Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Highlights • The mechanisms behind the effects of IN-applied substances need more attention.• The mechanisms involved in the brain-distribution of IN-OT are completely unexplored.• The possibly cascading effects of IN-OT on the intrinsic OT-system require serious investigation.• IN-OT induces clear and specific changes in neural activation.• IN-OT is a promising approach to treat certain clinical symptoms.

• Publication year

  2013

• Venue

  Neuroscience and Biobehavioral Reviews

• Publication date

  2013-05-04

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neubiorev.2013.04.012PMID 23648680PMCID 7112651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Blood-brain barrier in health and disease.

  2015cited by this paper
• The Olfactory System

  2014cited by this paper
• Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice.

  2013influential reference
• Effects of couple interactions and relationship quality on plasma oxytocin and cardiovascular reactivity: empirical findings and methodological considerations.

  2013cited by this paper
• Chronic intranasal oxytocin causes long-term impairments in partner preference formation in male prairie voles.

  2013cited by this paper
• Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: male juvenile versus female adult conspecifics.

  2013influential reference
• The circumventricular organs of the brain: conspicuity on clinical 3T MRI and a review of functional anatomy

  2013cited by this paper
• Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin.

  2012cited by this paper
• Brain meets body: the blood-brain barrier as an endocrine interface.

  2012cited by this paper
• Effects of manganese injected into rat nostrils: implications for in vivo functional study of olfaction using MEMRI.

  2012cited by this paper
• Intranasal oxytocin administration is reflected in human saliva.

  2012cited by this paper
• Evoked axonal oxytocin release in the central amygdala attenuates fear response.

  2012influential reference
• Dual Role of Respiratory Syncytial Virus Glycoprotein Fragment as a Mucosal Immunogen and Chemotactic Adjuvant

  2012cited by this paper
• Modulating social behavior with oxytocin: how does it work? What does it mean?

  2012cited by this paper
• Psychosocial and Psychophysiological Effects of Human-Animal Interactions: The Possible Role of Oxytocin

  2012cited by this paper
• Identification and molecular characterization of a novel flavivirus isolated from Pekin ducklings in China.

  2012cited by this paper
• Posttraumatic stress symptoms and health-related quality of life: a two year follow up study of injury treated at the emergency department

  2012cited by this paper
• Cyto‐ and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: A study of immunostaining and multiple fluorescent tract tracing

  2012cited by this paper
• Oxytocin plasma concentrations after single intranasal oxytocin administration - a study in healthy men.

  2012cited by this paper
• Effect of intranasal immunization with inactivated avian influenza virus on local and systemic immune responses in ducks.

  2012cited by this paper
• Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta)

  2012influential reference
• Intranasal drug delivery: an efficient and non-invasive route for systemic administration: focus on opioids.

  2012cited by this paper
• A sniff of trust: meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group.

  2012influential reference
• Olfactory ferric and ferrous iron absorption in iron-deficient rats.

  2012cited by this paper
• Oxytocin and mutual communication in mother-infant bonding

  2012influential reference
• Dendritic cell targeted chitosan nanoparticles for nasal DNA immunization against SARS CoV nucleocapsid protein.

  2012cited by this paper
• Overview and introduction: The blood–brain barrier in health and disease

  2012cited by this paper
• Bonding after trauma: on the role of social support and the oxytocin system in traumatic stress

  2012cited by this paper
• Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

  2012cited by this paper
• T Cell-Biased Immune Responses Generated by a Mucosally-targeted Adenovirus-Sigma 1 Vaccine

  2012cited by this paper
• The Nonpeptide Oxytocin Receptor Agonist WAY 267,464: Receptor‐Binding Profile, Prosocial Effects and Distribution of c‐Fos Expression in Adolescent Rats

  2012cited by this paper
• Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors.

  2012influential reference
• No Laughing Matter: Intranasal Oxytocin Administration Changes Functional Brain Connectivity during Exposure to Infant Laughter

  2012cited by this paper
• The blood–brain barrier in health and disease

  2012cited by this paper
• Vasopressin, oxytocin, and social odor recognition.

  2012cited by this paper
• Increased brain radioactivity by intranasal 32P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gels

  2012cited by this paper
• Intranasal delivery of biologics to the central nervous system.

  2012influential reference
• The role of oxytocin in mating and pregnancy.

  2012cited by this paper
• Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects

  2012cited by this paper
• Volume transmission of beta-endorphin via the cerebrospinal fluid; a review

  2012cited by this paper
• Iron-Responsive Olfactory Uptake of Manganese Improves Motor Function Deficits Associated with Iron Deficiency

  2012cited by this paper
• Endothelial Cells and Astrocytes: A Concerto en Duo in Ischemic Pathophysiology

  2012cited by this paper
• Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathway.

  2012cited by this paper
• Recent Advances in the Pharmacological Management of Pain

  2012cited by this paper
• Effects of a Common Variant in the CD38 Gene on Social Processing in an Oxytocin Challenge Study: Possible Links to Autism

  2012cited by this paper
• Susceptibility to Acute Mouse Adenovirus Type 1 Respiratory Infection and Establishment of Protective Immunity in Neonatal Mice

  2012cited by this paper
• Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration.

  2012cited by this paper
• Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: a review of single administration studies.

  2012cited by this paper
• Cholesterol-induced conformational changes in the oxytocin receptor.

  2011cited by this paper
• Distinct representations of olfactory information in different cortical centres

  2011cited by this paper
• Sensory maps in the olfactory cortex defined by long-range viral tracing of single neurons

  2011influential reference
• Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial.

  2011cited by this paper
• Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

  2011influential reference
• Different profiles of main and accessory olfactory bulb mitral/tufted cell projections revealed in mice using an anterograde tracer and a whole-mount, flattened cortex preparation.

  2011cited by this paper
• Oxytocin administration attenuates stress reactivity in borderline personality disorder: a pilot study.

  2011cited by this paper
• Oxytocin buffers cortisol responses to stress in individuals with impaired emotion regulation abilities.

  2011cited by this paper
• Maternal Defense

  2011cited by this paper
• Oxytocin suppresses basal glutamatergic transmission but facilitates activity‐dependent synaptic potentiation in the medial prefrontal cortex

  2011cited by this paper
• Nose-to-Brain Transport Pathways of Wheat Germ Agglutinin Conjugated PEG-PLA Nanoparticles

  2011cited by this paper
• Oxytocin increases autonomic cardiac control: moderation by loneliness.

  2011cited by this paper
• Cortical representations of olfactory input by trans-synaptic tracing

  2011influential reference
• The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice

  2011cited by this paper
• Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation

  2011cited by this paper
• Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

  2011cited by this paper
• Brain temperature in volunteers subjected to intranasal cooling

  2011cited by this paper
• Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia

  2011cited by this paper
• Selective influences of oxytocin on the evaluative processing of social stimuli

  2011cited by this paper
• Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

  2011cited by this paper
• Maternal Neglect: Oxytocin, Dopamine and the Neurobiology of Attachment

  2011cited by this paper
• Amygdaloid Projections to the Ventral Striatum in Mice: Direct and Indirect Chemosensory Inputs to the Brain Reward System

  2011cited by this paper
• Therapeutic Efficacy of Intranasally Delivered Mesenchymal Stem Cells in a Rat Model of Parkinson Disease

  2011cited by this paper
• Prosocial effects of oxytocin and clinical evidence for its therapeutic potential.

  2011cited by this paper
• Circumventricular organs

  2011influential reference
• A sex comparison of the anatomy and function of the main olfactory bulb-medial amygdala projection in mice.

  2011cited by this paper
• Anatomy and physiology of cerebrospinal fluid.

  2011cited by this paper
• The Accumbofrontal Fasciculus in the Human Brain: A Microsurgical Anatomical Study

  2011cited by this paper
• Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass

  2011cited by this paper
• Sex, drugs and gluttony: how the brain controls motivated behaviors.

  2011cited by this paper
• Data supporting a new physiological role for brain apelin in the regulation of hypothalamic oxytocin neurons in lactating rats.

  2011cited by this paper
• Oxytocin and vasopressin in the medial amygdala differentially modulate approach and avoidance behavior toward illness-related social odor.

  2010cited by this paper
• Intranasal oxytocin increases fathers' observed responsiveness during play with their children: a double-blind within-subject experiment.

  2010influential reference
• The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans.

  2010cited by this paper
• Oxytocin Selectively Improves Empathic Accuracy

  2010cited by this paper
• Performance, Properties and Plasticity of Identified Oxytocin and Vasopressin Neurones In Vitro

  2010cited by this paper
• Marital behavior, oxytocin, vasopressin, and wound healing.

  2010cited by this paper
• Extending the mirror neuron system model, II: what did I just do? A new role for mirror neurons

  2010cited by this paper
• REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

  2010cited by this paper
• Activity-induced manganese-dependent functional MRI of the rat visual cortex following intranasal manganese chloride administration.

  2010cited by this paper
• Where do mirror neurons come from?

  2010cited by this paper
• Mirror neuron dysfunction in autism spectrum disorders.

  2010cited by this paper
• Understanding Actions of Others: The Electrodynamics of the Left and Right Hemispheres. A High-Density EEG Neuroimaging Study

  2010cited by this paper
• The rodent accessory olfactory system

  2010cited by this paper
• Manipulation of the oxytocin system alters social behavior and attraction in pair-bonding primates, Callithrix penicillata.

  2010influential reference
• Olfactory bulb dysgenesis, mirror neuron system dysfunction, and autonomic dysregulation as the neural basis for autism.

  2010influential reference
• The effect of nasal oxytocin on pregnancy rates following intrauterine insemination: double-blind, randomized, clinical pilot study

  2010cited by this paper
• From music making to speaking: engaging the mirror neuron system in autism.

  2010cited by this paper
• Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat.

  2010cited by this paper
• The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations

  2010influential reference
• The discovery of central monoamine neurons gave volume transmission to the wired brain.

  2010cited by this paper
• Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans

  2010cited by this paper

• Oxytocin Experiments Shed Light on Mechanisms Shaping Prosocial and Antisocial Behaviors in Non-human Mammals.

  2017cites this paper
• 1.02 – Female Sexual Behavior in Rodents, Lagomorphs, and Goats

  2017cites this paper
• Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats

  2017cites this paper
• Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities

  2017cites this paper
• Oxytocin improves the ability of dogs to follow informative pointing: a neuroemotional hypothesis

  2017cites this paper
• Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance.

  2017cites this paper
• Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

  2017cites this paper
• Nasal application of HSV encoding human preproenkephalin blocks craniofacial pain in a rat model of traumatic brain injury

  2017cites this paper
• Repository of the Radboud

  2017influential citation
• Oxytocin and Vasopressin Receptor Gene Polymorphisms: Role in Social and Psychiatric Traits

  2016cites this paper
• Emerging Frontiers in Social Neuroendocrinology and the Study of Nonapeptides

  2016cites this paper
• The effects of oxytocin on social behaviour: the influence of context and individual differences

  2016influential citation
• Presence and Absence of Sex Differences in Structure and Function of the Brain Oxytocin System: Implications for Understanding the Regulation of Social Behavior

  2016cites this paper
• Non‐Mammalian Models for Neurohypophysial Peptides

  2016cites this paper
• Sniff and mimic - Intranasal oxytocin increases facial mimicry in a sample of men.

  2016cites this paper
• Intranasal oxytocin administration in relationship to social behaviour in domestic pigs.

  2016cites this paper
• Clinical Evaluation and Treatment of Disorders of Ejaculation

  2016cites this paper
• Effects of intranasal and peripheral oxytocin or gastrin-releasing peptide administration on social interaction and corticosterone levels in rats.

  2016cites this paper
• Oxytocin, Postnatal Depression, and Parenting: A Systematic Review

  2016cites this paper
• Vasopressin Hypersecretion-Associated Brain Edema Formation in Ischemic Stroke: Underlying Mechanisms.

  2016cites this paper
• Oxytocin and cardioprotection in diabetes and obesity

  2016cites this paper
• The Physio-Pharmacological Role of the NPS/NPSR System in Psychiatric Disorders: A Translational Overview.

  2016cites this paper
• Intranasal Oxytocin Selectively Modulates Social Perception, Craving, and Approach Behavior in Subjects With Alcohol Use Disorder

  2016cites this paper
• Seeing things differently: An experimental investigation of social cognition and interpersonal behavior in anorexia nervosa.

  2016cites this paper
• Intranasal oxytocin administration improves depression-like behaviors in adult rats that experienced neonatal maternal deprivation

  2016cites this paper
• Intermittent drinking, oxytocin and human health.

  2016cites this paper
• Effects of positive and negative human contacts and intranasal oxytocin on cerebrospinal fluid oxytocin.

  2016cites this paper
• Oxytocin Protects Hippocampal Memory and Plasticity from Uncontrollable Stress

  2015cites this paper
• Off-label intranasal oxytocin use in adults is associated with increased amygdala-cingulate resting-state connectivity

  2015cites this paper
• Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model.

  2015cites this paper
• Studying the neurobiology of human social interaction: Making the case for ecological validity

  2015cites this paper
• The role of early emotion impairments in the development of persistent antisocial behavior

  2015cites this paper
• Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study

  2015influential citation
• Cooperation and social bonds in common vampire bats

  2015cites this paper
• The effects of Beta-Endorphin: state change modification

  2015influential citation
• Neural targets in the study and treatment of social cognition in autism spectrum disorder.

  2015cites this paper
• Intranasal Delivery to the Central Nervous System

  2015cites this paper
• Does Oxytocin Increase Trust in Humans? A Critical Review of Research

  2015cites this paper
• The role of oxytocin in male and female reproductive behavior.

  2015cites this paper
• Using endophenotypes to examine molecules related to candidate genes as novel therapeutics: The "endophenotype-associated surrogate endpoint (EASE)" concept.

  2015cites this paper
• La oxitocina en el tratamiento de los déficits sociales asociados a los trastornos del espectro autista

  2015cites this paper
• [Oxytocin in the treatment of the social deficits associated to autism spectrum disorders].

  2015cites this paper
• Postnatal depression, oxytocin and maternal sensitivity

  2015cites this paper
• Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity.

  2015cites this paper
• Intranasal oxytocin increases social grooming and food sharing in the common vampire bat Desmodus rotundus.

  2015cites this paper
• Intranasal adminsitration of oxytocin in postnatal depression: implications for psychodynamic psychotherapy from a randomized double-blind pilot study

  2015cites this paper
• Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism.

  2015cites this paper
• The nasal approach to delivering treatment for brain diseases: an anatomic, physiologic, and delivery technology overview.

  2014cites this paper
• UvA-DARE ( Digital Academic Repository ) In brains we trust : How neuroeconomists stylize trust , the brain , and the social world

  2014cites this paper
• Intranasal Administration as a Route for Drug Delivery to the Brain: Evidence for a Unique Pathway for Albumin

  2014cites this paper
• A blueprint for research on Shankopathies: A view from research on autism spectrum disorder

  2014cites this paper
• Oxytocin promotes social bonding in dogs

  2014cites this paper
• Neural mechanisms of sexual behavior in the male rat: emphasis on ejaculation-related circuits.

  2014cites this paper
• Learning about oxytocin: pharmacologic and behavioral issues.

  2014cites this paper
• Ejaculatio praecox, erectio praecox, and detumescentia praecox as symptoms of a hypertonic state in lifelong premature ejaculation: a new hypothesis.

  2014cites this paper
• Oxytocin administration enhances controlled social cognition in patients with schizophrenia.

  2014cites this paper
• Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial

  2014cites this paper
• In brains we trust: How neuroeconomists stylize trust, the brain, and the social world

  2014cites this paper
• First principles of Hamiltonian medicine

  2014cites this paper
• Intranasal oxytocin enhances socially-reinforced learning in rhesus monkeys

  2014cites this paper
• Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review

  2014cites this paper
• Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism.

  2014cites this paper
• Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system.

  2014cites this paper
• A double‐blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome

  2014cites this paper
• Intranasal Oxytocin Administration is Associated With Enhanced Endogenous Pain Inhibition and Reduced Negative Mood States

  2014cites this paper
• Oxytocin treatment in pediatric populations

  2014influential citation
• Functional Activation and Connectivity under the Influence of Oxytocin: An Explorative Study using Functional Magnetic Resonance Imaging

  2014cites this paper
• The influence of Oxytocin on automatic motor simulation.

  2014cites this paper
• Oxytocin improves emotion recognition for older males.

  2014cites this paper
• Development of a new method of intranasal injection of GALP regarding clinical application to obese people

  2013cites this paper
• Tilburg University Polymorphisms of the OXTR Gene to explain why sales professionals love to help customers

  2013influential citation
• Chronic and Acute Intranasal Oxytocin Produce Divergent Social Effects in Mice

  2013cites this paper
• Social brains on drugs: tools for neuromodulation in social neuroscience

  2013cites this paper
• Polymorphisms of the OXTR gene explain why sales professionals love to help customers

  2013influential citation
• Oxytozin

  2013cites this paper