The connexin family of intercellular channel forming proteins.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Kidney International

• Publication date

  1995-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/KI.1995.398PMID 8569076
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interendothelial junctions in kidney vessels

  2004cited by this paper
• Myoendothelial contacts in glomerular arterioles and in renal interlobular arteries of rat, mouse and Tupaia belangeri

  2004cited by this paper
• Functional analysis of selective interactions among rodent connexins.

  1995cited by this paper
• Expression of a dominant negative inhibitor of intercellular communication in the early Xenopus embryo causes delamination and extrusion of cells.

  1995cited by this paper
• Expression of gap junction proteins Cx26, Cx31.1, Cx37, and Cx43 in developing and mature rat epidermis

  1994cited by this paper
• Voltage gating of connexins

  1994cited by this paper
• Opposite voltage gating polarities of two closely related onnexins

  1994cited by this paper
• Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins

  1994cited by this paper
• Molecular cloning and functional characterization of chick lens fiber connexin 45.6.

  1994cited by this paper
• Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells.

  1994cited by this paper
• Dissociation of PDGF receptor tyrosine kinase activity from PDGF‐mediated inhibition of gap junctional communication

  1994cited by this paper
• Expression of chimeric connexins reveals new properties of the formation and gating behavior of gap junction channels.

  1994cited by this paper
• MR diffusion tensor spectroscopy and imaging.

  1994cited by this paper
• Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein.

  1993cited by this paper
• Chick connexin-56, a novel lens gap junction protein. Molecular cloning and functional expression.

  1993cited by this paper
• Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase.

  1993cited by this paper
• Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins.

  1993cited by this paper
• Identification of a proline residue as a transduction element involved in voltage gating of gap junctions

  1993cited by this paper
• Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytes

  1993cited by this paper
• Structure-function studies of voltage sensitivity of connexins, the family of gap junction forming proteins.

  1993cited by this paper
• Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70.

  1992cited by this paper
• Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart.

  1992cited by this paper
• Multiple gap junction genes are utilized during rat skin and hair development.

  1992cited by this paper
• Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines

  1992cited by this paper
• Communication compartments in hair follicles and their implication in differentiative control.

  1992cited by this paper
• Multiple-channel conductance states and voltage regulation of embryonic chick cardiac gap junctions

  1992cited by this paper
• Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs.

  1992cited by this paper
• Voltage-dependent ion channels and their gating.

  1992cited by this paper
• Molecular analysis of voltage dependence of heterotypic gap junctions formed by connexins 26 and 32.

  1992cited by this paper
• Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine.

  1992cited by this paper
• Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin.

  1992cited by this paper
• Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes.

  1992cited by this paper
• A domain substitution procedure and its use to analyze voltage dependence of homotypic gap junctions formed by connexins 26 and 32.

  1992cited by this paper
• Gap junctions in development--a perspective.

  1992cited by this paper
• Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.

  1992cited by this paper
• The crystalline lens. A system networked by gap junctional intercellular communication.

  1992cited by this paper
• Biophysics of gap junctions.

  1992cited by this paper
• Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.

  1992cited by this paper
• The cell-cell channel in the control of growth.

  1992cited by this paper
• Erratum: Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage (Proc. Natl. Acad. Sci. USA (October 1, 1991) 88 (8410-8414))

  1992cited by this paper
• Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung

  1992cited by this paper
• Extent and modulation of junctional communication between pancreatic acinar cells in vivo.

  1991cited by this paper
• Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung

  1991cited by this paper
• Functional analysis of human cardiac gap junction channel mutants.

  1991cited by this paper
• Molecular cloning and characterization of a new member of the gap junction gene family, connexin-31.

  1991cited by this paper
• Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes

  1991cited by this paper
• Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.

  1991cited by this paper
• Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin 32.

  1990cited by this paper
• Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.

  1990cited by this paper
• Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells.

  1990cited by this paper
• Differential regulation of the levels of three gap junction mRNAs in Xenopus embryos

  1990cited by this paper
• Structure-activity relations of the cardiac gap junction channel.

  1990cited by this paper
• Molecular characterization and functional expression of the human cardiac gap junction channel

  1990cited by this paper
• Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts

  1990cited by this paper
• Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation

  1990cited by this paper
• The hormone-induced regulation of contact-dependent cell-cell communication by phosphorylation.

  1990cited by this paper
• Molecular cloning and developmental expression of two chick embryo gap junction proteins.

  1990cited by this paper
• Modulation of gap junction transcript and protein expression during pregnancy in the rat

  1990cited by this paper
• PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

  1990cited by this paper
• Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.

  1989cited by this paper
• The 43-kD polypeptide of heart gap junctions: immunolocalization, topology, and functional domains

  1989cited by this paper
• Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues

  1989cited by this paper
• Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes

  1989cited by this paper
• Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA

  1989cited by this paper
• Formation of hybrid cell-cell channels.

  1989cited by this paper
• Tissue‐specific granularity of gap junction cytoplasmic surface revealed by rapid‐freeze, deep‐etch replicas

  1989cited by this paper
• Improved propagation in myometrium associated with gap junctions during parturition.

  1989cited by this paper
• Formation of gap junctions by expression of connexins in Xenopus oocyte pairs.

  1989cited by this paper
• Structural parts involved in activation and inactivation of the sodium channel

  1989cited by this paper
• Cloning and expression of a Xenopus embryonic gap junction protein.

  1989cited by this paper
• Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-beta and peptide hormones in normal human keratinocytes.

  1989cited by this paper
• The gap junction: a channel for multiple functions?

  1988cited by this paper
• The cellular src gene product regulates junctional cell-to-cell communication.

  1988cited by this paper
• Topology of the 32‐kd liver gap junction protein determined by site‐directed antibody localizations.

  1988cited by this paper
• Altered junctional permeability between cells transformed by v-ras, v-mos, or v-src.

  1988cited by this paper
• Growth factors modulate junctional cell-to-cell communication

  1988cited by this paper
• Sequence and developmental expression of mRNA coding for a gap junction protein in Xenopus

  1988cited by this paper
• Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions

  1988cited by this paper
• Patterns of junctional communication during development of the early amphibian embryo.

  1988cited by this paper
• Homologies between gap junction proteins in lens, heart and liver

  1988cited by this paper
• Two homologous protein components of hepatic gap junctions

  1987cited by this paper
• Voltage‐clamp analysis of a crayfish rectifying synapse.

  1987cited by this paper
• Topological analysis of the major protein in isolated intact rat liver gap junctions and gap junction-derived single membrane structures.

  1987cited by this paper
• Expression of functional cell-cell channels from cloned rat liver gap junction complementary DNA.

  1987cited by this paper
• Connexin43: a protein from rat heart homologous to a gap junction protein from liver

  1987cited by this paper
• Existence of distinct sodium channel messenger RNAs in rat brain

  1986cited by this paper
• Molecular cloning of cDNA for rat liver gap junction protein

  1986cited by this paper
• Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein

  1986cited by this paper
• The Mr 28,000 gap junction proteins from rat heart and liver are different but related.

  1985cited by this paper
• Separation of developmental compartments by a cell type with reduced junctional permeability

  1984cited by this paper
• Patterns of junctional communication in the early amphibian embryo

  1984cited by this paper
• Comparative analysis of the gap junction protein from rat heart and liver: is there a tissue specificity of gap junctions?

  1983cited by this paper
• Control of intercellular communication by voltage dependence of gap junctional conductance

  1983cited by this paper
• Gap junctional communication compartments in the Drosophila wing disk.

  1982cited by this paper
• Isolation and protein composition of gap junctions from rabbit hearts.

  1982cited by this paper
• Permeability of gap junctions at the segmental border in insect epidermis.

  1982cited by this paper
• Kinetic properties of a voltage-dependent junctional conductance

  1981cited by this paper
• Equilibrium properties of a voltage-dependent junctional conductance

  1981cited by this paper
• Gap junctional communication in the post-implantation mouse embryo.

  1979cited by this paper
• Gap junctional communication in the preimplantation mouse embryo.

  1979cited by this paper

• Towards Clinical Application: Calcium Waves for In Vitro Qualitative Assessment of Propagated Primary Human Corneal Endothelial Cells

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• Intercellular junctions and cell–cell communication in the skeletal system

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• Human Pluripotent Stem Cell-Derived Cardiomyocytes with Ischemia Resistant Gap Junctions

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• From Hyperactive Connexin26 Hemichannels to Impairments in Epidermal Calcium Gradient and Permeability Barrier in the Keratitis-Ichthyosis-Deafness Syndrome.

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• Functional and Structural Study of Pannexin 1 Channels

  2015cites this paper
• Cell-Cell Communication in Bone

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• Mechanical stimulation-induced calcium wave propagation in cell monolayers: the example of bovine corneal endothelial cells.

  2013cites this paper
• Regulation of connexin‐ and pannexin‐based channels by post‐translational modifications

  2013cites this paper
• Reno-protective Effects of Eicosapentaenoic Acid (EPA) Against PAN Induced Nephrosis in WKY Rats

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• Human Neural Progenitor Cells Show Functional Neuronal Differentiation and Regional Preference After Engraftment onto Hippocampal Slice Cultures

  2012cites this paper
• Expression of gap junction protein connexin 43 in bovine urinary bladder tumours.

  2011cites this paper
• Gap Junctions and Biophysical Regulation of Bone Cells

  2010cites this paper
• Invited Review Gap junction channels: new roles in disease

  2010cites this paper
• Lens gap junctions in growth, differentiation, and homeostasis.

  2010cites this paper
• PKC gamma regulates connexin 57

  2010cites this paper
• Genetically modified mouse models for premature ovarian failure (POF).

  2010cites this paper
• Prevalence of GJB2 gene mutation 35delG among healthy population of Northwest Region of Russia

  2009cites this paper
• Connexins: a myriad of functions extending beyond assembly of gap junction channels

  2009cites this paper
• Pannexins, distant relatives of the connexin family with specific cellular functions?

  2009cites this paper
• A de novo GJB2 (connexin 26) mutation, R75W, in a Chinese pedigree with hearing loss and palmoplantar keratoderma

  2009cites this paper
• Gap Junctions in Growth , Differentiation , and Homeostasis

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• ATP release from vascular endothelia occurs through connexin 43 and is attenuated during hypoxia

  2009cites this paper
• Functional and Structural Study of Pannexin1 Channels

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• Altered expression of connexin-43 and impaired capacity of gap junctional intercellular communication in prostate cancer cells

  2007cites this paper
• Einfluss von oxLDL auf die Apoptoseinduktion und Zellkopplung über Gap Junctions

  2007cites this paper
• Altered expression of connexin-43 and impaired capacity of gap junctional intercellular communication in prostate cancer cells

  2007cites this paper
• Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.

  2007cites this paper
• Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats.

  2006cites this paper
• Cell death: initiation, propagation and clearance

  2006cites this paper
• possible role in diabetic nephropathy cell-to-cell communication in human collecting duct: a Glucose-evoked alterations in connexin43-mediated

  2006cites this paper
• Connexin43-dependent mechanism modulates renin secretion and hypertension.

  2006cites this paper
• Glucose-evoked alterations in connexin43-mediated cell-to-cell communication in human collecting duct: a possible role in diabetic nephropathy.

  2006cites this paper
• Gap junctions and the propagation of cell survival and cell death signals

  2005cites this paper
• Differential connexin expression in preglomerular and postglomerular vasculature: accentuation during diabetes.

  2005cites this paper
• Cell-to-cell interactions in bone.

  2005cites this paper
• Genetic heterogeneity of KID syndrome: identification of a Cx30 gene (GJB6) mutation in a patient with KID syndrome and congenital atrichia.

  2004cites this paper
• Contribution of connexins to the function of the vascular wall.

  2004cites this paper
• Modulation of prostate cancer growth in bone microenvironments

  2004cites this paper
• Molecular cloning, functional analysis, and RNA expression analysis of connexin45.6: a zebrafish cardiovascular connexin.

  2004cites this paper
• Gap junction-microtubule associations in rat alveolar epithelial cells.

  2003cites this paper
• Zebrafish Cx35: Cloning and characterization of a gap junction gene highly expressed in the retina

  2003cites this paper
• LacSwitch II regulation of connexin43 cDNA expression enables gap-junction single-channel analysis.

  2003cites this paper
• Expression of connexin48.5, connexin44.1, and connexin43 during zebrafish (Danio rerio) lens development

  2003cites this paper
• The Role of Connexins in Human Disease

  2003cites this paper
• Critical Role of the Transcriptional Repressor Neuron-restrictive Silencer Factor in the Specific Control of Connexin36 in Insulin-producing Cell Lines*

  2003cites this paper
• Einfluß der endothelialen Autakoide NO und PGI2 auf die Permeabilität endothelialer Gap Junctions

  2003cites this paper
• Connexin-36 Contributes to Control Function of Insulin-producing Cells*

  2003cites this paper
• Up-regulation of connexin43 in glomerular podocytes in response to injury.

  2002cites this paper
• Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells

  2002cites this paper
• Organization of cyclic AMP-dependent connexin 43 in Swiss 3T3 cells attached to a cellulose substratum.

  2002cites this paper
• Intercellular Junctions and Cell-Cell Communication in Bone

  2002cites this paper
• HETEROMULTIMERIC GAP JUNCTION CHANNELS: A CONNECTION WITH CARDIAC PHYSIOLOGY AND PATHOLOGY

  2002cites this paper
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  2002cites this paper
• Connexins 43 and 26 are differentially increased after rat bladder outlet obstruction.

  2002cites this paper
• Expression of Gap Junction Proteins (Connexin 26, 30, 32, 43) in Normal Mucosa, Hyperkeratosis and Carcinoma of the Human Larynx

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• Wound healing: the role of gap junctional communication in rat granulation tissue maturation.

  2002cites this paper
• The physiology, pathophysiology and therapeutic potential of gap junctions in smooth muscle.

  2002cites this paper
• Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension.

  2001cites this paper
• Role of Stem Cells and Gap Junctional Intercellular Communication in Human Carcinogenesis

  2001cites this paper
• Effects of Hyperglycemia and Protein Kinase C on Connexin43 Expression in Cultured Rat Retinal Pigment Epithelial Cells

  2001cites this paper
• Comparative analysis and application of fluorescent protein‐tagged connexins

  2001cites this paper
• Bimodal inhibition of connexin 43 gap junctions decreases ACTH-induced steroidogenesis and increases bovine adrenal cell population growth.

  2001cites this paper
• Inhibition of gap junctional intercellular communication in rat liver epithelial cells with transforming RNA

  2001cites this paper
• TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.

  2001cites this paper
• Emerging issues of connexin channels: biophysics fills the gap

  2001cites this paper
• Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression.

  2000cites this paper
• Connexin37 in normal and pathological development of mouse heart and great arteries

  2000cites this paper
• Cell coupling modulates the contraction of fibroblast‐populated collagen lattices

  2000cites this paper
• Comparative immunohistochemical distribution of connexin 37 and connexin 43 throughout folliculogenesis in the bovine ovary

  2000cites this paper
• Functional analysis of human Cx26 mutations associated with deafness.

  2000cites this paper
• PDGF regulates gap junction communication and connexin43 phosphorylation by PI 3-kinase in mesangial cells.

  2000cites this paper
• Defects in the germ line and gonads of mice lacking connexin43.

  1999cites this paper
• Gap junctional intercellular communication and connexin43 expression in human ovarian surface epithelial cells and ovarian carcinomas in vivo and in vitro.

  1999cites this paper
• Innexin-3 forms connexin-like intercellular channels.

  1999cites this paper
• Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance.

  1999cites this paper
• Molecular dissection of transjunctional voltage dependence in the connexin-32 and connexin-43 junctions.

  1999cites this paper
• A new exon in the 5' untranslated region of the connexin32 gene.

  1999cites this paper
• Functional characteristics of skate connexin35, a member of the γ subfamily of connexins expressed in the vertebrate retina

  1999cites this paper
• Chapter 8: Membrane Potential Dependence of Gap Junctions in Vertebrates

  1999cites this paper
• Genetic diseases and gene knockouts reveal diverse connexin functions.

  1999cites this paper
• Inhibitory effects of organochlorine pesticides on intercellular transfer of Lucifer Yellow in cultured bovine oviductal cells.

  1999cites this paper
• Genes and premature ovarian failure.

  1998cites this paper
• Connexin 32 gap junctions enhance stimulation of glucose output by glucagon and noradrenaline in mouse liver

  1998cites this paper
• Gap junctions: a novel route for direct cell-cell communication in the immune system?

  1998cites this paper
• Gap junctions: a novel route for direct cell–cell communication in the immune system?

  1998cites this paper
• Neoplastic phenotype of gap‐junctional intercellular communication–deficient WB rat liver epithelial cells and its reversal by forced expression of connexin 32

  1998cites this paper
• Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma

  1998cites this paper
• Altered gap and tight junctions in human thyroid oncocytic tumors: a study of 8 cases by freeze-fracture.

  1998cites this paper
• Cell-cell communication in carcinogenesis.

  1998cites this paper
• Assembly of Chimeric Connexin-Aequorin Proteins into Functional Gap Junction Channels

  1998cites this paper
• Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed.

  1998cites this paper
• Inhibition of gap junctional intercellular communication by tumor promoters in connexin43 and connexin32-expressing liver cells: cell specificity and role of protein kinase C.

  1998influential citation
• Novel mutations in the connexin 26 gene (GJB2) that cause autosomal recessive (DFNB1) hearing loss.

  1998cites this paper
• RT-PCR study of the distribution of connexin 43 mRNA in the glomerulus and renal tubular segments.

  1998cites this paper
• Immunorecognition, ultrastructure and phosphorylation status of astrocytic gap junctions and connexin43 in rat brain after cerebral focal ischaemia

  1998cites this paper
• Coexpression of connexin45 and -32 in oligodendrocytes of rat brain

  1997cites this paper
• Inhibition of connexin 43 synthesis by antisense RNA in rat glioma cells.

  1997cites this paper
• Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain.

  1997cites this paper