to tuberous sclerosis (TS)

  1997cited by this paper
• MDR1 Gene Expression in Brain of Patients with Medically Intractable Epilepsy

  1995cited by this paper
• Wild Type p53 Stimulates Expression from the Human Multidrug Resistance Promoter in a p53-negative Cell Line (*)

  1995cited by this paper
• NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter.

  1994cited by this paper
• The E. Donnall Thomas Lecture, 1993. The machinery of blood cell movements

  1994cited by this paper
• Biochemistry of multidrug resistance mediated by the multidrug transporter.

  1993cited by this paper
• A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase.

  1993cited by this paper
• Prognosis of Epilepsy in Newly Referred Patients: A Multicenter Prospective Study of the Effects of Monotherapy on the Long‐Term Course of Epilepsy

  1992cited by this paper
• Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

  1990cited by this paper
• Does P-glycoprotein predict response to chemotherapy?

  1989cited by this paper
• Natural History and Prognosis

  1987cited by this paper
• Proposal for Revised Clinical and Electroencephalographic Classification of Epileptic Seizures

  1981cited by this paper
• Increased lung uptake of thallium-201 during exercise myocardial imaging: clinical, hemodynamic and angiographic implications in patients with coronary artery disease.

  1980cited by this paper

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• Pharmacogenetics of anti-seizure medications in Arab countries: a comprehensive review

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• The microbiome: what a neurologist needs to know

  2025cites this paper
• Ferroptosis: is it both cause and effect in refractory epilepsy?

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• The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy

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• Nanocarriers-based therapeutic strategy for drug-resistant epilepsy: A systematic review.

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• Drug-resistant epilepsy and its selected complications in children

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• Real-world safety of Levetiracetam: Mining and analysis of its adverse drug reactions based on FAERS database.

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• A Revolutionary Approach for Combating Efflux Transporter-mediated Resistant Epilepsy: Advanced Drug Delivery Systems.

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  2024cites this paper
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  2024cites this paper
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• Revisiting the concept of drug‐resistant epilepsy: A TASK1 report of the ILAE/AES Joint Translational Task Force

  2023cites this paper
• Real-world safety of Lacosamide: A pharmacovigilance study based on spontaneous reports in the FDA adverse event reporting system.

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• Transcranial Focal Electric Stimulation Avoids P-Glycoprotein Over-Expression during Electrical Amygdala Kindling and Delays Epileptogenesis in Rats

  2023cites this paper
• Diagnosis and prognosis of serum Fut8 for epilepsy and refractory epilepsy in children

  2023cites this paper
• Astrocyte-neuron circuits in epilepsy

  2023cites this paper
• A Review of the Surgical Procedures for the Treatment of Drug-Resistant Epilepsy and Their Seizure Control Outcomes

  2023cites this paper
• Advances in Epilepsy: Mechanisms, Clinical Trials, and Drug Therapies.

  2023cites this paper
• Targeting ferroptosis as novel therapeutic approaches for epilepsy

  2023cites this paper
• Novel nasal niosomes loaded with lacosamide and coated with chitosan: A possible pathway to target the brain to control partial-onset seizures

  2023cites this paper
• Bacillus subtilis plays a role in the inhibition of transporter ABCB1 in Caco-2 cells.

  2022cites this paper
• Current Principles in the Management of Drug-Resistant Epilepsy

  2022cites this paper
• Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals

  2022cites this paper
• Association between G2677T/A polymorphism in ABCB1 gene and the risk of drug resistance epilepsy: An updated systematic review and meta-analysis.

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  2022cites this paper
• Effects of genetic polymorphism of drug-metabolizing enzymes on the plasma concentrations of antiepileptic drugs in Chinese population

  2022cites this paper
• Tissue Drug Concentration.

  2022cites this paper
• A complex systems view on the current hypotheses of epilepsy pharmacoresistance

  2022cites this paper
• Protein expression of P-glycoprotein in neocortex from patients with frontal lobe epilepsy.

  2022cites this paper
• Implication of ABC transporters in non-proliferative diseases.

  2022cites this paper
• Chaihu plus Longgu Muli Decoction Alleviated Brain Injury in Pentylenetetrazole-Kindled Epileptic Mice by Regulating Cyclooxygenase-2/Prostaglandin E2/Multidrug Transporter Pathway

  2021cites this paper
• The role of efflux transporters and metabolizing enzymes in brain and peripheral organs to explain drug‐resistant epilepsy

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• Drug Resistance in Epilepsy: Which Prospect to Tame its Stubbornness?

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• Multi‐omic strategies applied to the study of pharmacoresistance in mesial temporal lobe epilepsy

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• Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: Clues into the underlying mechanisms leading to disease.

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• Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level?

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Nose-to-brain delivery of levetiracetam after intranasal administration to mice.

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Plasma Glycoprotein Efflux Induced Resistance: Implications, Mechanism, Inhibitors, and Novel Strategies to Overcome

  2018cites this paper
• In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy.

  2018cites this paper
• The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Improving metabolic stability of fluorine-18 labeled verapamil analogs.

  2018cites this paper
• Prediction of human CNS pharmacokinetics using a physiologically‐based pharmacokinetic modeling approach

  2018influential citation
• Clinical predictors of treatment outcome in North Indian patients on antiepileptic drug therapy: A prospective observational study

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018influential citation
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  2017cites this paper
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  2017influential citation
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  2017cites this paper
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  2017cites this paper
• P-gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy.

  2017cites this paper
• Epileptology - The Modern State of Science

  2016cites this paper
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  2016cites this paper
• [Algorithms of mono- and polytherapy in clinical epileptology. Part 1. General principles of drug choice].

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper