Hedonic and motivational roles of opioids in food reward: implications for overeating disorders.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Pharmacology, Biochemistry and Behavior

• Publication date

  2010-11-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.pbb.2010.05.016PMID 20580734
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Convergent, not serial, striatal and pallidal circuits regulate opioid-induced food intake.

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• A Neural Computational Model of Incentive Salience

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• Reward processing by the opioid system in the brain.

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• 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders.

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• Is it possible to dissociate 'liking' and 'wanting' for foods in humans? A novel experimental procedure.

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• Ventral pallidum firing codes hedonic reward: when a bad taste turns good.

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• Brain, appetite and obesity.

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